PCD20_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PCD20_HUMAN
• UniProt AC: Q8N6Y1
• Protein Name: Protocadherin-20
• Gene Name: PCDH20
• Organism: Homo sapiens (Human).
• Sequence Length: 951
• Subcellular Localization: Cell membrane; Single-pass type I membrane protein.
• Protein Description: Potential calcium-dependent cell-adhesion protein..
• Protein Sequence: MRGRGNARSSQALGVSWCPATWHPRLDMGRLHRPRSSTSYRNLPHLFLFFLFVGPFSCLGSYSRATELLYSLNEGLPAGVLIGSLAEDLRLLPRSAGRPDPQSQLPERTGAEWNPPLSFSLASRGLSGQYVTLDNRSGELHTSAQEIDREALCVEGGGGTAWSGSVSISSSPSDSCLLLLDVLVLPQEYFRFVKVKIAIRDINDNAPQFPVSQISVWVPENAPVNTRLAIEHPAVDPDVGINGVQTYRLLDYHGMFTLDVEENENGERTPYLIVMGALDRETQDQYVSIIIAEDGGSPPLLGSATLTIGISDINDNCPLFTDSQINVTVYGNATVGTPIAAVQAVDKDLGTNAQITYSYSQKVPQASKDLFHLDENTGVIKLFSKIGGSVLESHKLTILANGPGCIPAVITALVSIIKVIFRPPEIVPRYIANEIDGVVYLKELEPVNTPIAFFTIRDPEGKYKVNCYLDGEGPFRLSPYKPYNNEYLLETTKPMDYELQQFYEVAVVAWNSEGFHVKRVIKVQLLDDNDNAPIFLQPLIELTIEENNSPNAFLTKLYATDADSEERGQVSYFLGPDAPSYFSLDSVTGILTVSTQLDREEKEKYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFINKDFSFFVPENFPGYGEIGVISVTDADAGRNGWVALSVVNQSDIFVIDTGKGMLRAKVSLDREQQSSYTLWVEAVDGGEPALSSTAKITILLLDINDNPPLVLFPQSNMSYLLVLPSTLPGSPVTEVYAVDKDTGMNAVIAYSIIGRRGPRPESFRIDPKTGNITLEEALLQTDYGLHRLLVKVSDHGYPEPLHSTVMVNLFVNDTVSNESYIESLLRKEPEINIEEKEPQISIEPTHRKVESVSCMPTLVALSVISLGSITLVTGMGIYICLRKGEKHPREDENLEVQIPLKGKIDLHMRERKPMDISNI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
66	Phosphorylation	LGSYSRATELLYSLN CCCHHHHHHHHHHHC	32.54	24719451
70	Phosphorylation	SRATELLYSLNEGLP HHHHHHHHHHCCCCC	42.79	24719451
84	Phosphorylation	PAGVLIGSLAEDLRL CHHHEEHHHHHHHCC	20.30	24719451
135	N-linked_Glycosylation	GQYVTLDNRSGELHT CCEEEECCCCCCEEC	11.76	UniProtKB CARBOHYD
326	N-linked_Glycosylation	LFTDSQINVTVYGNA CCCCCCEEEEEECCC	11.29	UniProtKB CARBOHYD
332	N-linked_Glycosylation	INVTVYGNATVGTPI EEEEEECCCCCCCCE	12.52	UniProtKB CARBOHYD
384	Phosphorylation	TGVIKLFSKIGGSVL CCHHEHHHCCCCCHH	13.82	24719451
397	Phosphorylation	VLESHKLTILANGPG HHHHCEEEEEECCCC	39.42	22210691
411	Phosphorylation	GCIPAVITALVSIIK CHHHHHHHHHHHHHH	1.96	22210691
415	Phosphorylation	AVITALVSIIKVIFR HHHHHHHHHHHHHHC	42.43	22210691
455	Phosphorylation	NTPIAFFTIRDPEGK CCCEEEEEEECCCCC	31.10	24719451
463	Phosphorylation	IRDPEGKYKVNCYLD EECCCCCEEEEEEEC	52.41	-
468	Phosphorylation	GKYKVNCYLDGEGPF CCEEEEEEECCCCCC	10.25	-
571	Phosphorylation	SEERGQVSYFLGPDA CCCCCEEEEEECCCC	46.24	27174698
572	Phosphorylation	EERGQVSYFLGPDAP CCCCEEEEEECCCCC	63.67	27174698
580	Phosphorylation	FLGPDAPSYFSLDSV EECCCCCCCCCCCCC	13.39	27174698
581	Phosphorylation	LGPDAPSYFSLDSVT ECCCCCCCCCCCCCC	8.43	27174698
583	Phosphorylation	PDAPSYFSLDSVTGI CCCCCCCCCCCCCEE	22.54	27174698
586	Phosphorylation	PSYFSLDSVTGILTV CCCCCCCCCCEEEEE	34.17	27174698
588	Phosphorylation	YFSLDSVTGILTVST CCCCCCCCEEEEEEE	40.83	27174698
592	Phosphorylation	DSVTGILTVSTQLDR CCCCEEEEEEECCCH	58.30	27174698
594	Phosphorylation	VTGILTVSTQLDREE CCEEEEEEECCCHHH	20.52	27174698
595	Phosphorylation	TGILTVSTQLDREEK CEEEEEEECCCHHHH	4.42	27174698
680	N-linked_Glycosylation	WVALSVVNQSDIFVI EEEEEEECCCCEEEE	20.14	UniProtKB CARBOHYD
748	N-linked_Glycosylation	LVLFPQSNMSYLLVL EEEECCCCCEEEEEE	19.92	UniProtKB CARBOHYD
750	Phosphorylation	LFPQSNMSYLLVLPS EECCCCCEEEEEECC	32.19	-
774	Phosphorylation	VYAVDKDTGMNAVIA EEEEECCCCCCEEEE	40.63	-
794	Phosphorylation	RRGPRPESFRIDPKT CCCCCCCCCEECCCC	3.36	24719451
803	N-linked_Glycosylation	RIDPKTGNITLEEAL EECCCCCCEEHHHHH	41.12	UniProtKB CARBOHYD
844	N-linked_Glycosylation	VMVNLFVNDTVSNES EEEEEEECCCCCCHH	43.06	UniProtKB CARBOHYD
849	N-linked_Glycosylation	FVNDTVSNESYIESL EECCCCCCHHHHHHH	31.66	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PCD20_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PCD20_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PCD20_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CCD51_HUMAN	CCDC51	physical	28514442
ST65G_HUMAN	SUPT7L	physical	28514442
LTBP1_HUMAN	LTBP1	physical	28514442
PCD17_HUMAN	PCDH17	physical	28514442
CBX6_HUMAN	CBX6	physical	28514442
TAF5L_HUMAN	TAF5L	physical	28514442
M3K7_HUMAN	MAP3K7	physical	28514442
CELR3_HUMAN	CELSR3	physical	28514442
TAF9B_HUMAN	TAF9B	physical	28514442
RL23_HUMAN	RPL23	physical	28514442
NMU_HUMAN	NMU	physical	28514442
AGAP1_HUMAN	AGAP1	physical	28514442
Z518A_HUMAN	ZNF518A	physical	28514442
RPP29_HUMAN	POP4	physical	28514442
PTPRD_HUMAN	PTPRD	physical	28514442
TAB1_HUMAN	TAB1	physical	28514442
ATF6A_HUMAN	ATF6	physical	28514442
PCDGB_HUMAN	PCDHGA11	physical	28514442
PCDH7_HUMAN	PCDH7	physical	28514442
DYR2_HUMAN	DHFRL1	physical	28514442
T2FA_HUMAN	GTF2F1	physical	28514442
MAP7_HUMAN	MAP7	physical	28514442
B4GN1_HUMAN	B4GALNT1	physical	28514442
MA7D3_HUMAN	MAP7D3	physical	28514442
E2AK3_HUMAN	EIF2AK3	physical	28514442
CHD8_HUMAN	CHD8	physical	28514442
T132A_HUMAN	TMEM132A	physical	28514442
CELR2_HUMAN	CELSR2	physical	28514442
ERD23_HUMAN	KDELR3	physical	28514442
ITA7_HUMAN	ITGA7	physical	28514442
TPC2A_HUMAN	TRAPPC2	physical	28514442
TPC2B_HUMAN	TRAPPC2	physical	28514442
BCD1_HUMAN	ZNHIT6	physical	28514442
CSTN1_HUMAN	CLSTN1	physical	28514442
TBB3_HUMAN	TUBB3	physical	28514442
ITA6_HUMAN	ITGA6	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.