PCD17_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PCD17_HUMAN
• UniProt AC: O14917
• Protein Name: Protocadherin-17
• Gene Name: PCDH17
• Organism: Homo sapiens (Human).
• Sequence Length: 1159
• Subcellular Localization: Cell membrane; Single-pass type I membrane protein.
• Protein Description: Potential calcium-dependent cell-adhesion protein..
• Protein Sequence: MYLSICCCFLLWAPALTLKNLNYSVPEEQGAGTVIGNIGRDARLQPGLPPAERGGGGRSKSGSYRVLENSAPHLLDVDADSGLLYTKQRIDRESLCRHNAKCQLSLEVFANDKEICMIKVEIQDINDNAPSFSSDQIEMDISENAAPGTRFPLTSAHDPDAGENGLRTYLLTRDDHGLFGLDVKSRGDGTKFPELVIQKALDREQQNHHTLVLTALDGGEPPRSATVQINVKVIDSNDNSPVFEAPSYLVELPENAPLGTVVIDLNATDADEGPNGEVLYSFSSYVPDRVRELFSIDPKTGLIRVKGNLDYEENGMLEIDVQARDLGPNPIPAHCKVTVKLIDRNDNAPSIGFVSVRQGALSEAAPPGTVIALVRVTDRDSGKNGQLQCRVLGGGGTGGGGGLGGPGGSVPFKLEENYDNFYTVVTDRPLDRETQDEYNVTIVARDGGSPPLNSTKSFAIKILDENDNPPRFTKGLYVLQVHENNIPGEYLGSVLAQDPDLGQNGTVSYSILPSHIGDVSIYTYVSVNPTNGAIYALRSFNFEQTKAFEFKVLAKDSGAPAHLESNATVRVTVLDVNDNAPVIVLPTLQNDTAELQVPRNAGLGYLVSTVRALDSDFGESGRLTYEIVDGNDDHLFEIDPSSGEIRTLHPFWEDVTPVVELVVKVTDHGKPTLSAVAKLIIRSVSGSLPEGVPRVNGEQHHWDMSLPLIVTLSTISIILLAAMITIAVKCKRENKEIRTYNCRIAEYSHPQLGGGKGKKKKINKNDIMLVQSEVEERNAMNVMNVVSSPSLATSPMYFDYQTRLPLSSPRSEVMYLKPASNNLTVPQGHAGCHTSFTGQGTNASETPATRMSIIQTDNFPAEPNYMGSRQQFVQSSSTFKDPERASLRDSGHGDSDQADSDQDTNKGSCCDMSVREALKMKTTSTKSQPLEQEPEECVNCTDECRVLGHSDRCWMPQFPAANQAENADYRTNLFVPTVEANVETETYETVNPTGKKTFCTFGKDKREHTILIANVKPYLKAKRALSPLLQEVPSASSSPTKACIEPCTSTKGSLDGCEAKPGALAEASSQYLPTDSQYLSPSKQPRDPPFMASDQMARVFADVHSRASRDSSEMGAVLEQLDHPNRDLGRESVDAEEVVREIDKLLQDCRGNDPVAVRK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22	N-linked_Glycosylation	ALTLKNLNYSVPEEQ HHHHCCCCCCCCHHH	36.11	UniProtKB CARBOHYD
64	Phosphorylation	GRSKSGSYRVLENSA CCCCCCCEEEECCCC	14.31	-
94	Phosphorylation	KQRIDRESLCRHNAK CCCCCHHHHHHCCCC	33.39	24719451
190	Phosphorylation	VKSRGDGTKFPELVI EECCCCCCCCCHHHH	33.96	24719451
224	Phosphorylation	DGGEPPRSATVQINV CCCCCCCCEEEEEEE	33.78	29449344
226	Phosphorylation	GEPPRSATVQINVKV CCCCCCEEEEEEEEE	17.75	29449344
240	Phosphorylation	VIDSNDNSPVFEAPS EECCCCCCCCEECCE	25.88	-
266	N-linked_Glycosylation	GTVVIDLNATDADEG EEEEEECCCCCCCCC	36.73	UniProtKB CARBOHYD
439	N-linked_Glycosylation	RETQDEYNVTIVARD CCCCCCEEEEEEEEC	23.55	UniProtKB CARBOHYD
453	N-linked_Glycosylation	DGGSPPLNSTKSFAI CCCCCCCCCCCEEEE	54.10	UniProtKB CARBOHYD
504	N-linked_Glycosylation	QDPDLGQNGTVSYSI CCCCCCCCCEEEEEE	46.43	UniProtKB CARBOHYD
566	N-linked_Glycosylation	APAHLESNATVRVTV CCCCCCCCCEEEEEE	30.20	UniProtKB CARBOHYD
590	N-linked_Glycosylation	IVLPTLQNDTAELQV EEEECCCCCCCEECC	52.27	UniProtKB CARBOHYD
642	Phosphorylation	LFEIDPSSGEIRTLH EEEECCCCCCEEECC	45.92	-
647	Phosphorylation	PSSGEIRTLHPFWED CCCCCEEECCCCCCC	34.77	-
656	Phosphorylation	HPFWEDVTPVVELVV CCCCCCCCCEEEEEE	23.76	-
672	Phosphorylation	VTDHGKPTLSAVAKL ECCCCCCCHHHHHHH	36.51	-
739	Phosphorylation	RENKEIRTYNCRIAE HCCCCEEEEEEEEEE	25.42	27174698
740	Phosphorylation	ENKEIRTYNCRIAEY CCCCEEEEEEEEEEC	11.47	27174698
747	Phosphorylation	YNCRIAEYSHPQLGG EEEEEEECCCCCCCC	11.85	25884760
800	Phosphorylation	TSPMYFDYQTRLPLS CCCCEECCCCCCCCC	11.24	25884760
807	Phosphorylation	YQTRLPLSSPRSEVM CCCCCCCCCCCCEEE	36.04	17081983
808	Phosphorylation	QTRLPLSSPRSEVMY CCCCCCCCCCCEEEE	31.83	17081983
811	Phosphorylation	LPLSSPRSEVMYLKP CCCCCCCCEEEEEEE	37.62	28842319
865	Phosphorylation	NFPAEPNYMGSRQQF CCCCCCCCCCCHHHH	17.36	-
895	Phosphorylation	RDSGHGDSDQADSDQ CCCCCCCCCCCCCCC	35.89	30576142
900	Phosphorylation	GDSDQADSDQDTNKG CCCCCCCCCCCCCCC	39.94	30576142
977	Phosphorylation	RTNLFVPTVEANVET CCCEEECEEEECEEC	26.19	-
1009	Phosphorylation	GKDKREHTILIANVK CCCCCEEEEEEEECH	16.84	-
1018	Phosphorylation	LIANVKPYLKAKRAL EEEECHHHHHHHHHH	18.34	-
1026	Phosphorylation	LKAKRALSPLLQEVP HHHHHHHHHHHHHCC	16.71	30576142
1034	Phosphorylation	PLLQEVPSASSSPTK HHHHHCCCCCCCCCE	46.06	30576142
1036	Phosphorylation	LQEVPSASSSPTKAC HHHCCCCCCCCCEEE	35.37	30576142
1037	Phosphorylation	QEVPSASSSPTKACI HHCCCCCCCCCEEEE	39.80	30576142
1038	Phosphorylation	EVPSASSSPTKACIE HCCCCCCCCCEEEEE	33.81	30576142
1040	Phosphorylation	PSASSSPTKACIEPC CCCCCCCCEEEEEEC	32.97	30576142
1074	Phosphorylation	ASSQYLPTDSQYLSP HHHCCCCCCCCCCCC	45.76	27732954
1076	Phosphorylation	SQYLPTDSQYLSPSK HCCCCCCCCCCCCCC	24.17	27732954
1078	Phosphorylation	YLPTDSQYLSPSKQP CCCCCCCCCCCCCCC	17.07	27732954
1080	Phosphorylation	PTDSQYLSPSKQPRD CCCCCCCCCCCCCCC	23.38	30576142
1082	Phosphorylation	DSQYLSPSKQPRDPP CCCCCCCCCCCCCCC	40.31	28387310
1111	Phosphorylation	HSRASRDSSEMGAVL HHHHHCCHHHHHHHH	27.39	25159151
1132	Phosphorylation	NRDLGRESVDAEEVV CCCCCCCCCCHHHHH	24.76	28857561

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PCD17_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PCD17_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PCD17_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of PCD17_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.