PCDGB_HUMAN - dbPTM
PCDGB_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PCDGB_HUMAN
UniProt AC Q9Y5H2
Protein Name Protocadherin gamma-A11
Gene Name PCDHGA11
Organism Homo sapiens (Human).
Sequence Length 935
Subcellular Localization Cell membrane
Single-pass type I membrane protein.
Protein Description Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain..
Protein Sequence MANRLQRGDRSRLLLLLCIFLGTLRGFRARQIRYSVPEETEKGSFVGNISKDLGLEPRELAKRGVRIVSRGKTQLFAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGVEVEIIDINDNAPSFQEDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSLQLRGRTDGAKNPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSVYRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTGEVQVRGSLDFEKYRFYEMEIQGQDGGGLFTTTTMLITVVDVNDNAPEITITSSINSILENSPPGTVIALLNVQDQDSGENGQVSCFIPNHLPFKLEKTYGNYYKLITSRVLDRELVQSYNITLTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDPDSKQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGDPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLKASEPGLFAVGEHTGEVRTARALLDRDALKQSLVVAVQDHGQPPLSATVTLTVAVADSIPEVLADLGSLESLANSETSDLSLYLVVAVAAVSCIFLVFVIVLLALRLWRWHKSRLLQASEGGLAGMPTSHFVGVDGVQAFLQTYSHEVSLIADSQKSHLIFPQPNYGDTLISQESCEKSEPLLIAEDSAIILGKCDPTSNQQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
23PhosphorylationLLCIFLGTLRGFRAR
HHHHHHHHHCCHHHH		18.54-
48N-linked_GlycosylationEKGSFVGNISKDLGL
CCCCCCEEHHHCCCC		30.02UniProtKB CARBOHYD
62AcetylationLEPRELAKRGVRIVS
CCHHHHHHCCCEEEE		63.4120167786
69PhosphorylationKRGVRIVSRGKTQLF
HCCCEEEECCCEEEE		32.70-
214PhosphorylationAAHLLLLTALDGGDP
HHHHHHHHHHHCCCC		25.7422817900
224MalonylationDGGDPIRKGAVPIRV
HCCCCCCCCCCCEEE		52.5230639696
255N-linked_GlycosylationYRVSVPENISSGTRV
EEEECCCCCCCCCEE		33.11UniProtKB CARBOHYD
266N-linked_GlycosylationGTRVLMVNATDPDEG
CCEEEEEECCCCCCC		24.13UniProtKB CARBOHYD
407PhosphorylationGNYYKLITSRVLDRE
CCHHHHHHHHHCCHH		22.4024719451
420N-linked_GlycosylationRELVQSYNITLTATD
HHHHHHCCEEEEEEC		26.47UniProtKB CARBOHYD
546N-linked_GlycosylationGDPPLSSNVSLSLFV
CCCCCCCCEEEEEEE		24.83UniProtKB CARBOHYD
629PhosphorylationEHTGEVRTARALLDR
CCCCCHHHHHHHHCH		26.1820068231
728UbiquitinationHKSRLLQASEGGLAG
HHHHHHHHCCCCCCC		14.9832142685
732UbiquitinationLLQASEGGLAGMPTS
HHHHCCCCCCCCCCH		14.3332142685
741UbiquitinationAGMPTSHFVGVDGVQ
CCCCCHHCCCCCHHH		5.2532142685
754PhosphorylationVQAFLQTYSHEVSLI
HHHHHHHHCCEEEEE		8.6225884760
782PhosphorylationNYGDTLISQESCEKS
CCCCCEECHHHHCCC		30.8929514088
785PhosphorylationDTLISQESCEKSEPL
CCEECHHHHCCCCCE		21.6829514088
822PhosphorylationPNTDWRFSQAQRPGT
CCCCCCCCCCCCCCC		18.9425003641
882PhosphorylationTMGLSARYGPQFTLQ
CCCCCCCCCCCEEEE		32.6425884760
887PhosphorylationARYGPQFTLQHVPDY
CCCCCCEEEEECCCC		21.9124961811
894PhosphorylationTLQHVPDYRQNVYIP
EEEECCCCCCCEEEC		14.1824927040
899PhosphorylationPDYRQNVYIPGSNAT
CCCCCCEEECCCCCE		14.6725884760
903PhosphorylationQNVYIPGSNATLTNA
CCEEECCCCCEECCC		20.2424719451
906PhosphorylationYIPGSNATLTNAAGK
EECCCCCEECCCCCC		38.0627050516
913UbiquitinationTLTNAAGKRDGKAPA
EECCCCCCCCCCCCC		42.4632142685
917UbiquitinationAAGKRDGKAPAGGNG
CCCCCCCCCCCCCCC		56.3332142685
926UbiquitinationPAGGNGNKKKSGKKE
CCCCCCCCCCCCCCC		64.0832142685
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PCDGB_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PCDGB_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PCDGB_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of PCDGB_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PCDGB_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
Anal. Sci. 24:161-166(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-214, AND MASSSPECTROMETRY.

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