T132A_HUMAN - dbPTM
T132A_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID T132A_HUMAN
UniProt AC Q24JP5
Protein Name Transmembrane protein 132A
Gene Name TMEM132A
Organism Homo sapiens (Human).
Sequence Length 1023
Subcellular Localization Golgi apparatus membrane
Single-pass type I membrane protein. Endoplasmic reticulum membrane
Single-pass type I membrane protein.
Protein Description May play a role in embryonic and postnatal development of the brain. Increased resistance to cell death induced by serum starvation in cultured cells. Regulates cAMP-induced GFAP gene expression via STAT3 phosphorylation (By similarity)..
Protein Sequence MCARMAGRTTAAPRGPYGPWLCLLVALALDVVRVDCGQAPLDPVYLPAALELLDAPEHFRVQQVGHYPPANSSLSSRSETFLLLQPWPRAQPLLRASYPPFATQQVVPPRVTEPHQRPVPWDVRAVSVEAAVTPAEPYARVLFHLKGQDWPPGSGSLPCARLHATHPAGTAHQACRFQPSLGACVVELELPSHWFSQASTTRAELAYTLEPAAEGPGGCGSGEENDPGEQALPVGGVELRPADPPQYQEVPLDEAVTLRVPDMPVRPGQLFSATLLLRHNFTASLLTLRIKVKKGLHVTAARPAQPTLWTAKLDRFKGSRHHTTLITCHRAGLTEPDSSPLELSEFLWVDFVVENSTGGGVAVTRPVTWQLEYPGQAPEAEKDKMVWEILVSERDIRALIPLAKAEELVNTAPLTGVPQHVPVRLVTVDGGGALVEVTEHVGCESANTQVLQVSEACDAVFVAGKESRGARGVRVDFWWRRLRASLRLTVWAPLLPLRIELTDTTLEQVRGWRVPGPAEGPAEPAAEASDEAERRARGCHLQYQRAGVRFLAPFAAHPLDGGRRLTHLLGPDWLLDVSHLVAPHARVLDSRVASLEGGRVVVGREPGVTSIEVRSPLSDSILGEQALAVTDDKVSVLELRVQPVMGISLTLSRGTAHPGEVTATCWAQSALPAPKQEVALSLWLSFSDHTVAPAELYDRRDLGLSVSAEEPGAILPAEEQGAQLGVVVSGAGAEGLPLHVALHPPEPCRRGRHRVPLASGTAWLGLPPASTPAPALPSSPAWSPPATEATMGGKRQVAGSVGGNTGVRGKFERAEEEARKEETEAREEEEEEEEEMVPAPQHVTELELGMYALLGVFCVAIFIFLVNGVVFVLRYQRKEPPDSATDPTSPQPHNWVWLGTDQEELSRQLDRQSPGPPKGEGSCPCESGGGGEAPTLAPGPPGGTTSSSSTLARKEAGGRRKRVEFVTFAPAPPAQSPEEPVGAPAVQSILVAGEEDIRWVCEDMGLKDPEELRNYMERIRGSS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
8MethylationMCARMAGRTTAAPRG
CCCCCCCCCCCCCCC		21.2630761387
76PhosphorylationPANSSLSSRSETFLL
CCCCCCCCCCCEEEE		45.15-
280N-linked_GlycosylationATLLLRHNFTASLLT
EEEHHHCCCCEEEEE		29.54UniProtKB CARBOHYD
384 (in isoform 4)Ubiquitination-46.5521906983
485PhosphorylationWWRRLRASLRLTVWA
HHHHHHHHCCEEEEC		13.9523532336
529PhosphorylationAEPAAEASDEAERRA
CCCCHHCCHHHHHHH		27.7329255136
530PhosphorylationEPAAEASDEAERRAR
CCCHHCCHHHHHHHC		67.2024719451
594PhosphorylationVLDSRVASLEGGRVV
HHHHCEEECCCCEEE		24.8926091039
633 (in isoform 1)Ubiquitination-38.9421906983
633UbiquitinationALAVTDDKVSVLELR
EEEECCCCEEEEEEE		38.942190698
634 (in isoform 2)Ubiquitination-6.5221906983
648PhosphorylationVQPVMGISLTLSRGT
EEEEEEEEEEEECCC		15.0130177828
650PhosphorylationPVMGISLTLSRGTAH
EEEEEEEEEECCCCC		18.8524719451
652PhosphorylationMGISLTLSRGTAHPG
EEEEEEEECCCCCCC		24.3530177828
669PhosphorylationTATCWAQSALPAPKQ
EEEEEECCCCCCCHH		24.83-
681PhosphorylationPKQEVALSLWLSFSD
CHHHHHHHHHHHCCC		14.0424043423
685PhosphorylationVALSLWLSFSDHTVA
HHHHHHHHCCCCCCC		15.8924043423
687PhosphorylationLSLWLSFSDHTVAPA
HHHHHHCCCCCCCCH		25.7124043423
690PhosphorylationWLSFSDHTVAPAELY
HHHCCCCCCCCHHHC		24.2924043423
697PhosphorylationTVAPAELYDRRDLGL
CCCCHHHCCCCCCCC		10.0224043423
770O-linked_GlycosylationWLGLPPASTPAPALP
ECCCCCCCCCCCCCC		40.47OGP
800O-linked_GlycosylationGKRQVAGSVGGNTGV
CEEEEECCCCCCCCC		14.0955827041
800PhosphorylationGKRQVAGSVGGNTGV
CEEEEECCCCCCCCC		14.0922210691
805O-linked_GlycosylationAGSVGGNTGVRGKFE
ECCCCCCCCCCCHHH		40.0955827045
878UbiquitinationFVLRYQRKEPPDSAT
HHHCCCCCCCCCCCC		60.0729901268
879UbiquitinationVLRYQRKEPPDSATD
HHCCCCCCCCCCCCC		65.3429901268
913PhosphorylationSRQLDRQSPGPPKGE
HHHHHHCCCCCCCCC		32.4925849741
914PhosphorylationRQLDRQSPGPPKGEG
HHHHHCCCCCCCCCC		51.4727251275
922PhosphorylationGPPKGEGSCPCESGG
CCCCCCCCCCCCCCC		15.5825022875
927PhosphorylationEGSCPCESGGGGEAP
CCCCCCCCCCCCCCC		49.8330576142
935PhosphorylationGGGGEAPTLAPGPPG
CCCCCCCCCCCCCCC		42.4725022875
944PhosphorylationAPGPPGGTTSSSSTL
CCCCCCCCCCCCHHH		29.4430576142
945PhosphorylationPGPPGGTTSSSSTLA
CCCCCCCCCCCHHHH		29.8628348404
946PhosphorylationGPPGGTTSSSSTLAR
CCCCCCCCCCHHHHC		28.2328348404
947PhosphorylationPPGGTTSSSSTLARK
CCCCCCCCCHHHHCH		26.6430576142
948PhosphorylationPGGTTSSSSTLARKE
CCCCCCCCHHHHCHH		27.4023312004
949PhosphorylationGGTTSSSSTLARKEA
CCCCCCCHHHHCHHH		29.4130576142
950PhosphorylationGTTSSSSTLARKEAG
CCCCCCHHHHCHHHC		26.7825022875
967PhosphorylationRKRVEFVTFAPAPPA
EEEEEEEEEECCCCC		21.2828102081
976PhosphorylationAPAPPAQSPEEPVGA
ECCCCCCCCCCCCCC		36.0628348404
977PhosphorylationPAPPAQSPEEPVGAP
CCCCCCCCCCCCCCC		37.5832142685
988PhosphorylationVGAPAVQSILVAGEE
CCCCCHHEEEECCHH		15.9928102081
1007UbiquitinationVCEDMGLKDPEELRN
HHHHCCCCCHHHHHH		66.5632142685
1008UbiquitinationCEDMGLKDPEELRNY
HHHCCCCCHHHHHHH		61.9732142685
1015PhosphorylationDPEELRNYMERIRGS
CHHHHHHHHHHHHCC		8.2325159151
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
529SPhosphorylationKinaseFAM20CQ8IXL6
Uniprot
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of T132A_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of T132A_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GRP78_HUMANHSPA5physical
12514190
CX6B1_HUMANCOX6B1physical
26496610
ACBP_HUMANDBIphysical
26496610
FYN_HUMANFYNphysical
26496610
GOGA2_HUMANGOLGA2physical
26496610
NDST1_HUMANNDST1physical
26496610
LIMS1_HUMANLIMS1physical
26496610
MYH6_HUMANMYH6physical
26496610
NPTX1_HUMANNPTX1physical
26496610
AAAT_HUMANSLC1A5physical
26496610
STX3_HUMANSTX3physical
26496610
ICAM5_HUMANICAM5physical
26496610
SEC62_HUMANSEC62physical
26496610
NCOA3_HUMANNCOA3physical
26496610
FZD6_HUMANFZD6physical
26496610
PAPS1_HUMANPAPSS1physical
26496610
MFHA1_HUMANMFHAS1physical
26496610
GOGA5_HUMANGOLGA5physical
26496610
UBP15_HUMANUSP15physical
26496610
RAD50_HUMANRAD50physical
26496610
SMYD5_HUMANSMYD5physical
26496610
NEST_HUMANNESphysical
26496610
WWP2_HUMANWWP2physical
26496610
TARA_HUMANTRIOBPphysical
26496610
WDFY3_HUMANWDFY3physical
26496610
ATG2A_HUMANATG2Aphysical
26496610
ECM29_HUMANKIAA0368physical
26496610
AR6P4_HUMANARL6IP4physical
26496610
GNB1L_HUMANGNB1Lphysical
26496610
LTOR1_HUMANLAMTOR1physical
26496610
ARGL1_HUMANARGLU1physical
26496610
CEP55_HUMANCEP55physical
26496610
ENOPH_HUMANENOPH1physical
26496610
GCC1_HUMANGCC1physical
26496610
KLF16_HUMANKLF16physical
26496610
MITD1_HUMANMITD1physical
26496610
SCLT1_HUMANSCLT1physical
26496610
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of T132A_HUMAN

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory