MITD1_HUMAN - dbPTM
MITD1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MITD1_HUMAN
UniProt AC Q8WV92
Protein Name MIT domain-containing protein 1
Gene Name MITD1
Organism Homo sapiens (Human).
Sequence Length 249
Subcellular Localization Late endosome membrane
Peripheral membrane protein
Cytoplasmic side. Midbody. Membrane
Peripheral membrane protein
Cytoplasmic side. During cytokinesis, recruited to the midbody via interaction with CHMP1A. Interacts with membranes enriched in ph
Protein Description Required for efficient abscission at the end of cytokinesis, together with components of the ESCRT-III complex..
Protein Sequence MAKSGLRQDPQSTAAATVLKRAVELDSESRYPQALVCYQEGIDLLLQVLKGTKDNTKRCNLREKISKYMDRAENIKKYLDQEKEDGKYHKQIKIEENATGFSYESLFREYLNETVTEVWIEDPYIRHTHQLYNFLRFCEMLIKRPCKVKTIHLLTSLDEGIEQVQQSRGLQEIEESLRSHGVLLEVQYSSSIHDREIRFNNGWMIKIGRGLDYFKKPQSRFSLGYCDFDLRPCHETTVDIFHKKHTKNI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MAKSGLRQDPQ
----CCCCCCCCCHH
33.2629759185
12PhosphorylationGLRQDPQSTAAATVL
CCCCCHHHHHHHHHH
25.9628787133
13PhosphorylationLRQDPQSTAAATVLK
CCCCHHHHHHHHHHH
18.3128787133
17PhosphorylationPQSTAAATVLKRAVE
HHHHHHHHHHHHHHH
22.9628787133
20UbiquitinationTAAATVLKRAVELDS
HHHHHHHHHHHHCCC
33.6929967540
38PhosphorylationYPQALVCYQEGIDLL
CCCEEHHHHHHHHHH
11.3418452278
67UbiquitinationNLREKISKYMDRAEN
CHHHHHHHHHHHHHH
48.33-
68PhosphorylationLREKISKYMDRAENI
HHHHHHHHHHHHHHH
9.4718452278
78PhosphorylationRAENIKKYLDQEKED
HHHHHHHHHHHHHCC
15.5426074081
87UbiquitinationDQEKEDGKYHKQIKI
HHHHCCCCEEEEEEC
57.41-
88PhosphorylationQEKEDGKYHKQIKIE
HHHCCCCEEEEEECE
21.5629496907
128PhosphorylationEDPYIRHTHQLYNFL
CCCCCCHHHHHHHHH
11.0629396449
132PhosphorylationIRHTHQLYNFLRFCE
CCHHHHHHHHHHHHH
9.4129396449

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MITD1_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MITD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MITD1_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of MITD1_HUMAN !!

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MITD1_HUMAN

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Related Literatures of Post-Translational Modification

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