NPTX1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NPTX1_HUMAN
• UniProt AC: Q15818
• Protein Name: Neuronal pentraxin-1
• Gene Name: NPTX1
• Organism: Homo sapiens (Human).
• Sequence Length: 432
• Subcellular Localization: Cytoplasmic vesicle, secretory vesicle .
• Protein Description: May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses..
• Protein Sequence: MPAGRAARTCALLALCLLGAGAQDFGPTRFICTSVPVDADMCAASVAAGGAEELRSSVLQLRETVLQQKETILSQKETIRELTAKLGRCESQSTLDPGAGEARAGGGRKQPGSGKNTMGDLSRTPAAETLSQLGQTLQSLKTRLENLEQYSRLNSSSQTNSLKDLLQSKIDELERQVLSRVNTLEEGKGGPRNDTEERVKIETALTSLHQRISELEKGQKDNRPGDKFQLTFPLRTNYMYAKVKKSLPEMYAFTVCMWLKSSATPGVGTPFSYAVPGQANELVLIEWGNNPMEILINDKVAKLPFVINDGKWHHICVTWTTRDGVWEAYQDGTQGGSGENLAPYHPIKPQGVLVLGQEQDTLGGGFDATQAFVGELAHFNIWDRKLTPGEVYNLATCSTKALSGNVIAWAESHIEIYGGATKWTFEACRQIN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	PAGRAARTCALLALC CCHHHHHHHHHHHHH	9.45	20068231
28	Phosphorylation	GAQDFGPTRFICTSV CCCCCCCCCEEEECC	38.29	20068231
56	Phosphorylation	GGAEELRSSVLQLRE CCHHHHHHHHHHHHH	37.11	26074081
57	Phosphorylation	GAEELRSSVLQLRET CHHHHHHHHHHHHHH	22.03	26074081
64	Phosphorylation	SVLQLRETVLQQKET HHHHHHHHHHHHHHH	21.78	26074081
69	Ubiquitination	RETVLQQKETILSQK HHHHHHHHHHHHCCH	43.81	29967540
76	Ubiquitination	KETILSQKETIRELT HHHHHCCHHHHHHHH	54.15	29967540
85	Ubiquitination	TIRELTAKLGRCESQ HHHHHHHHHCCCCCC	46.36	29967540
115	Ubiquitination	RKQPGSGKNTMGDLS CCCCCCCCCCCCCHH	51.44	29967540
122	Phosphorylation	KNTMGDLSRTPAAET CCCCCCHHCCHHHHH	38.56	18707149
131	Phosphorylation	TPAAETLSQLGQTLQ CHHHHHHHHHHHHHH	30.68	24076635
141	Ubiquitination	GQTLQSLKTRLENLE HHHHHHHHHHHHHHH	36.52	21963094
151	Phosphorylation	LENLEQYSRLNSSSQ HHHHHHHHHCCCCHH	29.95	-
154	N-linked_Glycosylation	LEQYSRLNSSSQTNS HHHHHHCCCCHHCHH	38.44	UniProtKB CARBOHYD
154	N-linked_Glycosylation	LEQYSRLNSSSQTNS HHHHHHCCCCHHCHH	38.44	20068230
156	Phosphorylation	QYSRLNSSSQTNSLK HHHHCCCCHHCHHHH	25.95	27174698
157	Phosphorylation	YSRLNSSSQTNSLKD HHHCCCCHHCHHHHH	40.62	27174698
159	Phosphorylation	RLNSSSQTNSLKDLL HCCCCHHCHHHHHHH	28.82	27174698
161	Phosphorylation	NSSSQTNSLKDLLQS CCCHHCHHHHHHHHH	39.94	27174698
169	Ubiquitination	LKDLLQSKIDELERQ HHHHHHHHHHHHHHH	41.01	29967540
188	Ubiquitination	VNTLEEGKGGPRNDT HHCCCCCCCCCCCCH	65.06	29967540
193	N-linked_Glycosylation	EGKGGPRNDTEERVK CCCCCCCCCHHHHHH	64.78	UniProtKB CARBOHYD
200	Ubiquitination	NDTEERVKIETALTS CCHHHHHHHHHHHHH	40.83	21963094
217	Ubiquitination	QRISELEKGQKDNRP HHHHHHHCCCCCCCC	78.31	29967540
227	Ubiquitination	KDNRPGDKFQLTFPL CCCCCCCCEEEEEEE	40.71	29967540
261	Phosphorylation	TVCMWLKSSATPGVG HHHHHHHHCCCCCCC	24.04	29978859
262	Phosphorylation	VCMWLKSSATPGVGT HHHHHHHCCCCCCCC	34.28	29978859
264	Phosphorylation	MWLKSSATPGVGTPF HHHHHCCCCCCCCCC	23.64	29978859
269	Phosphorylation	SATPGVGTPFSYAVP CCCCCCCCCCCEECC	20.82	29978859
272	Phosphorylation	PGVGTPFSYAVPGQA CCCCCCCCEECCCCC	17.24	29978859
273	Phosphorylation	GVGTPFSYAVPGQAN CCCCCCCEECCCCCC	16.40	29978859
302	Ubiquitination	LINDKVAKLPFVIND EECCCCCCCCEEEEC	60.73	29967540
344	Phosphorylation	SGENLAPYHPIKPQG CCCCCCCCCCCCCCE	18.02	22817900
385	Ubiquitination	HFNIWDRKLTPGEVY CCEECCCCCCCCCEE	54.99	21963094

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NPTX1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NPTX1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NPTX1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
OPA1_HUMAN	OPA1	physical	22939629
TCOF_HUMAN	TCOF1	physical	22939629

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.