SMYD5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SMYD5_HUMAN
• UniProt AC: Q6GMV2
• Protein Name: SET and MYND domain-containing protein 5
• Gene Name: SMYD5
• Organism: Homo sapiens (Human).
• Sequence Length: 418
• Protein Sequence: MAASMCDVFSFCVGVAGRARVSVEVRFVSSAKGKGLFATQLIRKGETIFVERPLVAAQFLWNALYRYRACDHCLRALEKAEENAQRLTGKPGQVLPHPELCTVRKDLHQNCPHCQVMYCSAECRLAATEQYHQVLCPGPSQDDPLHPLNKLQEAWRSIHYPPETASIMLMARMVATVKQAKDKDRWIRLFSQFCNKTANEEEEIVHKLLGDKFKGQLELLRRLFTEALYEEAVSQWFTPDGFRSLFALVGTNGQGIGTSSLSQWVHACDTLELKPQDREQLDAFIDQLYKDIEAATGEFLNCEGSGLFVLQSCCNHSCVPNAETSFPENNFLLHVTALEDIKPGEEICISYLDCCQRERSRHSRHKILRENYLFVCSCPKCLAEADEPNVTSEEEEEEEEEEEGEPEDAELGDEMTDV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MAASMCDVFSF ----CCHHHHHHHHH	15.48	24043423
10	Phosphorylation	ASMCDVFSFCVGVAG HHHHHHHHHHHHHCC	19.99	24043423
22	Phosphorylation	VAGRARVSVEVRFVS HCCCCEEEEEEEEEE	13.65	24719451
39	Phosphorylation	KGKGLFATQLIRKGE CCCCCEEEEHHHCCC	19.30	-
90	Ubiquitination	NAQRLTGKPGQVLPH HHHHHCCCCCCCCCC	40.51	29967540
105	Ubiquitination	PELCTVRKDLHQNCP HHHEECCHHHHHCCC	61.37	-
126	Ubiquitination	CSAECRLAATEQYHQ ECHHHHHHHCHHHCE	7.93	24816145
150	Ubiquitination	DPLHPLNKLQEAWRS CCCCHHHHHHHHHHH	60.26	-
155	Ubiquitination	LNKLQEAWRSIHYPP HHHHHHHHHHCCCCH	8.19	22817900
157	Phosphorylation	KLQEAWRSIHYPPET HHHHHHHHCCCCHHH	11.74	21406692
160	Ubiquitination	EAWRSIHYPPETASI HHHHHCCCCHHHHHH	20.86	22817900
160	Phosphorylation	EAWRSIHYPPETASI HHHHHCCCCHHHHHH	20.86	21406692
164	Phosphorylation	SIHYPPETASIMLMA HCCCCHHHHHHHHHH	31.32	21406692
166	Phosphorylation	HYPPETASIMLMARM CCCHHHHHHHHHHHH	18.89	21406692
176	Phosphorylation	LMARMVATVKQAKDK HHHHHHHHHHHHCCH	19.47	21406692
178	Ubiquitination	ARMVATVKQAKDKDR HHHHHHHHHHCCHHH	39.94	24816145
190	Ubiquitination	KDRWIRLFSQFCNKT HHHHHHHHHHHHCCC	3.76	24816145
196	Ubiquitination	LFSQFCNKTANEEEE HHHHHHCCCCCCHHH	50.63	-
196	Acetylation	LFSQFCNKTANEEEE HHHHHHCCCCCCHHH	50.63	25953088
207	Ubiquitination	EEEEIVHKLLGDKFK CHHHHHHHHHCHHHH	34.22	21906983
212	Ubiquitination	VHKLLGDKFKGQLEL HHHHHCHHHHHHHHH	47.37	22817900
212	2-Hydroxyisobutyrylation	VHKLLGDKFKGQLEL HHHHHCHHHHHHHHH	47.37	-
212	Acetylation	VHKLLGDKFKGQLEL HHHHHCHHHHHHHHH	47.37	25953088
214	Acetylation	KLLGDKFKGQLELLR HHHCHHHHHHHHHHH	52.03	25953088
219	Ubiquitination	KFKGQLELLRRLFTE HHHHHHHHHHHHHHH	6.48	22817900
224	Ubiquitination	LELLRRLFTEALYEE HHHHHHHHHHHHHHH	5.71	22817900
391	Phosphorylation	EADEPNVTSEEEEEE CCCCCCCCCHHHHHH	36.74	25954137
392	Phosphorylation	ADEPNVTSEEEEEEE CCCCCCCCHHHHHHH	38.43	25954137

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SMYD5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SMYD5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SMYD5_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of SMYD5_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.