ENOPH_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ENOPH_HUMAN
• UniProt AC: Q9UHY7
• Protein Name: Enolase-phosphatase E1 {ECO:0000255|HAMAP-Rule:MF_03117}
• Gene Name: ENOPH1 {ECO:0000255|HAMAP-Rule:MF_03117}
• Organism: Homo sapiens (Human).
• Sequence Length: 261
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene)..
• Protein Sequence: MVVLSVPAEVTVILLDIEGTTTPIAFVKDILFPYIEENVKEYLQTHWEEEECQQDVSLLRKQAEEDAHLDGAVPIPAASGNGVDDLQQMIQAVVDNVCWQMSLDRKTTALKQLQGHMWRAAFTAGRMKAEFFADVVPAVRKWREAGMKVYIYSSGSVEAQKLLFGHSTEGDILELVDGHFDTKIGHKVESESYRKIADSIGCSTNNILFLTDVTREASAAEEADVHVAVVVRPGNAGLTDDEKTYYSLITSFSELYLPSST

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
111	Ubiquitination	DRKTTALKQLQGHMW CHHHHHHHHHHHHHH	46.64	-
111	Malonylation	DRKTTALKQLQGHMW CHHHHHHHHHHHHHH	46.64	26320211
111	Acetylation	DRKTTALKQLQGHMW CHHHHHHHHHHHHHH	46.64	25953088
153	Phosphorylation	GMKVYIYSSGSVEAQ CCEEEEEECCCHHHH	20.75	27251275
154	Phosphorylation	MKVYIYSSGSVEAQK CEEEEEECCCHHHHH	20.37	25627689
183	Ubiquitination	VDGHFDTKIGHKVES HCCCCCCCCCCCCCC	48.84	-
187	Ubiquitination	FDTKIGHKVESESYR CCCCCCCCCCCHHHH	42.35	-
195	Ubiquitination	VESESYRKIADSIGC CCCHHHHHHHHHHCC	33.73	-
199	Phosphorylation	SYRKIADSIGCSTNN HHHHHHHHHCCCCCC	16.32	21406692
203	Phosphorylation	IADSIGCSTNNILFL HHHHHCCCCCCEEEE	29.02	21406692
204	Phosphorylation	ADSIGCSTNNILFLT HHHHCCCCCCEEEEE	36.04	21406692
211	Phosphorylation	TNNILFLTDVTREAS CCCEEEEEEHHCCCH	22.53	21406692
214	Phosphorylation	ILFLTDVTREASAAE EEEEEEHHCCCHHHH	26.12	21406692
251	Phosphorylation	TYYSLITSFSELYLP HHHHHHHHHHHHCCC	21.56	27251275
253	Phosphorylation	YSLITSFSELYLPSS HHHHHHHHHHCCCCC	26.85	27251275
256	Phosphorylation	ITSFSELYLPSST-- HHHHHHHCCCCCC--	16.71	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ENOPH_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ENOPH_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ENOPH_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CBS_HUMAN	CBS	physical	26344197
HDHD1_HUMAN	HDHD1	physical	26344197
IMDH2_HUMAN	IMPDH2	physical	26344197
MANF_HUMAN	MANF	physical	26344197
PRDX6_HUMAN	PRDX6	physical	26344197
SNX2_HUMAN	SNX2	physical	26344197
RNF41_HUMAN	RNF41	physical	28514442
CARD9_HUMAN	CARD9	physical	28514442
THEM4_HUMAN	THEM4	physical	28514442
VPS52_HUMAN	VPS52	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.