THEM4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: THEM4_HUMAN
• UniProt AC: Q5T1C6
• Protein Name: Acyl-coenzyme A thioesterase THEM4
• Gene Name: THEM4
• Organism: Homo sapiens (Human).
• Sequence Length: 240
• Subcellular Localization: Cell membrane . Cell projection, ruffle membrane . Cytoplasm . Mitochondrion . Mitochondrion inner membrane; Peripheral membrane protein . Mitochondrion intermembrane space . Released from the mitochondria into the cytosol in response to apoptotic st
• Protein Description: Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays an role in mitochondrial fatty acid metabolism. Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity. According to PubMed:11598301, inhibits AKT1 phosphorylation and activity. According to PubMed:17615157, enhances AKT1 activity by favoring its phosphorylation and translocation to plasma membrane..
• Protein Sequence: MLRSCAARLRTLGALCLPPVGRRLPGSEPRPELRSFSSEEVILKDCSVPNPSWNKDLRLLFDQFMKKCEDGSWKRLPSYKRTPTEWIQDFKTHFLDPKLMKEEQMSQAQLFTRSFDDGLGFEYVMFYNDIEKRMVCLFQGGPYLEGPPGFIHGGAIATMIDATVGMCAMMAGGIVMTANLNINYKRPIPLCSVVMINSQLDKVEGRKFFVSCNVQSVDEKTLYSEATSLFIKLNPAKSLT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
37	Phosphorylation	RPELRSFSSEEVILK CHHHHCCCCCEEEEE	37.78	22817900
38	Phosphorylation	PELRSFSSEEVILKD HHHHCCCCCEEEEEC	35.45	22817900
55	Succinylation	VPNPSWNKDLRLLFD CCCCCCCHHHHHHHH	52.46	-
55	Succinylation	VPNPSWNKDLRLLFD CCCCCCCHHHHHHHH	52.46	-
66	Succinylation	LLFDQFMKKCEDGSW HHHHHHHHHCCCCCC	56.41	-
66	Succinylation	LLFDQFMKKCEDGSW HHHHHHHHHCCCCCC	56.41	-
74	Acetylation	KCEDGSWKRLPSYKR HCCCCCCCCCCCCCC	45.84	-
74	Ubiquitination	KCEDGSWKRLPSYKR HCCCCCCCCCCCCCC	45.84	-
80	Ubiquitination	WKRLPSYKRTPTEWI CCCCCCCCCCCCHHH	54.88	-
98	Succinylation	KTHFLDPKLMKEEQM HHHCCCHHHCCHHHH	61.96	-
98	Succinylation	KTHFLDPKLMKEEQM HHHCCCHHHCCHHHH	61.96	-
192	Phosphorylation	KRPIPLCSVVMINSQ CCCCCEEEEEEECCC	25.98	20068231
198	Phosphorylation	CSVVMINSQLDKVEG EEEEEECCCEEECCC	22.61	20068231
207	Malonylation	LDKVEGRKFFVSCNV EEECCCCEEEEEEEC	54.75	26320211
207	Succinylation	LDKVEGRKFFVSCNV EEECCCCEEEEEEEC	54.75	-
207	Succinylation	LDKVEGRKFFVSCNV EEECCCCEEEEEEEC	54.75	-
221	Phosphorylation	VQSVDEKTLYSEATS CCCCCCCCCCCCHHH	28.96	20068231
223	Phosphorylation	SVDEKTLYSEATSLF CCCCCCCCCCHHHHH	15.08	20068231
224	Phosphorylation	VDEKTLYSEATSLFI CCCCCCCCCHHHHHH	24.70	20068231
227	Phosphorylation	KTLYSEATSLFIKLN CCCCCCHHHHHHHCC	23.16	20068231
228	Phosphorylation	TLYSEATSLFIKLNP CCCCCHHHHHHHCCC	28.47	20068231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of THEM4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of THEM4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of THEM4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AKT1_HUMAN	AKT1	physical	11598301
ALAT2_HUMAN	GPT2	physical	28514442
GSTT2_HUMAN	GSTT2	physical	28514442
DPS1_HUMAN	PDSS1	physical	28514442
HEM1_HUMAN	ALAS1	physical	28514442
DLP1_HUMAN	PDSS2	physical	28514442
ODB2_HUMAN	DBT	physical	28514442
FOLC_HUMAN	FPGS	physical	28514442
SIR5_HUMAN	SIRT5	physical	28514442
MRRP3_HUMAN	KIAA0391	physical	28514442
CARD9_HUMAN	CARD9	physical	28514442
KLC2_HUMAN	KLC2	physical	28514442
TOP3A_HUMAN	TOP3A	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.