ALAT2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ALAT2_HUMAN
• UniProt AC: Q8TD30
• Protein Name: Alanine aminotransferase 2
• Gene Name: GPT2
• Organism: Homo sapiens (Human).
• Sequence Length: 523
• Protein Description: Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate..
• Protein Sequence: MQRAAALVRRGCGPRTPSSWGRSQSSAAAEASAVLKVRPERSRRERILTLESMNPQVKAVEYAVRGPIVLKAGEIELELQRGIKKPFTEVIRANIGDAQAMGQQPITFLRQVMALCTYPNLLDSPSFPEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDLFNQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGICVVPGSGFGQREGTYHFRMTILPPVEKLKTVLQKVKDFHINFLEKYA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Phosphorylation	TPSSWGRSQSSAAAE CCCCCCCCCHHHHHH	30.40	28348404
25	Phosphorylation	SSWGRSQSSAAAEAS CCCCCCCHHHHHHHH	24.16	23911959
26	Phosphorylation	SWGRSQSSAAAEASA CCCCCCHHHHHHHHH	17.81	28348404
62	Phosphorylation	PQVKAVEYAVRGPIV HHHHHHHHEECCCEE	12.09	22817900
65	Methylation	KAVEYAVRGPIVLKA HHHHHEECCCEEEEC	36.68	-
88	Phosphorylation	RGIKKPFTEVIRANI CCCCCCHHHHHHHHC	37.56	21406692
205	Phosphorylation	LVSGGGKSRTGVMIP HHCCCCCCCCEEEEE	38.05	23684312
339	Phosphorylation	ELASFHSTSKGYMGE EEEEEECCCCCCCCC	26.36	20068231
340	Phosphorylation	LASFHSTSKGYMGEC EEEEECCCCCCCCCC	27.39	20068231
341	N6-(pyridoxal phosphate)lysine	ASFHSTSKGYMGECG EEEECCCCCCCCCCC	54.90	-
341	Other	ASFHSTSKGYMGECG EEEECCCCCCCCCCC	54.90	-
406	Ubiquitination	FEQFSREKESVLGNL HHHHHHHHHHHHHHH	54.93	-
415	Malonylation	SVLGNLAKKAKLTED HHHHHHHHHHHCCHH	57.33	26320211
415	Acetylation	SVLGNLAKKAKLTED HHHHHHHHHHHCCHH	57.33	-
415	Succinylation	SVLGNLAKKAKLTED HHHHHHHHHHHCCHH	57.33	23954790
491	Phosphorylation	FGQREGTYHFRMTIL CCCCCEEEEEEEEEC	15.15	26437602
505	Acetylation	LPPVEKLKTVLQKVK CCCHHHHHHHHHHHH	47.88	-
505	Malonylation	LPPVEKLKTVLQKVK CCCHHHHHHHHHHHH	47.88	26320211
512	Acetylation	KTVLQKVKDFHINFL HHHHHHHHHHCHHHH	62.81	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ALAT2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ALAT2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ALAT2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
PUR8_HUMAN	ADSL	physical	26344197
SAHH_HUMAN	AHCY	physical	26344197
KAT3_HUMAN	CCBL2	physical	26344197
COF1_HUMAN	CFL1	physical	26344197
AATC_HUMAN	GOT1	physical	26344197
GPD1L_HUMAN	GPD1L	physical	26344197
SODM_HUMAN	SOD2	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 616281: Mental retardation, autosomal recessive 49 (MRT49)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00160: L-Alanine
• DB00780: Phenelzine