| UniProt ID | GPD1L_HUMAN | |
|---|---|---|
| UniProt AC | Q8N335 | |
| Protein Name | Glycerol-3-phosphate dehydrogenase 1-like protein | |
| Gene Name | GPD1L | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 351 | |
| Subcellular Localization | Cytoplasm . Localized to the region of the plasma membrane. | |
| Protein Description | Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L.. | |
| Protein Sequence | MAAAPLKVCIVGSGNWGSAVAKIIGNNVKKLQKFASTVKMWVFEETVNGRKLTDIINNDHENVKYLPGHKLPENVVAMSNLSEAVQDADLLVFVIPHQFIHRICDEITGRVPKKALGITLIKGIDEGPEGLKLISDIIREKMGIDISVLMGANIANEVAAEKFCETTIGSKVMENGLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIAFARIFCKGQVSTATFLESCGVADLITTCYGGRNRRVAEAFARTGKTIEELEKEMLNGQKLQGPQTSAEVYRILKQKGLLDKFPLFTAVYQICYESRPVQEMLSCLQSHPEHT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 29 | Ubiquitination | KIIGNNVKKLQKFAS HHHCCHHHHHHHHHH | 50.30 | 29967540 | |
| 51 | Ubiquitination | EETVNGRKLTDIINN EECCCCEEHHHHHCC | 58.08 | 29967540 | |
| 132 | Ubiquitination | DEGPEGLKLISDIIR CCCHHHHHHHHHHHH | 55.41 | 29967540 | |
| 166 | Phosphorylation | AAEKFCETTIGSKVM HHHHHHHCCCCCHHH | 25.54 | 24505115 | |
| 167 | Phosphorylation | AEKFCETTIGSKVME HHHHHHCCCCCHHHH | 10.88 | 24505115 | |
| 170 | Phosphorylation | FCETTIGSKVMENGL HHHCCCCCHHHHCCC | 20.44 | 24505115 | |
| 173 | Sulfoxidation | TTIGSKVMENGLLFK CCCCCHHHHCCCCHH | 3.68 | 21406390 | |
| 185 | Phosphorylation | LFKELLQTPNFRITV CHHHHHCCCCCEEEE | 21.85 | 22210691 | |
| 191 | Phosphorylation | QTPNFRITVVDDADT CCCCCEEEEECCHHH | 15.38 | 22210691 | |
| 198 | Phosphorylation | TVVDDADTVELCGAL EEECCHHHHHHHHHH | 20.01 | 22210691 | |
| 291 | Succinylation | KTIEELEKEMLNGQK CCHHHHHHHHHCCCC | 62.13 | - | |
| 309 | Phosphorylation | PQTSAEVYRILKQKG CCCHHHHHHHHHHCC | 5.39 | 26437602 | |
| 328 | Phosphorylation | FPLFTAVYQICYESR CCHHHHHHHHHHHCC | 6.95 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GPD1L_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GPD1L_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GPD1L_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| ALDOA_HUMAN | ALDOA | physical | 26344197 | |
| ALDOC_HUMAN | ALDOC | physical | 26344197 | |
| CYC_HUMAN | CYCS | physical | 26344197 | |
| GNA1_HUMAN | GNPNAT1 | physical | 26344197 | |
| PGM1_HUMAN | PGM1 | physical | 26344197 | |
| TPIS_HUMAN | TPI1 | physical | 26344197 | |
| UPP1_HUMAN | UPP1 | physical | 26344197 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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