GNA1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GNA1_HUMAN
• UniProt AC: Q96EK6
• Protein Name: Glucosamine 6-phosphate N-acetyltransferase
• Gene Name: GNPNAT1
• Organism: Homo sapiens (Human).
• Sequence Length: 184
• Subcellular Localization: Golgi apparatus membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein.
• Protein Sequence: MKPDETPMFDPSLLKEVDWSQNTATFSPAISPTHPGEGLVLRPLCTADLNRGFFKVLGQLTETGVVSPEQFMKSFEHMKKSGDYYVTVVEDVTLGQIVATATLIIEHKFIHSCAKRGRVEDVVVSDECRGKQLGKLLLSTLTLLSKKLNCYKITLECLPQNVGFYKKFGYTVSEENYMCRRFLK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Ubiquitination	------MKPDETPMF ------CCCCCCCCC	62.26	-
6	Phosphorylation	--MKPDETPMFDPSL --CCCCCCCCCCHHH	27.68	21406692
12	Phosphorylation	ETPMFDPSLLKEVDW CCCCCCHHHHHCCCC	48.45	24719451
15	Ubiquitination	MFDPSLLKEVDWSQN CCCHHHHHCCCCCCC	62.07	-
23	Phosphorylation	EVDWSQNTATFSPAI CCCCCCCCCEECCCC	21.31	27251275
25	Phosphorylation	DWSQNTATFSPAISP CCCCCCCEECCCCCC	23.70	27690223
27	Phosphorylation	SQNTATFSPAISPTH CCCCCEECCCCCCCC	14.74	25159151
31	Phosphorylation	ATFSPAISPTHPGEG CEECCCCCCCCCCCC	26.33	26657352
33	Phosphorylation	FSPAISPTHPGEGLV ECCCCCCCCCCCCCC	33.63	27251275
46	Phosphorylation	LVLRPLCTADLNRGF CCCCEEEECCCCCCH	30.78	27251275
55	Ubiquitination	DLNRGFFKVLGQLTE CCCCCHHHHHHHHHH	34.00	22053931
67	Phosphorylation	LTETGVVSPEQFMKS HHHCCCCCHHHHHHH	21.95	24719451
72	Sulfoxidation	VVSPEQFMKSFEHMK CCCHHHHHHHHHHHH	3.38	21406390
73	Acetylation	VSPEQFMKSFEHMKK CCHHHHHHHHHHHHH	53.97	25953088
73	Ubiquitination	VSPEQFMKSFEHMKK CCHHHHHHHHHHHHH	53.97	-
84	Phosphorylation	HMKKSGDYYVTVVED HHHHHCCEEEEEEEC	11.89	-
85	Phosphorylation	MKKSGDYYVTVVEDV HHHHCCEEEEEEECC	8.39	-
113	S-nitrosocysteine	EHKFIHSCAKRGRVE HHHHHHHHHHCCCEE	2.98	-
113	S-nitrosylation	EHKFIHSCAKRGRVE HHHHHHHHHHCCCEE	2.98	19483679
115	Acetylation	KFIHSCAKRGRVEDV HHHHHHHHCCCEEEE	60.76	25953088
115	Ubiquitination	KFIHSCAKRGRVEDV HHHHHHHHCCCEEEE	60.76	-
128	S-nitrosocysteine	DVVVSDECRGKQLGK EEEECCHHCCHHHHH	9.25	-
128	S-nitrosylation	DVVVSDECRGKQLGK EEEECCHHCCHHHHH	9.25	19483679
139	Phosphorylation	QLGKLLLSTLTLLSK HHHHHHHHHHHHHHH	22.72	21406692
140	Phosphorylation	LGKLLLSTLTLLSKK HHHHHHHHHHHHHHH	24.59	21406692
142	Phosphorylation	KLLLSTLTLLSKKLN HHHHHHHHHHHHHCC	26.24	21406692
145	Phosphorylation	LSTLTLLSKKLNCYK HHHHHHHHHHCCCEE	30.75	24719451
147	Acetylation	TLTLLSKKLNCYKIT HHHHHHHHCCCEEEE	41.37	25953088
152	Ubiquitination	SKKLNCYKITLECLP HHHCCCEEEEHHHCC	31.26	-
152	Acetylation	SKKLNCYKITLECLP HHHCCCEEEEHHHCC	31.26	23954790
157	S-nitrosylation	CYKITLECLPQNVGF CEEEEHHHCCCCCCH	8.26	19483679
157	S-nitrosocysteine	CYKITLECLPQNVGF CEEEEHHHCCCCCCH	8.26	-
165	Phosphorylation	LPQNVGFYKKFGYTV CCCCCCHHHHHCCEE	13.82	-
166	Ubiquitination	PQNVGFYKKFGYTVS CCCCCHHHHHCCEEC	39.09	-
166	Acetylation	PQNVGFYKKFGYTVS CCCCCHHHHHCCEEC	39.09	23749302
167	Malonylation	QNVGFYKKFGYTVSE CCCCHHHHHCCEECH	32.42	26320211
167	Acetylation	QNVGFYKKFGYTVSE CCCCHHHHHCCEECH	32.42	25953088
167	Ubiquitination	QNVGFYKKFGYTVSE CCCCHHHHHCCEECH	32.42	-
173	Phosphorylation	KKFGYTVSEENYMCR HHHCCEECHHHHEHH	31.24	24719451
177	Phosphorylation	YTVSEENYMCRRFLK CEECHHHHEHHHHCC	10.81	25278378

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GNA1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GNA1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GNA1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NAGK_HUMAN	NAGK	physical	21988832
GNA1_HUMAN	GNPNAT1	physical	25416956
ASPD_HUMAN	ASPDH	physical	26344197
PCBP2_HUMAN	PCBP2	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.