HEM1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HEM1_HUMAN
• UniProt AC: P13196
• Protein Name: 5-aminolevulinate synthase, nonspecific, mitochondrial
• Gene Name: ALAS1
• Organism: Homo sapiens (Human).
• Sequence Length: 640
• Subcellular Localization: Mitochondrion matrix.
• Protein Sequence: MESVVRRCPFLSRVPQAFLQKAGKSLLFYAQNCPKMMEVGAKPAPRALSTAAVHYQQIKETPPASEKDKTAKAKVQQTPDGSQQSPDGTQLPSGHPLPATSQGTASKCPFLAAQMNQRGSSVFCKASLELQEDVQEMNAVRKEVAETSAGPSVVSVKTDGGDPSGLLKNFQDIMQKQRPERVSHLLQDNLPKSVSTFQYDRFFEKKIDEKKNDHTYRVFKTVNRRAHIFPMADDYSDSLITKKQVSVWCSNDYLGMSRHPRVCGAVMDTLKQHGAGAGGTRNISGTSKFHVDLERELADLHGKDAALLFSSCFVANDSTLFTLAKMMPGCEIYSDSGNHASMIQGIRNSRVPKYIFRHNDVSHLRELLQRSDPSVPKIVAFETVHSMDGAVCPLEELCDVAHEFGAITFVDEVHAVGLYGARGGGIGDRDGVMPKMDIISGTLGKAFGCVGGYIASTSSLIDTVRSYAAGFIFTTSLPPMLLAGALESVRILKSAEGRVLRRQHQRNVKLMRQMLMDAGLPVVHCPSHIIPVRVADAAKNTEVCDELMSRHNIYVQAINYPTVPRGEELLRIAPTPHHTPQMMNYFLENLLVTWKQVGLELKPHSSAECNFCRRPLHFEVMSEREKSYFSGLSKLVSAQA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
29	Phosphorylation	AGKSLLFYAQNCPKM HHHHHHHCCCCCHHH	13.77	29496907
42	Ubiquitination	KMMEVGAKPAPRALS HHHHCCCCCCCCHHH	35.47	-
55	Phosphorylation	LSTAAVHYQQIKETP HHHHHHHHHHHHCCC	8.77	27642862
74	Ubiquitination	KDKTAKAKVQQTPDG CCCCCHHHEEECCCC	39.61	-
78	Phosphorylation	AKAKVQQTPDGSQQS CHHHEEECCCCCCCC	13.27	28450419
82	Phosphorylation	VQQTPDGSQQSPDGT EEECCCCCCCCCCCC	32.21	28450419
85	Phosphorylation	TPDGSQQSPDGTQLP CCCCCCCCCCCCCCC	19.81	28450419
89	Phosphorylation	SQQSPDGTQLPSGHP CCCCCCCCCCCCCCC	34.02	28450419
93	Phosphorylation	PDGTQLPSGHPLPAT CCCCCCCCCCCCCCC	59.32	28450419
107	Ubiquitination	TSQGTASKCPFLAAQ CCCCHHHCCHHHHHH	43.38	-
142	Ubiquitination	QEMNAVRKEVAETSA HHHHHHHHHHHHCCC	50.36	-
147	Phosphorylation	VRKEVAETSAGPSVV HHHHHHHCCCCCEEE	17.71	23312004
148	Phosphorylation	RKEVAETSAGPSVVS HHHHHHCCCCCEEEE	23.80	23312004
152	Phosphorylation	AETSAGPSVVSVKTD HHCCCCCEEEEEEEC	33.94	23312004
155	Phosphorylation	SAGPSVVSVKTDGGD CCCCEEEEEEECCCC	18.75	23312004
157	Ubiquitination	GPSVVSVKTDGGDPS CCEEEEEEECCCCCC	33.13	21906983
158	Phosphorylation	PSVVSVKTDGGDPSG CEEEEEEECCCCCCH	37.41	23312004
164	Phosphorylation	KTDGGDPSGLLKNFQ EECCCCCCHHHHHHH	46.98	23312004
168	Ubiquitination	GDPSGLLKNFQDIMQ CCCCHHHHHHHHHHH	61.84	21906983
174 (in isoform 1)	Ubiquitination	-	5.68	21906983
176	Acetylation	NFQDIMQKQRPERVS HHHHHHHHHCHHHHH	30.78	7482707
176	Ubiquitination	NFQDIMQKQRPERVS HHHHHHHHHCHHHHH	30.78	-
185 (in isoform 1)	Ubiquitination	-	3.42	21906983
192	Ubiquitination	LLQDNLPKSVSTFQY HHHHCCCCCCCHHHH	67.66	-
210	Acetylation	FEKKIDEKKNDHTYR HHHHCCCCCCCHHHE	53.80	23749302
216	Phosphorylation	EKKNDHTYRVFKTVN CCCCCHHHEEEHHHC	11.02	22817900
220	Ubiquitination	DHTYRVFKTVNRRAH CHHHEEEHHHCCCCC	49.02	-
242	Ubiquitination	YSDSLITKKQVSVWC CCCCCCCHHHEEEEE	33.93	2190698
243	Ubiquitination	SDSLITKKQVSVWCS CCCCCCHHHEEEEEC	47.48	-
259 (in isoform 1)	Ubiquitination	-	13.76	21906983
269	Phosphorylation	VCGAVMDTLKQHGAG HHHHHHHHHHHCCCC	20.12	18767875
271	Ubiquitination	GAVMDTLKQHGAGAG HHHHHHHHHCCCCCC	42.20	-
280	Phosphorylation	HGAGAGGTRNISGTS CCCCCCCCCCCCCCC	21.45	12300637
284	Phosphorylation	AGGTRNISGTSKFHV CCCCCCCCCCCEEEE	39.30	12300647
287	Phosphorylation	TRNISGTSKFHVDLE CCCCCCCCEEEEEHH	36.53	12300657
288	Ubiquitination	RNISGTSKFHVDLER CCCCCCCEEEEEHHH	39.05	-
353	Ubiquitination	IRNSRVPKYIFRHND HHCCCCCCCHHCCCC	48.39	-
371	Phosphorylation	LRELLQRSDPSVPKI HHHHHHCCCCCCCEE	40.69	113305975
435	Ubiquitination	DRDGVMPKMDIISGT CCCCCCCCHHEECCH	30.98	-
445	Other	IISGTLGKAFGCVGG EECCHHHHHHCCHHH	43.59	-
445	N6-(pyridoxal phosphate)lysine	IISGTLGKAFGCVGG EECCHHHHHHCCHHH	43.59	-
488	Phosphorylation	LLAGALESVRILKSA HHHHHHHHHHHHHHC	19.97	108417771
539	Ubiquitination	VRVADAAKNTEVCDE CHHHHHHCCHHHHHH	67.15	-
548	Sulfoxidation	TEVCDELMSRHNIYV HHHHHHHHHHCCEEE	2.88	21406390
602	Ubiquitination	KQVGLELKPHSSAEC HHHCCEECCCCCCCC	31.17	-
626	Ubiquitination	EVMSEREKSYFSGLS HHCCHHHHHHHHHHH	57.59	-
628	Phosphorylation	MSEREKSYFSGLSKL CCHHHHHHHHHHHHH	16.90	6885281
630	Phosphorylation	EREKSYFSGLSKLVS HHHHHHHHHHHHHHH	30.50	25690035
634	Ubiquitination	SYFSGLSKLVSAQA- HHHHHHHHHHHCCC-	58.93	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HEM1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HEM1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HEM1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VHL_HUMAN	VHL	physical	16234850
UROK_HUMAN	PLAU	physical	21988832
HEM1_HUMAN	ALAS1	physical	25416956
BCL7A_HUMAN	BCL7A	physical	25416956
PEPL_HUMAN	PPL	physical	25416956
TCEA2_HUMAN	TCEA2	physical	25416956
TYB4_HUMAN	TMSB4X	physical	25416956
WIPF1_HUMAN	WIPF1	physical	25416956
ZN175_HUMAN	ZNF175	physical	25416956
TYB10_HUMAN	TMSB10	physical	25416956
UBP20_HUMAN	USP20	physical	25416956
ZFY26_HUMAN	ZFYVE26	physical	25416956
PDIP2_HUMAN	POLDIP2	physical	25416956
CCHCR_HUMAN	CCHCR1	physical	25416956
GNL3L_HUMAN	GNL3L	physical	25416956
CB042_HUMAN	C2orf42	physical	25416956
EP400_HUMAN	EP400	physical	25416956
SH24A_HUMAN	SH2D4A	physical	25416956
CERK1_HUMAN	CERK	physical	25416956
TTC23_HUMAN	TTC23	physical	25416956
CDC73_HUMAN	CDC73	physical	25416956
ZMAT1_HUMAN	ZMAT1	physical	25416956
LONF1_HUMAN	LONRF1	physical	25416956
MTFR2_HUMAN	MTFR2	physical	25416956
SNX20_HUMAN	SNX20	physical	25416956
DUS19_HUMAN	DUSP19	physical	25416956
TEKT4_HUMAN	TEKT4	physical	25416956
ZN564_HUMAN	ZNF564	physical	25416956
KLH35_HUMAN	KLHL35	physical	25416956
RTL8B_HUMAN	FAM127C	physical	25416956
PDIP2_HUMAN	POLDIP2	physical	21516116
EP400_HUMAN	EP400	physical	21516116
TYB10_HUMAN	TMSB10	physical	21516116

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00145: Glycine