DUS19_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DUS19_HUMAN
• UniProt AC: Q8WTR2
• Protein Name: Dual specificity protein phosphatase 19
• Gene Name: DUSP19
• Organism: Homo sapiens (Human).
• Sequence Length: 217
• Protein Description: Has a dual specificity toward Ser/Thr and Tyr-containing proteins..
• Protein Sequence: MYSLNQEIKAFSRNNLRKQCTRVTTLTGKKIIETWKDARIHVVEEVEPSSGGGCGYVQDLSSDLQVGVIKPWLLLGSQDAAHDLDTLKKNKVTHILNVAYGVENAFLSDFTYKSISILDLPETNILSYFPECFEFIEEAKRKDGVVLVHCNAGVSRAAAIVIGFLMNSEQTSFTSAFSLVKNARPSICPNSGFMEQLRTYQEGKESNKCDRIQENSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MYSLNQEI -------CCCCHHHH	4.65	22814378
2	Phosphorylation	------MYSLNQEIK ------CCCCHHHHH	23.12	19664995
21	Phosphorylation	NNLRKQCTRVTTLTG CCHHHHCCEEEECCC	26.19	29083192
24	Phosphorylation	RKQCTRVTTLTGKKI HHHCCEEEECCCHHH	16.88	29083192
25	Phosphorylation	KQCTRVTTLTGKKII HHCCEEEECCCHHHH	21.33	29083192
27	Phosphorylation	CTRVTTLTGKKIIET CCEEEECCCHHHHHH	44.88	29083192
34	O-linked_Glycosylation	TGKKIIETWKDARIH CCHHHHHHHHCCCEE	27.66	30379171

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DUS19_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DUS19_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DUS19_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MP2K7_HUMAN	MAP2K7	physical	11959862
M3K5_HUMAN	MAP3K5	physical	11959862
MP2K7_HUMAN	MAP2K7	physical	11959861
MK09_HUMAN	MAPK9	physical	11959861
ACD11_HUMAN	ACAD11	physical	26186194
ACTB_HUMAN	ACTB	physical	26186194
ACTA_HUMAN	ACTA2	physical	26186194
HDGR2_HUMAN	HDGFRP2	physical	26186194
FEN1_HUMAN	FEN1	physical	26186194
HEM1_HUMAN	ALAS1	physical	26186194
SYNC_HUMAN	NARS	physical	26186194
TCEA1_HUMAN	TCEA1	physical	26186194
CUED1_HUMAN	CUEDC1	physical	26186194
HEM1_HUMAN	ALAS1	physical	21516116
ACTS_HUMAN	ACTA1	physical	27880917
ACTBL_HUMAN	ACTBL2	physical	27880917
ACTG_HUMAN	ACTG1	physical	27880917
PP2AA_HUMAN	PPP2CA	physical	27880917
2AAA_HUMAN	PPP2R1A	physical	27880917
2ABA_HUMAN	PPP2R2A	physical	27880917
2A5D_HUMAN	PPP2R5D	physical	27880917
DUS19_HUMAN	DUSP19	physical	27432908
2A5B_HUMAN	PPP2R5B	physical	27432908
CPNS1_HUMAN	CAPNS1	physical	27432908
NAA30_HUMAN	NAA30	physical	27432908
NAA35_HUMAN	NAA35	physical	27432908
NUD10_HUMAN	NUDT10	physical	27432908
TIDC1_HUMAN	TIMMDC1	physical	27432908
TMOD3_HUMAN	TMOD3	physical	27432908
PRDX5_HUMAN	PRDX5	physical	27432908
NDKA_HUMAN	NME1	physical	27432908
RHEB_HUMAN	RHEB	physical	27432908
RAP1A_HUMAN	RAP1A	physical	27432908
MK01_HUMAN	MAPK1	physical	27432908
CAN2_HUMAN	CAPN2	physical	27432908
RAB13_HUMAN	RAB13	physical	27432908
ARF5_HUMAN	ARF5	physical	27432908
MTFP1_HUMAN	MTFP1	physical	27432908
ARL8B_HUMAN	ARL8B	physical	27432908
BIEA_HUMAN	BLVRA	physical	27432908
TI17B_HUMAN	TIMM17B	physical	27432908
ATPK_HUMAN	ATP5J2	physical	27432908
SPEE_HUMAN	SRM	physical	27432908
AP3S1_HUMAN	AP3S1	physical	27432908
HDDC2_HUMAN	HDDC2	physical	27432908
ES1_HUMAN	C21orf33	physical	27432908
TM223_HUMAN	TMEM223	physical	27432908
DCTN2_HUMAN	DCTN2	physical	27432908
GALD1_HUMAN	PDDC1	physical	27432908
COX41_HUMAN	COX4I1	physical	27432908
PFD4_HUMAN	PFDN4	physical	27432908
HIG1A_HUMAN	HIGD1A	physical	27432908
DYR2_HUMAN	DHFRL1	physical	27432908
COX5A_HUMAN	COX5A	physical	27432908
BACH_HUMAN	ACOT7	physical	27432908
IF5A1_HUMAN	EIF5A	physical	27432908
STK26_HUMAN	STK26	physical	27432908
PARK7_HUMAN	PARK7	physical	27432908
DHYS_HUMAN	DHPS	physical	27432908
HEM1_HUMAN	ALAS1	physical	28514442
TCEA1_HUMAN	TCEA1	physical	28514442
ACD11_HUMAN	ACAD11	physical	28514442
FEN1_HUMAN	FEN1	physical	28514442
SYNC_HUMAN	NARS	physical	28514442
ACTBL_HUMAN	ACTBL2	physical	28514442
ACTA_HUMAN	ACTA2	physical	28514442
ACTB_HUMAN	ACTB	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.