2A5B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: 2A5B_HUMAN
• UniProt AC: Q15173
• Protein Name: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform
• Gene Name: PPP2R5B
• Organism: Homo sapiens (Human).
• Sequence Length: 497
• Subcellular Localization: Cytoplasm .
• Protein Description: As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation..
• Protein Sequence: METKLPPASTPTSPSSPGLSPVPPPDKVDGFSRRSLRRARPRRSHSSSQFRYQSNQQELTPLPLLKDVPASELHELLSRKLAQCGVMFDFLDCVADLKGKEVKRAALNELVECVGSTRGVLIEPVYPDIIRMISVNIFRTLPPSENPEFDPEEDEPNLEPSWPHLQLVYEFFLRFLESPDFQPSVAKRYVDQKFVLMLLELFDSEDPREREYLKTILHRVYGKFLGLRAYIRKQCNHIFLRFIYEFEHFNGVAELLEILGSIINGFALPLKTEHKQFLVRVLIPLHSVKSLSVFHAQLAYCVVQFLEKDATLTEHVIRGLLKYWPKTCTQKEVMFLGEMEEILDVIEPSQFVKIQEPLFKQVARCVSSPHFQVAERALYFWNNEYILSLIEDNCHTVLPAVFGTLYQVSKEHWNQTIVSLIYNVLKTFMEMNGKLFDELTASYKLEKQQEQQKAQERQELWQGLEELRLRRLQGTQGAKEAPLQRLTPQVAASGGQS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	ETKLPPASTPTSPSS CCCCCCCCCCCCCCC	40.47	23186163
10	Phosphorylation	TKLPPASTPTSPSSP CCCCCCCCCCCCCCC	32.46	23186163
12	Phosphorylation	LPPASTPTSPSSPGL CCCCCCCCCCCCCCC	54.05	23186163
13	Phosphorylation	PPASTPTSPSSPGLS CCCCCCCCCCCCCCC	24.80	25850435
15	Phosphorylation	ASTPTSPSSPGLSPV CCCCCCCCCCCCCCC	49.27	25850435
16	Phosphorylation	STPTSPSSPGLSPVP CCCCCCCCCCCCCCC	26.77	25850435
20	Phosphorylation	SPSSPGLSPVPPPDK CCCCCCCCCCCCCCC	29.75	25159151
32	Phosphorylation	PDKVDGFSRRSLRRA CCCCCCCCHHHHHHC	32.11	21329884
35	Phosphorylation	VDGFSRRSLRRARPR CCCCCHHHHHHCCCC	25.72	21329884
44	Phosphorylation	RRARPRRSHSSSQFR HHCCCCCCCCCHHHC	29.06	21329884
46	Phosphorylation	ARPRRSHSSSQFRYQ CCCCCCCCCHHHCCC	32.69	21329884
47	Phosphorylation	RPRRSHSSSQFRYQS CCCCCCCCHHHCCCC	23.80	21329884
48	Phosphorylation	PRRSHSSSQFRYQSN CCCCCCCHHHCCCCC	36.03	21329884
52	Phosphorylation	HSSSQFRYQSNQQEL CCCHHHCCCCCCCCC	19.99	30177828
54	Phosphorylation	SSQFRYQSNQQELTP CHHHCCCCCCCCCCC	27.89	28857561
78	Phosphorylation	SELHELLSRKLAQCG HHHHHHHHHHHHHCC	39.74	24719451
126	Phosphorylation	GVLIEPVYPDIIRMI CEEEEECCHHHHHHH	13.10	-
187	Malonylation	DFQPSVAKRYVDQKF CCCHHHHHHHCCHHH	41.95	26320211
327	Phosphorylation	LLKYWPKTCTQKEVM HHHHCCCCCCHHHHH	19.39	29978859
329	Phosphorylation	KYWPKTCTQKEVMFL HHCCCCCCHHHHHHH	48.16	29978859
349	Phosphorylation	ILDVIEPSQFVKIQE HHHHCCHHHCCCCCH	24.38	29978859
368	Phosphorylation	QVARCVSSPHFQVAE HHHHHHCCCCHHHHH	11.29	17200115
406	Phosphorylation	PAVFGTLYQVSKEHW HHHHHHHHHHCHHHH	13.50	26074081
409	Phosphorylation	FGTLYQVSKEHWNQT HHHHHHHCHHHHHHH	19.46	26074081
479	Ubiquitination	LQGTQGAKEAPLQRL HHCCCCHHHCCHHHH	62.32	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
32	S	Phosphorylation	Kinase	CLK2	P49760	Uniprot
35	S	Phosphorylation	Kinase	CLK2	P49760	Uniprot
44	S	Phosphorylation	Kinase	CLK2	P49760	Uniprot
46	S	Phosphorylation	Kinase	CLK2	P49760	Uniprot
47	S	Phosphorylation	Kinase	CLK2	P49760	Uniprot
48	S	Phosphorylation	Kinase	CLK2	P49760	Uniprot
-	K	Ubiquitination	E3 ubiquitin ligase	KLHL15	Q96M94	PMID:23135275

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of 2A5B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of 2A5B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PP2AA_HUMAN	PPP2CA	physical	8703017
2AAB_HUMAN	PPP2R1B	physical	8703017
IEX1_HUMAN	IER3	physical	16456541
PP2AA_HUMAN	PPP2CA	physical	16456541
PIM1_HUMAN	PIM1	physical	17297438

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.