CUED1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CUED1_HUMAN
• UniProt AC: Q9NWM3
• Protein Name: CUE domain-containing protein 1
• Gene Name: CUEDC1
• Organism: Homo sapiens (Human).
• Sequence Length: 386
• Protein Sequence: MTSLFRRSSSGSGGGGTAGARGGGGGTAAPQELNNSRPARQVRRLEFNQAMDDFKTMFPNMDYDIIECVLRANSGAVDATIDQLLQMNLEGGGSSGGVYEDSSDSEDSIPPEILERTLEPDSSDEEPPPVYSPPAYHMHVFDRPYPLAPPTPPPRIDALGSGAPTSQRRYRNWNPPLLGNLPDDFLRILPQQLDSIQGNAGGPKPGSGEGCPPAMAGPGPGDQESRWKQYLEDERIALFLQNEEFMKELQRNRDFLLALERDRLKYESQKSKSSSVAVGNDFGFSSPVPGTGDANPAVSEDALFRDKLKHMGKSTRRKLFELARAFSEKTKMRKSKRKHLLKHQSLGAAASTANLLDDVEGHACDEDFRGRRQEAPKVEEGLREGQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MTSLFRRSSS -----CCCCCCCCCC	24.98	24719451
8	Phosphorylation	MTSLFRRSSSGSGGG CCCCCCCCCCCCCCC	25.30	24425749
9	Phosphorylation	TSLFRRSSSGSGGGG CCCCCCCCCCCCCCC	36.59	25849741
10	Phosphorylation	SLFRRSSSGSGGGGT CCCCCCCCCCCCCCC	37.92	25849741
12	Phosphorylation	FRRSSSGSGGGGTAG CCCCCCCCCCCCCCC	35.89	26853621
17	Phosphorylation	SGSGGGGTAGARGGG CCCCCCCCCCCCCCC	25.78	-
21	Methylation	GGGTAGARGGGGGTA CCCCCCCCCCCCCCC	43.29	-
36	Phosphorylation	APQELNNSRPARQVR CCHHHHCCCCHHHHH	38.27	28555341
63	Phosphorylation	TMFPNMDYDIIECVL HHCCCCCHHHHHHHH	9.77	27642862
117	Phosphorylation	PPEILERTLEPDSSD CHHHHHHHCCCCCCC	26.54	27251275
122	Phosphorylation	ERTLEPDSSDEEPPP HHHCCCCCCCCCCCC	50.86	29523821
123	Phosphorylation	RTLEPDSSDEEPPPV HHCCCCCCCCCCCCC	57.32	29523821
132	Phosphorylation	EEPPPVYSPPAYHMH CCCCCCCCCCCEEEE	25.33	27251275
136	Phosphorylation	PVYSPPAYHMHVFDR CCCCCCCEEEEECCC	12.88	27251275
145	Phosphorylation	MHVFDRPYPLAPPTP EEECCCCCCCCCCCC	16.27	27251275
151	Phosphorylation	PYPLAPPTPPPRIDA CCCCCCCCCCCCCCC	47.57	23312004
161	Phosphorylation	PRIDALGSGAPTSQR CCCCCCCCCCCCHHH	32.41	29978859
165	Phosphorylation	ALGSGAPTSQRRYRN CCCCCCCCHHHHHHH	36.64	29978859
166	Phosphorylation	LGSGAPTSQRRYRNW CCCCCCCHHHHHHHC	22.19	29978859
228	Ubiquitination	GDQESRWKQYLEDER CCHHHHHHHHHHHHH	28.14	21890473
228 (in isoform 1)	Ubiquitination	-	28.14	21890473
230	Phosphorylation	QESRWKQYLEDERIA HHHHHHHHHHHHHHH	14.34	-
244 (in isoform 2)	Ubiquitination	-	59.60	21890473
247	Ubiquitination	LQNEEFMKELQRNRD HCCHHHHHHHHHCHH	61.67	-
265	Ubiquitination	ALERDRLKYESQKSK HHHHHHHHHHHHCCC	48.11	-
266	Phosphorylation	LERDRLKYESQKSKS HHHHHHHHHHHCCCC	25.96	28152594
268	Phosphorylation	RDRLKYESQKSKSSS HHHHHHHHHCCCCCC	39.56	28152594
272 (in isoform 1)	Ubiquitination	-	62.48	21890473
272	Ubiquitination	KYESQKSKSSSVAVG HHHHHCCCCCCEEEC	62.48	21906983
285	Phosphorylation	VGNDFGFSSPVPGTG ECCCCCCCCCCCCCC	33.83	28348404
286	Phosphorylation	GNDFGFSSPVPGTGD CCCCCCCCCCCCCCC	27.88	28348404
290 (in isoform 2)	Ubiquitination	-	42.43	21890473
307	Ubiquitination	EDALFRDKLKHMGKS HHHHHHHHHHHCCHH	56.00	-
314 (in isoform 2)	Ubiquitination	-	22.78	21890473
318	Ubiquitination	MGKSTRRKLFELARA CCHHHHHHHHHHHHH	54.99	21890473
318 (in isoform 1)	Ubiquitination	-	54.99	21890473
327	Phosphorylation	FELARAFSEKTKMRK HHHHHHHHHHHHCCH	36.88	24719451
330	Phosphorylation	ARAFSEKTKMRKSKR HHHHHHHHHCCHHHH	26.48	-
342	Ubiquitination	SKRKHLLKHQSLGAA HHHHHHHHHHHHHHH	46.05	21890473
342 (in isoform 1)	Ubiquitination	-	46.05	21890473
345	Phosphorylation	KHLLKHQSLGAAAST HHHHHHHHHHHHHHH	28.61	26657352
351	Phosphorylation	QSLGAAASTANLLDD HHHHHHHHHHHHHHH	24.27	25849741
352	Phosphorylation	SLGAAASTANLLDDV HHHHHHHHHHHHHHH	18.16	27251275
377	Ubiquitination	GRRQEAPKVEEGLRE CCCCCCCCHHHHHHC	70.13	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	SMURF1	Q9HCE7	PMID:20804422

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CUED1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CUED1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CUED1_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.