dbPTM

RHEB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RHEB_HUMAN
UniProt AC	Q15382
Protein Name	GTP-binding protein Rheb
Gene Name	RHEB
Organism	Homo sapiens (Human).
Sequence Length	184
Subcellular Localization	Endomembrane system Lipid-anchor Cytoplasmic side . Golgi apparatus membrane Lipid-anchor Cytoplasmic side . Cytoplasm, cytosol . Endoplasmic reticulum membrane Lipid-anchor Cytoplasmic side .
Protein Description	Activates the protein kinase activity of mTORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Has low intrinsic GTPase activity..
Protein Sequence	MPQSKSRKIAILGYRSVGKSSLTIQFVEGQFVDSYDPTIENTFTKLITVNGQEYHLQLVDTAGQDEYSIFPQTYSIDINGYILVYSVTSIKSFEVIKVIHGKLLDMVGKVQIPIMLVGNKKDLHMERVISYEEGKALAESWNAAFLESSAKENQTAVDVFRRIILEAEKMDGAASQGKSSCSVM

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	RKIAILGYRSVGKSS CCEEEECEEECCCCE	9.03	28102081
16	Phosphorylation	IAILGYRSVGKSSLT EEEECEEECCCCEEE	27.09	25159151
102	Ubiquitination	VIKVIHGKLLDMVGK EEEEECCHHHHHHCC	31.54	-
109	Ubiquitination	KLLDMVGKVQIPIML HHHHHHCCEEEEEEE	21.40	-
120	Ubiquitination	PIMLVGNKKDLHMER EEEEECCCCCCCEEE	41.56	21890473
120	2-Hydroxyisobutyrylation	PIMLVGNKKDLHMER EEEEECCCCCCCEEE	41.56	-
121	Ubiquitination	IMLVGNKKDLHMERV EEEECCCCCCCEEEE	70.31	-
121	2-Hydroxyisobutyrylation	IMLVGNKKDLHMERV EEEECCCCCCCEEEE	70.31	-
130	Phosphorylation	LHMERVISYEEGKAL CCEEEEEEHHHHHHH	24.51	21336308
135	Ubiquitination	VISYEEGKALAESWN EEEHHHHHHHHHHHH	43.43	21890473
140	Phosphorylation	EGKALAESWNAAFLE HHHHHHHHHHHHHHH	21.74	20068231
151	Ubiquitination	AFLESSAKENQTAVD HHHHHHHCCCHHHHH	60.18	21890473
169	Ubiquitination	RIILEAEKMDGAASQ HHHHHHHHHCCCHHC	49.71	21890473
170	Sulfoxidation	IILEAEKMDGAASQG HHHHHHHHCCCHHCC	4.29	28183972
175	Phosphorylation	EKMDGAASQGKSSCS HHHCCCHHCCCCCCC	38.64	29214152
181	Farnesylation	ASQGKSSCSVM---- HHCCCCCCCCC----	4.60	22002721
181	Farnesylation	ASQGKSSCSVM---- HHCCCCCCCCC----	4.60	22002721
181	Methylation	ASQGKSSCSVM---- HHCCCCCCCCC----	4.60	22002721

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
130	S	Phosphorylation	Kinase	MAPKAPK5	Q8IW41	Uniprot
130	S	Phosphorylation	Kinase	MAPKAPK5	O54992	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	RNF152	Q8N8N0	PMID:32296023

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RHEB_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RHEB_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TSC2_HUMAN	TSC2	physical	12842888
ATM_HUMAN	ATM	physical	15854902
ATR_HUMAN	ATR	physical	15854902
MTOR_HUMAN	MTOR	physical	15854902
MTOR_HUMAN	MTOR	physical	15878852
MTOR_HUMAN	MTOR	physical	15772076
MTOR_HUMAN	MTOR	physical	16915281
RASH_HUMAN	HRAS	physical	15854902
RAF1_HUMAN	RAF1	physical	15854902
RAF1_HUMAN	RAF1	physical	15150271
RAP1A_HUMAN	RAP1A	physical	15854902
TSC2_HUMAN	TSC2	physical	15854902
RAB7A_HUMAN	RAB7A	physical	15809346
RAB9A_HUMAN	RAB9A	physical	15809346
RPTOR_HUMAN	RPTOR	physical	15854902
RAF1_HUMAN	RAF1	physical	9001246
BNIP3_HUMAN	BNIP3	physical	17928295
BNI3L_HUMAN	BNIP3L	physical	17928295
PRAF1_HUMAN	RABAC1	physical	17928295
DP13A_MOUSE	Appl1	physical	20368287
GO45_MOUSE	Blzf1	physical	20368287
TRAF2_HUMAN	TRAF2	physical	20368287
TRAF2_MOUSE	Traf2	physical	20368287
FKBP8_HUMAN	FKBP8	physical	17991864
RPTOR_HUMAN	RPTOR	physical	24337580
PLD1_HUMAN	PLD1	physical	18550814
MTOR_HUMAN	MTOR	physical	18550814
RPTOR_HUMAN	RPTOR	physical	25446900
UBB_HUMAN	UBB	physical	28514442
LAMP2_HUMAN	LAMP2	physical	28514442
SRPRB_HUMAN	SRPRB	physical	28514442
HD_HUMAN	HTT	physical	25351248
MTOR_HUMAN	MTOR	physical	25351248

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RHEB_HUMAN

Related Literatures of Post-Translational Modification

Prenylation
Reference	PubMed
"A tagging-via-substrate technology for detection and proteomics offarnesylated proteins."; Kho Y., Kim S.C., Jiang C., Barma D., Kwon S.W., Cheng J.,Jaunbergs J., Weinbaum C., Tamanoi F., Falck J., Zhao Y.; Proc. Natl. Acad. Sci. U.S.A. 101:12479-12484(2004). Cited for: ISOPRENYLATION AT CYS-181.	15308774 [Abstract]