dbPTM

DP13A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DP13A_MOUSE
UniProt AC	Q8K3H0
Protein Name	DCC-interacting protein 13-alpha
Gene Name	Appl1
Organism	Mus musculus (Mouse).
Sequence Length	707
Subcellular Localization	Early endosome membrane Peripheral membrane protein . Nucleus . Early endosomal membrane-bound and nuclear. Translocated into the nucleus upon release from endosomal membranes following internalization of EGF (By similarity).
Protein Description	Adapter protein that interacts with proteins involved in different cellular signaling pathways. Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction. Involved in the regulation of the insulin receptor signaling pathway.; Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction (By similarity)..
Protein Sequence	MPGIDKLPIEETLEDSPQTRSLLGVFEEDATAISNYMNQLYQAMHRIYDAQNELSAATHLTSKLLKEYEKQRFPLGGDDEVMSSTLQQFSKVIDELSSCHAVLSTQLADAMMFPISQFKERDLKEILTLKEVFQIASNDHDAAINRYSRLSKKRENDKVKYEVTEDVYTSRKKQHQTMMHYFCALNTLQYKKKIALLEPLLGYMQAQISFFKMGSENLNGQLEEFLANIGTSVQNVRREMDGDVETMQQTIEDLEVASDPLYLPDPDPTKFPINRNLTRKAGYLNARNKTGLVSSTWDRQFYFTQGGNLMSQARGDVAGGLAMDIDNCSVMAVDCEDRRYCFQITSFDGKKSSILQAESKKDHEEWICTINNISKQIYLSENPEETAARVNQSALEAVTPSPSFQQRHESLRPGGQSRPPTARTSSSGSLGSESTNLAALSLDSLVAPDTPIQFDIISPVCEDQPGQAKAFGQGGRRTNPFGESGGSTKSETEDSILHQLFIVRFLGSMEVKSDDHPDVVYETMRQILAARAIHNIFRMTESHLLVTCDCLKLIDPQTQVTRLTFPLPCVVLYATHQENKRLFGFVLRTSGGRSESNLSSVCYIFESNNEGEKICDSVGLAKQIALHAELDRRASEKQKEIERVKEKQQKELSKQKQIEKDLEEQSRLIAASSRPNQAGSEGQLVLSSSQSEESDLGEEGKKRESEA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
63	Ubiquitination	AATHLTSKLLKEYEK HHHHHHHHHHHHHHH	53.24	22790023
63	Acetylation	AATHLTSKLLKEYEK HHHHHHHHHHHHHHH	53.24	23954790
66	Ubiquitination	HLTSKLLKEYEKQRF HHHHHHHHHHHHHCC	69.55	22790023
70	Ubiquitination	KLLKEYEKQRFPLGG HHHHHHHHHCCCCCC	45.96	22790023
161	Phosphorylation	RENDKVKYEVTEDVY CCCCCCCEEEEHHHH	20.72	21183079
164	Phosphorylation	DKVKYEVTEDVYTSR CCCCEEEEHHHHHCC	17.96	28576409
168	Phosphorylation	YEVTEDVYTSRKKQH EEEEHHHHHCCHHHH	16.00	22817900
169	Phosphorylation	EVTEDVYTSRKKQHQ EEEHHHHHCCHHHHH	23.15	28576409
170	Phosphorylation	VTEDVYTSRKKQHQT EEHHHHHCCHHHHHH	25.15	28576409
393	Phosphorylation	TAARVNQSALEAVTP HHHHHHHHHHHHHCC	29.62	25619855
399	Phosphorylation	QSALEAVTPSPSFQQ HHHHHHHCCCCHHHH	25.70	24925903
401	Phosphorylation	ALEAVTPSPSFQQRH HHHHHCCCCHHHHHH	24.66	24925903
403	Phosphorylation	EAVTPSPSFQQRHES HHHCCCCHHHHHHHH	39.77	25521595
410	Phosphorylation	SFQQRHESLRPGGQS HHHHHHHHCCCCCCC	24.45	24719451
424	Phosphorylation	SRPPTARTSSSGSLG CCCCCCCCCCCCCCC	30.42	23984901
425	Phosphorylation	RPPTARTSSSGSLGS CCCCCCCCCCCCCCC	19.56	23649490
426	Phosphorylation	PPTARTSSSGSLGSE CCCCCCCCCCCCCCC	37.80	23649490
427	Phosphorylation	PTARTSSSGSLGSES CCCCCCCCCCCCCCH	31.97	23984901
429	Phosphorylation	ARTSSSGSLGSESTN CCCCCCCCCCCCHHC	31.35	24224561
432	Phosphorylation	SSSGSLGSESTNLAA CCCCCCCCCHHCEEE	33.40	23984901
434	Phosphorylation	SGSLGSESTNLAALS CCCCCCCHHCEEEEC	25.05	23649490
435	Phosphorylation	GSLGSESTNLAALSL CCCCCCHHCEEEECC	30.14	23984901
444	Phosphorylation	LAALSLDSLVAPDTP EEEECCCCCCCCCCC	30.00	23649490
458	Phosphorylation	PIQFDIISPVCEDQP CEEEEEEECCCCCCC	16.18	29899451
483	Ubiquitination	RRTNPFGESGGSTKS CCCCCCCCCCCCCCC	46.73	27667366
488	Phosphorylation	FGESGGSTKSETEDS CCCCCCCCCCCCHHH	41.69	19060867
490	Phosphorylation	ESGGSTKSETEDSIL CCCCCCCCCCHHHHH	50.25	27180971
492	Phosphorylation	GGSTKSETEDSILHQ CCCCCCCCHHHHHHH	52.78	22324799
495	Phosphorylation	TKSETEDSILHQLFI CCCCCHHHHHHHHHH	22.33	22324799
508	Phosphorylation	FIVRFLGSMEVKSDD HHHHHHCCCEECCCC	17.57	25195567
512	Ubiquitination	FLGSMEVKSDDHPDV HHCCCEECCCCCCHH	34.56	22790023
550	Ubiquitination	HLLVTCDCLKLIDPQ HHEEEECHHHHCCCC	3.82	27667366
589	Phosphorylation	LFGFVLRTSGGRSES EEEEEEECCCCCCCC	27.80	30635358
590	Phosphorylation	FGFVLRTSGGRSESN EEEEEECCCCCCCCC	32.58	30635358
594	Phosphorylation	LRTSGGRSESNLSSV EECCCCCCCCCCCEE	48.96	30635358
596	Phosphorylation	TSGGRSESNLSSVCY CCCCCCCCCCCEEEE	44.30	30635358
599	Phosphorylation	GRSESNLSSVCYIFE CCCCCCCCEEEEEEE	25.60	30635358
600	Phosphorylation	RSESNLSSVCYIFES CCCCCCCEEEEEEEC	21.26	30635358
603	Phosphorylation	SNLSSVCYIFESNNE CCCCEEEEEEECCCC	13.39	30635358
635	Phosphorylation	AELDRRASEKQKEIE HHHHHHHHHHHHHHH	43.44	26824392
636	Ubiquitination	ELDRRASEKQKEIER HHHHHHHHHHHHHHH	59.53	27667366
660	Ubiquitination	SKQKQIEKDLEEQSR HHHHHHHHHHHHHHH	70.06	27667366
672	Phosphorylation	QSRLIAASSRPNQAG HHHHHHHCCCCCCCC	20.18	29899451
673	Phosphorylation	SRLIAASSRPNQAGS HHHHHHCCCCCCCCC	47.21	29899451
680	Phosphorylation	SRPNQAGSEGQLVLS CCCCCCCCCCEEEEC	41.38	29514104
687	Phosphorylation	SEGQLVLSSSQSEES CCCEEEECCCCCCCC	22.06	21183079
688	Phosphorylation	EGQLVLSSSQSEESD CCEEEECCCCCCCCC	28.38	25293948
689	Phosphorylation	GQLVLSSSQSEESDL CEEEECCCCCCCCCC	34.06	25521595
691	Phosphorylation	LVLSSSQSEESDLGE EEECCCCCCCCCCCH	45.33	25521595
694	Phosphorylation	SSSQSEESDLGEEGK CCCCCCCCCCCHHHH	33.80	25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
410	S	Phosphorylation	Kinase	PKA	-	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
410	S	Phosphorylation		-
Phosphorylation at Ser-410 by PKA severely impairs binding to OCRL.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DP13A_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of DP13A_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DP13A_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteomic analysis of the developing mouse brain."; Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.; Mol. Cell. Proteomics 3:1093-1101(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-401, AND MASSSPECTROMETRY.	15345747 [Abstract]

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