dbPTM

ATR_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ATR_HUMAN
UniProt AC	Q13535
Protein Name	Serine/threonine-protein kinase ATR
Gene Name	ATR
Organism	Homo sapiens (Human).
Sequence Length	2644
Subcellular Localization	Nucleus . Nucleus, PML body . Chromosome . Depending on the cell type, it can also be found in PML nuclear bodies. Recruited to chromatin during S-phase. Redistributes to discrete nuclear foci upon DNA damage, hypoxia or replication fork stalling.
Protein Description	Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication..
Protein Sequence	MGEHGLELASMIPALRELGSATPEEYNTVVQKPRQILCQFIDRILTDVNVVAVELVKKTDSQPTSVMLLDFIQHIMKSSPLMFVNVSGSHEAKGSCIEFSNWIITRLLRIAATPSCHLLHKKICEVICSLLFLFKSKSPAIFGVLTKELLQLFEDLVYLHRRNVMGHAVEWPVVMSRFLSQLDEHMGYLQSAPLQLMSMQNLEFIEVTLLMVLTRIIAIVFFRRQELLLWQIGCVLLEYGSPKIKSLAISFLTELFQLGGLPAQPASTFFSSFLELLKHLVEMDTDQLKLYEEPLSKLIKTLFPFEAEAYRNIEPVYLNMLLEKLCVMFEDGVLMRLKSDLLKAALCHLLQYFLKFVPAGYESALQVRKVYVRNICKALLDVLGIEVDAEYLLGPLYAALKMESMEIIEEIQCQTQQENLSSNSDGISPKRRRLSSSLNPSKRAPKQTEEIKHVDMNQKSILWSALKQKAESLQISLEYSGLKNPVIEMLEGIAVVLQLTALCTVHCSHQNMNCRTFKDCQHKSKKKPSVVITWMSLDFYTKVLKSCRSLLESVQKLDLEATIDKVVKIYDALIYMQVNSSFEDHILEDLCGMLSLPWIYSHSDDGCLKLTTFAANLLTLSCRISDSYSPQAQSRCVFLLTLFPRRIFLEWRTAVYNWALQSSHEVIRASCVSGFFILLQQQNSCNRVPKILIDKVKDDSDIVKKEFASILGQLVCTLHGMFYLTSSLTEPFSEHGHVDLFCRNLKATSQHECSSSQLKASVCKPFLFLLKKKIPSPVKLAFIDNLHHLCKHLDFREDETDVKAVLGTLLNLMEDPDKDVRVAFSGNIKHILESLDSEDGFIKELFVLRMKEAYTHAQISRNNELKDTLILTTGDIGRAAKGDLVPFALLHLLHCLLSKSASVSGAAYTEIRALVAAKSVKLQSFFSQYKKPICQFLVESLHSSQMTALPNTPCQNADVRKQDVAHQREMALNTLSEIANVFDFPDLNRFLTRTLQVLLPDLAAKASPAASALIRTLGKQLNVNRREILINNFKYIFSHLVCSCSKDELERALHYLKNETEIELGSLLRQDFQGLHNELLLRIGEHYQQVFNGLSILASFASSDDPYQGPRDIISPELMADYLQPKLLGILAFFNMQLLSSSVGIEDKKMALNSLMSLMKLMGPKHVSSVRVKMMTTLRTGLRFKDDFPELCCRAWDCFVRCLDHACLGSLLSHVIVALLPLIHIQPKETAAIFHYLIIENRDAVQDFLHEIYFLPDHPELKKIKAVLQEYRKETSESTDLQTTLQLSMKAIQHENVDVRIHALTSLKETLYKNQEKLIKYATDSETVEPIISQLVTVLLKGCQDANSQARLLCGECLGELGAIDPGRLDFSTTETQGKDFTFVTGVEDSSFAYGLLMELTRAYLAYADNSRAQDSAAYAIQELLSIYDCREMETNGPGHQLWRRFPEHVREILEPHLNTRYKSSQKSTDWSGVKKPIYLSKLGSNFAEWSASWAGYLITKVRHDLASKIFTCCSIMMKHDFKVTIYLLPHILVYVLLGCNQEDQQEVYAEIMAVLKHDDQHTINTQDIASDLCQLSTQTVFSMLDHLTQWARHKFQALKAEKCPHSKSNRNKVDSMVSTVDYEDYQSVTRFLDLIPQDTLAVASFRSKAYTRAVMHFESFITEKKQNIQEHLGFLQKLYAAMHEPDGVAGVSAIRKAEPSLKEQILEHESLGLLRDATACYDRAIQLEPDQIIHYHGVVKSMLGLGQLSTVITQVNGVHANRSEWTDELNTYRVEAAWKLSQWDLVENYLAADGKSTTWSVRLGQLLLSAKKRDITAFYDSLKLVRAEQIVPLSAASFERGSYQRGYEYIVRLHMLCELEHSIKPLFQHSPGDSSQEDSLNWVARLEMTQNSYRAKEPILALRRALLSLNKRPDYNEMVGECWLQSARVARKAGHHQTAYNALLNAGESRLAELYVERAKWLWSKGDVHQALIVLQKGVELCFPENETPPEGKNMLIHGRAMLLVGRFMEETANFESNAIMKKYKDVTACLPEWEDGHFYLAKYYDKLMPMVTDNKMEKQGDLIRYIVLHFGRSLQYGNQFIYQSMPRMLTLWLDYGTKAYEWEKAGRSDRVQMRNDLGKINKVITEHTNYLAPYQFLTAFSQLISRICHSHDEVFVVLMEIIAKVFLAYPQQAMWMMTAVSKSSYPMRVNRCKEILNKAIHMKKSLEKFVGDATRLTDKLLELCNKPVDGSSSTLSMSTHFKMLKKLVEEATFSEILIPLQSVMIPTLPSILGTHANHASHEPFPGHWAYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVYMTGKELRQCMLPKSAALSEKLKVFREFLLPRHPPIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNCLFNKGETFEVPEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTMRLMRDQREPLMSVLKTFLHDPLVEWSKPVKGHSKAPLNETGEVVNEKAKTHVLDIEQRLQGVIKTRNRVTGLPLSIEGHVHYLIQEATDENLLCQMYLGWTPYM

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Phosphorylation	PALRELGSATPEEYN HHHHHHCCCCHHHHH	41.41	29954749
26	Phosphorylation	GSATPEEYNTVVQKP CCCCHHHHHHHCCCH	17.93	22817900
32	Ubiquitination	EYNTVVQKPRQILCQ HHHHHCCCHHHHHHH	30.47	21906983
32 (in isoform 1)	Ubiquitination	-	30.47	21890473
32 (in isoform 2)	Ubiquitination	-	30.47	21890473
32 (in isoform 3)	Ubiquitination	-	30.47	21906983
58	Ubiquitination	VAVELVKKTDSQPTS EEEEEHHCCCCCCCH	50.51	-
61	Phosphorylation	ELVKKTDSQPTSVML EEHHCCCCCCCHHHH	43.20	-
177	Methylation	EWPVVMSRFLSQLDE HHHHHHHHHHHHHHH	20.59	-
291	Phosphorylation	DTDQLKLYEEPLSKL CHHHHHHCHHHHHHH	19.36	22817900
297	Ubiquitination	LYEEPLSKLIKTLFP HCHHHHHHHHHHHCC	63.01	29967540
300	Ubiquitination	EPLSKLIKTLFPFEA HHHHHHHHHHCCCCH	50.00	-
310	Phosphorylation	FPFEAEAYRNIEPVY CCCCHHHHHCCCHHH	8.83	22817900
317	Phosphorylation	YRNIEPVYLNMLLEK HHCCCHHHHHHHHHH	11.76	22817900
415	Phosphorylation	IEEIQCQTQQENLSS HHHHHHHHHHHHHCC	39.59	30108239
421	Phosphorylation	QTQQENLSSNSDGIS HHHHHHHCCCCCCCC	38.77	30108239
422	Phosphorylation	TQQENLSSNSDGISP HHHHHHCCCCCCCCH	43.44	30108239
424	Phosphorylation	QENLSSNSDGISPKR HHHHCCCCCCCCHHH	38.88	30108239
428	Phosphorylation	SSNSDGISPKRRRLS CCCCCCCCHHHHHHH	29.87	30278072
435	Phosphorylation	SPKRRRLSSSLNPSK CHHHHHHHHCCCCCC	18.97	22322096
435 (in isoform 2)	Phosphorylation	-	18.97	25849741
436	Phosphorylation	PKRRRLSSSLNPSKR HHHHHHHHCCCCCCC	43.36	30266825
436 (in isoform 2)	Phosphorylation	-	43.36	29116813
437	Phosphorylation	KRRRLSSSLNPSKRA HHHHHHHCCCCCCCC	28.88	30266825
437 (in isoform 2)	Phosphorylation	-	28.88	29116813
441	Phosphorylation	LSSSLNPSKRAPKQT HHHCCCCCCCCCCCC	33.43	23927012
442	Ubiquitination	SSSLNPSKRAPKQTE HHCCCCCCCCCCCCH	54.56	22817900
442 (in isoform 1)	Ubiquitination	-	54.56	21890473
442 (in isoform 2)	Ubiquitination	-	54.56	21890473
442 (in isoform 3)	Ubiquitination	-	54.56	21906983
446	Ubiquitination	NPSKRAPKQTEEIKH CCCCCCCCCCHHCCC	69.71	22817900
459	Ubiquitination	KHVDMNQKSILWSAL CCCCCCHHHHHHHHH	34.16	29967540
464	Phosphorylation	NQKSILWSALKQKAE CHHHHHHHHHHHHHH	21.93	27251275
480	Phosphorylation	LQISLEYSGLKNPVI CCCHHHHCCCCCHHH	28.42	11418864
533	Phosphorylation	KKPSVVITWMSLDFY CCCCEEEEEEEHHHH	11.96	-
549	Phosphorylation	KVLKSCRSLLESVQK HHHHHHHHHHHHHHH	41.45	11418864
625	Phosphorylation	LTLSCRISDSYSPQA HHHHCCCCCCCCHHH	10.93	28270605
627	Phosphorylation	LSCRISDSYSPQAQS HHCCCCCCCCHHHHH	22.25	28270605
628	Phosphorylation	SCRISDSYSPQAQSR HCCCCCCCCHHHHHH	29.39	28270605
629	Phosphorylation	CRISDSYSPQAQSRC CCCCCCCCHHHHHHH	17.94	28270605
634	Phosphorylation	SYSPQAQSRCVFLLT CCCHHHHHHHEHHHH	30.57	28270605
682	Ubiquitination	FFILLQQQNSCNRVP HHHHHCCCCCCCCCC	30.73	21963094
695	Ubiquitination	VPKILIDKVKDDSDI CCEEHHHCCCCCCHH	44.16	29967540
746	Methylation	DLFCRNLKATSQHEC HHHCCCCCCCCCCCC	53.84	-
746	Ubiquitination	DLFCRNLKATSQHEC HHHCCCCCCCCCCCC	53.84	21963094
759	Methylation	ECSSSQLKASVCKPF CCCHHHHHHHHHHHH	30.86	-
764	Acetylation	QLKASVCKPFLFLLK HHHHHHHHHHHHHHH	36.33	26051181
764	Ubiquitination	QLKASVCKPFLFLLK HHHHHHHHHHHHHHH	36.33	-
771	Acetylation	KPFLFLLKKKIPSPV HHHHHHHHCCCCCCC	54.92	26051181
776	Phosphorylation	LLKKKIPSPVKLAFI HHHCCCCCCCHHHHH	45.88	24702127
791	Ubiquitination	DNLHHLCKHLDFRED HCHHHHHHCCCCCCC	54.27	29967540
802	Ubiquitination	FREDETDVKAVLGTL CCCCHHHHHHHHHHH	5.83	21963094
802 (in isoform 2)	Ubiquitination	-	5.83	21890473
818	Ubiquitination	NLMEDPDKDVRVAFS HHHCCCCCCCEEEEC	64.61	29967540
851	Ubiquitination	ELFVLRMKEAYTHAQ HHHHHHHHHHHHHHH	32.53	-
854	Ubiquitination	VLRMKEAYTHAQISR HHHHHHHHHHHHHHC	10.51	23000965
857	Ubiquitination	MKEAYTHAQISRNNE HHHHHHHHHHHCCCC	10.70	23000965
866	Ubiquitination	ISRNNELKDTLILTT HHCCCCCCCEEEEEC	42.35	21906983
866 (in isoform 1)	Ubiquitination	-	42.35	21890473
866 (in isoform 3)	Ubiquitination	-	42.35	21906983
868	Phosphorylation	RNNELKDTLILTTGD CCCCCCCEEEEECCH	17.70	24719451
873	Phosphorylation	KDTLILTTGDIGRAA CCEEEEECCHHHHHC	29.43	24719451
904	Phosphorylation	LSKSASVSGAAYTEI HHCCCCCCCCHHHHH	21.88	25690035
908	Phosphorylation	ASVSGAAYTEIRALV CCCCCCHHHHHHHHH	12.36	25690035
918	Ubiquitination	IRALVAAKSVKLQSF HHHHHHHHCHHHHHH	46.15	23000965
919	Phosphorylation	RALVAAKSVKLQSFF HHHHHHHCHHHHHHH	21.54	17924679
921	Ubiquitination	LVAAKSVKLQSFFSQ HHHHHCHHHHHHHHH	48.15	23000965
941	Ubiquitination	CQFLVESLHSSQMTA HHHHHHHHCCCCCCC	2.62	21963094
941 (in isoform 2)	Ubiquitination	-	2.62	21890473
952	Phosphorylation	QMTALPNTPCQNADV CCCCCCCCCCCCCCH	24.41	28348404
993	Ubiquitination	DLNRFLTRTLQVLLP CHHHHHHHHHHHHCH	35.27	22053931
1005	Ubiquitination	LLPDLAAKASPAASA HCHHHHHHCCHHHHH	43.73	21906983
1005 (in isoform 1)	Ubiquitination	-	43.73	21890473
1005 (in isoform 3)	Ubiquitination	-	43.73	21906983
1007	Phosphorylation	PDLAAKASPAASALI HHHHHHCCHHHHHHH	17.86	26270265
1011	Phosphorylation	AKASPAASALIRTLG HHCCHHHHHHHHHHH	26.22	26270265
1016	Phosphorylation	AASALIRTLGKQLNV HHHHHHHHHHHHCCC	32.63	26270265
1019	Ubiquitination	ALIRTLGKQLNVNRR HHHHHHHHHCCCCHH	55.51	-
1057	Ubiquitination	ERALHYLKNETEIEL HHHHHHHHCCHHHHH	45.64	22053931
1057 (in isoform 1)	Ubiquitination	-	45.64	21890473
1122	Phosphorylation	SPELMADYLQPKLLG CHHHHHHHHHHHHHH	9.56	-
1140	Phosphorylation	FFNMQLLSSSVGIED HHCHHHHHCCCCCCC	29.20	24719451
1154	Phosphorylation	DKKMALNSLMSLMKL CHHHHHHHHHHHHHH	26.71	20068231
1157	Phosphorylation	MALNSLMSLMKLMGP HHHHHHHHHHHHHCC	30.52	29759185
1165	Ubiquitination	LMKLMGPKHVSSVRV HHHHHCCCCHHHHHH	51.41	29967540
1168	Phosphorylation	LMGPKHVSSVRVKMM HHCCCCHHHHHHHHH	23.88	20068231
1169	Phosphorylation	MGPKHVSSVRVKMMT HCCCCHHHHHHHHHH	16.92	20068231
1173	Acetylation	HVSSVRVKMMTTLRT CHHHHHHHHHHHHCC	16.64	7666237
1173	Ubiquitination	HVSSVRVKMMTTLRT CHHHHHHHHHHHHCC	16.64	-
1185	Ubiquitination	LRTGLRFKDDFPELC HCCCCCCCCCHHHHH	50.37	-
1198	Ubiquitination	LCCRAWDCFVRCLDH HHHHHHHHHHHHHCH	2.07	21963094
1199	Ubiquitination	CCRAWDCFVRCLDHA HHHHHHHHHHHHCHH	3.44	22817900
1201	Ubiquitination	RAWDCFVRCLDHACL HHHHHHHHHHCHHHH	8.60	22817900
1244	Ubiquitination	LIIENRDAVQDFLHE HHHCCHHHHHHHHHH	9.53	21963094
1249	Ubiquitination	RDAVQDFLHEIYFLP HHHHHHHHHHHHCCC	4.82	22817900
1262	Ubiquitination	LPDHPELKKIKAVLQ CCCCHHHHHHHHHHH	51.28	21963094
1263	Ubiquitination	PDHPELKKIKAVLQE CCCHHHHHHHHHHHH	63.16	22817900
1265	Ubiquitination	HPELKKIKAVLQEYR CHHHHHHHHHHHHHH	41.12	22817900
1275	Phosphorylation	LQEYRKETSESTDLQ HHHHHHHCCCCCCHH	40.61	-
1308	Ubiquitination	IHALTSLKETLYKNQ HHHHHHHHHHHHHCH	48.71	21963094
1313	Ubiquitination	SLKETLYKNQEKLIK HHHHHHHHCHHHHHH	56.09	22817900
1333	Phosphorylation	ETVEPIISQLVTVLL CCHHHHHHHHHHHHH	20.41	-
1399	Ubiquitination	FAYGLLMELTRAYLA HHHHHHHHHHHHHHH	47.13	22817900
1401	Ubiquitination	YGLLMELTRAYLAYA HHHHHHHHHHHHHHH	10.43	22817900
1403	Ubiquitination	LLMELTRAYLAYADN HHHHHHHHHHHHHCC	9.84	21963094
1405	Ubiquitination	MELTRAYLAYADNSR HHHHHHHHHHHCCCC	2.61	21963094
1463	Ubiquitination	PHLNTRYKSSQKSTD HHHCCCCCCCCCCCC	40.10	22817900
1465	Ubiquitination	LNTRYKSSQKSTDWS HCCCCCCCCCCCCCC	37.16	22817900
1467	Ubiquitination	TRYKSSQKSTDWSGV CCCCCCCCCCCCCCC	58.22	21963094
1469	Ubiquitination	YKSSQKSTDWSGVKK CCCCCCCCCCCCCCC	48.82	21963094
1475	Ubiquitination	STDWSGVKKPIYLSK CCCCCCCCCCEEHHH	57.25	29967540
1476	Ubiquitination	TDWSGVKKPIYLSKL CCCCCCCCCEEHHHC	33.95	29967540
1479	Phosphorylation	SGVKKPIYLSKLGSN CCCCCCEEHHHCCCC	17.28	29759185
1544	Ubiquitination	LLGCNQEDQQEVYAE HHCCCHHHHHHHHHH	45.78	22817900
1546	Ubiquitination	GCNQEDQQEVYAEIM CCCHHHHHHHHHHHH	55.21	22817900
1549	Ubiquitination	QEDQQEVYAEIMAVL HHHHHHHHHHHHHHH	9.58	22817900
1549 (in isoform 2)	Ubiquitination	-	9.58	21890473
1551	Ubiquitination	DQQEVYAEIMAVLKH HHHHHHHHHHHHHHC	18.66	22817900
1566	Phosphorylation	DDQHTINTQDIASDL CCCCCCCHHHHHHHH	24.62	21908846
1578	Phosphorylation	SDLCQLSTQTVFSML HHHHHHHHHHHHHHH	36.53	21908846
1589	Phosphorylation	FSMLDHLTQWARHKF HHHHHHHHHHHHHHH	20.74	21908846
1600	Ubiquitination	RHKFQALKAEKCPHS HHHHHHHHHHCCCCC	58.47	33845483
1608	Ubiquitination	AEKCPHSKSNRNKVD HHCCCCCCCCCCCCC	49.03	22817900
1610	Ubiquitination	KCPHSKSNRNKVDSM CCCCCCCCCCCCCCC	56.11	22817900
1613	Ubiquitination	HSKSNRNKVDSMVST CCCCCCCCCCCCCEE	44.15	22817900
1613 (in isoform 1)	Ubiquitination	-	44.15	21890473
1613 (in isoform 3)	Ubiquitination	-	44.15	21906983
1615	Ubiquitination	KSNRNKVDSMVSTVD CCCCCCCCCCCEECC	32.40	22817900
1616	Phosphorylation	SNRNKVDSMVSTVDY CCCCCCCCCCEECCH	24.87	28555341
1639	Ubiquitination	FLDLIPQDTLAVASF HHHCCCCCCEEHHHH	38.03	21963094
1639 (in isoform 2)	Ubiquitination	-	38.03	21890473
1641	Ubiquitination	DLIPQDTLAVASFRS HCCCCCCEEHHHHHC	4.93	21963094
1645	Phosphorylation	QDTLAVASFRSKAYT CCCEEHHHHHCHHHH	18.00	24719451
1648	Phosphorylation	LAVASFRSKAYTRAV EEHHHHHCHHHHHHH	21.45	24719451
1651	Phosphorylation	ASFRSKAYTRAVMHF HHHHCHHHHHHHHHH	10.65	24719451
1652	Phosphorylation	SFRSKAYTRAVMHFE HHHCHHHHHHHHHHH	19.60	28348404
1666	Ubiquitination	ESFITEKKQNIQEHL HHHHHHHHHHHHHHH	42.20	29967540
1680	Phosphorylation	LGFLQKLYAAMHEPD HHHHHHHHHHHCCCC	10.19	24043423
1693	Phosphorylation	PDGVAGVSAIRKAEP CCCCCCHHHHHHCCC	19.63	24043423
1697	Ubiquitination	AGVSAIRKAEPSLKE CCHHHHHHCCCCHHH	51.49	-
1703	Ubiquitination	RKAEPSLKEQILEHE HHCCCCHHHHHHHHH	52.49	21906983
1703 (in isoform 1)	Ubiquitination	-	52.49	21890473
1703 (in isoform 3)	Ubiquitination	-	52.49	21906983
1705	Ubiquitination	AEPSLKEQILEHESL CCCCHHHHHHHHHHH	43.93	21963094
1732	Ubiquitination	AIQLEPDQIIHYHGV CCCCCHHHHHEHHHH	47.45	21963094
1734	Ubiquitination	QLEPDQIIHYHGVVK CCCHHHHHEHHHHHH	1.88	21963094
1760	Ubiquitination	ITQVNGVHANRSEWT HHHHCCCCCCCHHHC	20.77	21963094
1760 (in isoform 2)	Ubiquitination	-	20.77	21890473
1762	Ubiquitination	QVNGVHANRSEWTDE HHCCCCCCCHHHCHH	32.88	21963094
1796	Ubiquitination	NYLAADGKSTTWSVR HHHHCCCCCCCHHHH	45.22	21963094
1798	Ubiquitination	LAADGKSTTWSVRLG HHCCCCCCCHHHHHH	35.45	21963094
1812	Ubiquitination	GQLLLSAKKRDITAF HHHHHHHHHCCCHHH	44.99	-
1824	Ubiquitination	TAFYDSLKLVRAEQI HHHHHHHHHHCHHHH	49.22	21906983
1824 (in isoform 1)	Ubiquitination	-	49.22	21890473
1824 (in isoform 3)	Ubiquitination	-	49.22	21906983
1826	Ubiquitination	FYDSLKLVRAEQIVP HHHHHHHHCHHHHEE	5.35	21963094
1871	Phosphorylation	IKPLFQHSPGDSSQE CHHHHCCCCCCCCHH	21.57	20363803
1875	Phosphorylation	FQHSPGDSSQEDSLN HCCCCCCCCHHHHHH	39.58	18691976
1876	Phosphorylation	QHSPGDSSQEDSLNW CCCCCCCCHHHHHHH	42.18	20363803
1880	Phosphorylation	GDSSQEDSLNWVARL CCCCHHHHHHHHHHH	23.89	27732954
1890	Phosphorylation	WVARLEMTQNSYRAK HHHHHHHCCCCHHCC	18.41	26552605
1893	Phosphorylation	RLEMTQNSYRAKEPI HHHHCCCCHHCCHHH	13.23	26552605
1894	Phosphorylation	LEMTQNSYRAKEPIL HHHCCCCHHCCHHHH	23.34	26552605
1897	Ubiquitination	TQNSYRAKEPILALR CCCCHHCCHHHHHHH	55.83	-
1912	Ubiquitination	RALLSLNKRPDYNEM HHHHHCCCCCCHHHH	71.28	-
1933	Ubiquitination	QSARVARKAGHHQTA HHHHHHHHHCCHHHH	49.32	29967540
1956	Phosphorylation	ESRLAELYVERAKWL HHHHHHHHHHHHHHH	7.56	21955146
1989	Phosphorylation	LCFPENETPPEGKNM EECCCCCCCCCCCCC	56.58	25159151
1994	Ubiquitination	NETPPEGKNMLIHGR CCCCCCCCCCEEHHH	37.21	-
2013	Phosphorylation	VGRFMEETANFESNA HHHHHHHHCCCCCCH	17.37	30257219
2026	Acetylation	NAIMKKYKDVTACLP CHHHHHHCCCCCCCC	55.38	26051181
2026	Ubiquitination	NAIMKKYKDVTACLP CHHHHHHCCCCCCCC	55.38	29967540
2048	Ubiquitination	YLAKYYDKLMPMVTD HHHHHHHHHHCHHCC	30.48	29967540
2057	Ubiquitination	MPMVTDNKMEKQGDL HCHHCCCCHHHCCHH	51.77	-
2075	O-linked_Glycosylation	IVLHFGRSLQYGNQF HHHHCCCCCHHCCHH	21.87	30379171
2106	Ubiquitination	TKAYEWEKAGRSDRV CCCHHHHHCCCCCCC	58.16	29967540
2121	Ubiquitination	QMRNDLGKINKVITE CHHHCHHHHHHHHHH	50.86	29967540
2171	Phosphorylation	IAKVFLAYPQQAMWM HHHHHHHCHHHHHHH	12.06	26552605
2180	Phosphorylation	QQAMWMMTAVSKSSY HHHHHHHHHHCCCCC	14.06	24043423
2183	Phosphorylation	MWMMTAVSKSSYPMR HHHHHHHCCCCCCCC	25.10	24043423
2186	Phosphorylation	MTAVSKSSYPMRVNR HHHHCCCCCCCCHHH	36.67	-
2187	Phosphorylation	TAVSKSSYPMRVNRC HHHCCCCCCCCHHHH	14.24	-
2200	Ubiquitination	RCKEILNKAIHMKKS HHHHHHHHHHHHHHH	45.32	29967540
2210	Ubiquitination	HMKKSLEKFVGDATR HHHHHHHHHHCHHHH	51.12	29967540
2221	Ubiquitination	DATRLTDKLLELCNK HHHHHHHHHHHHCCC	50.14	29967540
2228	Acetylation	KLLELCNKPVDGSSS HHHHHCCCCCCCCCC	45.48	26051181
2228	Ubiquitination	KLLELCNKPVDGSSS HHHHHCCCCCCCCCC	45.48	-
2313	Phosphorylation	LQKPKKISLKGSDGK CCCCCCEEEECCCCE	32.67	-
2343	Phosphorylation	CRLMEFNSLINKCLR HHHHHHHHHHHHHHH	35.63	24719451
2347	Ubiquitination	EFNSLINKCLRKDAE HHHHHHHHHHHHCHH	27.87	29967540
2397	Ubiquitination	LTKLYKEKGVYMTGK HHHHHHHHCCCCCHH	49.91	-
2404	Acetylation	KGVYMTGKELRQCML HCCCCCHHHHHHCCC	44.39	26051181
2404	Ubiquitination	KGVYMTGKELRQCML HCCCCCHHHHHHCCC	44.39	29967540
2414	O-linked_Glycosylation	RQCMLPKSAALSEKL HHCCCCCCHHHHHHH	19.48	30379171
2420	Ubiquitination	KSAALSEKLKVFREF CCHHHHHHHHHHHHH	50.67	29967540
2506	Ubiquitination	FNKGETFEVPEIVPF ECCCCCCCCCCEEEE	65.66	22817900
2508	Ubiquitination	KGETFEVPEIVPFRL CCCCCCCCCEEEEEC	20.56	22817900
2510	Ubiquitination	ETFEVPEIVPFRLTH CCCCCCCEEEEECCC	3.79	21963094
2512	Ubiquitination	FEVPEIVPFRLTHNM CCCCCEEEEECCCCC	17.82	21963094
2516	Phosphorylation	EIVPFRLTHNMVNGM CEEEEECCCCCCCCC	13.62	24043423
2523	Ubiquitination	THNMVNGMGPMGTEG CCCCCCCCCCCCHHH	4.61	21963094
2523 (in isoform 2)	Ubiquitination	-	4.61	21890473
2525	Ubiquitination	NMVNGMGPMGTEGLF CCCCCCCCCCHHHHH	14.78	21963094
2527	Ubiquitination	VNGMGPMGTEGLFRR CCCCCCCCHHHHHHH	24.61	22817900
2528	Phosphorylation	NGMGPMGTEGLFRRA CCCCCCCHHHHHHHH	22.19	24043423
2540	Ubiquitination	RRACEVTMRLMRDQR HHHHHHHHHHHHHCC	3.60	21890473
2540 (in isoform 2)	Ubiquitination	-	3.60	21890473
2542	Ubiquitination	ACEVTMRLMRDQREP HHHHHHHHHHHCCHH	1.99	21890473
2567	Ubiquitination	DPLVEWSKPVKGHSK CCCCCCCCCCCCCCC	55.70	29967540
2570	Ubiquitination	VEWSKPVKGHSKAPL CCCCCCCCCCCCCCC	60.47	22817900
2572	Ubiquitination	WSKPVKGHSKAPLNE CCCCCCCCCCCCCCC	22.02	22817900
2574	Ubiquitination	KPVKGHSKAPLNETG CCCCCCCCCCCCCCC	48.63	21963094
2576	Ubiquitination	VKGHSKAPLNETGEV CCCCCCCCCCCCCCC	39.18	21963094
2587	Ubiquitination	TGEVVNEKAKTHVLD CCCCCCHHHHHHCCC	50.40	21906983
2587 (in isoform 1)	Ubiquitination	-	50.40	21890473
2589	Ubiquitination	EVVNEKAKTHVLDIE CCCCHHHHHHCCCHH	50.67	21963094
2591	Ubiquitination	VNEKAKTHVLDIEQR CCHHHHHHCCCHHHH	19.89	22817900
2604	Ubiquitination	QRLQGVIKTRNRVTG HHHHHHHHCCCCCCC	38.74	22817900
2604 (in isoform 1)	Ubiquitination	-	38.74	21890473
2606	Ubiquitination	LQGVIKTRNRVTGLP HHHHHHCCCCCCCCC	24.77	21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
291	Y	Phosphorylation	Kinase	ABL1	P00519	GPS
310	Y	Phosphorylation	Kinase	ABL1	P00519	GPS
428	S	Phosphorylation	Kinase	CDK1	P06493	PSP
435	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
1989	T	Phosphorylation	Kinase	ATM	Q13315	GPS
1989	T	Phosphorylation	Kinase	ATR	Q13535	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ATR_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ATR_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BRCA1_HUMAN	BRCA1	physical	11114888
P53_HUMAN	TP53	physical	15159397
ABL1_HUMAN	ABL1	physical	10608806
AP1B1_HUMAN	AP1B1	physical	10608806
ARHG1_HUMAN	ARHGEF1	physical	10608806
ATM_HUMAN	ATM	physical	10608806
ATR_HUMAN	ATR	physical	10608806
BRCA1_HUMAN	BRCA1	physical	10608806
BRCA2_HUMAN	BRCA2	physical	10608806
CHK1_HUMAN	CHEK1	physical	10608806
E4F1_HUMAN	E4F1	physical	10608806
DNLI4_HUMAN	LIG4	physical	10608806
MRE11_HUMAN	MRE11A	physical	10608806
NBN_HUMAN	NBN	physical	10608806
PA2G4_HUMAN	PA2G4	physical	10608806
PK3CA_HUMAN	PIK3CA	physical	10608806
DPOD1_HUMAN	POLD1	physical	10608806
RAD17_HUMAN	RAD17	physical	10608806
RFA1_HUMAN	RPA1	physical	10608806
P53_HUMAN	TP53	physical	10608806
WRN_HUMAN	WRN	physical	10608806
MCM2_HUMAN	MCM2	physical	15210935
MSH2_HUMAN	MSH2	physical	14657349
CLSPN_HUMAN	CLSPN	physical	12766152
CHD4_HUMAN	CHD4	physical	10545197
HDAC2_HUMAN	HDAC2	physical	10545197
HDAC1_HUMAN	HDAC1	physical	10545197
MTA1_HUMAN	MTA1	physical	10545197
MTA2_HUMAN	MTA2	physical	10545197
ATRIP_HUMAN	ATRIP	physical	14657349
ATRIP_HUMAN	ATRIP	physical	11721054
RAD17_HUMAN	RAD17	physical	11418864
H2AX_HUMAN	H2AFX	physical	19805520
XPC_HUMAN	XPC	physical	19805520
MSH6_HUMAN	MSH6	physical	20029092
FANCA_HUMAN	FANCA	physical	19109555
ATRIP_HUMAN	ATRIP	physical	19097996
TOPB1_HUMAN	TOPBP1	physical	19097996
ATM_HUMAN	ATM	physical	17124492
RFA2_HUMAN	RPA2	physical	17035231
CHK2_HUMAN	CHEK2	physical	17035231
RENT1_HUMAN	UPF1	physical	16488880
CE164_HUMAN	CEP164	physical	18283122
ATRIP_HUMAN	ATRIP	physical	18283122
ATRIP_HUMAN	ATRIP	physical	15451423
RAD1_HUMAN	RAD1	physical	18162465
HUS1_HUMAN	HUS1	physical	18162465
RAD9A_HUMAN	RAD9A	physical	18162465
RFA1_HUMAN	RPA1	physical	18162465
ATRIP_HUMAN	ATRIP	physical	18162465
ATRIP_HUMAN	ATRIP	physical	21285353
MSH2_HUMAN	MSH2	physical	21285353
DPOLN_HUMAN	POLN	physical	21242293
BLM_HUMAN	BLM	physical	14729972
EP300_HUMAN	EP300	physical	17272271
MTA1_HUMAN	MTA1	physical	20427275
ATRIP_HUMAN	ATRIP	physical	17384638
WRN_HUMAN	WRN	physical	17118963
FACD2_HUMAN	FANCD2	physical	16943440
E2F1_HUMAN	E2F1	physical	11459832
P53_HUMAN	TP53	physical	11459832
P53_HUMAN	TP53	physical	20798688
ABL1_HUMAN	ABL1	physical	20798688
CHK2_HUMAN	CHEK2	physical	10973490
HS90A_HUMAN	HSP90AA1	physical	21566061
HSP74_HUMAN	HSPA4	physical	21566061
ATRIP_HUMAN	ATRIP	physical	15758953
WRN_HUMAN	WRN	physical	22159421
P53_HUMAN	TP53	physical	10435622
CDC5L_HUMAN	CDC5L	physical	19633697
BRCA1_HUMAN	BRCA1	physical	11016625
CHK1_HUMAN	CHEK1	physical	19330022
DCAF1_HUMAN	VPRBP	physical	22184063
H2AX_HUMAN	H2AFX	physical	22184063
DCR1C_HUMAN	DCLRE1C	physical	15456891
BRCA1_HUMAN	BRCA1	physical	11278964
DTL_HUMAN	DTL	physical	23029527
SOCS1_HUMAN	SOCS1	physical	20005840
CHK1_HUMAN	CHEK1	physical	11390642
XPA_HUMAN	XPA	physical	16540648
CCNB2_HUMAN	CCNB2	physical	22939629
P53_HUMAN	TP53	physical	15775976
CHK1_HUMAN	CHEK1	physical	15775976
ATRIP_HUMAN	ATRIP	physical	14724280
RAD17_HUMAN	RAD17	physical	14724280
CDN2C_HUMAN	CDKN2C	physical	15680327
CREB1_HUMAN	CREB1	physical	16293623
P53_HUMAN	TP53	physical	16293623
RAD17_HUMAN	RAD17	physical	20424596
BID_MOUSE	Bid	physical	16122425
ATRIP_HUMAN	ATRIP	physical	17686975
CHK1_HUMAN	CHEK1	physical	17686975
BID_MOUSE	Bid	physical	16122426
CINP_HUMAN	CINP	physical	19889979
ATRIP_HUMAN	ATRIP	physical	19889979
CHK1_HUMAN	CHEK1	physical	21566061
XPC_HUMAN	XPC	physical	23422745
CLH1_HUMAN	CLTC	physical	25852190
YBOX3_HUMAN	YBX3	physical	25852190
F133B_HUMAN	FAM133B	physical	25852190
PABP2_HUMAN	PABPN1	physical	25852190
NOSIP_HUMAN	NOSIP	physical	26344197
P2R3A_HUMAN	PPP2R3A	physical	10608806
RASF1_HUMAN	RASSF1	physical	10608806
AP3B1_HUMAN	AP3B1	physical	10608806
TERT_HUMAN	TERT	genetic	23284306
ETV1_HUMAN	ETV1	physical	23284306
ETV1_HUMAN	ETV1	genetic	23284306
UBP20_HUMAN	USP20	physical	25326330
FACD2_HUMAN	FANCD2	physical	14988723
ATR_HUMAN	ATR	physical	22258451
FACD2_HUMAN	FANCD2	physical	22258451
FANCI_HUMAN	FANCI	physical	22258451
TELO2_HUMAN	TELO2	physical	17384638
TELO2_HUMAN	TELO2	physical	19097996

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
210600	Seckel syndrome 1 (SCKL1)
614564	Cutaneous telangiectasia and cancer syndrome, familial (FCTCS)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ATR_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-428; SER-435 ANDTHR-1989, AND MASS SPECTROMETRY.	18691976 [Abstract]
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-919, AND MASSSPECTROMETRY.	17924679 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1989, AND MASSSPECTROMETRY.	18669648 [Abstract]