RAD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RAD1_HUMAN
• UniProt AC: O60671
• Protein Name: Cell cycle checkpoint protein RAD1
• Gene Name: RAD1
• Organism: Homo sapiens (Human).
• Sequence Length: 282
• Subcellular Localization: Nucleus .
• Protein Description: Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. [PubMed: 10846170]
• Protein Sequence: MPLLTQQIQDEDDQYSLVASLDNVRNLSTILKAIHFREHATCFATKNGIKVTVENAKCVQANAFIQAGIFQEFKVQEESVTFRINLTVLLDCLSIFGSSPMPGTLTALRMCYQGYGYPLMLFLEEGGVVTVCKINTQEPEETLDFDFCSTNVINKIILQSEGLREAFSELDMTSEVLQITMSPDKPYFRLSTFGNAGSSHLDYPKDSDLMEAFHCNQTQVNRYKISLLKPSTKALVLSCKVSIRTDNRGFLSLQYMIRNEDGQICFVEYYCCPDEEVPESES

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MPLLTQQIQDED ---CCCCCCCCCCCC	26.55	29523821
15	Phosphorylation	IQDEDDQYSLVASLD CCCCCCCEEEEEEHH	15.80	27642862
16	Phosphorylation	QDEDDQYSLVASLDN CCCCCCEEEEEEHHH	15.67	28122231
20	Phosphorylation	DQYSLVASLDNVRNL CCEEEEEEHHHHHCH	28.86	20873877
32	Ubiquitination	RNLSTILKAIHFREH HCHHHHHHHHHHHHC	41.25	-
46	Ubiquitination	HATCFATKNGIKVTV CCEEEEECCCEEEEE	50.15	-
50	Ubiquitination	FATKNGIKVTVENAK EEECCCEEEEEECCE	33.00	-
57	Ubiquitination	KVTVENAKCVQANAF EEEEECCEEEECCHH	46.66	-
106	Phosphorylation	SPMPGTLTALRMCYQ CCCCCHHHHHHHHHC	24.39	24719451
205	Ubiquitination	SSHLDYPKDSDLMEA CCCCCCCCCCCHHHH	64.73	-
224	Ubiquitination	QTQVNRYKISLLKPS CHHCCEEEEEEECCC	23.68	-
226	Phosphorylation	QVNRYKISLLKPSTK HCCEEEEEEECCCCE	24.40	24719451
229	Ubiquitination	RYKISLLKPSTKALV EEEEEEECCCCEEEE	42.06	-
233	Ubiquitination	SLLKPSTKALVLSCK EEECCCCEEEEEEEE	44.02	-
240	Ubiquitination	KALVLSCKVSIRTDN EEEEEEEEEEEECCC	35.32	-
280	Phosphorylation	PDEEVPESES----- CCCCCCCCCC-----	36.75	20545769
282	Phosphorylation	EEVPESES------- CCCCCCCC-------	55.59	20545769

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
280	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
282	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RAD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RAD1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HUS1_HUMAN	HUS1	physical	9872989
RAD9A_HUMAN	RAD9A	physical	9872989
HUS1B_HUMAN	HUS1B	physical	11944979
RAD9A_HUMAN	RAD9A	physical	11994305
RAD17_HUMAN	RAD17	physical	11418864
RFA1_HUMAN	RPA1	physical	15897895
RFA2_HUMAN	RPA2	physical	15897895
HUS1_HUMAN	HUS1	physical	20847938
CSN5_HUMAN	COPS5	physical	17583730
MSH2_HUMAN	MSH2	physical	20188637
MSH6_HUMAN	MSH6	physical	20188637
MSH3_HUMAN	MSH3	physical	20188637
FEN1_HUMAN	FEN1	physical	15556996
ZBT14_HUMAN	ZBTB14	physical	26186194
RAD9A_HUMAN	RAD9A	physical	26186194
ZBT14_HUMAN	ZBTB14	physical	28514442
RAD9A_HUMAN	RAD9A	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.