ZBT14_HUMAN - dbPTM
ZBT14_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ZBT14_HUMAN
UniProt AC O43829
Protein Name Zinc finger and BTB domain-containing protein 14
Gene Name ZBTB14
Organism Homo sapiens (Human).
Sequence Length 449
Subcellular Localization Nucleus . Colocalizes with ZBTB21 in nucleus in HEK293 cells.
Protein Description Transcriptional activator of the dopamine transporter (DAT), binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. Binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. Transcriptional repressor of MYC and thymidine kinase promoters..
Protein Sequence MEFFISMSETIKYNDDDHKTLFLKTLNEQRLEGEFCDIAIVVEDVKFRAHRCVLAACSTYFKKLFKKLEVDSSSVIEIDFLRSDIFEEVLNYMYTAKISVKKEDVNLMMSSGQILGIRFLDKLCSQKRDVSSPDENNGQSKSKYCLKINRPIGDAADTQDDDVEEIGDQDDSPSDDTVEGTPPSQEDGKSPTTTLRVQEAILKELGSEEVRKVNCYGQEVESMETPESKDLGSQTPQALTFNDGMSEVKDEQTPGWTTAASDMKFEYLLYGHHREQIACQACGKTFSDEGRLRKHEKLHTADRPFVCEMCTKGFTTQAHLKEHLKIHTGYKPYSCEVCGKSFIRAPDLKKHERVHSNERPFACHMCDKAFKHKSHLKDHERRHRGEKPFVCGSCTKAFAKASDLKRHENNMHSERKQVTPSAIQSETEQLQAAAMAAEAEQQLETIACS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
24UbiquitinationDHKTLFLKTLNEQRL
CCCEEEEHHHCHHHH		21890473
46SumoylationAIVVEDVKFRAHRCV
EEEEECCCHHHHHHH		28112733
74PhosphorylationKLEVDSSSVIEIDFL
HCCCCCCCEEEEEEE		-
122AcetylationLGIRFLDKLCSQKRD
EHHHHHHHHHCCCCC		26051181
125PhosphorylationRFLDKLCSQKRDVSS
HHHHHHHCCCCCCCC		26074081
131PhosphorylationCSQKRDVSSPDENNG
HCCCCCCCCCCCCCC		25262027
132PhosphorylationSQKRDVSSPDENNGQ
CCCCCCCCCCCCCCC		25159151
172PhosphorylationEIGDQDDSPSDDTVE
HHCCCCCCCCCCCCC		25921289
174PhosphorylationGDQDDSPSDDTVEGT
CCCCCCCCCCCCCCC		30576142
181PhosphorylationSDDTVEGTPPSQEDG
CCCCCCCCCCCCCCC		30576142
184PhosphorylationTVEGTPPSQEDGKSP
CCCCCCCCCCCCCCC		30257219
190PhosphorylationPSQEDGKSPTTTLRV
CCCCCCCCCCHHHHH		20363803
192PhosphorylationQEDGKSPTTTLRVQE
CCCCCCCCHHHHHHH		25159151
203SumoylationRVQEAILKELGSEEV
HHHHHHHHHHCCHHH		28112733
203UbiquitinationRVQEAILKELGSEEV
HHHHHHHHHHCCHHH		-
207PhosphorylationAILKELGSEEVRKVN
HHHHHHCCHHHHCCC		21815630
222PhosphorylationCYGQEVESMETPESK
CCCCEEEECCCCCCC		25849741
225PhosphorylationQEVESMETPESKDLG
CEEEECCCCCCCCCC		21815630
228PhosphorylationESMETPESKDLGSQT
EECCCCCCCCCCCCC		26714015
233PhosphorylationPESKDLGSQTPQALT
CCCCCCCCCCCCEEE		30266825
235PhosphorylationSKDLGSQTPQALTFN
CCCCCCCCCCEEEEC		30266825
240PhosphorylationSQTPQALTFNDGMSE
CCCCCEEEECCCCCC		30266825
246PhosphorylationLTFNDGMSEVKDEQT
EEECCCCCCCCCCCC		29978859
249SumoylationNDGMSEVKDEQTPGW
CCCCCCCCCCCCCCC		28112733
253PhosphorylationSEVKDEQTPGWTTAA
CCCCCCCCCCCEECH		21815630
257PhosphorylationDEQTPGWTTAASDMK
CCCCCCCEECHHHCC		29978859
258PhosphorylationEQTPGWTTAASDMKF
CCCCCCEECHHHCCE		29978859
261PhosphorylationPGWTTAASDMKFEYL
CCCEECHHHCCEEEH		29978859
284AcetylationIACQACGKTFSDEGR
HHHHHCCCCCCCCCC		26051181
285PhosphorylationACQACGKTFSDEGRL
HHHHCCCCCCCCCCC		22817900
287PhosphorylationQACGKTFSDEGRLRK
HHCCCCCCCCCCCHH		22817900
300PhosphorylationRKHEKLHTADRPFVC
HHHCHHCCCCCCCHH		25159151
321UbiquitinationFTTQAHLKEHLKIHT
CCCHHHHHHHHCCCC		-
328PhosphorylationKEHLKIHTGYKPYSC
HHHHCCCCCCCCEEE		28555341
341PhosphorylationSCEVCGKSFIRAPDL
EEEECCCEEECCCCC		28555341
356PhosphorylationKKHERVHSNERPFAC
CCCCCCCCCCCCCHH		25159151
393PhosphorylationEKPFVCGSCTKAFAK
CCCCCCCHHHHHHHH		25627689
419PhosphorylationHSERKQVTPSAIQSE
CCCCCCCCHHHHHHH		27251275
421PhosphorylationERKQVTPSAIQSETE
CCCCCCHHHHHHHHH		27251275
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ZBT14_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ZBT14_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ZBT14_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ZBT14_HUMANZBTB14physical
10080939
ZBT21_HUMANZBTB21physical
15629158
NAA10_HUMANNAA10physical
25416956
AP1M1_HUMANAP1M1physical
25416956
MD2BP_HUMANMAD2L1BPphysical
25416956
MO4L2_HUMANMORF4L2physical
25416956
EPMIP_HUMANEPM2AIP1physical
25416956
KAT5_HUMANKAT5physical
25416956
RNPS1_HUMANRNPS1physical
25416956
PNKP_HUMANPNKPphysical
25416956
THIOM_HUMANTXN2physical
25416956
GORS2_HUMANGORASP2physical
25416956
BAZ2B_HUMANBAZ2Bphysical
25416956
CDKL3_HUMANCDKL3physical
25416956
ZCH10_HUMANZCCHC10physical
25416956
F90A1_HUMANFAM90A1physical
25416956
CBX8_HUMANCBX8physical
25416956
INT3_HUMANINTS3physical
25416956
SCNM1_HUMANSCNM1physical
25416956
SYT16_HUMANSYT16physical
25416956
ENKD1_HUMANENKD1physical
25416956
F161A_HUMANFAM161Aphysical
25416956
EIF1A_HUMANEIF1ADphysical
25416956
CEP19_HUMANCEP19physical
25416956
EAF1_HUMANEAF1physical
25416956
ZMAT2_HUMANZMAT2physical
25416956
TEANC_HUMANTCEANCphysical
25416956
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ZBT14_HUMAN

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Related Literatures of Post-Translational Modification

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