THIOM_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: THIOM_HUMAN
• UniProt AC: Q99757
• Protein Name: Thioredoxin, mitochondrial
• Gene Name: TXN2
• Organism: Homo sapiens (Human).
• Sequence Length: 166
• Subcellular Localization: Mitochondrion .
• Protein Description: Important for the control of mitochondrial reactive oxygen species homeostasis, apoptosis regulation and cell viability. Possesses a dithiol-reducing activity..
• Protein Sequence: MAQRLLLRRFLASVISRKPSQGQWPPLTSRALQTPQCSPGGLTVTPNPARTIYTTRISLTTFNIQDGPDFQDRVVNSETPVVVDFHAQWCGPCKILGPRLEKMVAKQHGKVVMAKVDIDDHTDLAIEYEVSAVPTVLAMKNGDVVDKFVGIKDEDQLEAFLKKLIG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
94	Acetylation	AQWCGPCKILGPRLE CCCCCCCEEHHHHHH	44.06	26051181
102	Acetylation	ILGPRLEKMVAKQHG EHHHHHHHHHHHHCC	43.18	25953088
102	Ubiquitination	ILGPRLEKMVAKQHG EHHHHHHHHHHHHCC	43.18	21890473
102	2-Hydroxyisobutyrylation	ILGPRLEKMVAKQHG EHHHHHHHHHHHHCC	43.18	-
106	2-Hydroxyisobutyrylation	RLEKMVAKQHGKVVM HHHHHHHHHCCCEEE	31.27	-
128	Phosphorylation	HTDLAIEYEVSAVPT CCCEEEEEEECCCCE	18.60	28258704
131	Phosphorylation	LAIEYEVSAVPTVLA EEEEEEECCCCEEEE	16.17	28258704
133	Ubiquitination	IEYEVSAVPTVLAMK EEEEECCCCEEEEEC	2.96	21890473
152	Acetylation	VDKFVGIKDEDQLEA EEEECCCCCHHHHHH	49.49	19608861
152	Succinylation	VDKFVGIKDEDQLEA EEEECCCCCHHHHHH	49.49	-
152	2-Hydroxyisobutyrylation	VDKFVGIKDEDQLEA EEEECCCCCHHHHHH	49.49	-
152	Succinylation	VDKFVGIKDEDQLEA EEEECCCCCHHHHHH	49.49	23954790
162	2-Hydroxyisobutyrylation	DQLEAFLKKLIG--- HHHHHHHHHHHC---	38.80	-
162	Acetylation	DQLEAFLKKLIG--- HHHHHHHHHHHC---	38.80	25953088

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of THIOM_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of THIOM_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of THIOM_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TOM22_HUMAN	TOMM22	physical	22939629
TPM4_HUMAN	TPM4	physical	22939629
VIME_HUMAN	VIM	physical	21988832
GCR_HUMAN	NR3C1	physical	19570036
TF65_HUMAN	RELA	physical	19570036
RABX5_HUMAN	RABGEF1	physical	25416956
ATRAP_HUMAN	AGTRAP	physical	25416956
PACE1_HUMAN	SCYL3	physical	25416956
COAC_HUMAN	PPCDC	physical	25416956
TIFA_HUMAN	TIFA	physical	25416956
REEP6_HUMAN	REEP6	physical	25416956
CC114_HUMAN	CCDC114	physical	25416956
MR1L1_HUMAN	MRFAP1L1	physical	25416956
K1C40_HUMAN	KRT40	physical	25416956
RBM45_HUMAN	RBM45	physical	25416956
FAM9B_HUMAN	FAM9B	physical	25416956
ANXA6_HUMAN	ANXA6	physical	26344197
FA98B_HUMAN	FAM98B	physical	26344197
SODC_HUMAN	SOD1	physical	26344197
THIO_HUMAN	TXN	physical	26344197
WDR12_HUMAN	WDR12	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-152, AND MASS SPECTROMETRY.
PubMed: 19608861