PACE1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PACE1_HUMAN
• UniProt AC: Q8IZE3
• Protein Name: Protein-associating with the carboxyl-terminal domain of ezrin
• Gene Name: SCYL3
• Organism: Homo sapiens (Human).
• Sequence Length: 742
• Subcellular Localization: Cytoplasm . Golgi apparatus . Cell projection, lamellipodium . Colocalized with EZR/VIL2, actin and CD44 in lamellipodia.
• Protein Description: May play a role in regulating cell adhesion/migration complexes in migrating cells..
• Protein Sequence: MGSENSALKSYTLREPPFTLPSGLAVYPAVLQDGKFASVFVYKRENEDKVNKAAKHLKTLRHPCLLRFLSCTVEADGIHLVTERVQPLEVALETLSSAEVCAGIYDILLALIFLHDRGHLTHNNVCLSSVFVSEDGHWKLGGMETVCKVSQATPEFLRSIQSIRDPASIPPEEMSPEFTTLPECHGHARDAFSFGTLVESLLTILNEQVSADVLSSFQQTLHSTLLNPIPKCRPALCTLLSHDFFRNDFLEVVNFLKSLTLKSEEEKTEFFKFLLDRVSCLSEELIASRLVPLLLNQLVFAEPVAVKSFLPYLLGPKKDHAQGETPCLLSPALFQSRVIPVLLQLFEVHEEHVRMVLLSHIEAYVEHFTQEQLKKVILPQVLLGLRDTSDSIVAITLHSLAVLVSLLGPEVVVGGERTKIFKRTAPSFTKNTDLSLEDSPMCVVCSHHSQISPILENPFSSIFPKCFFSGSTPINSKKHIQRDYYNTLLQTGDPFSQPIKFPINGLSDVKNTSEDSENFPSSSKKSEEWPDWSEPEEPENQTVNIQIWPREPCDDVKSQCTTLDVEESSWDDCEPSSLDTKVNPGGGITATKPVTSGEQKPIPALLSLTEESMPWKSSLPQKISLVQRGDDADQIEPPKVSSQERPLKVPSELGLGEEFTIQVKKKPVKDPEMDWFADMIPEIKPSAAFLILPELRTEMVPKKDDVSPVMQFSSKFAAAEITEGEAEGWEEEGELNWEDNNW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGSENSALK ------CCCCCCCCC	43.60	12651155
2	N-myristoyl glycine	------MGSENSALK ------CCCCCCCCC	43.60	-
12	Phosphorylation	NSALKSYTLREPPFT CCCCCCCCCCCCCCC	26.82	24719451
70	Phosphorylation	PCLLRFLSCTVEADG HHHHHHHHCEEEECC	12.67	24247654
72	Phosphorylation	LLRFLSCTVEADGIH HHHHHHCEEEECCEE	20.29	27251275
125	Ubiquitination	GHLTHNNVCLSSVFV CCCCCCCEEEEEEEE	4.16	23000965
130	Ubiquitination	NNVCLSSVFVSEDGH CCEEEEEEEECCCCC	5.02	21890473
153	Phosphorylation	VCKVSQATPEFLRSI EEEHHHCCHHHHHHH	18.73	23927012
258	Phosphorylation	EVVNFLKSLTLKSEE HHHHHHHHCCCCCHH	28.82	24719451
267	Ubiquitination	TLKSEEEKTEFFKFL CCCCHHHHHHHHHHH	57.54	23000965
272 (in isoform 2)	Ubiquitination	-	40.18	21890473
272 (in isoform 1)	Ubiquitination	-	40.18	21890473
272	Ubiquitination	EEKTEFFKFLLDRVS HHHHHHHHHHHHHHH	40.18	23000965
308	Acetylation	AEPVAVKSFLPYLLG CCCCHHHHHHHHHHC	25.97	19413330
364	Phosphorylation	LLSHIEAYVEHFTQE HHHHHHHHHHHCCHH	8.12	-
369	Phosphorylation	EAYVEHFTQEQLKKV HHHHHHCCHHHHHHH	32.86	-
389	Phosphorylation	LLGLRDTSDSIVAIT HHCCCCCCCHHHHHH	33.38	-
391	Phosphorylation	GLRDTSDSIVAITLH CCCCCCCHHHHHHHH	20.80	-
405	Phosphorylation	HSLAVLVSLLGPEVV HHHHHHHHHHCCEEE	17.45	-
424	Phosphorylation	RTKIFKRTAPSFTKN CEEEEECCCCCCCCC	43.44	23312004
427	Phosphorylation	IFKRTAPSFTKNTDL EEECCCCCCCCCCCC	42.98	24719451
429	Phosphorylation	KRTAPSFTKNTDLSL ECCCCCCCCCCCCCC	27.94	23312004
430	Ubiquitination	RTAPSFTKNTDLSLE CCCCCCCCCCCCCCC	56.70	29967540
435 (in isoform 2)	Phosphorylation	-	32.30	21815630
439	Phosphorylation	TDLSLEDSPMCVVCS CCCCCCCCCEEEEEC	12.73	-
446	Ubiquitination	SPMCVVCSHHSQISP CCEEEEECCCCCCHH	16.78	29967540
476	Phosphorylation	SGSTPINSKKHIQRD CCCCCCCCCHHHCHH	43.74	24260401
484	Phosphorylation	KKHIQRDYYNTLLQT CHHHCHHHHHHHHHC	10.78	21082442
487	Phosphorylation	IQRDYYNTLLQTGDP HCHHHHHHHHHCCCC	16.84	21082442
500	Ubiquitination	DPFSQPIKFPINGLS CCCCCCCCCCCCCCC	52.34	-
513	Phosphorylation	LSDVKNTSEDSENFP CCCCCCCCCCCCCCC	49.12	21815630
515	Phosphorylation	DVKNTSEDSENFPSS CCCCCCCCCCCCCCC	62.10	33259812
516	Phosphorylation	VKNTSEDSENFPSSS CCCCCCCCCCCCCCC	30.32	21815630
521	Phosphorylation	EDSENFPSSSKKSEE CCCCCCCCCCCCCCC	43.01	25627689
522	Phosphorylation	DSENFPSSSKKSEEW CCCCCCCCCCCCCCC	46.55	25627689
524	Ubiquitination	ENFPSSSKKSEEWPD CCCCCCCCCCCCCCC	63.37	-
526	Phosphorylation	FPSSSKKSEEWPDWS CCCCCCCCCCCCCCC	44.47	28122231
533	Phosphorylation	SEEWPDWSEPEEPEN CCCCCCCCCCCCCCC	51.13	26657352
542	Phosphorylation	PEEPENQTVNIQIWP CCCCCCCCEEEEEEC	27.40	28122231
558	Phosphorylation	EPCDDVKSQCTTLDV CCCCCHHHCCEEEEC	30.27	28348404
561	Phosphorylation	DDVKSQCTTLDVEES CCHHHCCEEEECCCC	23.82	28348404
568	Phosphorylation	TTLDVEESSWDDCEP EEEECCCCCCCCCCC	24.19	25849741
569	Phosphorylation	TLDVEESSWDDCEPS EEECCCCCCCCCCCH	37.49	26657352
576	Phosphorylation	SWDDCEPSSLDTKVN CCCCCCCHHCCCCCC	22.65	28348404
577	Phosphorylation	WDDCEPSSLDTKVNP CCCCCCHHCCCCCCC	40.77	28348404
641	Phosphorylation	QIEPPKVSSQERPLK HCCCCCCCCCCCCCC	32.22	28102081
642	Phosphorylation	IEPPKVSSQERPLKV CCCCCCCCCCCCCCC	38.76	25159151
651	Phosphorylation	ERPLKVPSELGLGEE CCCCCCCCCCCCCCC	48.73	26074081
653	Phosphorylation	PLKVPSELGLGEEFT CCCCCCCCCCCCCEE	8.89	32645325
707	Phosphorylation	VPKKDDVSPVMQFSS CCCCCCCCHHHHHHH	20.83	30266825
713	Phosphorylation	VSPVMQFSSKFAAAE CCHHHHHHHHHEEEE	18.74	26330541
714	Phosphorylation	SPVMQFSSKFAAAEI CHHHHHHHHHEEEEC	32.83	26330541

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PACE1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PACE1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PACE1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LHX8_HUMAN	LHX8	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.