COAC_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COAC_HUMAN
• UniProt AC: Q96CD2
• Protein Name: Phosphopantothenoylcysteine decarboxylase
• Gene Name: PPCDC
• Organism: Homo sapiens (Human).
• Sequence Length: 204
• Protein Description: Necessary for the biosynthesis of coenzyme A. Catalyzes the decarboxylation of 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine..
• Protein Sequence: MEPKASCPAAAPLMERKFHVLVGVTGSVAALKLPLLVSKLLDIPGLEVAVVTTERAKHFYSPQDIPVTLYSDADEWEIWKSRSDPVLHIDLRRWADLLLVAPLDANTLGKVASGICDNLLTCVMRAWDRSKPLLFCPAMNTAMWEHPITAQQVDQLKAFGYVEIPCVAKKLVCGDEGLGAMAEVGTIVDKVKEVLFQHSGFQQS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
25	Phosphorylation	FHVLVGVTGSVAALK EEEEEECCCCHHHHH	20.15	21406692
27	Phosphorylation	VLVGVTGSVAALKLP EEEECCCCHHHHHHH	10.14	21406692
107	Phosphorylation	VAPLDANTLGKVASG EEECCHHHHHHHHHC	38.31	-
110	Ubiquitination	LDANTLGKVASGICD CCHHHHHHHHHCHHH	37.43	-
130	Phosphorylation	VMRAWDRSKPLLFCP HHHHHCCCCCEEEEC	35.83	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COAC_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COAC_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COAC_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
COAC_HUMAN	PPCDC	physical	25416956
FOXR1_HUMAN	FOXR1	physical	25416956
SR1IP_HUMAN	SREK1IP1	physical	25416956
COAC_HUMAN	PPCDC	physical	21516116
ZN232_HUMAN	ZNF232	physical	21516116

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.