dbPTM

ANXA6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ANXA6_HUMAN
UniProt AC	P08133
Protein Name	Annexin A6
Gene Name	ANXA6
Organism	Homo sapiens (Human).
Sequence Length	673
Subcellular Localization	Cytoplasm. Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Protein Description	May associate with CD21. May regulate the release of Ca(2+) from intracellular stores..
Protein Sequence	MAKPAQGAKYRGSIHDFPGFDPNQDAEALYTAMKGFGSDKEAILDIITSRSNRQRQEVCQSYKSLYGKDLIADLKYELTGKFERLIVGLMRPPAYCDAKEIKDAISGIGTDEKCLIEILASRTNEQMHQLVAAYKDAYERDLEADIIGDTSGHFQKMLVVLLQGTREEDDVVSEDLVQQDVQDLYEAGELKWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEKLMLAVVKCIRSTPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSLYSMIKNDTSGEYKKTLLKLSGGDDDAAGQFFPEAAQVAYQMWELSAVARVELKGTVRPANDFNPDADAKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMTDLKSEISGDLARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAINEAYKEDYHKSLEDALSSDTSGHFRRILISLATGHREEGGENLDQAREDAQVAAEILEIADTPSGDKTSLETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDAFVAIVQSVKNKPLFFADKLYKSMKGAGTDEKTLTRIMVSRSEIDLLNIRREFIEKYDKSLHQAIEGDTSGDFLKALLALCGGED

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAKPAQGAK ------CCCCCCCCC	26.92	25944712
3	Acetylation	-----MAKPAQGAKY -----CCCCCCCCCC	39.32	23749302
9	2-Hydroxyisobutyrylation	AKPAQGAKYRGSIHD CCCCCCCCCCCCCCC	42.16	-
9	Acetylation	AKPAQGAKYRGSIHD CCCCCCCCCCCCCCC	42.16	23749302
9	Ubiquitination	AKPAQGAKYRGSIHD CCCCCCCCCCCCCCC	42.16	-
10	Phosphorylation	KPAQGAKYRGSIHDF CCCCCCCCCCCCCCC	21.48	26657352
11	Methylation	PAQGAKYRGSIHDFP CCCCCCCCCCCCCCC	31.51	-
13	Phosphorylation	QGAKYRGSIHDFPGF CCCCCCCCCCCCCCC	14.04	28258704
30	Phosphorylation	NQDAEALYTAMKGFG CCCHHHHHHHHHCCC	10.25	21082442
31	Acetylation	QDAEALYTAMKGFGS CCHHHHHHHHHCCCC	22.56	19608861
31	Phosphorylation	QDAEALYTAMKGFGS CCHHHHHHHHHCCCC	22.56	28796482
31	Ubiquitination	QDAEALYTAMKGFGS CCHHHHHHHHHCCCC	22.56	19608861
33	Sulfoxidation	AEALYTAMKGFGSDK HHHHHHHHHCCCCCH	3.17	30846556
34	Ubiquitination	EALYTAMKGFGSDKE HHHHHHHHCCCCCHH	48.93	-
36	Acetylation	LYTAMKGFGSDKEAI HHHHHHCCCCCHHHH	7.65	19608861
36	Ubiquitination	LYTAMKGFGSDKEAI HHHHHHCCCCCHHHH	7.65	19608861
38	Phosphorylation	TAMKGFGSDKEAILD HHHHCCCCCHHHHHH	43.16	30108239
40	Acetylation	MKGFGSDKEAILDII HHCCCCCHHHHHHHH	51.23	23954790
40	Ubiquitination	MKGFGSDKEAILDII HHCCCCCHHHHHHHH	51.23	-
43	Acetylation	FGSDKEAILDIITSR CCCCHHHHHHHHHCC	3.58	19608861
48	Phosphorylation	EAILDIITSRSNRQR HHHHHHHHCCCHHHH	20.58	20068231
49	Acetylation	AILDIITSRSNRQRQ HHHHHHHCCCHHHHH	24.25	19608861
49	Phosphorylation	AILDIITSRSNRQRQ HHHHHHHCCCHHHHH	24.25	20068231
49	Ubiquitination	AILDIITSRSNRQRQ HHHHHHHCCCHHHHH	24.25	19608861
51	Phosphorylation	LDIITSRSNRQRQEV HHHHHCCCHHHHHHH	35.81	24043423
61	Phosphorylation	QRQEVCQSYKSLYGK HHHHHHHHHHHHHCC	29.42	24275569
63	Acetylation	QEVCQSYKSLYGKDL HHHHHHHHHHHCCHH	38.95	19608861
63	Malonylation	QEVCQSYKSLYGKDL HHHHHHHHHHHCCHH	38.95	26320211
63	Ubiquitination	QEVCQSYKSLYGKDL HHHHHHHHHHHCCHH	38.95	19608861
64	Phosphorylation	EVCQSYKSLYGKDLI HHHHHHHHHHCCHHH	20.70	28258704
66	Phosphorylation	CQSYKSLYGKDLIAD HHHHHHHHCCHHHHH	29.26	28258704
68	Ubiquitination	SYKSLYGKDLIADLK HHHHHHCCHHHHHHH	35.49	21890473
68	Acetylation	SYKSLYGKDLIADLK HHHHHHCCHHHHHHH	35.49	19608861
68	Ubiquitination	SYKSLYGKDLIADLK HHHHHHCCHHHHHHH	35.49	21890473
75	2-Hydroxyisobutyrylation	KDLIADLKYELTGKF CHHHHHHHHHHCCCC	36.91	-
75	Acetylation	KDLIADLKYELTGKF CHHHHHHHHHHCCCC	36.91	19608861
75	Ubiquitination	KDLIADLKYELTGKF CHHHHHHHHHHCCCC	36.91	19608861
76	Phosphorylation	DLIADLKYELTGKFE HHHHHHHHHHCCCCH	24.38	20560785
81	Ubiquitination	LKYELTGKFERLIVG HHHHHCCCCHHHHHH	38.52	21890473
81	2-Hydroxyisobutyrylation	LKYELTGKFERLIVG HHHHHCCCCHHHHHH	38.52	-
81	Acetylation	LKYELTGKFERLIVG HHHHHCCCCHHHHHH	38.52	19608861
81	Ubiquitination	LKYELTGKFERLIVG HHHHHCCCCHHHHHH	38.52	21890473
90	Sulfoxidation	ERLIVGLMRPPAYCD HHHHHHHCCCCCCCC	5.07	30846556
95	Phosphorylation	GLMRPPAYCDAKEIK HHCCCCCCCCHHHHH	9.17	30108239
99	Acetylation	PPAYCDAKEIKDAIS CCCCCCHHHHHHHHC	46.88	23749302
99	Malonylation	PPAYCDAKEIKDAIS CCCCCCHHHHHHHHC	46.88	26320211
99	Ubiquitination	PPAYCDAKEIKDAIS CCCCCCHHHHHHHHC	46.88	-
102	2-Hydroxyisobutyrylation	YCDAKEIKDAISGIG CCCHHHHHHHHCCCC	42.05	-
102	Acetylation	YCDAKEIKDAISGIG CCCHHHHHHHHCCCC	42.05	23749302
102	Ubiquitination	YCDAKEIKDAISGIG CCCHHHHHHHHCCCC	42.05	21906983
106	Phosphorylation	KEIKDAISGIGTDEK HHHHHHHCCCCCCHH	26.53	20873877
110	Phosphorylation	DAISGIGTDEKCLIE HHHCCCCCCHHHHHH	38.78	26437602
113	2-Hydroxyisobutyrylation	SGIGTDEKCLIEILA CCCCCCHHHHHHHHH	36.83	-
113	Acetylation	SGIGTDEKCLIEILA CCCCCCHHHHHHHHH	36.83	26822725
113	Ubiquitination	SGIGTDEKCLIEILA CCCCCCHHHHHHHHH	36.83	21906983
114	S-nitrosocysteine	GIGTDEKCLIEILAS CCCCCHHHHHHHHHH	4.32	-
114	S-nitrosylation	GIGTDEKCLIEILAS CCCCCHHHHHHHHHH	4.32	19483679
114	S-palmitoylation	GIGTDEKCLIEILAS CCCCCHHHHHHHHHH	4.32	29575903
121	Phosphorylation	CLIEILASRTNEQMH HHHHHHHHCCHHHHH	35.87	21712546
127	Sulfoxidation	ASRTNEQMHQLVAAY HHCCHHHHHHHHHHH	1.45	30846556
135	Ubiquitination	HQLVAAYKDAYERDL HHHHHHHHHHHHHHH	31.02	21890473
135	2-Hydroxyisobutyrylation	HQLVAAYKDAYERDL HHHHHHHHHHHHHHH	31.02	-
135	Acetylation	HQLVAAYKDAYERDL HHHHHHHHHHHHHHH	31.02	26822725
135	Ubiquitination	HQLVAAYKDAYERDL HHHHHHHHHHHHHHH	31.02	21906983
150	Phosphorylation	EADIIGDTSGHFQKM HCCCCCCCCHHHHHH	31.25	30108239
151	Phosphorylation	ADIIGDTSGHFQKML CCCCCCCCHHHHHHH	34.70	30108239
173	Phosphorylation	REEDDVVSEDLVQQD CCCCCCCCHHHHHHH	25.82	20873877
185	Phosphorylation	QQDVQDLYEAGELKW HHHHHHHHHHCCCCC	16.42	50565703
201	Phosphorylation	TDEAQFIYILGNRSK CCHHHEEEEECCCCH	7.44	21082442
218	Nitration	LRLVFDEYLKTTGKP HHHHHHHHHHHHCCC	18.49	-
220	Acetylation	LVFDEYLKTTGKPIE HHHHHHHHHHCCCCC	43.04	26051181
220	Ubiquitination	LVFDEYLKTTGKPIE HHHHHHHHHHCCCCC	43.04	-
221	O-linked_Glycosylation	VFDEYLKTTGKPIEA HHHHHHHHHCCCCCH	37.88	30379171
221	Phosphorylation	VFDEYLKTTGKPIEA HHHHHHHHHCCCCCH	37.88	20068231
222	O-linked_Glycosylation	FDEYLKTTGKPIEAS HHHHHHHHCCCCCHH	41.44	30379171
222	Phosphorylation	FDEYLKTTGKPIEAS HHHHHHHHCCCCCHH	41.44	20068231
224	Acetylation	EYLKTTGKPIEASIR HHHHHHCCCCCHHHC	40.50	26051181
224	Ubiquitination	EYLKTTGKPIEASIR HHHHHHCCCCCHHHC	40.50	-
229	Phosphorylation	TGKPIEASIRGELSG HCCCCCHHHCCCCCC	10.46	20068231
235	Phosphorylation	ASIRGELSGDFEKLM HHHCCCCCCCHHHHH	31.82	26657352
240	Ubiquitination	ELSGDFEKLMLAVVK CCCCCHHHHHHHHHH	38.91	-
247	Ubiquitination	KLMLAVVKCIRSTPE HHHHHHHHHHHCCHH	19.83	-
251	Phosphorylation	AVVKCIRSTPEYFAE HHHHHHHCCHHHHHH	28.53	20068231
252	Phosphorylation	VVKCIRSTPEYFAER HHHHHHCCHHHHHHH	15.42	22210691
255	Phosphorylation	CIRSTPEYFAERLFK HHHCCHHHHHHHHHH	14.86	22210691
259	Methylation	TPEYFAERLFKAMKG CHHHHHHHHHHHHCC	41.83	-
265	Acetylation	ERLFKAMKGLGTRDN HHHHHHHCCCCCCCC	56.71	25953088
265	Malonylation	ERLFKAMKGLGTRDN HHHHHHHCCCCCCCC	56.71	26320211
267	Acetylation	LFKAMKGLGTRDNTL HHHHHCCCCCCCCHH	5.44	19608861
269	Phosphorylation	KAMKGLGTRDNTLIR HHHCCCCCCCCHHEE	39.63	17494752
273	Phosphorylation	GLGTRDNTLIRIMVS CCCCCCCHHEEEEEE	28.05	54887405
274	Acetylation	LGTRDNTLIRIMVSR CCCCCCHHEEEEEEH	2.88	19608861
282	Phosphorylation	IRIMVSRSELDMLDI EEEEEEHHHHCCCCH	34.70	63735769
286	Sulfoxidation	VSRSELDMLDIREIF EEHHHHCCCCHHHHH	5.91	21406390
297	Phosphorylation	REIFRTKYEKSLYSM HHHHHHHHHHHHHHH	28.16	29759185
299	Acetylation	IFRTKYEKSLYSMIK HHHHHHHHHHHHHHH	42.54	23236377
299	Malonylation	IFRTKYEKSLYSMIK HHHHHHHHHHHHHHH	42.54	26320211
299	Ubiquitination	IFRTKYEKSLYSMIK HHHHHHHHHHHHHHH	42.54	19608861
300	Phosphorylation	FRTKYEKSLYSMIKN HHHHHHHHHHHHHHC	22.17	28258704
302	Phosphorylation	TKYEKSLYSMIKNDT HHHHHHHHHHHHCCC	11.86	21082442
303	Phosphorylation	KYEKSLYSMIKNDTS HHHHHHHHHHHCCCC	21.23	28258704
306	Acetylation	KSLYSMIKNDTSGEY HHHHHHHHCCCCCHH	39.88	19608861
306	Malonylation	KSLYSMIKNDTSGEY HHHHHHHHCCCCCHH	39.88	26320211
306	Ubiquitination	KSLYSMIKNDTSGEY HHHHHHHHCCCCCHH	39.88	19608861
310	Phosphorylation	SMIKNDTSGEYKKTL HHHHCCCCCHHHHEE	32.27	26437602
313	Phosphorylation	KNDTSGEYKKTLLKL HCCCCCHHHHEEEHH	22.70	11079915
314	Acetylation	NDTSGEYKKTLLKLS CCCCCHHHHEEEHHC	34.67	25953088
338	Acetylation	FFPEAAQVAYQMWEL HCHHHHHHHHHHHHH	4.61	19608861
338	Ubiquitination	FFPEAAQVAYQMWEL HCHHHHHHHHHHHHH	4.61	19608861
340	Phosphorylation	PEAAQVAYQMWELSA HHHHHHHHHHHHHHC	10.47	119653
342	Sulfoxidation	AAQVAYQMWELSAVA HHHHHHHHHHHHCEE	1.63	30846556
354	Acetylation	AVARVELKGTVRPAN CEEEEEECCEECCCH	38.74	25953088
354	Malonylation	AVARVELKGTVRPAN CEEEEEECCEECCCH	38.74	26320211
356	Phosphorylation	ARVELKGTVRPANDF EEEEECCEECCCHHC	16.26	21406692
370	Acetylation	FNPDADAKALRKAMK CCCCHHHHHHHHHHH	48.80	19608861
370	Malonylation	FNPDADAKALRKAMK CCCCHHHHHHHHHHH	48.80	26320211
370	Ubiquitination	FNPDADAKALRKAMK CCCCHHHHHHHHHHH	48.80	19608861
377	Ubiquitination	KALRKAMKGLGTDED HHHHHHHHCCCCCHH	56.71	21890473
377	Acetylation	KALRKAMKGLGTDED HHHHHHHHCCCCCHH	56.71	25953088
377	Ubiquitination	KALRKAMKGLGTDED HHHHHHHHCCCCCHH	56.71	21890473
381	Phosphorylation	KAMKGLGTDEDTIID HHHHCCCCCHHHHHH	41.06	28450419
385	Phosphorylation	GLGTDEDTIIDIITH CCCCCHHHHHHHHHC	20.13	25338102
386	Acetylation	LGTDEDTIIDIITHR CCCCHHHHHHHHHCC	4.05	19608861
386	Ubiquitination	LGTDEDTIIDIITHR CCCCHHHHHHHHHCC	4.05	19608861
391	Phosphorylation	DTIIDIITHRSNVQR HHHHHHHHCCHHHHH	16.15	18767875
406	Acetylation	QQIRQTFKSHFGRDL HHHHHHHHHHHCHHH	46.54	25953088
406	Malonylation	QQIRQTFKSHFGRDL HHHHHHHHHHHCHHH	46.54	26320211
406	Ubiquitination	QQIRQTFKSHFGRDL HHHHHHHHHHHCHHH	46.54	-
410	Acetylation	QTFKSHFGRDLMTDL HHHHHHHCHHHHHHH	19.44	19608861
418	Acetylation	RDLMTDLKSEISGDL HHHHHHHHHHHCHHH	49.18	19608861
418	Ubiquitination	RDLMTDLKSEISGDL HHHHHHHHHHHCHHH	49.18	21906983
419	Phosphorylation	DLMTDLKSEISGDLA HHHHHHHHHHCHHHH	47.67	23911959
422	Phosphorylation	TDLKSEISGDLARLI HHHHHHHCHHHHHHH	23.39	73401921
433	Sulfoxidation	ARLILGLMMPPAHYD HHHHHHHHCCCCCCC	3.44	30846556
434	Sulfoxidation	RLILGLMMPPAHYDA HHHHHHHCCCCCCCH	4.29	30846556
442	Acetylation	PPAHYDAKQLKKAME CCCCCCHHHHHHHHC	53.95	23954790
442	Malonylation	PPAHYDAKQLKKAME CCCCCCHHHHHHHHC	53.95	26320211
445	Acetylation	HYDAKQLKKAMEGAG CCCHHHHHHHHCCCC	35.67	23749302
446	Ubiquitination	YDAKQLKKAMEGAGT CCHHHHHHHHCCCCC	62.65	-
448	Sulfoxidation	AKQLKKAMEGAGTDE HHHHHHHHCCCCCCH	7.20	30846556
451	Acetylation	LKKAMEGAGTDEKAL HHHHHCCCCCCHHHH	12.38	19608861
456	Acetylation	EGAGTDEKALIEILA CCCCCCHHHHHHHHH	51.83	25953088
456	Ubiquitination	EGAGTDEKALIEILA CCCCCCHHHHHHHHH	51.83	-
464	Phosphorylation	ALIEILATRTNAEIR HHHHHHHHCCHHHHH	34.28	21406692
478	Acetylation	RAINEAYKEDYHKSL HHHHHHHHHHHHHHH	51.67	23749302
478	Ubiquitination	RAINEAYKEDYHKSL HHHHHHHHHHHHHHH	51.67	-
483	Acetylation	AYKEDYHKSLEDALS HHHHHHHHHHHHHHH	50.97	19608861
483	Ubiquitination	AYKEDYHKSLEDALS HHHHHHHHHHHHHHH	50.97	19608861
484	Phosphorylation	YKEDYHKSLEDALSS HHHHHHHHHHHHHHC	24.55	23312004
490	Phosphorylation	KSLEDALSSDTSGHF HHHHHHHHCCCCHHH	28.08	30108239
491	Phosphorylation	SLEDALSSDTSGHFR HHHHHHHCCCCHHHH	45.84	30108239
493	Phosphorylation	EDALSSDTSGHFRRI HHHHHCCCCHHHHHH	38.26	30108239
494	Phosphorylation	DALSSDTSGHFRRIL HHHHCCCCHHHHHHH	34.95	30108239
503	Phosphorylation	HFRRILISLATGHRE HHHHHHHHHHHCCCH	14.43	23312004
506	Phosphorylation	RILISLATGHREEGG HHHHHHHHCCCHHCC	38.52	23312004
535	Phosphorylation	EILEIADTPSGDKTS HHHHHCCCCCCCCCC	15.44	26657352
537	Phosphorylation	LEIADTPSGDKTSLE HHHCCCCCCCCCCHH	62.81	26471730
540	Acetylation	ADTPSGDKTSLETRF CCCCCCCCCCHHHHH	43.47	26051181
540	Ubiquitination	ADTPSGDKTSLETRF CCCCCCCCCCHHHHH	43.47	21890473
548	Sulfoxidation	TSLETRFMTILCTRS CCHHHHHHHHHHCCC	1.73	21406390
549	Phosphorylation	SLETRFMTILCTRSY CHHHHHHHHHHCCCC	14.21	26074081
568	Acetylation	RVFQEFIKMTNYDVE HHHHHHHHHHCCCHH	45.02	26051181
568	Ubiquitination	RVFQEFIKMTNYDVE HHHHHHHHHHCCCHH	45.02	21906983
569	Sulfoxidation	VFQEFIKMTNYDVEH HHHHHHHHHCCCHHH	2.22	30846556
570	Phosphorylation	FQEFIKMTNYDVEHT HHHHHHHHCCCHHHH	26.14	28270605
572	Phosphorylation	EFIKMTNYDVEHTIK HHHHHHCCCHHHHHH	16.52	46164741
575	Acetylation	KMTNYDVEHTIKKEM HHHCCCHHHHHHHHH	32.20	19608861
579	2-Hydroxyisobutyrylation	YDVEHTIKKEMSGDV CCHHHHHHHHHCCCH	43.78	-
579	Acetylation	YDVEHTIKKEMSGDV CCHHHHHHHHHCCCH	43.78	25953088
579	Malonylation	YDVEHTIKKEMSGDV CCHHHHHHHHHCCCH	43.78	26320211
579	Ubiquitination	YDVEHTIKKEMSGDV CCHHHHHHHHHCCCH	43.78	-
580	Acetylation	DVEHTIKKEMSGDVR CHHHHHHHHHCCCHH	55.59	19809363
583	Phosphorylation	HTIKKEMSGDVRDAF HHHHHHHCCCHHHHH	32.69	10398665
588	Acetylation	EMSGDVRDAFVAIVQ HHCCCHHHHHHHHHH	44.18	19608861
588	Ubiquitination	EMSGDVRDAFVAIVQ HHCCCHHHHHHHHHH	44.18	19608861
596	Phosphorylation	AFVAIVQSVKNKPLF HHHHHHHHHCCCCCC	24.94	63774529
600	2-Hydroxyisobutyrylation	IVQSVKNKPLFFADK HHHHHCCCCCCCHHH	37.06	-
600	Acetylation	IVQSVKNKPLFFADK HHHHHCCCCCCCHHH	37.06	26051181
600	Ubiquitination	IVQSVKNKPLFFADK HHHHHCCCCCCCHHH	37.06	-
607	2-Hydroxyisobutyrylation	KPLFFADKLYKSMKG CCCCCHHHHHHHCCC	50.73	-
607	Acetylation	KPLFFADKLYKSMKG CCCCCHHHHHHHCCC	50.73	19608861
607	Ubiquitination	KPLFFADKLYKSMKG CCCCCHHHHHHHCCC	50.73	19608861
609	Phosphorylation	LFFADKLYKSMKGAG CCCHHHHHHHCCCCC	13.52	25147952
610	Acetylation	FFADKLYKSMKGAGT CCHHHHHHHCCCCCC	55.28	27178108
611	Phosphorylation	FADKLYKSMKGAGTD CHHHHHHHCCCCCCC	16.51	22468782
613	Acetylation	DKLYKSMKGAGTDEK HHHHHHCCCCCCCHH	53.34	25953088
620	2-Hydroxyisobutyrylation	KGAGTDEKTLTRIMV CCCCCCHHHHHHHHH	52.20	-
620	Acetylation	KGAGTDEKTLTRIMV CCCCCCHHHHHHHHH	52.20	19608861
620	Malonylation	KGAGTDEKTLTRIMV CCCCCCHHHHHHHHH	52.20	26320211
620	Ubiquitination	KGAGTDEKTLTRIMV CCCCCCHHHHHHHHH	52.20	19608861
628	Phosphorylation	TLTRIMVSRSEIDLL HHHHHHHCHHHHCHH	16.83	30108239
630	Phosphorylation	TRIMVSRSEIDLLNI HHHHHCHHHHCHHHH	31.25	63774319
644	Acetylation	IRREFIEKYDKSLHQ HHHHHHHHHCHHHHH	54.67	26051181
644	Ubiquitination	IRREFIEKYDKSLHQ HHHHHHHHHCHHHHH	54.67	-
645	Phosphorylation	RREFIEKYDKSLHQA HHHHHHHHCHHHHHH	18.80	24275569
647	Acetylation	EFIEKYDKSLHQAIE HHHHHHCHHHHHHHC	52.40	25953088
647	Malonylation	EFIEKYDKSLHQAIE HHHHHHCHHHHHHHC	52.40	26320211
647	Ubiquitination	EFIEKYDKSLHQAIE HHHHHHCHHHHHHHC	52.40	-
648	Phosphorylation	FIEKYDKSLHQAIEG HHHHHCHHHHHHHCC	28.34	26437602
657	Phosphorylation	HQAIEGDTSGDFLKA HHHHCCCCCHHHHHH	45.53	69003001
658	Phosphorylation	QAIEGDTSGDFLKAL HHHCCCCCHHHHHHH	40.90	28857561
663	Ubiquitination	DTSGDFLKALLALCG CCCHHHHHHHHHHCC	36.66	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	SMURF1	Q9HCE7	PMID:20804422

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ANXA6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ANXA6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CDC73_HUMAN	CDC73	physical	16169070
RASA1_RAT	Rasa1	physical	8798684
S10A1_HUMAN	S100A1	physical	9883272
S100B_HUMAN	S100B	physical	9883272
PURA2_HUMAN	ADSS	physical	22863883
HPRT_HUMAN	HPRT1	physical	22863883
IDHC_HUMAN	IDH1	physical	22863883
NAMPT_HUMAN	NAMPT	physical	22863883

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ANXA6_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Structure and properties of calphobindin II, an anticoagulant proteinfrom human placenta."; Yoshizaki H., Mizoguchi T., Arai K., Shiratsuchi M., Shidara Y.,Maki M.; J. Biochem. 107:43-50(1990). Cited for: PROTEIN SEQUENCE OF 2-673.	2139657 [Abstract]
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-63; LYS-68; LYS-75; LYS-81;LYS-299; LYS-306; LYS-370; LYS-418; LYS-483; LYS-607 AND LYS-620, ANDMASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-30, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer."; Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.; Cell 131:1190-1203(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-30, AND MASSSPECTROMETRY.	18083107 [Abstract]