HPRT_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HPRT_HUMAN
• UniProt AC: P00492
• Protein Name: Hypoxanthine-guanine phosphoribosyltransferase
• Gene Name: HPRT1
• Organism: Homo sapiens (Human).
• Sequence Length: 218
• Subcellular Localization: Cytoplasm.
• Protein Description: Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway..
• Protein Sequence: MATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MATRSPGVV ------CCCCCCCEE	16.24	7107641
3	Phosphorylation	-----MATRSPGVVI -----CCCCCCCEEE	30.31	28450419
5	Phosphorylation	---MATRSPGVVISD ---CCCCCCCEEECC	22.96	25159151
11	Phosphorylation	RSPGVVISDDEPGYD CCCCEEECCCCCCCC	27.65	28464451
17	Phosphorylation	ISDDEPGYDLDLFCI ECCCCCCCCCEEEEE	24.85	28464451
23	Glutathionylation	GYDLDLFCIPNHYAE CCCCEEEEECCCHHH	7.03	22555962
28	Phosphorylation	LFCIPNHYAEDLERV EEEECCCHHHHHHHH	20.51	25278378
43	Sulfoxidation	FIPHGLIMDRTERLA EECCCCCCCHHHHHH	3.24	21406390
66	Glutathionylation	GHHIVALCVLKGGYK CCEEEEEEEECCCHH	2.13	22555962
69	Acetylation	IVALCVLKGGYKFFA EEEEEEECCCHHHHH	29.87	26051181
73	Ubiquitination	CVLKGGYKFFADLLD EEECCCHHHHHHHHH	36.96	-
81	Phosphorylation	FFADLLDYIKALNRN HHHHHHHHHHHHCCC	12.32	-
83	Acetylation	ADLLDYIKALNRNSD HHHHHHHHHHCCCCC	40.36	21466224
92	Phosphorylation	LNRNSDRSIPMTVDF HCCCCCCCCCCEEEE	35.71	-
96	Phosphorylation	SDRSIPMTVDFIRLK CCCCCCCEEEEEEEH	16.15	-
103	Ubiquitination	TVDFIRLKSYCNDQS EEEEEEEHHHHCCCC	29.54	-
103	2-Hydroxyisobutyrylation	TVDFIRLKSYCNDQS EEEEEEEHHHHCCCC	29.54	-
103	Acetylation	TVDFIRLKSYCNDQS EEEEEEEHHHHCCCC	29.54	25953088
103	Methylation	TVDFIRLKSYCNDQS EEEEEEEHHHHCCCC	29.54	54387133
104	Phosphorylation	VDFIRLKSYCNDQST EEEEEEHHHHCCCCC	39.24	28152594
105	Phosphorylation	DFIRLKSYCNDQSTG EEEEEHHHHCCCCCC	8.16	28152594
106	S-nitrosylation	FIRLKSYCNDQSTGD EEEEHHHHCCCCCCC	6.13	19483679
106	Glutathionylation	FIRLKSYCNDQSTGD EEEEHHHHCCCCCCC	6.13	22555962
106	S-nitrosocysteine	FIRLKSYCNDQSTGD EEEEHHHHCCCCCCC	6.13	-
110	Phosphorylation	KSYCNDQSTGDIKVI HHHHCCCCCCCEEEE	36.90	30108239
111	Phosphorylation	SYCNDQSTGDIKVIG HHHCCCCCCCEEEEC	32.99	28192239
115	Sumoylation	DQSTGDIKVIGGDDL CCCCCCEEEECCCCH	32.32	25114211
115	Acetylation	DQSTGDIKVIGGDDL CCCCCCEEEECCCCH	32.32	23954790
115	Ubiquitination	DQSTGDIKVIGGDDL CCCCCCEEEECCCCH	32.32	-
123	Phosphorylation	VIGGDDLSTLTGKNV EECCCCHHHHCCCCE	28.50	20068231
124	Phosphorylation	IGGDDLSTLTGKNVL ECCCCHHHHCCCCEE	35.32	20068231
126	Phosphorylation	GDDLSTLTGKNVLIV CCCHHHHCCCCEEEE	46.31	20068231
128	Ubiquitination	DLSTLTGKNVLIVED CHHHHCCCCEEEEEE	38.35	-
139	Phosphorylation	IVEDIIDTGKTMQTL EEEEEHHCCHHHHHH	30.12	24076635
142	Phosphorylation	DIIDTGKTMQTLLSL EEHHCCHHHHHHHHH	18.82	20068231
145	Phosphorylation	DTGKTMQTLLSLVRQ HCCHHHHHHHHHHHH	20.88	20068231
148	Phosphorylation	KTMQTLLSLVRQYNP HHHHHHHHHHHHHCH	28.12	20068231
156	Acetylation	LVRQYNPKMVKVASL HHHHHCHHHHHHHHH	53.33	25953088
159	Ubiquitination	QYNPKMVKVASLLVK HHCHHHHHHHHHHCC	28.69	-
162	Phosphorylation	PKMVKVASLLVKRTP HHHHHHHHHHCCCCC	25.81	27135362
166	Succinylation	KVASLLVKRTPRSVG HHHHHHCCCCCCCCC	50.99	23954790
166	Ubiquitination	KVASLLVKRTPRSVG HHHHHHCCCCCCCCC	50.99	-
166	Acetylation	KVASLLVKRTPRSVG HHHHHHCCCCCCCCC	50.99	25953088
171	Phosphorylation	LVKRTPRSVGYKPDF HCCCCCCCCCCCCCC	22.54	20068231
175	Ubiquitination	TPRSVGYKPDFVGFE CCCCCCCCCCCCCEE	31.98	21906983
198	Phosphorylation	YALDYNEYFRDLNHV EEECHHHHHHCCCCE	10.56	-
206	Glutathionylation	FRDLNHVCVISETGK HHCCCCEEEEECCCC	1.42	22555962
213	Acetylation	CVISETGKAKYKA-- EEEECCCCCCCCC--	49.47	25953088
213	Ubiquitination	CVISETGKAKYKA-- EEEECCCCCCCCC--	49.47	-
215	Ubiquitination	ISETGKAKYKA---- EECCCCCCCCC----	51.25	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HPRT_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HPRT_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HPRT_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NTAQ1_HUMAN	WDYHV1	physical	16189514
PRDC1_HUMAN	PRTFDC1	physical	16189514
MTAP_HUMAN	MTAP	physical	22863883
SERC_HUMAN	PSAT1	physical	22863883
TEBP_HUMAN	PTGES3	physical	22863883
HPRT_HUMAN	HPRT1	physical	25416956
SDCB1_HUMAN	SDCBP	physical	25416956
ISCU_HUMAN	ISCU	physical	25416956
NTAQ1_HUMAN	WDYHV1	physical	25416956
PRDC1_HUMAN	PRTFDC1	physical	25416956
PUR1_HUMAN	PPAT	physical	26344197
PRDC1_HUMAN	PRTFDC1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 300322: Lesch-Nyhan syndrome (LNS)
• 300323: Gout HPRT-related (GOUT-HPRT)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00993: Azathioprine
• DB01033: Mercaptopurine
• DB00352: Tioguanine