RASA1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RASA1_RAT
• UniProt AC: P50904
• Protein Name: Ras GTPase-activating protein 1
• Gene Name: Rasa1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 1038
• Subcellular Localization: Cytoplasm.
• Protein Description: Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21 (By similarity)..
• Protein Sequence: MMAAEAGSEEGGPATAGTGGAAATGSSAYPAACRVKLPAAPPMAVAPCPGLADTDLAAALGGGAASGSGFLGTGPVSGVLGGAALTGGAAAGVAGAAAAGPAGDIALTKGTLSLPAETLGPGGGFPPLPPPPLLPPLGSGLGTVDEGDSLDGPEYEEEEVAIPLTAPPTNQWYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQTNVVNHFRIIAMCGDYYIGGRRFSSLSDLIGYYSHVSCLLKGEKLLYPVAPPEPVEDRRRVRAILPYTKVPDTDEISFLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVGREEDPHEGKIWFHGKISKQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPNNQFMMGGRYYNSIGDIIDHYRKEQIVEGYYLKEPVPMQDQGQVLNDTVDGKEIYNTIRRKTKDAFYKNIVKKGYLLKKGKGKRWKNLYFILEGSDAQLIYFESEKRATKPKGLIDLSVCSVYVVHDSLFGRPNCFQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCSLRKSSPGTSNKRLRQVSSLVLHIEEAHKLPVKHFTNPYCNIYLNSVQVAKTHAREGQNPVWSEEFVFDDLPPDINRFEITLSNKTKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPGSLRVRARYSMEKIMPEEEYSEFKELILQKELHVVYALSHVCGQDRTLLASILLKIFLHEKLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMKATATQFVHHALKDSILKIMESKQSCELSPSKLEKNEDVNTNLAHLLSILSELVEKIFMASEILPPTLRYIYGCLQKSVQHKWPTNNTMRTRVVSGFVFLRLICPAILNPRMFNIISDSPSPIAARTLTLVAKSVQNLANLVEFGAKEPYMEGVNPFIKSNKHRMIMFLDELGNVPELPDTTEHSRTDLSRDLAALHEICVAHSDELRTLSNERGVQQHVLKKLLAITELLQQKQNQYTKTNDVR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MMAAEAGS -------CCCCCCCC	20.15	-
26	Phosphorylation	GGAAATGSSAYPAAC CCCCCCCCCCCCCCC	13.87	26022182
27	Phosphorylation	GAAATGSSAYPAACR CCCCCCCCCCCCCCC	32.92	26022182
29	Phosphorylation	AATGSSAYPAACRVK CCCCCCCCCCCCCCC	8.71	26022182
451	Phosphorylation	TVDGKEIYNTIRRKT CCCHHHHHHHHHHHC	13.82	1850098
606	Phosphorylation	VKHFTNPYCNIYLNS CCCCCCCCCCEEECC	10.53	-
822	Phosphorylation	SKQSCELSPSKLEKN HHCCCCCCHHHHCCC	12.58	-
884	Phosphorylation	PTNNTMRTRVVSGFV CCCCCCCHHHHCHHH	19.59	26022182
888	Phosphorylation	TMRTRVVSGFVFLRL CCCHHHHCHHHHHHH	24.53	25575281

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
451	Y	Phosphorylation	Kinase	EGFR	P00533	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RASA1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RASA1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of RASA1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.