CDKL3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CDKL3_HUMAN
• UniProt AC: Q8IVW4
• Protein Name: Cyclin-dependent kinase-like 3 {ECO:0000305}
• Gene Name: CDKL3 {ECO:0000312|HGNC:HGNC:15483}
• Organism: Homo sapiens (Human).
• Sequence Length: 592
• Subcellular Localization: Cytoplasm.
• Protein Sequence: MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHHENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYTDYVATRWYRAPELVLKDTSYGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVVLPQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFTRDGFIEKFMPELKAKLLQEAKVNSLIKPKESSKENELRKDERKTVYTNTLLSSSVLGKEIEKEKKPKEIKVRVIKVKGGRGDISEPKKKEYEGGLGQQDANENVHPMSPDTKLVTIEPPNPINPSTNCNGLKENPHCGGSVTMPPINLTNSNLMAANLSSNLFHPSVRLTERAKKRRTSSQSIGQVMPNSRQEDPGPIQSQMEKGIFNERTGHSDQMANENKRKLNFSRSDRKEFHFPELPVTIQSKDTKGMEVKQIKMLKRESKKTESSKIPTLLNVDQNQEKQEGGDGHCEGKNLKRNRFFFW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MEMYETLGKVG ----CCCHHCCCCCC	7.77	29523821
6	Phosphorylation	--MEMYETLGKVGEG --CCCHHCCCCCCCC	24.27	29523821
26	Phosphorylation	MKCKHKNTGQIVAIK EEEECCCCCCEEEEE	34.95	22210691
36	Phosphorylation	IVAIKIFYERPEQSV EEEEEEEECCCHHHH	17.94	22210691
105	Phosphorylation	ESKRLRKYLFQILRA CCHHHHHHHHHHHHH	13.30	21082442
158	Phosphorylation	AAPGDIYTDYVATRW CCCCCHHHHHCCCCE	22.61	-
160	Phosphorylation	PGDIYTDYVATRWYR CCCHHHHHCCCCEEC	5.56	26074081
163	Phosphorylation	IYTDYVATRWYRAPE HHHHHCCCCEECCCE	16.22	26074081
229	Phosphorylation	PHLQNIFSKSPIFAG HHHHHHHHCCCCEEE	28.55	24719451
311	Phosphorylation	LQEAKVNSLIKPKES HHHHHHHHHCCCCCC	34.16	24719451
333	Phosphorylation	KDERKTVYTNTLLSS HHHCHHHHHHHHHHH	10.25	25690035
334	Phosphorylation	DERKTVYTNTLLSSS HHCHHHHHHHHHHHH	19.86	25690035
340	Phosphorylation	YTNTLLSSSVLGKEI HHHHHHHHHHCCHHH	25.16	25690035
341	Phosphorylation	TNTLLSSSVLGKEIE HHHHHHHHHCCHHHH	20.27	-
457	Phosphorylation	FHPSVRLTERAKKRR CCCHHHHHHHHHHHC	16.92	22210691
542	Trimethylation	DTKGMEVKQIKMLKR CCCCCCHHHHHHHHH	32.76	-
542	Methylation	DTKGMEVKQIKMLKR CCCCCCHHHHHHHHH	32.76	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CDKL3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CDKL3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CDKL3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
GGA1_HUMAN	GGA1	physical	21988832
RU17_HUMAN	SNRNP70	physical	21988832
TTF2_HUMAN	TTF2	physical	21988832
LZTS2_HUMAN	LZTS2	physical	25416956
ATG4A_HUMAN	ATG4A	physical	25416956
PIHD3_HUMAN	PIH1D3	physical	25416956
KASH5_HUMAN	CCDC155	physical	25416956
KR109_HUMAN	KRTAP10-9	physical	25416956
ZBT8A_HUMAN	ZBTB8A	physical	25416956
STABP_HUMAN	STAMBP	physical	26186194
STABP_HUMAN	STAMBP	physical	28514442
HSP7C_HUMAN	HSPA8	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.