dbPTM

TTF2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TTF2_HUMAN
UniProt AC	Q9UNY4
Protein Name	Transcription termination factor 2
Gene Name	TTF2
Organism	Homo sapiens (Human).
Sequence Length	1162
Subcellular Localization	Cytoplasm . Nucleus . Cytoplasmic during interphase. Relocates to the nucleus as cells enter mitosis.
Protein Description	DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing..
Protein Sequence	MEEVRCPEHGTFCFLKTGVRDGPNKGKSFYVCRADTCSFVRATDIPVSHCLLHEDFVVELQGLLLPQDKKEYRLFFRCIRSKAEGKRWCGSIPWQDPDSKEHSVSNKSQHASETFHHSSNWLRNPFKVLDKNQEPALWKQLIKGEGEEKKADKKQREKGDQLFDQKKEQKPEMMEKDLSSGLVPKKKQSVVQEKKQEEGAEIQCEAETGGTHKRDFSEIKSQQCQGNELTRPSASSQEKSSGKSQDVQRESEPLREKVTQLLPQNVHSHNSISKPQKGGPLNKEYTNWEAKETKAKDGPSIQATQKSLPQGHFQERPETHSVPAPGGPAAQAAPAAPGLSLGEGREAATSSDDEEEDDVVFVSSKPGSPLLFDSTLDLETKENLQFPDRSVQRKVSPASGVSKKVEPSDPVARRVYLTTQLKQKKSTLASVNIQALPDKGQKLIKQIQELEEVLSGLTLSPEQGTNEKSNSQVPQQSHFTKTTTGPPHLVPPQPLPRRGTQPVGSLELKSACQVTAGGSSQCYRGHTNQDHVHAVWKITSEAIGQLHRSLESCPGETVVAEDPAGLKVPLLLHQKQALAWLLWRESQKPQGGILADDMGLGKTLTMIALILTQKNQEKKEEKEKSTALTWLSKDDSCDFTSHGTLIICPASLIHHWKNEVEKRVNSNKLRVYLYHGPNRDSRARVLSTYDIVITTYSLVAKEIPTNKQEAEIPGANLNVEGTSTPLLRIAWARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLRCSPFDEFNLWRSQVDNGSKKGGERLSILTKSLLLRRTKDQLDSTGRPLVILPQRKFQLHHLKLSEDEETVYNVFFARSRSALQSYLKRHESRGNQSGRSPNNPFSRVALEFGSEEPRHSEAADSPRSSTVHILSQLLRLRQCCCHLSLLKSALDPMELKGEGLVLSLEEQLSALTLSELRDSEPSSTVSLNGTFFKMELFEGMRESTKISSLLAELEAIQRNSASQKSVIVSQWTNMLKVVALHLKKHGLTYATIDGSVNPKQRMDLVEAFNHSRGPQVMLISLLAGGVGLNLTGGNHLFLLDMHWNPSLEDQACDRIYRVGQQKDVVIHRFVCEGTVEEKILQLQEKKKDLAKQVLSGSGESVTKLTLADLRVLFGI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Ubiquitination	HGTFCFLKTGVRDGP CCCEEEEECCCCCCC	23.99	29967540
30	Phosphorylation	PNKGKSFYVCRADTC CCCCCEEEEEECCCC	13.01	-
100	Ubiquitination	PWQDPDSKEHSVSNK CCCCCCCCCCCCCCC	67.82	-
107	Ubiquitination	KEHSVSNKSQHASET CCCCCCCCCHHHHHH	43.94	29967540
108	Phosphorylation	EHSVSNKSQHASETF CCCCCCCCHHHHHHH	31.30	28555341
127	Ubiquitination	NWLRNPFKVLDKNQE CHHCCCEEECCCCCC	43.05	33845483
139	Ubiquitination	NQEPALWKQLIKGEG CCCHHHHHHHHCCCC	35.76	21890473
139 (in isoform 1)	Ubiquitination	-	35.76	21890473
139 (in isoform 2)	Ubiquitination	-	35.76	21890473
143	Sumoylation	ALWKQLIKGEGEEKK HHHHHHHCCCCHHHH	60.55	28112733
176	Acetylation	QKPEMMEKDLSSGLV CCHHHHHHHHHCCCC	46.18	30593145
179	Phosphorylation	EMMEKDLSSGLVPKK HHHHHHHHCCCCCHH	32.28	30001349
180	Phosphorylation	MMEKDLSSGLVPKKK HHHHHHHCCCCCHHH	43.36	20860994
204	Glutathionylation	EEGAEIQCEAETGGT HCCCCCEEEECCCCC	7.03	22555962
217	Phosphorylation	GTHKRDFSEIKSQQC CCCCCCHHHHHCCCC	42.58	-
220	Ubiquitination	KRDFSEIKSQQCQGN CCCHHHHHCCCCCCC	37.85	29967540
221	Phosphorylation	RDFSEIKSQQCQGNE CCHHHHHCCCCCCCC	31.01	-
233	Phosphorylation	GNELTRPSASSQEKS CCCCCCCCCCHHHCC	37.18	25159151
235	Phosphorylation	ELTRPSASSQEKSSG CCCCCCCCHHHCCCC	36.57	25159151
236	Phosphorylation	LTRPSASSQEKSSGK CCCCCCCHHHCCCCC	41.92	25159151
244	Phosphorylation	QEKSSGKSQDVQRES HHCCCCCCCCHHHCC	34.83	25159151
251	Phosphorylation	SQDVQRESEPLREKV CCCHHHCCHHHHHHH	46.86	20068231
268	Phosphorylation	LLPQNVHSHNSISKP HCCCCHHCCCCCCCC	21.78	25850435
271	Phosphorylation	QNVHSHNSISKPQKG CCHHCCCCCCCCCCC	23.86	25850435
273	Phosphorylation	VHSHNSISKPQKGGP HHCCCCCCCCCCCCC	37.80	28857561
285	Phosphorylation	GGPLNKEYTNWEAKE CCCCCCCCCCHHHHH	13.64	28796482
286	Phosphorylation	GPLNKEYTNWEAKET CCCCCCCCCHHHHHC	34.64	29978859
349	Phosphorylation	GEGREAATSSDDEEE CCCCCCCCCCCCCCC	35.49	20363803
350	Phosphorylation	EGREAATSSDDEEED CCCCCCCCCCCCCCC	27.35	20363803
351	Phosphorylation	GREAATSSDDEEEDD CCCCCCCCCCCCCCC	44.73	25159151
363	Phosphorylation	EDDVVFVSSKPGSPL CCCEEEEECCCCCCC	22.60	26074081
364	Phosphorylation	DDVVFVSSKPGSPLL CCEEEEECCCCCCCE	37.25	26074081
368	Phosphorylation	FVSSKPGSPLLFDST EEECCCCCCCEEECC	22.39	19664994
374	Phosphorylation	GSPLLFDSTLDLETK CCCCEEECCCCCCCH	24.44	20068231
375	Phosphorylation	SPLLFDSTLDLETKE CCCEEECCCCCCCHH	26.57	20068231
380	Phosphorylation	DSTLDLETKENLQFP ECCCCCCCHHHCCCC	51.46	20068231
389	Methylation	ENLQFPDRSVQRKVS HHCCCCCHHHCCCCC	38.68	115919109
390	Phosphorylation	NLQFPDRSVQRKVSP HCCCCCHHHCCCCCC	29.95	26074081
394	Ubiquitination	PDRSVQRKVSPASGV CCHHHCCCCCCCCCC	29.94	29967540
396	Phosphorylation	RSVQRKVSPASGVSK HHHCCCCCCCCCCCC	20.13	25159151
399	Phosphorylation	QRKVSPASGVSKKVE CCCCCCCCCCCCCCC	43.01	24732914
402	Phosphorylation	VSPASGVSKKVEPSD CCCCCCCCCCCCCCC	30.22	24732914
403	Ubiquitination	SPASGVSKKVEPSDP CCCCCCCCCCCCCCH	59.43	24816145
404	Ubiquitination	PASGVSKKVEPSDPV CCCCCCCCCCCCCHH	44.30	29967540
416	Phosphorylation	DPVARRVYLTTQLKQ CHHHHHHHHHHHHHH	9.12	28152594
418	Phosphorylation	VARRVYLTTQLKQKK HHHHHHHHHHHHHCC	8.53	28152594
419	Phosphorylation	ARRVYLTTQLKQKKS HHHHHHHHHHHHCCC	29.34	30301811
422	Ubiquitination	VYLTTQLKQKKSTLA HHHHHHHHHCCCCHH	50.70	29967540
425	Ubiquitination	TTQLKQKKSTLASVN HHHHHHCCCCHHCCC	46.29	29967540
439	Ubiquitination	NIQALPDKGQKLIKQ CCCCCCHHHHHHHHH	62.39	29967540
442	Ubiquitination	ALPDKGQKLIKQIQE CCCHHHHHHHHHHHH	61.93	-
445	Ubiquitination	DKGQKLIKQIQELEE HHHHHHHHHHHHHHH	52.35	29967540
455	Phosphorylation	QELEEVLSGLTLSPE HHHHHHHHCCCCCCC	36.61	24732914
458	Phosphorylation	EEVLSGLTLSPEQGT HHHHHCCCCCCCCCC	28.81	24732914
460	Phosphorylation	VLSGLTLSPEQGTNE HHHCCCCCCCCCCCC	22.58	26055452
465	Phosphorylation	TLSPEQGTNEKSNSQ CCCCCCCCCCCCCCC	39.64	24732914
468	Ubiquitination	PEQGTNEKSNSQVPQ CCCCCCCCCCCCCCC	57.94	29967540
469	Phosphorylation	EQGTNEKSNSQVPQQ CCCCCCCCCCCCCCC	35.22	26714015
471	Phosphorylation	GTNEKSNSQVPQQSH CCCCCCCCCCCCCCC	39.38	28555341
481	Ubiquitination	PQQSHFTKTTTGPPH CCCCCCCCCCCCCCC	42.82	29967540
500	Phosphorylation	QPLPRRGTQPVGSLE CCCCCCCCCCCCCEE	28.08	20068231
505	Phosphorylation	RGTQPVGSLELKSAC CCCCCCCCEEEEEEE	20.92	25159151
520	Phosphorylation	QVTAGGSSQCYRGHT EEEECCCCCCCCCCC	27.78	-
523	Phosphorylation	AGGSSQCYRGHTNQD ECCCCCCCCCCCCCC	16.40	22817900
537	Ubiquitination	DHVHAVWKITSEAIG CHHHEEHHHHHHHHH	29.52	29967540
567	Ubiquitination	AEDPAGLKVPLLLHQ EECCCCCCCCCHHHH	40.67	21963094
574	Ubiquitination	KVPLLLHQKQALAWL CCCCHHHHHHHHHHH	39.25	21963094
588	Ubiquitination	LLWRESQKPQGGILA HHHHHCCCCCCCCCC	48.89	21906983
588 (in isoform 1)	Ubiquitination	-	48.89	21890473
588 (in isoform 2)	Ubiquitination	-	48.89	21890473
595	Ubiquitination	KPQGGILADDMGLGK CCCCCCCCCCCCHHH	14.61	22817900
598	Sulfoxidation	GGILADDMGLGKTLT CCCCCCCCCHHHHHH	4.99	21406390
623	Ubiquitination	QEKKEEKEKSTALTW HHHHHHHHHHCHHHH	56.36	27667366
624	Ubiquitination	EKKEEKEKSTALTWL HHHHHHHHHCHHHHH	65.26	27667366
625	Phosphorylation	KKEEKEKSTALTWLS HHHHHHHHCHHHHHC	21.72	20068231
625 (in isoform 2)	Phosphorylation	-	21.72	20068231
626 (in isoform 2)	Phosphorylation	-	36.43	20068231
629 (in isoform 2)	Phosphorylation	-	23.15	20068231
630	Ubiquitination	EKSTALTWLSKDDSC HHHCHHHHHCCCCCC	10.25	27667366
631	Ubiquitination	KSTALTWLSKDDSCD HHCHHHHHCCCCCCC	3.72	27667366
633 (in isoform 2)	Ubiquitination	-	64.48	-
657	Ubiquitination	ASLIHHWKNEVEKRV HHHHHHHHHHHHHHH	38.58	29967540
662	Ubiquitination	HWKNEVEKRVNSNKL HHHHHHHHHHHCCCE	67.81	29967540
667	Ubiquitination	VEKRVNSNKLRVYLY HHHHHHCCCEEEEEE	42.02	27667366
668	Ubiquitination	EKRVNSNKLRVYLYH HHHHHCCCEEEEEEE	37.17	27667366
672	Phosphorylation	NSNKLRVYLYHGPNR HCCCEEEEEEECCCC	8.63	25367160
674	Phosphorylation	NKLRVYLYHGPNRDS CCEEEEEEECCCCHH	6.24	25367160
674	Ubiquitination	NKLRVYLYHGPNRDS CCEEEEEEECCCCHH	6.24	27667366
675	Ubiquitination	KLRVYLYHGPNRDSR CEEEEEEECCCCHHH	42.51	27667366
696	Phosphorylation	YDIVITTYSLVAKEI HCEEEEEEEHHHCCC	7.43	23312004
697	Phosphorylation	DIVITTYSLVAKEIP CEEEEEEEHHHCCCC	17.80	20860994
700	Ubiquitination	ITTYSLVAKEIPTNK EEEEEHHHCCCCCCC	14.73	23503661
701	Ubiquitination	TTYSLVAKEIPTNKQ EEEEHHHCCCCCCCC	49.01	23503661
706	Ubiquitination	VAKEIPTNKQEAEIP HHCCCCCCCCCCCCC	38.36	21963094
707	Ubiquitination	AKEIPTNKQEAEIPG HCCCCCCCCCCCCCC	52.58	21906983
707 (in isoform 1)	Ubiquitination	-	52.58	21890473
708	Ubiquitination	KEIPTNKQEAEIPGA CCCCCCCCCCCCCCC	58.14	23503661
713	Ubiquitination	NKQEAEIPGANLNVE CCCCCCCCCCCCCCC	27.61	22817900
714	Ubiquitination	KQEAEIPGANLNVEG CCCCCCCCCCCCCCC	32.53	21963094
742	Ubiquitination	ILDEAHNVKNPRVQT HHHHHHCCCCCCHHH	4.56	22817900
743	Ubiquitination	LDEAHNVKNPRVQTS HHHHHCCCCCCHHHH	67.56	21906983
743 (in isoform 1)	Ubiquitination	-	67.56	21890473
750	Ubiquitination	KNPRVQTSIAVCKLQ CCCCHHHHHHHHHHH	7.46	22817900
754	Ubiquitination	VQTSIAVCKLQACAR HHHHHHHHHHHHHHH	2.42	21963094
755	Ubiquitination	QTSIAVCKLQACARW HHHHHHHHHHHHHHH	36.71	21963094
762	Ubiquitination	KLQACARWAVTGTPI HHHHHHHHHHHCCCC	4.06	21963094
763	Ubiquitination	LQACARWAVTGTPIQ HHHHHHHHHHCCCCC	5.39	22817900
764	Ubiquitination	QACARWAVTGTPIQN HHHHHHHHHCCCCCC	3.94	22817900
770	Ubiquitination	AVTGTPIQNNLLDMY HHHCCCCCCCHHHHH	33.68	22817900
771	Ubiquitination	VTGTPIQNNLLDMYS HHCCCCCCCHHHHHH	41.66	22817900
775	Ubiquitination	PIQNNLLDMYSLLKF CCCCCHHHHHHHHHH	36.82	21963094
776	Ubiquitination	IQNNLLDMYSLLKFL CCCCHHHHHHHHHHH	2.18	21963094
777	Phosphorylation	QNNLLDMYSLLKFLR CCCHHHHHHHHHHHC	8.88	24719451
778	Phosphorylation	NNLLDMYSLLKFLRC CCHHHHHHHHHHHCC	22.16	24719451
782	Ubiquitination	DMYSLLKFLRCSPFD HHHHHHHHHCCCCCC	5.40	21963094
783	Ubiquitination	MYSLLKFLRCSPFDE HHHHHHHHCCCCCCH	5.29	21963094
803	Ubiquitination	SQVDNGSKKGGERLS HHCCCCCCCCHHHHH	57.76	24816145
804	Ubiquitination	QVDNGSKKGGERLSI HCCCCCCCCHHHHHH	74.06	24816145
810	Phosphorylation	KKGGERLSILTKSLL CCCHHHHHHHHHHHH	23.05	20068231
811	Ubiquitination	KGGERLSILTKSLLL CCHHHHHHHHHHHHH	7.20	24816145
813	Phosphorylation	GERLSILTKSLLLRR HHHHHHHHHHHHHHH	19.54	20068231
813	Ubiquitination	GERLSILTKSLLLRR HHHHHHHHHHHHHHH	19.54	23000965
814	Ubiquitination	ERLSILTKSLLLRRT HHHHHHHHHHHHHHC	35.34	23000965
814 (in isoform 1)	Ubiquitination	-	35.34	21890473
815	Phosphorylation	RLSILTKSLLLRRTK HHHHHHHHHHHHHCH	21.00	20068231
821	Ubiquitination	KSLLLRRTKDQLDST HHHHHHHCHHHHHCC	32.32	23000965
822	Ubiquitination	SLLLRRTKDQLDSTG HHHHHHCHHHHHCCC	41.48	29967540
824	Ubiquitination	LLRRTKDQLDSTGRP HHHHCHHHHHCCCCC	49.04	24816145
825	Ubiquitination	LRRTKDQLDSTGRPL HHHCHHHHHCCCCCE	8.89	24816145
831	Ubiquitination	QLDSTGRPLVILPQR HHHCCCCCEEEECCC	32.12	24816145
832	Ubiquitination	LDSTGRPLVILPQRK HHCCCCCEEEECCCC	3.45	24816145
834	Ubiquitination	STGRPLVILPQRKFQ CCCCCEEEECCCCEE	6.47	23000965
835	Ubiquitination	TGRPLVILPQRKFQL CCCCEEEECCCCEEE	2.00	23000965
839	Ubiquitination	LVILPQRKFQLHHLK EEEECCCCEEEEEEE	32.01	29967540
841	Ubiquitination	ILPQRKFQLHHLKLS EECCCCEEEEEEECC	42.81	23000965
842	Ubiquitination	LPQRKFQLHHLKLSE ECCCCEEEEEEECCC	2.86	23000965
868	Phosphorylation	RSRSALQSYLKRHES CCHHHHHHHHHHHHH	33.03	25159151
869	Phosphorylation	SRSALQSYLKRHESR CHHHHHHHHHHHHHH	11.86	21712546
870	Ubiquitination	RSALQSYLKRHESRG HHHHHHHHHHHHHHC	4.81	21963094
871	Ubiquitination	SALQSYLKRHESRGN HHHHHHHHHHHHHCC	43.40	21906983
871 (in isoform 1)	Ubiquitination	-	43.40	21890473
875	Phosphorylation	SYLKRHESRGNQSGR HHHHHHHHHCCCCCC	39.09	23401153
876	Methylation	YLKRHESRGNQSGRS HHHHHHHHCCCCCCC	45.13	58854991
878	Ubiquitination	KRHESRGNQSGRSPN HHHHHHCCCCCCCCC	31.56	21963094
880	Phosphorylation	HESRGNQSGRSPNNP HHHHCCCCCCCCCCC	39.93	28176443
883	Phosphorylation	RGNQSGRSPNNPFSR HCCCCCCCCCCCCHH	35.19	30266825
889	Phosphorylation	RSPNNPFSRVALEFG CCCCCCCHHHHHHCC	27.40	23403867
890	Methylation	SPNNPFSRVALEFGS CCCCCCHHHHHHCCC	20.36	58854999
891	Ubiquitination	PNNPFSRVALEFGSE CCCCCHHHHHHCCCC	7.45	21963094
892	Ubiquitination	NNPFSRVALEFGSEE CCCCHHHHHHCCCCC	10.56	21963094
897	Phosphorylation	RVALEFGSEEPRHSE HHHHHCCCCCCCCCC	44.07	21815630
898	Ubiquitination	VALEFGSEEPRHSEA HHHHCCCCCCCCCCC	72.84	21963094
899	Ubiquitination	ALEFGSEEPRHSEAA HHHCCCCCCCCCCCC	49.70	21963094
903	Phosphorylation	GSEEPRHSEAADSPR CCCCCCCCCCCCCCC	30.15	24732914
908	Phosphorylation	RHSEAADSPRSSTVH CCCCCCCCCCHHHHH	19.93	28112733
918	Phosphorylation	SSTVHILSQLLRLRQ HHHHHHHHHHHHHHH	20.41	-
931	Phosphorylation	RQCCCHLSLLKSALD HHHHHHHHHHHHCCC	14.16	24719451
991	Ubiquitination	FEGMRESTKISSLLA HHHHHHHHHHHHHHH	27.87	21963094
992	Ubiquitination	EGMRESTKISSLLAE HHHHHHHHHHHHHHH	50.28	21906983
992 (in isoform 1)	Ubiquitination	-	50.28	21890473
999	Ubiquitination	KISSLLAELEAIQRN HHHHHHHHHHHHHHC	47.30	21963094
1007	Phosphorylation	LEAIQRNSASQKSVI HHHHHHCCCCCCHHH	31.33	23312004
1009	Phosphorylation	AIQRNSASQKSVIVS HHHHCCCCCCHHHHH	37.65	23312004
1011	Ubiquitination	QRNSASQKSVIVSQW HHCCCCCCHHHHHHH	44.16	-
1012	Ubiquitination	RNSASQKSVIVSQWT HCCCCCCHHHHHHHH	14.94	21963094
1013	Ubiquitination	NSASQKSVIVSQWTN CCCCCCHHHHHHHHH	6.89	21963094
1019	Phosphorylation	SVIVSQWTNMLKVVA HHHHHHHHHHHHHHH	11.78	-
1019	Ubiquitination	SVIVSQWTNMLKVVA HHHHHHHHHHHHHHH	11.78	21963094
1020	Ubiquitination	VIVSQWTNMLKVVAL HHHHHHHHHHHHHHH	30.72	21963094
1030	Ubiquitination	KVVALHLKKHGLTYA HHHHHHHHHCCCEEE	31.79	29967540
1031	Ubiquitination	VVALHLKKHGLTYAT HHHHHHHHCCCEEEE	49.63	29967540
1036	Phosphorylation	LKKHGLTYATIDGSV HHHCCCEEEEECCCC	13.54	22817900
1038	Phosphorylation	KHGLTYATIDGSVNP HCCCEEEEECCCCCH	14.80	24719451
1045	Ubiquitination	TIDGSVNPKQRMDLV EECCCCCHHHHHHHH	31.81	21963094
1046	Ubiquitination	IDGSVNPKQRMDLVE ECCCCCHHHHHHHHH	45.38	21963094
1046 (in isoform 1)	Ubiquitination	-	45.38	21890473
1053	Ubiquitination	KQRMDLVEAFNHSRG HHHHHHHHHHHCCCC	55.64	21963094
1066	Ubiquitination	RGPQVMLISLLAGGV CCHHHHHHHHHCCCC	1.15	21963094
1067	Ubiquitination	GPQVMLISLLAGGVG CHHHHHHHHHCCCCE	17.23	21963094
1073	Ubiquitination	ISLLAGGVGLNLTGG HHHHCCCCEEECCCC	8.46	21963094
1074	Ubiquitination	SLLAGGVGLNLTGGN HHHCCCCEEECCCCC	16.48	21963094
1109	Ubiquitination	IYRVGQQKDVVIHRF HEECCCCCCEEEEEE	44.60	-
1124	Ubiquitination	VCEGTVEEKILQLQE EECCCHHHHHHHHHH	40.85	21963094
1125	Ubiquitination	CEGTVEEKILQLQEK ECCCHHHHHHHHHHH	34.90	21963094
1132	Ubiquitination	KILQLQEKKKDLAKQ HHHHHHHHCHHHHHH	52.76	21963094
1138	Ubiquitination	EKKKDLAKQVLSGSG HHCHHHHHHHHCCCC	48.51	29967540
1142	Phosphorylation	DLAKQVLSGSGESVT HHHHHHHCCCCCHHH	31.86	21406692
1144	Phosphorylation	AKQVLSGSGESVTKL HHHHHCCCCCHHHEE	35.69	21406692
1145	Ubiquitination	KQVLSGSGESVTKLT HHHHCCCCCHHHEEE	34.42	21963094
1146	Ubiquitination	QVLSGSGESVTKLTL HHHCCCCCHHHEEEH	43.67	21963094
1147	Phosphorylation	VLSGSGESVTKLTLA HHCCCCCHHHEEEHH	38.32	21406692
1149	Phosphorylation	SGSGESVTKLTLADL CCCCCHHHEEEHHHH	29.61	21406692
1150	Ubiquitination	GSGESVTKLTLADLR CCCCHHHEEEHHHHH	37.00	29967540
1152	Ubiquitination	GESVTKLTLADLRVL CCHHHEEEHHHHHHH	22.81	21963094
1153	Ubiquitination	ESVTKLTLADLRVLF CHHHEEEHHHHHHHH	5.17	21963094

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TTF2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TTF2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TTF2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NC2A_HUMAN	DRAP1	physical	12927788
CDC5L_HUMAN	CDC5L	physical	12927788
TNIP1_HUMAN	TNIP1	physical	12927788
DCP1A_HUMAN	DCP1A	physical	12927788
PDC6I_HUMAN	PDCD6IP	physical	12927788
PRDX4_HUMAN	PRDX4	physical	12927788
CLPB_HUMAN	CLPB	physical	12927788
TACC3_HUMAN	TACC3	physical	12927788
NVL_HUMAN	NVL	physical	12927788
ZSCA1_HUMAN	ZSCAN1	physical	20211142
TOP3A_HUMAN	TOP3A	physical	26344197
MYBB_HUMAN	MYBL2	physical	12927788

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TTF2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-460 AND SER-883, ANDMASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-460, AND MASSSPECTROMETRY.	18691976 [Abstract]
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-396, AND MASSSPECTROMETRY.	17924679 [Abstract]