PRDX4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PRDX4_HUMAN
• UniProt AC: Q13162
• Protein Name: Peroxiredoxin-4
• Gene Name: PRDX4
• Organism: Homo sapiens (Human).
• Sequence Length: 271
• Subcellular Localization: Cytoplasm . Endoplasmic reticulum . Cotranslationally translocated to and retained within the endoplasmic reticulum. A small fraction of the protein is cytoplasmic.
• Protein Description: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation..
• Protein Sequence: MEALPLLAATTPDHGRHRRLLLLPLLLFLLPAGAVQGWETEERPRTREEECHFYAGGQVYPGEASRVSVADHSLHLSKAKISKPAPYWEGTAVIDGEFKELKLTDYRGKYLVFFFYPLDFTFVCPTEIIAFGDRLEEFRSINTEVVACSVDSQFTHLAWINTPRRQGGLGPIRIPLLSDLTHQISKDYGVYLEDSGHTLRGLFIIDDKGILRQITLNDLPVGRSVDETLRLVQAFQYTDKHGEVCPAGWKPGSETIIPDPAGKLKYFDKLN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
46	Phosphorylation	ETEERPRTREEECHF CCCCCCCCCCCCCEE	45.15	28152594
51	Glutathionylation	PRTREEECHFYAGGQ CCCCCCCCEEECCCE	2.81	22555962
54	Phosphorylation	REEECHFYAGGQVYP CCCCCEEECCCEECC	4.81	28152594
60	Phosphorylation	FYAGGQVYPGEASRV EECCCEECCCCCCEE	9.53	28152594
65	Phosphorylation	QVYPGEASRVSVADH EECCCCCCEEEECCC	28.98	28152594
68	Phosphorylation	PGEASRVSVADHSLH CCCCCEEEECCCEEE	15.52	25693802
73	Phosphorylation	RVSVADHSLHLSKAK EEEECCCEEEECCCC	20.31	25693802
77	Phosphorylation	ADHSLHLSKAKISKP CCCEEEECCCCCCCC	21.59	23312004
78	2-Hydroxyisobutyrylation	DHSLHLSKAKISKPA CCEEEECCCCCCCCC	61.12	-
78	Ubiquitination	DHSLHLSKAKISKPA CCEEEECCCCCCCCC	61.12	-
83	Acetylation	LSKAKISKPAPYWEG ECCCCCCCCCCCCCC	48.98	26051181
99	Acetylation	AVIDGEFKELKLTDY EEECCCEEEEEEEEC	58.81	24846207
99	2-Hydroxyisobutyrylation	AVIDGEFKELKLTDY EEECCCEEEEEEEEC	58.81	-
99	Ubiquitination	AVIDGEFKELKLTDY EEECCCEEEEEEEEC	58.81	-
102	Ubiquitination	DGEFKELKLTDYRGK CCCEEEEEEEECCCC	50.89	-
102	2-Hydroxyisobutyrylation	DGEFKELKLTDYRGK CCCEEEEEEEECCCC	50.89	-
148	S-nitrosylation	INTEVVACSVDSQFT CCCEEEEEEECCCCE	2.48	25040305
173	Methylation	QGGLGPIRIPLLSDL CCCCCCCCHHHHHHH	27.83	24387909
186	Acetylation	DLTHQISKDYGVYLE HHHHHHHHHCCEEEE	57.51	27452117
188	Phosphorylation	THQISKDYGVYLEDS HHHHHHHCCEEEECC	16.54	28152594
191	Phosphorylation	ISKDYGVYLEDSGHT HHHHCCEEEECCCCE	10.46	28152594
208	Ubiquitination	GLFIIDDKGILRQIT EEEEECCCCEEEEEE	44.07	21890473
208	Acetylation	GLFIIDDKGILRQIT EEEEECCCCEEEEEE	44.07	30591537
224	Phosphorylation	NDLPVGRSVDETLRL CCCCCCCCHHHHHHH	28.17	21815630
228	Phosphorylation	VGRSVDETLRLVQAF CCCCHHHHHHHHHHH	16.83	-
230	Methylation	RSVDETLRLVQAFQY CCHHHHHHHHHHHHC	39.99	115488749
237	Phosphorylation	RLVQAFQYTDKHGEV HHHHHHHCCCCCCCC	15.51	28152594
238	Phosphorylation	LVQAFQYTDKHGEVC HHHHHHCCCCCCCCC	27.99	28152594
240	Acetylation	QAFQYTDKHGEVCPA HHHHCCCCCCCCCCC	45.79	26051181
245	Glutathionylation	TDKHGEVCPAGWKPG CCCCCCCCCCCCCCC	1.34	22555962
250	Methylation	EVCPAGWKPGSETII CCCCCCCCCCCCEEC	38.29	-
250	Acetylation	EVCPAGWKPGSETII CCCCCCCCCCCCEEC	38.29	26051181
253	Phosphorylation	PAGWKPGSETIIPDP CCCCCCCCCEECCCC	39.84	30622161
255	Phosphorylation	GWKPGSETIIPDPAG CCCCCCCEECCCCCC	26.38	30622161
255	O-linked_Glycosylation	GWKPGSETIIPDPAG CCCCCCCEECCCCCC	26.38	OGP
263	Ubiquitination	IIPDPAGKLKYFDKL ECCCCCCCCCEECCC	43.86	-
265	Ubiquitination	PDPAGKLKYFDKLN- CCCCCCCCEECCCC-	47.56	-
266	Phosphorylation	DPAGKLKYFDKLN-- CCCCCCCEECCCC--	27.70	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PRDX4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PRDX4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PRDX4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PRDX4_HUMAN	PRDX4	physical	9388242
PRDX1_HUMAN	PRDX1	physical	9388242
ZN593_HUMAN	ZNF593	physical	22939629
ST2A1_HUMAN	SULT2A1	physical	21988832
VTNC_HUMAN	VTN	physical	21988832
ZN363_HUMAN	RCHY1	physical	21988832
TLN1_HUMAN	TLN1	physical	22863883

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.