ST2A1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ST2A1_HUMAN
• UniProt AC: Q06520
• Protein Name: Bile salt sulfotransferase
• Gene Name: SULT2A1
• Organism: Homo sapiens (Human).
• Sequence Length: 285
• Subcellular Localization: Cytoplasm.
• Protein Description: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands..
• Protein Sequence: MSDDFLWFEGIAFPTMGFRSETLRKVRDEFVIRDEDVIILTYPKSGTNWLAEILCLMHSKGDAKWIQSVPIWERSPWVESEIGYTALSETESPRLFSSHLPIQLFPKSFFSSKAKVIYLMRNPRDVLVSGYFFWKNMKFIKKPKSWEEYFEWFCQGTVLYGSWFDHIHGWMPMREEKNFLLLSYEELKQDTGRTIEKICQFLGKTLEPEELNLILKNSSFQSMKENKMSNYSLLSVDYVVDKAQLLRKGVSGDWKNHFTVAQAEDFDKLFQEKMADLPRELFPWE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Phosphorylation	FPTMGFRSETLRKVR CCCCCCCCHHHHHHH	32.45	24275569
41	Phosphorylation	DEDVIILTYPKSGTN CCCEEEEECCCCCCH	27.63	26074081
42	Phosphorylation	EDVIILTYPKSGTNW CCEEEEECCCCCCHH	12.76	26074081
90	Phosphorylation	GYTALSETESPRLFS CCEECCCCCCCCCHH	38.09	-
111	Phosphorylation	LFPKSFFSSKAKVIY CCCHHHHCCCCEEEE	28.99	24719451
112	Phosphorylation	FPKSFFSSKAKVIYL CCHHHHCCCCEEEEE	31.32	28060719
129	Phosphorylation	NPRDVLVSGYFFWKN CHHHEEEEEEEEHHC	24.50	24719451
135	Acetylation	VSGYFFWKNMKFIKK EEEEEEHHCCCEECC	41.84	11565425
177	Acetylation	WMPMREEKNFLLLSY ECCCHHCCCEEEEEH	48.52	20167786
183	Phosphorylation	EKNFLLLSYEELKQD CCCEEEEEHHHHHHH	30.39	29978859
184	Phosphorylation	KNFLLLSYEELKQDT CCEEEEEHHHHHHHH	17.25	29978859
191	Phosphorylation	YEELKQDTGRTIEKI HHHHHHHHCCHHHHH	26.52	29978859
218	Phosphorylation	LNLILKNSSFQSMKE HHHHHHCCCHHHHHH	30.83	30576142
219	Phosphorylation	NLILKNSSFQSMKEN HHHHHCCCHHHHHHC	36.38	30576142
222	Phosphorylation	LKNSSFQSMKENKMS HHCCCHHHHHHCCCC	29.79	30576142
231	Phosphorylation	KENKMSNYSLLSVDY HHCCCCCCEEEEEEE	8.06	-
251	Phosphorylation	QLLRKGVSGDWKNHF HHHHCCCCCCHHHCE	39.44	20166139

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ST2A1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ST2A1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ST2A1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TMX1_HUMAN	TMX1	physical	21988832
ST1B1_HUMAN	SULT1B1	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB05812: Abiraterone
• DB00316: Acetaminophen