NC2A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NC2A_HUMAN
• UniProt AC: Q14919
• Protein Name: Dr1-associated corepressor
• Gene Name: DRAP1
• Organism: Homo sapiens (Human).
• Sequence Length: 205
• Subcellular Localization: Nucleus .
• Protein Description: The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own..
• Protein Sequence: MPSKKKKYNARFPPARIKKIMQTDEEIGKVAAAVPVIISRALELFLESLLKKACQVTQSRNAKTMTTSHLKQCIELEQQFDFLKDLVASVPDMQGDGEDNHMDGDKGARRGRKPGSGGRKNGGMGTKSKDKKLSGTDSEQEDESEDTDTDGEEETSQPPPQASHPSAHFQSPPTPFLPFASTLPLPPAPPGPSAPDEEDEEDYDS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Ubiquitination	--MPSKKKKYNARFP --CCCCCHHCCCCCC	65.31	24816145
8	Phosphorylation	MPSKKKKYNARFPPA CCCCCHHCCCCCCHH	23.96	-
21	Sulfoxidation	PARIKKIMQTDEEIG HHHHHHHHHCHHHHH	4.88	21406390
23	Phosphorylation	RIKKIMQTDEEIGKV HHHHHHHCHHHHHHH	28.18	-
29 (in isoform 2)	Ubiquitination	-	34.07	21906983
29 (in isoform 1)	Ubiquitination	-	34.07	21906983
29	Ubiquitination	QTDEEIGKVAAAVPV HCHHHHHHHHHHHHH	34.07	21906983
39	Phosphorylation	AAVPVIISRALELFL HHHHHHHHHHHHHHH	10.61	-
48	Phosphorylation	ALELFLESLLKKACQ HHHHHHHHHHHHHHH	40.94	24719451
51	Ubiquitination	LFLESLLKKACQVTQ HHHHHHHHHHHHHHH	43.55	33845483
51 (in isoform 2)	Ubiquitination	-	43.55	21906983
51 (in isoform 1)	Ubiquitination	-	43.55	21906983
52	Ubiquitination	FLESLLKKACQVTQS HHHHHHHHHHHHHHH	55.13	27667366
59	Phosphorylation	KACQVTQSRNAKTMT HHHHHHHHCCCCCCC	20.38	22210691
63	Ubiquitination	VTQSRNAKTMTTSHL HHHHCCCCCCCHHHH	42.23	27667366
63	Acetylation	VTQSRNAKTMTTSHL HHHHCCCCCCCHHHH	42.23	25953088
89	Phosphorylation	FLKDLVASVPDMQGD HHHHHHHCCCCCCCC	27.06	25849741
106	Acetylation	DNHMDGDKGARRGRK CCCCCCCCHHCCCCC	61.06	25953088
106	Ubiquitination	DNHMDGDKGARRGRK CCCCCCCCHHCCCCC	61.06	29967540
112 (in isoform 2)	Phosphorylation	-	39.94	-
116	Phosphorylation	RRGRKPGSGGRKNGG CCCCCCCCCCCCCCC	46.75	-
120	Acetylation	KPGSGGRKNGGMGTK CCCCCCCCCCCCCCC	64.32	20167786
126	Phosphorylation	RKNGGMGTKSKDKKL CCCCCCCCCCCCCCC	24.21	23532336
129	Acetylation	GGMGTKSKDKKLSGT CCCCCCCCCCCCCCC	75.11	20167786
136	Phosphorylation	KDKKLSGTDSEQEDE CCCCCCCCCCCCCCC	32.73	25137130
138	Phosphorylation	KKLSGTDSEQEDESE CCCCCCCCCCCCCCC	40.80	25137130
144	Phosphorylation	DSEQEDESEDTDTDG CCCCCCCCCCCCCCC	53.76	25137130
147	Phosphorylation	QEDESEDTDTDGEEE CCCCCCCCCCCCCCC	36.43	25137130
149	Phosphorylation	DESEDTDTDGEEETS CCCCCCCCCCCCCCC	48.25	25137130
205	Phosphorylation	EDEEDYDS------- CCCCCCCC-------	35.57	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NC2A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NC2A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NC2A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DPOE3_HUMAN	POLE3	physical	16189514
TAF9B_HUMAN	TAF9B	physical	16189514
NC2B_HUMAN	DR1	physical	8972183
NC2B_HUMAN	DR1	physical	8608938
TBP_HUMAN	TBP	physical	11461703
TBP_HUMAN	TBP	physical	15574413
NC2B_HUMAN	DR1	physical	15574413
A4_HUMAN	APP	physical	21832049
NC2B_HUMAN	DR1	physical	22939629
HPBP1_HUMAN	HSPBP1	physical	22863883
RD23B_HUMAN	RAD23B	physical	22863883
SUMO3_HUMAN	SUMO3	physical	22863883
TPD54_HUMAN	TPD52L2	physical	22863883
NC2A_HUMAN	DRAP1	physical	25416956
TAF9B_HUMAN	TAF9B	physical	25416956
DPOE3_HUMAN	POLE3	physical	25416956
NC2B_SCHPO	SPBC30D10.02	physical	26771498
NC2B_HUMAN	DR1	physical	26771498
RBTN2_HUMAN	LMO2	physical	21516116
TAF9_HUMAN	TAF9	physical	21516116
PKHF2_HUMAN	PLEKHF2	physical	21516116

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.