dbPTM

F133B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	F133B_HUMAN
UniProt AC	Q5BKY9
Protein Name	Protein FAM133B
Gene Name	FAM133B
Organism	Homo sapiens (Human).
Sequence Length	247
Subcellular Localization
Protein Description
Protein Sequence	MGKRDNRVAYMNPIAMARSRGPIQSSGPTIQDYLNRPRPTWEEVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKHKKHSKKKKKKAASSSPDSP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	KRDNRVAYMNPIAMA CCCCCCEECCHHHHH	8.45	28796482
18	Methylation	MNPIAMARSRGPIQS CCHHHHHHHCCCCCC	17.50	-
19	Phosphorylation	NPIAMARSRGPIQSS CHHHHHHHCCCCCCC	31.86	-
20	Methylation	PIAMARSRGPIQSSG HHHHHHHCCCCCCCC	49.72	-
33	Phosphorylation	SGPTIQDYLNRPRPT CCCCHHHHHCCCCCC	6.90	27642862
35	Ubiquitination	PTIQDYLNRPRPTWE CCHHHHHCCCCCCHH	45.76	29967540
45	Ubiquitination	RPTWEEVKEQLEKKK CCCHHHHHHHHHHHH	42.92	29967540
56	Ubiquitination	EKKKKGSKALAEFEE HHHHCCHHHHHHHHH	56.97	-
72 (in isoform 2)	Phosphorylation	-	59.44	-
74 (in isoform 2)	Phosphorylation	-	48.16	-
79	Ubiquitination	ELEKHREKLLSGSES HHHHHHHHHHCCCCC	55.47	24816145
82	Phosphorylation	KHREKLLSGSESSSK HHHHHHHCCCCCHHH	51.19	29255136
84	Phosphorylation	REKLLSGSESSSKKR HHHHHCCCCCHHHHH	30.81	29255136
86	Phosphorylation	KLLSGSESSSKKRQR HHHCCCCCHHHHHHH	41.42	25159151
87	Phosphorylation	LLSGSESSSKKRQRK HHCCCCCHHHHHHHH	41.97	25159151
88	Phosphorylation	LSGSESSSKKRQRKK HCCCCCHHHHHHHHH	52.02	25159151
89	Acetylation	SGSESSSKKRQRKKK CCCCCHHHHHHHHHH	54.65	25953088
89	Ubiquitination	SGSESSSKKRQRKKK CCCCCHHHHHHHHHH	54.65	24816145
101	Phosphorylation	KKKEKKKSGRYSSSS HHHHHHHHCCCCCCC	37.06	-
104	Phosphorylation	EKKKSGRYSSSSSSS HHHHHCCCCCCCCCC	19.21	26552605
105	Phosphorylation	KKKSGRYSSSSSSSS HHHHCCCCCCCCCCC	23.53	26552605
106	Phosphorylation	KKSGRYSSSSSSSSD HHHCCCCCCCCCCCC	25.88	26552605
107	Phosphorylation	KSGRYSSSSSSSSDS HHCCCCCCCCCCCCC	28.44	26552605
108	Phosphorylation	SGRYSSSSSSSSDSS HCCCCCCCCCCCCCC	35.87	26552605
109	Phosphorylation	GRYSSSSSSSSDSSS CCCCCCCCCCCCCCC	35.87	26552605
110	Phosphorylation	RYSSSSSSSSDSSSS CCCCCCCCCCCCCCC	35.49	26552605
111	Phosphorylation	YSSSSSSSSDSSSSS CCCCCCCCCCCCCCC	39.86	26552605
112	Phosphorylation	SSSSSSSSDSSSSSS CCCCCCCCCCCCCCC	43.38	26552605
114	Phosphorylation	SSSSSSDSSSSSSDS CCCCCCCCCCCCCCC	33.78	26552605
115	Phosphorylation	SSSSSDSSSSSSDSE CCCCCCCCCCCCCCC	38.95	26552605
116	Phosphorylation	SSSSDSSSSSSDSED CCCCCCCCCCCCCCC	37.89	26552605
117	Phosphorylation	SSSDSSSSSSDSEDE CCCCCCCCCCCCCCH	35.49	26552605
118	Phosphorylation	SSDSSSSSSDSEDED CCCCCCCCCCCCCHH	39.86	26552605
119	Phosphorylation	SDSSSSSSDSEDEDK CCCCCCCCCCCCHHH	47.29	26552605
121	Phosphorylation	SSSSSSDSEDEDKKQ CCCCCCCCCCHHHHH	49.23	26552605
139	Phosphorylation	RKKKKNRSHKSSESS HHHHHCCCCCCCHHH	44.66	23909892
142 (in isoform 2)	Phosphorylation	-	33.64	-
142	Phosphorylation	KKNRSHKSSESSMSE HHCCCCCCCHHHCCC	33.64	20873877
143	Phosphorylation	KNRSHKSSESSMSET HCCCCCCCHHHCCCC	46.42	26074081
145	Phosphorylation	RSHKSSESSMSETES CCCCCCHHHCCCCCC	33.03	26074081
146	Phosphorylation	SHKSSESSMSETESD CCCCCHHHCCCCCCC	23.44	26074081
148	Phosphorylation	KSSESSMSETESDSK CCCHHHCCCCCCCCH	43.23	30576142
150	Phosphorylation	SESSMSETESDSKDS CHHHCCCCCCCCHHH	33.22	20873877
152	Phosphorylation	SSMSETESDSKDSLK HHCCCCCCCCHHHHH	55.38	20873877
154	Phosphorylation	MSETESDSKDSLKKK CCCCCCCCHHHHHHH	47.87	26074081
157	Phosphorylation	TESDSKDSLKKKKKS CCCCCHHHHHHHHHC	45.91	26074081
180	Ubiquitination	DIKGLSKKRKMYSED HHHHHHHHHHCCCCC	54.60	21906983
181 (in isoform 2)	Phosphorylation	-	32.48	-
182 (in isoform 2)	Phosphorylation	-	51.58	-
182	Ubiquitination	KGLSKKRKMYSEDKP HHHHHHHHCCCCCCC	51.58	21906983
184 (in isoform 2)	Phosphorylation	-	16.37	-
184	Phosphorylation	LSKKRKMYSEDKPLS HHHHHHCCCCCCCCC	16.37	23663014
185	Phosphorylation	SKKRKMYSEDKPLSS HHHHHCCCCCCCCCC	35.50	22115753
186 (in isoform 2)	Phosphorylation	-	53.20	-
188	Ubiquitination	RKMYSEDKPLSSESL HHCCCCCCCCCCCCC	43.75	21906983
191	Phosphorylation	YSEDKPLSSESLSES CCCCCCCCCCCCCHH	40.36	25159151
192	Phosphorylation	SEDKPLSSESLSESE CCCCCCCCCCCCHHH	38.60	25159151
194	Phosphorylation	DKPLSSESLSESEYI CCCCCCCCCCHHHHH	38.86	25159151
196	Phosphorylation	PLSSESLSESEYIEE CCCCCCCCHHHHHHH	48.64	25159151
197	Ubiquitination	LSSESLSESEYIEEV CCCCCCCHHHHHHHH	53.54	24816145
198	Phosphorylation	SSESLSESEYIEEVR CCCCCCHHHHHHHHH	32.12	22115753
200	Phosphorylation	ESLSESEYIEEVRAK CCCCHHHHHHHHHHH	23.94	22115753
207	Ubiquitination	YIEEVRAKKKKSSEE HHHHHHHHHCCCHHH	55.34	24816145
211	Phosphorylation	VRAKKKKSSEEREKA HHHHHCCCHHHHHHH	52.43	20068231
219	Phosphorylation	SEEREKATEKTKKKK HHHHHHHHHHHHHHH	49.43	20068231
236	Phosphorylation	KKHSKKKKKKAASSS HHHCHHHHHHHHHCC	69.27	33259812
243	Phosphorylation	KKKAASSSPDSP--- HHHHHHCCCCCC---	30.17	28985074
246	Phosphorylation	AASSSPDSP------ HHHCCCCCC------	35.57	33259812

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of F133B_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of F133B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of F133B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of F133B_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-196, AND MASSSPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-191; SER-192; SER-194AND SER-196, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-191; SER-192; SER-194AND SER-196, AND MASS SPECTROMETRY.	17081983 [Abstract]