HIG1A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HIG1A_HUMAN
• UniProt AC: Q9Y241
• Protein Name: HIG1 domain family member 1A, mitochondrial
• Gene Name: HIGD1A
• Organism: Homo sapiens (Human).
• Sequence Length: 93
• Subcellular Localization: Mitochondrion membrane ; Multi-pass membrane protein . Mitochondrion inner membrane .
• Protein Description: Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May play a role in the assembly of respiratory supercomplexes..
• Protein Sequence: MSTDTGVSLPSYEEDQGSKLIRKAKEAPFVPVGIAGFAAIVAYGLYKLKSRGNTKMSIHLIHMRVAAQGFVVGAMTVGMGYSMYREFWAKPKP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSTDTGVSL ------CCCCCCCCC	34.68	30108239
2	Acetylation	------MSTDTGVSL ------CCCCCCCCC	34.68	-
3	Phosphorylation	-----MSTDTGVSLP -----CCCCCCCCCC	35.96	30108239
5	Phosphorylation	---MSTDTGVSLPSY ---CCCCCCCCCCCC	39.30	30108239
8	Phosphorylation	MSTDTGVSLPSYEED CCCCCCCCCCCCCCC	35.59	28355574
11	Phosphorylation	DTGVSLPSYEEDQGS CCCCCCCCCCCCHHH	50.93	25849741
12	Phosphorylation	TGVSLPSYEEDQGSK CCCCCCCCCCCHHHH	22.77	23186163
18	Phosphorylation	SYEEDQGSKLIRKAK CCCCCHHHHHHHHHH	20.75	22199227
19	Ubiquitination	YEEDQGSKLIRKAKE CCCCHHHHHHHHHHH	55.55	23000965
23	Ubiquitination	QGSKLIRKAKEAPFV HHHHHHHHHHHCCCC	57.74	23000965
25	Ubiquitination	SKLIRKAKEAPFVPV HHHHHHHHHCCCCCC	58.40	23000965
25	Phosphorylation	SKLIRKAKEAPFVPV HHHHHHHHHCCCCCC	58.40	33259812
33	Ubiquitination	EAPFVPVGIAGFAAI HCCCCCCCHHHHHHH	9.65	21890473
33 (in isoform 2)	Ubiquitination	-	9.65	-
37	Ubiquitination	VPVGIAGFAAIVAYG CCCCHHHHHHHHHHH	2.83	23000965
39	Ubiquitination	VGIAGFAAIVAYGLY CCHHHHHHHHHHHHH	8.43	23000965
54	Phosphorylation	KLKSRGNTKMSIHLI HHHHCCCCCEEEEEE	30.83	24275569
57	Phosphorylation	SRGNTKMSIHLIHMR HCCCCCEEEEEEHHH	14.38	24275569
90	Ubiquitination	MYREFWAKPKP---- HHHHHHCCCCC----	44.14	-
104 (in isoform 2)	Ubiquitination	-		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HIG1A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HIG1A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HIG1A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IPO13_HUMAN	IPO13	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.