dbPTM

MTFP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MTFP1_HUMAN
UniProt AC	Q9UDX5
Protein Name	Mitochondrial fission process protein 1
Gene Name	MTFP1
Organism	Homo sapiens (Human).
Sequence Length	166
Subcellular Localization	Mitochondrion inner membrane Multi-pass membrane protein .
Protein Description	Involved in the mitochondrial division probably by regulating membrane fission. Loss-of-function induces the release of cytochrome c, which activates the caspase cascade and leads to apoptosis..
Protein Sequence	MSEPQPRGAERDLYRDTWVRYLGYANEVGEAFRSLVPAAVVWLSYGVASSYVLADAIDKGKKAGEVPSPEAGRSARVTVAVVDTFVWQALASVAIPGFTINRVCAASLYVLGTATRWPLAVRKWTTTALGLLTIPIIIHPIDRSVDFLLDSSLRKLYPTVGKPSSS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
74	Phosphorylation	PSPEAGRSARVTVAV CCHHCCCCCCEEEEE	21.36	-
78	Phosphorylation	AGRSARVTVAVVDTF CCCCCCEEEEEEEHH	9.37	-
123	Succinylation	RWPLAVRKWTTTALG CCCCHHHHHHHHHHH	42.15	-
123	Succinylation	RWPLAVRKWTTTALG CCCCHHHHHHHHHHH	42.15	-
157	Phosphorylation	DSSLRKLYPTVGKPS CHHHHHHCCCCCCCC	10.41	29496907
159	Phosphorylation	SLRKLYPTVGKPSSS HHHHHCCCCCCCCCC	28.47	29083192
162	Ubiquitination	KLYPTVGKPSSS--- HHCCCCCCCCCC---	37.07	-
164	Phosphorylation	YPTVGKPSSS----- CCCCCCCCCC-----	46.85	29083192
165	Phosphorylation	PTVGKPSSS------ CCCCCCCCC------	48.90	29083192
166	Phosphorylation	TVGKPSSS------- CCCCCCCC-------	48.88	29083192

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MTFP1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MTFP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MTFP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of MTFP1_HUMAN !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MTFP1_HUMAN

Related Literatures of Post-Translational Modification