KLH35_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KLH35_HUMAN
• UniProt AC: Q6PF15
• Protein Name: Kelch-like protein 35
• Gene Name: KLHL35
• Organism: Homo sapiens (Human).
• Sequence Length: 583
• Protein Sequence: MRQGHAPEESEPGCEAPCAGPCHAQRVLQALNAYRRSGTLTDVVLRAGGRDFPCHRAALSAGSAYFRSLFAAGRPERGPAVVPVVPVAPEAPGTSPAGAAAALAVVLDYVYGAGVRLRAEDEAAAVLALAERLGVAGLREACVRFLEGRLRAANSLALRRVAAAFSLAPLAERCGRVLRQAFAEVARHADFLELAPDEVVALLADPALGVAREEAVFEAAMRWVRHDAPARRGQLRRLLEHVRLPLLAPAYFLEKVEADELLQACGECRPLLLEARACFILGREAGALRTRPRRFMDLAEVIVVIGGCDRKGLLKLPFADAYHPESQRWTPLPSLPGYTRSEFAACALRNDVYVSGGHINSHDVWMFSSHLHTWIKVASLHKGRWRHKMAVVQGQLFAVGGFDGLRRLHSVERYDPFSNTWAAAAPLPEAVSSAAVASCAGKLFVIGGARQGGVNTDKVQCFDPKEDRWSLRSPAPFSQRCLEAVSLEDTIYVMGGLMSKIFTYDPGTDVWGEAAVLPSPVESCGVTVCDGKVHILGGRDDRGESTDKVFTFDPSSGQVEVQPSLQRCTSSHGCVTIIQSLGR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
341	Phosphorylation	SLPGYTRSEFAACAL CCCCCCHHHHHHHHH	12.16	28348404
456	Phosphorylation	ARQGGVNTDKVQCFD CCCCCCCCCCCCCCC		-
458	Ubiquitination	QGGVNTDKVQCFDPK CCCCCCCCCCCCCCC		29967540
470	Phosphorylation	DPKEDRWSLRSPAPF CCCCCCCCCCCCCCC		24719451
473	O-linked_Glycosylation	EDRWSLRSPAPFSQR CCCCCCCCCCCCCHH		30379171
490	Phosphorylation	EAVSLEDTIYVMGGL HHCCHHHEEEEECCH		21060948
492	Phosphorylation	VSLEDTIYVMGGLMS CCHHHEEEEECCHHH		21060948
499	Phosphorylation	YVMGGLMSKIFTYDP EEECCHHHHHCEECC		21060948
503	Phosphorylation	GLMSKIFTYDPGTDV CHHHHHCEECCCCCC		-
527	Phosphorylation	PVESCGVTVCDGKVH CCHHCCEEEECCEEE		-
548	Ubiquitination	DRGESTDKVFTFDPS CCCCCCCCEEEECCC		29967540
564	Phosphorylation	GQVEVQPSLQRCTSS CCEEEECHHHHCCCC		26091039

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KLH35_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KLH35_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KLH35_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of KLH35_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.