TEKT4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TEKT4_HUMAN
• UniProt AC: Q8WW24
• Protein Name: Tektin-4
• Gene Name: TEKT4
• Organism: Homo sapiens (Human).
• Sequence Length: 435
• Subcellular Localization: Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, flagellum axoneme. Cytoplasm, cytoskeleton, cilium axoneme. Found in the abaxial (convex) surface of outer dense fibers in sperm flagella..
• Protein Description: Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules (By similarity)..
• Protein Sequence: MAQTVPPCELPCKEYDVARNTGAYTSSGLATASFRTSKYLLEEWFQNCYARYHQAFADRDQSERQRHESQQLATETQALAQRTQQDSTRTVGERLQDTHSWKSELQREMEALAAETNLLLAQKQRLERALDATEVPFSITTDNLQCRERREHPNLVRDHVETELLKEAELIRNIQELLKRTIMQAVSQIRLNREHKETCEMDWSDKMEAYNIDETCGRHHSQSTEVQAHPYSTTFQESASTPETRAKFTQDNLCRAQRERLASANLRVLVDCILRDTSEDLRLQCDAVNLAFGRRCEELEDARYKLHHHLHKTLREITDQEHNVAALKQAIKDKEAPLHVAQTRLYLRSHRPNMELCRDAAQFRLLSEVEELNMSLTALREKLLEAEQSLRNLEDIHMSLEKDIAAMTNSLFIDRQKCMAHRTRYPTILQLAGYQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Acetylation	PPCELPCKEYDVARN CCCCCCCCCCCCCCC	58.32	25038526
38	Acetylation	TASFRTSKYLLEEWF CCHHHHHHHHHHHHH	39.03	25038526
116	Phosphorylation	MEALAAETNLLLAQK HHHHHHHHHHHHHHH	26.83	-
166	Acetylation	HVETELLKEAELIRN HHHHHHHHHHHHHHH	68.45	25038526
181	Phosphorylation	IQELLKRTIMQAVSQ HHHHHHHHHHHHHHH	21.15	-
187	O-linked_Glycosylation	RTIMQAVSQIRLNRE HHHHHHHHHHHCCHH	23.94	30620550
210	Phosphorylation	WSDKMEAYNIDETCG HHHHHHHCCCCCCCC	10.19	-
377	Phosphorylation	EELNMSLTALREKLL HHHCHHHHHHHHHHH	19.15	24719451
389	Phosphorylation	KLLEAEQSLRNLEDI HHHHHHHHHCCHHHH	22.32	29083192

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TEKT4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TEKT4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TEKT4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KR261_HUMAN	KRTAP26-1	physical	25416956
VP33A_HUMAN	VPS33A	physical	26186194
COG2_HUMAN	COG2	physical	26186194
NEK1_HUMAN	NEK1	physical	26186194
COG4_HUMAN	COG4	physical	26186194
CLOCK_HUMAN	CLOCK	physical	26186194
NDE1_HUMAN	NDE1	physical	26186194
ABRX1_HUMAN	FAM175A	physical	26186194
CU002_HUMAN	C21orf2	physical	26186194
CRY2_HUMAN	CRY2	physical	26186194
CRY1_HUMAN	CRY1	physical	26186194
PUR8_HUMAN	ADSL	physical	26186194
CEP55_HUMAN	CEP55	physical	26186194
IKZF3_HUMAN	IKZF3	physical	21516116
NEK1_HUMAN	NEK1	physical	28514442
CRY1_HUMAN	CRY1	physical	28514442
CRY2_HUMAN	CRY2	physical	28514442
CU002_HUMAN	C21orf2	physical	28514442
CLOCK_HUMAN	CLOCK	physical	28514442
COG2_HUMAN	COG2	physical	28514442
ABRX1_HUMAN	FAM175A	physical	28514442
PUR8_HUMAN	ADSL	physical	28514442
NDE1_HUMAN	NDE1	physical	28514442
COG4_HUMAN	COG4	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.