dbPTM

IKZF3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	IKZF3_HUMAN
UniProt AC	Q9UKT9
Protein Name	Zinc finger protein Aiolos
Gene Name	IKZF3
Organism	Homo sapiens (Human).
Sequence Length	509
Subcellular Localization	Nucleus. Cytoplasm.
Protein Description	Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner..
Protein Sequence	MEDIQTNAELKSTQEQSVPAESAAVLNDYSLTKSHEMENVDSGEGPANEDEDIGDDSMKVKDEYSERDENVLKSEPMGNAEEPEIPYSYSREYNEYENIKLERHVVSFDSSRPTSGKMNCDVCGLSCISFNVLMVHKRSHTGERPFQCNQCGASFTQKGNLLRHIKLHTGEKPFKCHLCNYACQRRDALTGHLRTHSVEKPYKCEFCGRSYKQRSSLEEHKERCRTFLQSTDPGDTASAEARHIKAEMGSERALVLDRLASNVAKRKSSMPQKFIGEKRHCFDVNYNSSYMYEKESELIQTRMMDQAINNAISYLGAEALRPLVQTPPAPTSEMVPVISSMYPIALTRAEMSNGAPQELEKKSIHLPEKSVPSERGLSPNNSGHDSTDTDSNHEERQNHIYQQNHMVLSRARNGMPLLKEVPRSYELLKPPPICPRDSVKVINKEGEVMDVYRCDHCRVLFLDYVMFTIHMGCHGFRDPFECNMCGYRSHDRYEFSSHIARGEHRALLK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6 (in isoform 7)	Phosphorylation	-	36.41	24043423
6 (in isoform 8)	Phosphorylation	-	36.41	24043423
12	Phosphorylation	QTNAELKSTQEQSVP HHHHHHHCCCCCCCC	48.20	27282143
12 (in isoform 7)	Phosphorylation	-	48.20	24043423
12 (in isoform 8)	Phosphorylation	-	48.20	24043423
13	Phosphorylation	TNAELKSTQEQSVPA HHHHHHCCCCCCCCH	34.24	27282143
13 (in isoform 7)	Phosphorylation	-	34.24	24043423
13 (in isoform 8)	Phosphorylation	-	34.24	24043423
17	Phosphorylation	LKSTQEQSVPAESAA HHCCCCCCCCHHHHH	29.34	27282143
17 (in isoform 7)	Phosphorylation	-	29.34	24043423
17 (in isoform 8)	Phosphorylation	-	29.34	24043423
18	Ubiquitination	KSTQEQSVPAESAAV HCCCCCCCCHHHHHH	5.35	24816145
22	Phosphorylation	EQSVPAESAAVLNDY CCCCCHHHHHHHHCC	24.51	30108239
23 (in isoform 7)	Phosphorylation	-	7.97	24043423
23 (in isoform 8)	Phosphorylation	-	7.97	24043423
26	Ubiquitination	PAESAAVLNDYSLTK CHHHHHHHHCCCCCC	3.28	-
26	Ubiquitination	PAESAAVLNDYSLTK CHHHHHHHHCCCCCC	3.28	29967540
42	Phosphorylation	HEMENVDSGEGPANE EECCCCCCCCCCCCC	34.17	23401153
57	Phosphorylation	DEDIGDDSMKVKDEY CCCCCCCCCCCCHHH	25.83	30108239
61	Sumoylation	GDDSMKVKDEYSERD CCCCCCCCHHHHHHH	39.05	28112733
63	Ubiquitination	DSMKVKDEYSERDEN CCCCCCHHHHHHHHC	45.28	22817900
64	Phosphorylation	SMKVKDEYSERDENV CCCCCHHHHHHHHCC	26.43	27251275
65	Phosphorylation	MKVKDEYSERDENVL CCCCHHHHHHHHCCC	24.90	30108239
66	Ubiquitination	KVKDEYSERDENVLK CCCHHHHHHHHCCCC	64.35	29967540
73	Sumoylation	ERDENVLKSEPMGNA HHHHCCCCCCCCCCC	48.79	28112733
73	Ubiquitination	ERDENVLKSEPMGNA HHHHCCCCCCCCCCC	48.79	-
74	Phosphorylation	RDENVLKSEPMGNAE HHHCCCCCCCCCCCC	42.65	50564293
83	Ubiquitination	PMGNAEEPEIPYSYS CCCCCCCCCCCCCCC	36.00	24816145
88	Phosphorylation	EEPEIPYSYSREYNE CCCCCCCCCCCCCCC	15.98	30108239
90	Phosphorylation	PEIPYSYSREYNEYE CCCCCCCCCCCCCCC	16.82	50564299
91	Ubiquitination	EIPYSYSREYNEYEN CCCCCCCCCCCCCCC	42.03	29967540
93	Phosphorylation	PYSYSREYNEYENIK CCCCCCCCCCCCCEE	16.51	23025827
96	Phosphorylation	YSREYNEYENIKLER CCCCCCCCCCEEEEE	15.61	23025827
100	Sumoylation	YNEYENIKLERHVVS CCCCCCEEEEEEEEE	56.74	-
100	Sumoylation	YNEYENIKLERHVVS CCCCCCEEEEEEEEE	56.74	28112733
100	Ubiquitination	YNEYENIKLERHVVS CCCCCCEEEEEEEEE	56.74	29967540
102	Ubiquitination	EYENIKLERHVVSFD CCCCEEEEEEEEEEC	35.42	22817900
107	Phosphorylation	KLERHVVSFDSSRPT EEEEEEEEECCCCCC	23.42	23401153
114	Ubiquitination	SFDSSRPTSGKMNCD EECCCCCCCCCCCCC	49.34	-
115	Ubiquitination	FDSSRPTSGKMNCDV ECCCCCCCCCCCCCC	38.81	-
115	Phosphorylation	FDSSRPTSGKMNCDV ECCCCCCCCCCCCCC	38.81	46161063
122	Ubiquitination	SGKMNCDVCGLSCIS CCCCCCCCCCCEEEE	2.80	-
122	Ubiquitination	SGKMNCDVCGLSCIS CCCCCCCCCCCEEEE	2.80	24816145
130	Ubiquitination	CGLSCISFNVLMVHK CCCEEEEEEEEEEEC	3.57	29967540
139	Phosphorylation	VLMVHKRSHTGERPF EEEEECCCCCCCCCC	30.15	28450419
139 (in isoform 15)	Phosphorylation	-	30.15	-
139 (in isoform 2)	Phosphorylation	-	30.15	-
141	Phosphorylation	MVHKRSHTGERPFQC EEECCCCCCCCCCCC	41.82	28450419
141 (in isoform 15)	Phosphorylation	-	41.82	-
141 (in isoform 2)	Phosphorylation	-	41.82	-
141 (in isoform 5)	Phosphorylation	-	41.82	-
146 (in isoform 15)	Phosphorylation	-	18.95	-
146 (in isoform 2)	Phosphorylation	-	18.95	-
150	Ubiquitination	ERPFQCNQCGASFTQ CCCCCCCCCCCCEEC	34.35	22817900
150 (in isoform 5)	Ubiquitination	-	34.35	21906983
154	Phosphorylation	QCNQCGASFTQKGNL CCCCCCCCEECCCCC	17.70	27080861
156	Phosphorylation	NQCGASFTQKGNLLR CCCCCCEECCCCCEE	27.20	27080861
158	Ubiquitination	CGASFTQKGNLLRHI CCCCEECCCCCEEEE	46.86	22817900
169	Phosphorylation	LRHIKLHTGEKPFKC EEEEEEECCCCCEEE	58.43	18669648
170	Ubiquitination	RHIKLHTGEKPFKCH EEEEEECCCCCEEEE	30.13	24816145
172	Ubiquitination	IKLHTGEKPFKCHLC EEEECCCCCEEEEEC	58.04	-
172	Sumoylation	IKLHTGEKPFKCHLC EEEECCCCCEEEEEC	58.04	-
172	Sumoylation	IKLHTGEKPFKCHLC EEEECCCCCEEEEEC	58.04	-
172	Ubiquitination	IKLHTGEKPFKCHLC EEEECCCCCEEEEEC	58.04	22817900
178	Ubiquitination	EKPFKCHLCNYACQR CCCEEEEECCHHHHC	2.58	24816145
182	Ubiquitination	KCHLCNYACQRRDAL EEEECCHHHHCCHHH	2.96	-
182	Ubiquitination	KCHLCNYACQRRDAL EEEECCHHHHCCHHH	2.96	22817900
186	Ubiquitination	CNYACQRRDALTGHL CCHHHHCCHHHCCCC	14.00	29967540
189	Ubiquitination	ACQRRDALTGHLRTH HHHCCHHHCCCCCCC	7.45	22817900
189 (in isoform 2)	Ubiquitination	-	7.45	21906983
190	Phosphorylation	CQRRDALTGHLRTHS HHCCHHHCCCCCCCC	25.03	29083192
192	Ubiquitination	RRDALTGHLRTHSVE CCHHHCCCCCCCCCC	13.60	24816145
195	Phosphorylation	ALTGHLRTHSVEKPY HHCCCCCCCCCCCCC	25.51	29083192
197	Ubiquitination	TGHLRTHSVEKPYKC CCCCCCCCCCCCCCC	31.21	-
197	Phosphorylation	TGHLRTHSVEKPYKC CCCCCCCCCCCCCCC	31.21	29083192
200	Ubiquitination	LRTHSVEKPYKCEFC CCCCCCCCCCCCCCC	52.03	29967540
202	Phosphorylation	THSVEKPYKCEFCGR CCCCCCCCCCCCCCC	39.06	29083192
203	Ubiquitination	HSVEKPYKCEFCGRS CCCCCCCCCCCCCCC	35.50	-
206	Ubiquitination	EKPYKCEFCGRSYKQ CCCCCCCCCCCCHHC	8.20	22817900
206 (in isoform 3)	Ubiquitination	-	8.20	21906983
208	Ubiquitination	PYKCEFCGRSYKQRS CCCCCCCCCCHHCCC	27.22	22817900
209	Ubiquitination	YKCEFCGRSYKQRSS CCCCCCCCCHHCCCC	37.68	24816145
211	Ubiquitination	CEFCGRSYKQRSSLE CCCCCCCHHCCCCHH	15.13	22817900
215	Phosphorylation	GRSYKQRSSLEEHKE CCCHHCCCCHHHHHH	36.46	-
216	Phosphorylation	RSYKQRSSLEEHKER CCHHCCCCHHHHHHH	41.82	-
217	Ubiquitination	SYKQRSSLEEHKERC CHHCCCCHHHHHHHH	10.64	29967540
221	Ubiquitination	RSSLEEHKERCRTFL CCCHHHHHHHHHHHH	50.57	-
226	Ubiquitination	EHKERCRTFLQSTDP HHHHHHHHHHHCCCC	32.12	24816145
230	Phosphorylation	RCRTFLQSTDPGDTA HHHHHHHCCCCCCCC	36.60	30108239
231	Phosphorylation	CRTFLQSTDPGDTAS HHHHHHCCCCCCCCH	33.00	30108239
231	Ubiquitination	CRTFLQSTDPGDTAS HHHHHHCCCCCCCCH	33.00	24816145
234	Ubiquitination	FLQSTDPGDTASAEA HHHCCCCCCCCHHHH	47.95	29967540
236	Phosphorylation	QSTDPGDTASAEARH HCCCCCCCCHHHHHH	28.55	30108239
238	Phosphorylation	TDPGDTASAEARHIK CCCCCCCHHHHHHHH	28.83	30108239
239	Ubiquitination	DPGDTASAEARHIKA CCCCCCHHHHHHHHH	16.41	29967540
245	Sumoylation	SAEARHIKAEMGSER HHHHHHHHHHHCCHH	31.97	-
245	Acetylation	SAEARHIKAEMGSER HHHHHHHHHHHCCHH	31.97	30586829
245	Sumoylation	SAEARHIKAEMGSER HHHHHHHHHHHCCHH	31.97	28112733
245	Ubiquitination	SAEARHIKAEMGSER HHHHHHHHHHHCCHH	31.97	21906983
245 (in isoform 1)	Ubiquitination	-	31.97	21906983
247	Ubiquitination	EARHIKAEMGSERAL HHHHHHHHHCCHHHH	38.79	22817900
250	Phosphorylation	HIKAEMGSERALVLD HHHHHHCCHHHHHHH	23.69	26714015
261	Phosphorylation	LVLDRLASNVAKRKS HHHHHHHHHHHHHHC	36.11	25003641
265	Ubiquitination	RLASNVAKRKSSMPQ HHHHHHHHHHCCCCH	56.95	24816145
268	Phosphorylation	SNVAKRKSSMPQKFI HHHHHHHCCCCHHHC	35.58	24719451
269	Phosphorylation	NVAKRKSSMPQKFIG HHHHHHCCCCHHHCC	37.20	24719451
273	Acetylation	RKSSMPQKFIGEKRH HHCCCCHHHCCCCCE	32.83	25953088
273	Ubiquitination	RKSSMPQKFIGEKRH HHCCCCHHHCCCCCE	32.83	29967540
286	Phosphorylation	RHCFDVNYNSSYMYE CEEEECCCCCHHHHH	19.10	17053785
286	Ubiquitination	RHCFDVNYNSSYMYE CEEEECCCCCHHHHH	19.10	22817900
290	Phosphorylation	DVNYNSSYMYEKESE ECCCCCHHHHHHHHH	11.97	171903
295	Ubiquitination	SSYMYEKESELIQTR CHHHHHHHHHHHHHH	37.19	22817900
326	Phosphorylation	ALRPLVQTPPAPTSE HHHHHHCCCCCCCHH	24.62	26074081
334	Ubiquitination	PPAPTSEMVPVISSM CCCCCHHCCCCHHHH	4.07	22817900
334 (in isoform 5)	Ubiquitination	-	4.07	21906983
342	Ubiquitination	VPVISSMYPIALTRA CCCHHHHHHHEEHHH	8.07	22817900
351	Ubiquitination	IALTRAEMSNGAPQE HEEHHHHHCCCCCHH	3.53	22817900
351 (in isoform 6)	Ubiquitination	-	3.53	21906983
352	Phosphorylation	ALTRAEMSNGAPQEL EEHHHHHCCCCCHHH	24.50	30108239
356	Ubiquitination	AEMSNGAPQELEKKS HHHCCCCCHHHHHHC	29.58	22817900
361	Ubiquitination	GAPQELEKKSIHLPE CCCHHHHHHCCCCCC	65.53	-
362	Ubiquitination	APQELEKKSIHLPEK CCHHHHHHCCCCCCC	45.31	-
363	Phosphorylation	PQELEKKSIHLPEKS CHHHHHHCCCCCCCC	26.72	26714015
369	Acetylation	KSIHLPEKSVPSERG HCCCCCCCCCCCCCC	55.61	25953088
369	Ubiquitination	KSIHLPEKSVPSERG HCCCCCCCCCCCCCC	55.61	-
370	Phosphorylation	SIHLPEKSVPSERGL CCCCCCCCCCCCCCC	37.28	30108239
373	Phosphorylation	LPEKSVPSERGLSPN CCCCCCCCCCCCCCC	37.46	26714015
373	Ubiquitination	LPEKSVPSERGLSPN CCCCCCCCCCCCCCC	37.46	22817900
373 (in isoform 2)	Ubiquitination	-	37.46	21906983
378	Phosphorylation	VPSERGLSPNNSGHD CCCCCCCCCCCCCCC	28.53	23401153
382	Phosphorylation	RGLSPNNSGHDSTDT CCCCCCCCCCCCCCC	44.11	30108239
386	Phosphorylation	PNNSGHDSTDTDSNH CCCCCCCCCCCCCCH	23.62	30108239
387	Phosphorylation	NNSGHDSTDTDSNHE CCCCCCCCCCCCCHH	49.31	30108239
389	Phosphorylation	SGHDSTDTDSNHEER CCCCCCCCCCCHHHH	41.22	30108239
390	Ubiquitination	GHDSTDTDSNHEERQ CCCCCCCCCCHHHHH	50.69	22817900
390 (in isoform 3)	Ubiquitination	-	50.69	21906983
390 (in isoform 4)	Ubiquitination	-	50.69	21906983
391	Phosphorylation	HDSTDTDSNHEERQN CCCCCCCCCHHHHHH	42.02	30108239
395	Ubiquitination	DTDSNHEERQNHIYQ CCCCCHHHHHHHHHH	52.60	22817900
401	Phosphorylation	EERQNHIYQQNHMVL HHHHHHHHHHHHHHH	9.11	28674151
409	Phosphorylation	QQNHMVLSRARNGMP HHHHHHHHHHHCCCH	16.69	24043423
419	Ubiquitination	RNGMPLLKEVPRSYE HCCCHHHCCCCCCHH	65.43	-
425	Phosphorylation	LKEVPRSYELLKPPP HCCCCCCHHHCCCCC	16.33	27642862
429	Ubiquitination	PRSYELLKPPPICPR CCCHHHCCCCCCCCC	69.01	22817900
429 (in isoform 1)	Ubiquitination	-	69.01	21906983
438	Phosphorylation	PPICPRDSVKVINKE CCCCCCCCEEEECCC	25.72	30108239
444	Ubiquitination	DSVKVINKEGEVMDV CCEEEECCCCCEEEE	56.84	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	CRBN	Q96SW2	PMID:29496670

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of IKZF3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of IKZF3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SIN3A_HUMAN	SIN3A	physical	12015313
SIN3B_HUMAN	SIN3B	physical	12015313
HDAC2_HUMAN	HDAC2	physical	12015313
HDAC4_HUMAN	HDAC4	physical	12015313
HDAC5_HUMAN	HDAC5	physical	12015313
HDAC7_HUMAN	HDAC7	physical	12015313
CHD4_HUMAN	CHD4	physical	12015313
IKZF4_HUMAN	IKZF4	physical	10978333
IKZF5_HUMAN	IKZF5	physical	10978333
RASH_HUMAN	HRAS	physical	10369681
B2CL1_HUMAN	BCL2L1	physical	11714801
FOXP3_HUMAN	FOXP3	physical	20676092
IKZF3_HUMAN	IKZF3	physical	25416956
ABLM3_HUMAN	ABLIM3	physical	25416956
PP16B_HUMAN	PPP1R16B	physical	25416956
DPOLM_HUMAN	POLM	physical	25416956
OSGI1_HUMAN	OSGIN1	physical	25416956
CHCH2_HUMAN	CHCHD2	physical	25416956
SPG21_HUMAN	SPG21	physical	25416956
OAZ3_HUMAN	OAZ3	physical	25416956
CA109_HUMAN	C1orf109	physical	25416956
MGN2_HUMAN	MAGOHB	physical	25416956
FANCL_HUMAN	FANCL	physical	25416956
TB22B_HUMAN	TBC1D22B	physical	25416956
RCOR3_HUMAN	RCOR3	physical	25416956
PCID2_HUMAN	PCID2	physical	25416956
CABP5_HUMAN	CABP5	physical	25416956
PPL13_HUMAN	LGALS14	physical	25416956
EXOS5_HUMAN	EXOSC5	physical	25416956
STALP_HUMAN	STAMBPL1	physical	25416956
TPC6A_HUMAN	TRAPPC6A	physical	25416956
ARMC7_HUMAN	ARMC7	physical	25416956
TSSK3_HUMAN	TSSK3	physical	25416956
ING5_HUMAN	ING5	physical	25416956
ZGPAT_HUMAN	ZGPAT	physical	25416956
FBF1_HUMAN	FBF1	physical	25416956
ATPF2_HUMAN	ATPAF2	physical	25416956
EFHC1_HUMAN	EFHC1	physical	25416956
RM53_HUMAN	MRPL53	physical	25416956
EXOC8_HUMAN	EXOC8	physical	25416956
TEKT4_HUMAN	TEKT4	physical	25416956
TSTD2_HUMAN	TSTD2	physical	25416956
NATD1_HUMAN	NATD1	physical	25416956
MORN3_HUMAN	MORN3	physical	25416956
TRI42_HUMAN	TRIM42	physical	25416956
ARMC8_HUMAN	ARMC8	physical	26186194
IKZF4_HUMAN	IKZF4	physical	26186194
SETMR_HUMAN	SETMAR	physical	26186194
DGC14_HUMAN	DGCR14	physical	26186194
GID4_HUMAN	GID4	physical	26186194
MD1L1_HUMAN	MAD1L1	physical	26186194
LDOC1_HUMAN	LDOC1	physical	21516116
NATD1_HUMAN	NATD1	physical	21516116
STK26_HUMAN	STK26	physical	21516116
MGN2_HUMAN	MAGOHB	physical	21516116
AAKB2_HUMAN	PRKAB2	physical	21516116
RCOR3_HUMAN	RCOR3	physical	21516116
UBC9_HUMAN	UBE2I	physical	21516116
SUMO1_HUMAN	SUMO1	physical	21516116
ATPF2_HUMAN	ATPAF2	physical	21516116
TCAF1_HUMAN	FAM115A	physical	21516116
PRDM1_HUMAN	PRDM1	physical	26823144
IKZF1_HUMAN	IKZF1	physical	26823144
CRBN_HUMAN	CRBN	physical	27294876
IKZF4_HUMAN	IKZF4	physical	28514442
SETMR_HUMAN	SETMAR	physical	28514442
DGC14_HUMAN	DGCR14	physical	28514442
P66B_HUMAN	GATAD2B	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of IKZF3_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-169, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Tyrosine phosphorylated Par3 regulates epithelial tight junctionassembly promoted by EGFR signaling."; Wang Y., Du D., Fang L., Yang G., Zhang C., Zeng R., Ullrich A.,Lottspeich F., Chen Z.; EMBO J. 25:5058-5070(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-286 AND TYR-290, ANDMASS SPECTROMETRY.	17053785 [Abstract]