ABLM3_HUMAN - dbPTM
ABLM3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ABLM3_HUMAN
UniProt AC O94929
Protein Name Actin-binding LIM protein 3
Gene Name ABLIM3
Organism Homo sapiens (Human).
Sequence Length 683
Subcellular Localization Cytoplasm.
Protein Description May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity..
Protein Sequence MNTSIPYQQNPYNPRGSSNVIQCYRCGDTCKGEVVRVHNNHFHIRCFTCQVCGCGLAQSGFFFKNQEYICTQDYQQLYGTRCDSCRDFITGEVISALGRTYHPKCFVCSLCRKPFPIGDKVTFSGKECVCQTCSQSMASSKPIKIRGPSHCAGCKEEIKHGQSLLALDKQWHVSCFKCQTCSVILTGEYISKDGVPYCESDYHAQFGIKCETCDRYISGRVLEAGGKHYHPTCARCVRCHQMFTEGEEMYLTGSEVWHPICKQAARAEKKLKHRRTSETSISPPGSSIGSPNRVICAKVDNEILNYKDLAALPKVKSIYEVQRPDLISYEPHSRYMSDEMLERCGYGESLGTLSPYSQDIYENLDLRQRRASSPGYIDSPTYSRQGMSPTFSRSPHHYYRSGPESGRSSPYHSQLDVRSSTPTSYQAPKHFHIPAGDSNIYRKPPIYKRHGDLSTATKSKTSEDISQTSKYSPIYSPDPYYASESEYWTYHGSPKVPRARRFSSGGEEDDFDRSMHKLQSGIGRLILKEEMKARSSSYADPWTPPRSSTSSREALHTAGYEMSLNGSPRSHYLADSDPLISKSASLPAYRRNGLHRTPSADLFHYDSMNAVNWGMREYKIYPYELLLVTTRGRNRLPKDVDRTRLERHLSQEEFYQVFGMTISEFDRLALWKRNELKKQARLF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MNTSIPYQ
-------CCCCCCCC		12.7722814378
3Phosphorylation-----MNTSIPYQQN
-----CCCCCCCCCC		27.0822199227
4Phosphorylation----MNTSIPYQQNP
----CCCCCCCCCCC		19.3022199227
17PhosphorylationNPYNPRGSSNVIQCY
CCCCCCCCCCCEEEE		21.7328555341
109PhosphorylationHPKCFVCSLCRKPFP
CCCCEEECCCCCCCC		25.7950558847
136PhosphorylationVCQTCSQSMASSKPI
EEECCCHHHHCCCCC		10.4628555341
163PhosphorylationEEIKHGQSLLALDKQ
HHHHCCCCEEHHCCC		29.919446887
174PhosphorylationLDKQWHVSCFKCQTC
HCCCCCCEEEECCCC		10.8429083192
218PhosphorylationETCDRYISGRVLEAG
CCCCCEECCCEEECC		16.1850558839
276PhosphorylationKKLKHRRTSETSISP
HHHHCCCCCCCCCCC		30.7630266825
276 (in isoform 2)Phosphorylation-30.7623090842
276 (in isoform 3)Phosphorylation-30.7623090842
277PhosphorylationKLKHRRTSETSISPP
HHHCCCCCCCCCCCC		36.7530266825
277 (in isoform 2)Phosphorylation-36.7523090842
277 (in isoform 3)Phosphorylation-36.7523090842
279PhosphorylationKHRRTSETSISPPGS
HCCCCCCCCCCCCCC		31.0030266825
279 (in isoform 2)Phosphorylation-31.0023090842
279 (in isoform 3)Phosphorylation-31.0023090842
280PhosphorylationHRRTSETSISPPGSS
CCCCCCCCCCCCCCC		19.6030266825
280 (in isoform 2)Phosphorylation-19.6023090842
280 (in isoform 3)Phosphorylation-19.6023090842
282PhosphorylationRTSETSISPPGSSIG
CCCCCCCCCCCCCCC		25.4730266825
282 (in isoform 2)Phosphorylation-25.4723090842
282 (in isoform 3)Phosphorylation-25.4723090842
286PhosphorylationTSISPPGSSIGSPNR
CCCCCCCCCCCCCCC		25.2630266825
286 (in isoform 2)Phosphorylation-25.2623090842
286 (in isoform 3)Phosphorylation-25.2623090842
287PhosphorylationSISPPGSSIGSPNRV
CCCCCCCCCCCCCCE		36.5630266825
287 (in isoform 2)Phosphorylation-36.5623090842
287 (in isoform 3)Phosphorylation-36.5623090842
290PhosphorylationPPGSSIGSPNRVICA
CCCCCCCCCCCEEEE		19.8230266825
290 (in isoform 2)Phosphorylation-19.8223090842
290 (in isoform 3)Phosphorylation-19.8223090842
299 (in isoform 2)Phosphorylation-5.2025106551
299 (in isoform 3)Phosphorylation-5.2025106551
310 (in isoform 2)Phosphorylation-19.6525849741
310 (in isoform 3)Phosphorylation-19.6525849741
311 (in isoform 2)Phosphorylation-31.5225849741
311 (in isoform 3)Phosphorylation-31.5225849741
319PhosphorylationLPKVKSIYEVQRPDL
CCCCEEEEEECCCCC		19.6927642862
326 (in isoform 2)Phosphorylation-2.8830153514
332 (in isoform 2)Phosphorylation-16.9929743597
337PhosphorylationEPHSRYMSDEMLERC
CCCCCCCCHHHHHHC		22.8322798277
350 (in isoform 2)Phosphorylation-5.4529743597
356PhosphorylationSLGTLSPYSQDIYEN
CCCCCCCCCHHHHHC		18.657453035
361PhosphorylationSPYSQDIYENLDLRQ
CCCCHHHHHCCCHHH		13.6822817900
372PhosphorylationDLRQRRASSPGYIDS
CHHHHHCCCCCCCCC		34.9422167270
373PhosphorylationLRQRRASSPGYIDSP
HHHHHCCCCCCCCCC		22.7422167270
376PhosphorylationRRASSPGYIDSPTYS
HHCCCCCCCCCCCCC		12.6323927012
379PhosphorylationSSPGYIDSPTYSRQG
CCCCCCCCCCCCCCC		15.0222167270
381PhosphorylationPGYIDSPTYSRQGMS
CCCCCCCCCCCCCCC		37.7722167270
382PhosphorylationGYIDSPTYSRQGMSP
CCCCCCCCCCCCCCC		12.7723403867
383O-linked_GlycosylationYIDSPTYSRQGMSPT
CCCCCCCCCCCCCCC		22.1728657654
383PhosphorylationYIDSPTYSRQGMSPT
CCCCCCCCCCCCCCC		22.1724702127
388PhosphorylationTYSRQGMSPTFSRSP
CCCCCCCCCCCCCCC		27.8422167270
390PhosphorylationSRQGMSPTFSRSPHH
CCCCCCCCCCCCCCC		27.2522167270
392PhosphorylationQGMSPTFSRSPHHYY
CCCCCCCCCCCCCCC		34.0323403867
394PhosphorylationMSPTFSRSPHHYYRS
CCCCCCCCCCCCCCC		27.6423927012
398PhosphorylationFSRSPHHYYRSGPES
CCCCCCCCCCCCCCC		9.5023403867
399PhosphorylationSRSPHHYYRSGPESG
CCCCCCCCCCCCCCC		8.2423403867
401PhosphorylationSPHHYYRSGPESGRS
CCCCCCCCCCCCCCC		42.4522617229
405PhosphorylationYYRSGPESGRSSPYH
CCCCCCCCCCCCCCC		42.5125072903
408PhosphorylationSGPESGRSSPYHSQL
CCCCCCCCCCCCCCC		38.9125072903
409PhosphorylationGPESGRSSPYHSQLD
CCCCCCCCCCCCCCC		28.2816219945
411PhosphorylationESGRSSPYHSQLDVR
CCCCCCCCCCCCCCC		18.9551457533
413PhosphorylationGRSSPYHSQLDVRSS
CCCCCCCCCCCCCCC		26.9625072903
421PhosphorylationQLDVRSSTPTSYQAP
CCCCCCCCCCCCCCC		31.6528857561
424O-linked_GlycosylationVRSSTPTSYQAPKHF
CCCCCCCCCCCCCCC		19.2228657654
441PhosphorylationPAGDSNIYRKPPIYK
CCCCCCCCCCCCCHH		19.4827642862
459PhosphorylationDLSTATKSKTSEDIS
CCCCCCCCCCCCCHH		36.4928060719
461O-linked_GlycosylationSTATKSKTSEDISQT
CCCCCCCCCCCHHHC		44.4328657654
461PhosphorylationSTATKSKTSEDISQT
CCCCCCCCCCCHHHC		44.4381442323
462O-linked_GlycosylationTATKSKTSEDISQTS
CCCCCCCCCCHHHCC		36.6928657654
462PhosphorylationTATKSKTSEDISQTS
CCCCCCCCCCHHHCC		36.6928060719
466PhosphorylationSKTSEDISQTSKYSP
CCCCCCHHHCCCCCC		39.4628270605
468PhosphorylationTSEDISQTSKYSPIY
CCCCHHHCCCCCCCC		22.0111350905
469PhosphorylationSEDISQTSKYSPIYS
CCCHHHCCCCCCCCC		23.2028270605
471PhosphorylationDISQTSKYSPIYSPD
CHHHCCCCCCCCCCC		21.3223403867
472PhosphorylationISQTSKYSPIYSPDP
HHHCCCCCCCCCCCC		14.4623403867
475PhosphorylationTSKYSPIYSPDPYYA
CCCCCCCCCCCCCCC		19.9623403867
476PhosphorylationSKYSPIYSPDPYYAS
CCCCCCCCCCCCCCC		24.4423403867
480PhosphorylationPIYSPDPYYASESEY
CCCCCCCCCCCHHHC		21.0223403867
481PhosphorylationIYSPDPYYASESEYW
CCCCCCCCCCHHHCE		14.7223403867
483PhosphorylationSPDPYYASESEYWTY
CCCCCCCCHHHCEEE		26.0746157265
485PhosphorylationDPYYASESEYWTYHG
CCCCCCHHHCEEECC		33.2323403867
487PhosphorylationYYASESEYWTYHGSP
CCCCHHHCEEECCCC		16.6023403867
489PhosphorylationASESEYWTYHGSPKV
CCHHHCEEECCCCCC		12.5323403867
490PhosphorylationSESEYWTYHGSPKVP
CHHHCEEECCCCCCC		7.0523403867
493PhosphorylationEYWTYHGSPKVPRAR
HCEEECCCCCCCCCC		14.2923927012
503PhosphorylationVPRARRFSSGGEEDD
CCCCCCCCCCCCCCC		26.6829255136
504PhosphorylationPRARRFSSGGEEDDF
CCCCCCCCCCCCCCH		48.3729255136
514PhosphorylationEEDDFDRSMHKLQSG
CCCCHHHHHHHHHHH		27.3823403867
535PhosphorylationKEEMKARSSSYADPW
HHHHHHCCCCCCCCC		28.6128152594
536PhosphorylationEEMKARSSSYADPWT
HHHHHCCCCCCCCCC		23.0928152594
537PhosphorylationEMKARSSSYADPWTP
HHHHCCCCCCCCCCC		26.1128152594
538PhosphorylationMKARSSSYADPWTPP
HHHCCCCCCCCCCCC		19.5721082442
543PhosphorylationSSYADPWTPPRSSTS
CCCCCCCCCCCCCCC		28.8927273156
547PhosphorylationDPWTPPRSSTSSREA
CCCCCCCCCCCCHHH		43.6830576142
548PhosphorylationPWTPPRSSTSSREAL
CCCCCCCCCCCHHHH		33.3228348404
549PhosphorylationWTPPRSSTSSREALH
CCCCCCCCCCHHHHH		31.7828348404
550PhosphorylationTPPRSSTSSREALHT
CCCCCCCCCHHHHHH		29.3728348404
551PhosphorylationPPRSSTSSREALHTA
CCCCCCCCHHHHHHC		33.9428348404
557PhosphorylationSSREALHTAGYEMSL
CCHHHHHHCCCEECC		23.7228348404
560PhosphorylationEALHTAGYEMSLNGS
HHHHHCCCEECCCCC		13.1423927012
563PhosphorylationHTAGYEMSLNGSPRS
HHCCCEECCCCCCCC		13.5230266825
567PhosphorylationYEMSLNGSPRSHYLA
CEECCCCCCCCCCCC		18.9630266825
572PhosphorylationNGSPRSHYLADSDPL
CCCCCCCCCCCCCCC		12.5825394399
576PhosphorylationRSHYLADSDPLISKS
CCCCCCCCCCCCCCC		35.2023927012
581PhosphorylationADSDPLISKSASLPA
CCCCCCCCCCCCCCC		28.3928555341
583PhosphorylationSDPLISKSASLPAYR
CCCCCCCCCCCCCHH		19.1223403867
585PhosphorylationPLISKSASLPAYRRN
CCCCCCCCCCCHHHC		41.8123927012
589PhosphorylationKSASLPAYRRNGLHR
CCCCCCCHHHCCCCC		14.2523403867
597PhosphorylationRRNGLHRTPSADLFH
HHCCCCCCCCCCCCC		15.7323403867
599PhosphorylationNGLHRTPSADLFHYD
CCCCCCCCCCCCCHH		33.5323403867
605PhosphorylationPSADLFHYDSMNAVN
CCCCCCCHHHCCCCC		11.4623403867
607PhosphorylationADLFHYDSMNAVNWG
CCCCCHHHCCCCCCC		13.5323403867
631MethylationELLLVTTRGRNRLPK
EEEEEECCCCCCCCC		32.48-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ABLM3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ABLM3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ABLM3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ACTC_HUMANACTC1physical
15337165
CCD33_HUMANCCDC33physical
25416956
ADIP_HUMANSSX2IPphysical
25416956
BRCA1_HUMANBRCA1physical
25184681
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ABLM3_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale phosphoproteome analysis of human liver tissue byenrichment and fractionation of phosphopeptides with strong anionexchange chromatography.";
Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D.,Zou H., Gu J.;
Proteomics 8:1346-1361(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-503 AND SER-504, ANDMASS SPECTROMETRY.
"Phosphoproteome of resting human platelets.";
Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.;
J. Proteome Res. 7:526-534(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-372; SER-373 ANDSER-388, AND MASS SPECTROMETRY.
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-394; SER-503 ANDSER-504, AND MASS SPECTROMETRY.

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