dbPTM

ACTC_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ACTC_HUMAN
UniProt AC	P68032
Protein Name	Actin, alpha cardiac muscle 1
Gene Name	ACTC1
Organism	Homo sapiens (Human).
Sequence Length	377
Subcellular Localization	Cytoplasm, cytoskeleton.
Protein Description	Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells..
Protein Sequence	MCDDEETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDEAGPSIVHRKCF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MCDDEETTA ------CCCHHHCEE	10.18	-
3	Acetylation	-----MCDDEETTAL -----CCCHHHCEEE	66.12	-
35	Phosphorylation	APRAVFPSIVGRPRH CCCCCCHHHCCCCCC	20.59	30266825
46	Oxidation	RPRHQGVMVGMGQKD CCCCCCEEEECCCCC	2.49	-
49	Oxidation	HQGVMVGMGQKDSYV CCCEEEECCCCCCCC	3.32	-
52	Methylation	VMVGMGQKDSYVGDE EEEECCCCCCCCCCH	42.80	-
52	Acetylation	VMVGMGQKDSYVGDE EEEECCCCCCCCCCH	42.80	15605075
52	Ubiquitination	VMVGMGQKDSYVGDE EEEECCCCCCCCCCH	42.80	21890473
54	Phosphorylation	VGMGQKDSYVGDEAQ EECCCCCCCCCCHHH	28.84	23401153
55	Phosphorylation	GMGQKDSYVGDEAQS ECCCCCCCCCCHHHC	20.70	27273156
62	Phosphorylation	YVGDEAQSKRGILTL CCCCHHHCCCCEEEE	31.22	23401153
63	Acetylation	VGDEAQSKRGILTLK CCCHHHCCCCEEEEE	42.43	15603157
63	Sumoylation	VGDEAQSKRGILTLK CCCHHHCCCCEEEEE	42.43	-
63	Ubiquitination	VGDEAQSKRGILTLK CCCHHHCCCCEEEEE	42.43	21890473
63	Sumoylation	VGDEAQSKRGILTLK CCCHHHCCCCEEEEE	42.43	-
68	Phosphorylation	QSKRGILTLKYPIEH HCCCCEEEEECEECC	21.20	22617229
70	Methylation	KRGILTLKYPIEHGI CCCEEEEECEECCCC	43.69	19608861
70	Acetylation	KRGILTLKYPIEHGI CCCEEEEECEECCCC	43.69	19608861
70	Ubiquitination	KRGILTLKYPIEHGI CCCEEEEECEECCCC	43.69	21906983
71	Phosphorylation	RGILTLKYPIEHGII CCEEEEECEECCCCC	16.74	28348404
75	Methylation	TLKYPIEHGIITNWD EEECEECCCCCCCHH	33.21	30626964
79	Phosphorylation	PIEHGIITNWDDMEK EECCCCCCCHHHHHH	28.47	36012735
86	Methylation	TNWDDMEKIWHHTFY CCHHHHHHHHHHHHH	44.45	23673617
86	Acetylation	TNWDDMEKIWHHTFY CCHHHHHHHHHHHHH	44.45	25825284
86	Ubiquitination	TNWDDMEKIWHHTFY CCHHHHHHHHHHHHH	44.45	21906983
86	Sumoylation	TNWDDMEKIWHHTFY CCHHHHHHHHHHHHH	44.45	23673617
91	Phosphorylation	MEKIWHHTFYNELRV HHHHHHHHHHCCCCC	18.22	27273156
93	Phosphorylation	KIWHHTFYNELRVAP HHHHHHHHCCCCCCC	14.64	27273156
105	Phosphorylation	VAPEEHPTLLTEAPL CCCCCCCCCCCCCCC	35.99	26437602
108	Phosphorylation	EEHPTLLTEAPLNPK CCCCCCCCCCCCCCC	32.96	21406692
115	Acetylation	TEAPLNPKANREKMT CCCCCCCCCCHHHHH	58.16	30586031
115	Ubiquitination	TEAPLNPKANREKMT CCCCCCCCCCHHHHH	58.16	21890473
122	Phosphorylation	KANREKMTQIMFETF CCCHHHHHHHHHHHC	26.47	-
128	Phosphorylation	MTQIMFETFNVPAMY HHHHHHHHCCHHHHH	14.83	-
145	Phosphorylation	IQAVLSLYASGRTTG HHHHHHHHHCCCCEE	8.71	30803931
150	Phosphorylation	SLYASGRTTGIVLDS HHHHCCCCEEEEEEC	32.66	26657352
151	Phosphorylation	LYASGRTTGIVLDSG HHHCCCCEEEEEECC	24.45	26437602
157	Phosphorylation	TTGIVLDSGDGVTHN CEEEEEECCCCCCCC	34.32	10632791
162	Phosphorylation	LDSGDGVTHNVPIYE EECCCCCCCCCCEEC	17.17	26437602
168	Phosphorylation	VTHNVPIYEGYALPH CCCCCCEECCCCHHH	9.38	7561247
171	Phosphorylation	NVPIYEGYALPHAIM CCCEECCCCHHHHHH	7.94	7330091
188	Phosphorylation	DLAGRDLTDYLMKIL HCCCCCHHHHHHHHH	27.21	28152594
190	Phosphorylation	AGRDLTDYLMKILTE CCCCHHHHHHHHHHH	11.94	26846344
192	Sulfoxidation	RDLTDYLMKILTERG CCHHHHHHHHHHHCC	1.75	31801345
193	Methylation	DLTDYLMKILTERGY CHHHHHHHHHHHCCC	31.78	-
193	Acetylation	DLTDYLMKILTERGY CHHHHHHHHHHHCCC	31.78	22646659
193	Ubiquitination	DLTDYLMKILTERGY CHHHHHHHHHHHCCC	31.78	21890473
196	Phosphorylation	DYLMKILTERGYSFV HHHHHHHHHCCCCCE	27.40	46158449
198	Methylation	LMKILTERGYSFVTT HHHHHHHCCCCCEEH	44.08	-
200	Phosphorylation	KILTERGYSFVTTAE HHHHHCCCCCEEHHC	12.73	54893
201	Phosphorylation	ILTERGYSFVTTAER HHHHCCCCCEEHHCH	18.96	36642193
204	Phosphorylation	ERGYSFVTTAEREIV HCCCCCEEHHCHHHH	20.48	26657352
205	Phosphorylation	RGYSFVTTAEREIVR CCCCCEEHHCHHHHH	22.63	28857561
215	Acetylation	REIVRDIKEKLCYVA HHHHHHHHHHHCEEE	53.75	15604255
215	Ubiquitination	REIVRDIKEKLCYVA HHHHHHHHHHHCEEE	53.75	21890473
217	Methylation	IVRDIKEKLCYVALD HHHHHHHHHCEEEEE	38.56	-
219	Glutathionylation	RDIKEKLCYVALDFE HHHHHHHCEEEEECC	3.68	22555962
219	S-nitrosylation	RDIKEKLCYVALDFE HHHHHHHCEEEEECC	3.68	25040305
220	Phosphorylation	DIKEKLCYVALDFEN HHHHHHCEEEEECCH	10.13	29396449
231	Phosphorylation	DFENEMATAASSSSL ECCHHHHHHCCCCCC	22.80	26657352
234	Phosphorylation	NEMATAASSSSLEKS HHHHHHCCCCCCCHH	28.43	26657352
235	Phosphorylation	EMATAASSSSLEKSY HHHHHCCCCCCCHHE	21.15	35096073
236	Phosphorylation	MATAASSSSLEKSYE HHHHCCCCCCCHHEE	36.13	26657352
237	Phosphorylation	ATAASSSSLEKSYEL HHHCCCCCCCHHEEC	42.36	29396449
240	Ubiquitination	ASSSSLEKSYELPDG CCCCCCCHHEECCCC	64.73	-
241	Phosphorylation	SSSSLEKSYELPDGQ CCCCCCHHEECCCCC	17.92	29255136
242	Phosphorylation	SSSLEKSYELPDGQV CCCCCHHEECCCCCE	32.33	29255136
251	Phosphorylation	LPDGQVITIGNERFR CCCCCEEEECCCEEC	24.79	26846344
262	Phosphorylation	ERFRCPETLFQPSFI CEECCCCHHCCCCCC	20.29	-
267	Phosphorylation	PETLFQPSFIGMESA CCHHCCCCCCCHHCC	20.79	46158533
273	Phosphorylation	PSFIGMESAGIHETT CCCCCHHCCCCCCCC	23.93	22210691
280	Phosphorylation	SAGIHETTYNSIMKC CCCCCCCCCHHHHCC	20.09	-
281	Phosphorylation	AGIHETTYNSIMKCD CCCCCCCCHHHHCCC	17.84	3828983
283	Phosphorylation	IHETTYNSIMKCDID CCCCCCHHHHCCCCE	17.41	-
293	Ubiquitination	KCDIDIRKDLYANNV CCCCEECHHHHHCCC	53.04	-
293	Malonylation	KCDIDIRKDLYANNV CCCCEECHHHHHCCC	53.04	26320211
296	Phosphorylation	IDIRKDLYANNVLSG CEECHHHHHCCCCCC	19.88	20563989
302	Phosphorylation	LYANNVLSGGTTMYP HHHCCCCCCCCCCCC	30.78	21406692
305	Phosphorylation	NNVLSGGTTMYPGIA CCCCCCCCCCCCCHH	16.35	21406692
306	Phosphorylation	NVLSGGTTMYPGIAD CCCCCCCCCCCCHHH	20.27	21406692
308	Phosphorylation	LSGGTTMYPGIADRM CCCCCCCCCCHHHHH	9.01	20563997
317	Sumoylation	GIADRMQKEITALAP CHHHHHHHHHHHHCC	41.56	-
317	Ubiquitination	GIADRMQKEITALAP CHHHHHHHHHHHHCC	41.56	21890473
317	Sumoylation	GIADRMQKEITALAP CHHHHHHHHHHHHCC	41.56	-
320	Phosphorylation	DRMQKEITALAPSTM HHHHHHHHHHCCCCE	19.40	30266825
325	Phosphorylation	EITALAPSTMKIKII HHHHHCCCCEEEEEE	35.21	23401153
326	Phosphorylation	ITALAPSTMKIKIIA HHHHCCCCEEEEEEC	22.79	46158473
328	Methylation	ALAPSTMKIKIIAPP HHCCCCEEEEEECCC	40.72	-
328	Acetylation	ALAPSTMKIKIIAPP HHCCCCEEEEEECCC	40.72	15603733
328	Sumoylation	ALAPSTMKIKIIAPP HHCCCCEEEEEECCC	40.72	-
328	Ubiquitination	ALAPSTMKIKIIAPP HHCCCCEEEEEECCC	40.72	21890473
328	Sumoylation	ALAPSTMKIKIIAPP HHCCCCEEEEEECCC	40.72	-
330	Acetylation	APSTMKIKIIAPPER CCCCEEEEEECCCCC	23.65	15626297
330	Sumoylation	APSTMKIKIIAPPER CCCCEEEEEECCCCC	23.65	-
330	Ubiquitination	APSTMKIKIIAPPER CCCCEEEEEECCCCC	23.65	21890473
330	Sumoylation	APSTMKIKIIAPPER CCCCEEEEEECCCCC	23.65	-
338	Sumoylation	IIAPPERKYSVWIGG EECCCCCCEEEEECH	39.97	-
350	Phosphorylation	IGGSILASLSTFQQM ECHHHHHHHHHHHHH	21.29	-
364	Phosphorylation	MWISKQEYDEAGPSI HHHCHHHHCCCCCCC	19.31	20068231
370	Phosphorylation	EYDEAGPSIVHRKCF HHCCCCCCCCCCCCC	36.00	26657352
375	Ubiquitination	GPSIVHRKCF----- CCCCCCCCCC-----	25.72	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ACTC_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
46	M	Oxidation	-
Oxidation of Met-46 and Met-49 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization.
49	M	Oxidation	-
Oxidation of Met-46 and Met-49 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization.
75	H	Methylation	30626964
Methylated at His-75 by SETD3.
86	K	Methylation	23673617
Monomethylation at Lys-86 (K86me1) regulates actin-myosin interaction and actomyosin-dependent processes.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ACTC_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SYNE2_HUMAN	SYNE2	physical	12118075
PDC6I_HUMAN	PDCD6IP	physical	12771190
KLHL2_HUMAN	KLHL2	physical	10397770
TPM1_HUMAN	TPM1	physical	22939629
MYH10_HUMAN	MYH10	physical	22939629
BC11A_HUMAN	BCL11A	physical	21988832

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
613424	Cardiomyopathy, dilated 1R (CMD1R)
612098	Cardiomyopathy, familial hypertrophic 11 (CMH11)
612794	Atrial septal defect 5 (ASD5)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ACTC_HUMAN

Related Literatures of Post-Translational Modification

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