KLHL2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KLHL2_HUMAN
• UniProt AC: O95198
• Protein Name: Kelch-like protein 2
• Gene Name: KLHL2
• Organism: Homo sapiens (Human).
• Sequence Length: 593
• Subcellular Localization: Cytoplasm, cytoskeleton. Cell projection, ruffle. Cell projection. Cell projection, lamellipodium. Cytoplasm, cytosol. A proportion colocalizes with the actin cytoskeleton. When over-expressed, colocalizes with NPTXR in perinuclear aggresomes (By sim
• Protein Description: Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation (By similarity). Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4. Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in oligodendrocyte precursors..
• Protein Sequence: METPPLPPACTKQGHQKPLDSKDDNTEKHCPVTVNPWHMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVIDKPL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
80	Phosphorylation	VLAACSPYFHAMFTG HHHHHCHHHHHHHHC	7.54	22817900
90	Phosphorylation	AMFTGEMSESRAKRV HHHHCCCCHHHHCCE	28.28	24719451
122	Phosphorylation	YTAEIQVTEENVQVL EEEEEEECCCHHHEE	22.62	-
301	Phosphorylation	SVRTRLRTPMNLPKL HHHHHCCCCCCCCCE	31.33	-
329	Ubiquitination	SVECYDFKEERWHQV EEECEECCHHHHHHH	56.63	-
333 (in isoform 2)	Ubiquitination	-	6.91	-
455	Phosphorylation	LLYAVGGYDGASRQC HHHHCCCCCCCCCCE	12.79	-
511	Ubiquitination	HDGPLVRKSVEVYDP CCCCCCCCEEEEECC	51.91	-
515 (in isoform 2)	Ubiquitination	-	6.52	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KLHL2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KLHL2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KLHL2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KLH12_HUMAN	KLHL12	physical	16189514
KEAP1_HUMAN	KEAP1	physical	15383316
KLHL2_HUMAN	KLHL2	physical	10397770
ACTC_HUMAN	ACTC1	physical	10397770
WNK1_HUMAN	WNK1	physical	23838290
WNK2_HUMAN	WNK2	physical	23838290
WNK3_HUMAN	WNK3	physical	23838290
WNK4_HUMAN	WNK4	physical	23838290
UB2D1_HUMAN	UBE2D1	physical	23838290
WNK1_HUMAN	WNK1	physical	24641320
WNK4_HUMAN	WNK4	physical	24641320
KLHL2_HUMAN	KLHL2	physical	25416956
TNPO2_HUMAN	TNPO2	physical	25416956
TXD12_HUMAN	TXNDC12	physical	25416956
TMA16_HUMAN	TMA16	physical	25416956
CCD43_HUMAN	CCDC43	physical	25416956
ZN114_HUMAN	ZNF114	physical	25416956
TXD12_HUMAN	TXNDC12	physical	21516116
KLH12_HUMAN	KLHL12	physical	21516116
KLHL3_HUMAN	KLHL3	physical	28514442
UCK1_HUMAN	UCK1	physical	28514442
KLH17_HUMAN	KLHL17	physical	28514442
TRI47_HUMAN	TRIM47	physical	28514442
P3C2B_HUMAN	PIK3C2B	physical	28514442
WNK3_HUMAN	WNK3	physical	28514442
SCYL1_HUMAN	SCYL1	physical	28514442
TRIM9_HUMAN	TRIM9	physical	28514442
DJC13_HUMAN	DNAJC13	physical	28514442
XIAP_HUMAN	XIAP	physical	28514442
UBP28_HUMAN	USP28	physical	28514442
F16B1_HUMAN	FAM160B1	physical	28514442
SI1L1_HUMAN	SIPA1L1	physical	28514442
WNK1_HUMAN	WNK1	physical	28514442
FXL17_HUMAN	FBXL17	physical	28514442
TRIM8_HUMAN	TRIM8	physical	28514442
ARP10_HUMAN	ACTR10	physical	28514442
CUL7_HUMAN	CUL7	physical	28514442
FBXW8_HUMAN	FBXW8	physical	28514442
UPP_HUMAN	UPRT	physical	28514442
DCTN6_HUMAN	DCTN6	physical	28514442
FBX33_HUMAN	FBXO33	physical	28514442
ACINU_HUMAN	ACIN1	physical	28514442
DCTN5_HUMAN	DCTN5	physical	28514442
DCTN4_HUMAN	DCTN4	physical	28514442
UCKL1_HUMAN	UCKL1	physical	28514442
ACTY_HUMAN	ACTR1B	physical	28514442
PHLB3_HUMAN	PHLDB3	physical	28514442
ARHG7_HUMAN	ARHGEF7	physical	28514442
GIT2_HUMAN	GIT2	physical	28514442
CCDC8_HUMAN	CCDC8	physical	28514442
DCTN3_HUMAN	DCTN3	physical	28514442
KEAP1_HUMAN	KEAP1	physical	28514442
GASP2_HUMAN	GPRASP2	physical	28514442
DBLOH_HUMAN	DIABLO	physical	28514442
ACTZ_HUMAN	ACTR1A	physical	28514442
EPDR1_HUMAN	EPDR1	physical	28514442
KLH12_HUMAN	KLHL12	physical	28514442
TCF25_HUMAN	TCF25	physical	28514442
CSKP_HUMAN	CASK	physical	28514442
SYYM_HUMAN	YARS2	physical	28514442
RRBP1_HUMAN	RRBP1	physical	28514442
SAMD1_HUMAN	SAMD1	physical	28514442
OBSL1_HUMAN	OBSL1	physical	28514442
IMDH1_HUMAN	IMPDH1	physical	28514442
DP13A_HUMAN	APPL1	physical	28514442
RNPS1_HUMAN	RNPS1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.