PHLB3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PHLB3_HUMAN
• UniProt AC: Q6NSJ2
• Protein Name: Pleckstrin homology-like domain family B member 3
• Gene Name: PHLDB3
• Organism: Homo sapiens (Human).
• Sequence Length: 640
• Protein Sequence: MGTRSSPEEGTPPPLVPECDVEVQPQGHPEESREQEASEVLAEPSSRGGAEQQAEEEEVGEGSSTESSRDAPEATPPIAMAATPPASTSSREGVRGAARRLQGQQLEALTRVALMEQRVKELQRQRKELRIEMEVEVALLRGELAGERVAARREEEQLRELLEQQAASEQRGRQQREQEQRRLSQERDRLEGLRQRLRKAQGQLDSQPEDQRERLLQGVQEMREQLDVAQRAYEDLEFQQLERESRQEEEDRDSPGPQVPDPKVQELQASMAQHRRGALQHRIRVLEEQLKSLGEQMAAESRGLSRKKEEALQALSQERSRLLELNCLQGTPGGDFSEPNPALTKLLFTQKTDRQLLVLQDAVAHSAATPTSSCLFSVHSSLQGSIGLQRTGSLPRKRGERGSQRGSPRPLSFHCTESLEASALPPAVGDSGRYPLYQLLNCGRGNSCGAIHPDIAHMERLLQQAMAERERLLKAREGTRRGTEGSSGPAVPAITAPPTPPHPPGPRILDLRQHLEGWGHNPENCPHVQVSGCCCRGPLVKMGGRIKTWRKRWFCFDRQARRLAYYADKEETKLKGVIYFQAIEEVYYDHLRCAFKSPNPRLTFCVKTYERLFYMVAPSPEAMRIWMDVIVTAADENHAP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MGTRSSPEEG -----CCCCCCCCCC	26.53	27251275
5	Phosphorylation	---MGTRSSPEEGTP ---CCCCCCCCCCCC	50.51	27251275
6	Phosphorylation	--MGTRSSPEEGTPP --CCCCCCCCCCCCC	32.80	27794612
11	Phosphorylation	RSSPEEGTPPPLVPE CCCCCCCCCCCCCCC	35.58	27251275
46	Phosphorylation	EVLAEPSSRGGAEQQ HHHCCCCCCCCHHHH	45.73	-
63	Phosphorylation	EEEVGEGSSTESSRD HHCCCCCCCCCCCCC	29.77	24719451
64	Phosphorylation	EEVGEGSSTESSRDA HCCCCCCCCCCCCCC	47.23	28985074
65	Phosphorylation	EVGEGSSTESSRDAP CCCCCCCCCCCCCCC	41.40	26471730
67	Phosphorylation	GEGSSTESSRDAPEA CCCCCCCCCCCCCCC	30.66	26471730
68	Phosphorylation	EGSSTESSRDAPEAT CCCCCCCCCCCCCCC	28.13	26471730
83	Phosphorylation	PPIAMAATPPASTSS CCCEEEECCCCCCCC	21.92	25850435
87	Phosphorylation	MAATPPASTSSREGV EEECCCCCCCCHHHH	34.30	25850435
88	Phosphorylation	AATPPASTSSREGVR EECCCCCCCCHHHHH	32.59	25850435
89	Phosphorylation	ATPPASTSSREGVRG ECCCCCCCCHHHHHH	25.54	25850435
90	Phosphorylation	TPPASTSSREGVRGA CCCCCCCCHHHHHHH	34.14	25850435
184	Phosphorylation	EQEQRRLSQERDRLE HHHHHHHHHHHHHHH	28.34	29214152
233	Phosphorylation	LDVAQRAYEDLEFQQ HHHHHHHHHHHHHHH	16.50	28796482
245	Phosphorylation	FQQLERESRQEEEDR HHHHHHHHHHHHHHC	45.55	23312004
254	Phosphorylation	QEEEDRDSPGPQVPD HHHHHCCCCCCCCCC	32.42	30266825
270	Phosphorylation	KVQELQASMAQHRRG HHHHHHHHHHHHHHH	11.16	-
301	Phosphorylation	GEQMAAESRGLSRKK HHHHHHHHCCCCHHH	27.24	29083192
308	Ubiquitination	SRGLSRKKEEALQAL HCCCCHHHHHHHHHH	60.73	-
345	Ubiquitination	EPNPALTKLLFTQKT CCCHHHHHHHHCCCC	44.00	-
351	Ubiquitination	TKLLFTQKTDRQLLV HHHHHCCCCCCEEEH	49.70	-
391	Phosphorylation	GSIGLQRTGSLPRKR CCCCCCCCCCCCCCC	20.40	-
393	Phosphorylation	IGLQRTGSLPRKRGE CCCCCCCCCCCCCCC	34.29	24719451
407	Phosphorylation	ERGSQRGSPRPLSFH CCCCCCCCCCCCEEE	21.67	28348404
412	Phosphorylation	RGSPRPLSFHCTESL CCCCCCCEEECCCCH	18.67	28348404
416	Phosphorylation	RPLSFHCTESLEASA CCCEEECCCCHHHCC	21.75	28348404
418	Phosphorylation	LSFHCTESLEASALP CEEECCCCHHHCCCC	17.23	28348404
431	Phosphorylation	LPPAVGDSGRYPLYQ CCCCCCCCCCCCHHH	21.17	-
434	Phosphorylation	AVGDSGRYPLYQLLN CCCCCCCCCHHHHHC	10.91	-
437	Phosphorylation	DSGRYPLYQLLNCGR CCCCCCHHHHHCCCC	7.81	25839225
444	Methylation	YQLLNCGRGNSCGAI HHHHCCCCCCCCCCC	43.23	54558001
447	Phosphorylation	LNCGRGNSCGAIHPD HCCCCCCCCCCCCCC	19.42	27050516
479	Phosphorylation	LLKAREGTRRGTEGS HHHHHHCCCCCCCCC	16.67	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PHLB3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PHLB3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PHLB3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MDM2_HUMAN	MDM2	physical	28008906
BMAL1_HUMAN	ARNTL	physical	27173435
RPR1A_HUMAN	RPRD1A	physical	27173435
HAUS6_HUMAN	HAUS6	physical	27173435
CAVN1_HUMAN	PTRF	physical	27173435
PF21A_HUMAN	PHF21A	physical	27173435
MS18B_HUMAN	OIP5	physical	27173435
CCD93_HUMAN	CCDC93	physical	27173435
VPS50_HUMAN	CCDC132	physical	27173435
RCOR1_HUMAN	RCOR1	physical	27173435
GRAP1_HUMAN	GRIPAP1	physical	27173435
DZIP3_HUMAN	DZIP3	physical	27173435
VPS53_HUMAN	VPS53	physical	27173435
PSMD9_HUMAN	PSMD9	physical	27173435
CLOCK_HUMAN	CLOCK	physical	27173435
GOGA5_HUMAN	GOLGA5	physical	27173435
TUFT1_HUMAN	TUFT1	physical	27173435
YETS4_HUMAN	YEATS4	physical	27173435
CCHCR_HUMAN	CCHCR1	physical	27173435
TFPT_HUMAN	TFPT	physical	27173435
NCK5L_HUMAN	NCKAP5L	physical	27173435
PKN3_HUMAN	PKN3	physical	27173435
RABX5_HUMAN	RABGEF1	physical	27173435
NUF2_HUMAN	NUF2	physical	27173435
THA11_HUMAN	THAP11	physical	27173435
KDM1A_HUMAN	KDM1A	physical	27173435
VPS51_HUMAN	VPS51	physical	27173435
JUN_HUMAN	JUN	physical	27173435

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.