DZIP3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DZIP3_HUMAN
• UniProt AC: Q86Y13
• Protein Name: E3 ubiquitin-protein ligase DZIP3
• Gene Name: DZIP3
• Organism: Homo sapiens (Human).
• Sequence Length: 1208
• Subcellular Localization: Cytoplasm .
• Protein Description: E3 Ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Able to specifically bind RNA..
• Protein Sequence: MDSLPDEFFVRHPAVEDQRKEETENKLEKSSGQLNKQENDIPTDLVPVNLLLEVKKLLNAINTLPKGVVPHIKKFLQEDFSFQTMQREVAANSQNGEEIVPALTLRFLITQLEAALRNIQAGNYTAHQINIGYYLTLLFLYGVALTERGKKEDYTEAENKFLVMKMMIQENEICENFMSLVYFGRGLLRCAQKRYNGGLLEFHKSLQEIGDKNDHWFDIDPTEDEDLPTTFKDLLNNFIKTTESNIMKQTICSYLDCERSCEADILKNTSYKGFFQLMCSKSCCVYFHKICWKKFKNLKYPGENDQSFSGKKCLKEGCTGDMVRMLQCDVPGIVKILFEVVRKDEYITIENLGASYRKLISLKITDTDIRPKISLKFNTKDEMPIFKLDYNYFYHLLHIIIISGTDIVRQIFDEAMPPPLLKKELLIHKNVLESYYNHLWTNHPLGGSWHLLYPPNKELPQSKQFDLCLLLALIKHLNVFPAPKKGWNMEPPSSDISKSADILRLCKYRDILLSEILMNGLTESQFNSIWKKVSDILLRLGMMQEDIDKVKENPIENISLDYHQLSVYLGIPVPEIIQRMLSCYQQGIALQSITGSQRIEIEELQNEEEELSPPLMEYNINVKSHPEIQFAEINKDGTSIPSESSTESLKDLQEVKSKQRKKKKTKNKKNKDSKEDQVPYVVEKEEQLRKEQANPHSVSRLIKDDASDVQEDSAMEDKFYSLDELHILDMIEQGSAGKVTTDYGETEKERLARQRQLYKLHYQCEDFKRQLRTVTFRWQENQMQIKKKDKIIASLNQQVAFGINKVSKLQRQIHAKDNEIKNLKEQLSMKRSQWEMEKHNLESTMKTYVSKLNAETSRALTAEVYFLQCRRDFGLLHLEQTEKECLNQLARVTHMAASNLESLQLKAAVDSWNAIVADVRNKIAFLRTQYNEQINKVKQGFALSTLPPVQLPPPPPSPEILMQQFLGRPLVKESFFRPILTVPQMPAVCPGVVSATGQPRAPLMTGIAWALPAPVGDAVPPSAGLRSDPSIMNWERITDRLKTAFPQQTRKELTDFLRKLKDAYGKSLSELTFDEIVCKISQFIDPKKSQSQGKSVSNVNCVSPSHSPSQPDAAQPPKPAWRPLTSQGPATWEGASNPDEEEEEEEPCVICHENLSPENLSVLPCAHKFHAQCIRPWLMQQGTCPTCRLHVLLPEEFPGHPSRQLPKI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MDSLPDEFFV -----CCCCCCCCCC	54.37	23186163
29	Ubiquitination	ETENKLEKSSGQLNK HHHHHHHHHCCCCCC	61.43	27667366
30	Phosphorylation	TENKLEKSSGQLNKQ HHHHHHHHCCCCCCC	30.26	25690035
36	Ubiquitination	KSSGQLNKQENDIPT HHCCCCCCCCCCCCC	68.53	29967540
55	Ubiquitination	VNLLLEVKKLLNAIN HHHHHHHHHHHHHHH	28.47	29967540
124	Phosphorylation	RNIQAGNYTAHQINI HHHHCCCCEECCCCH	12.37	22817900
141	Phosphorylation	YLTLLFLYGVALTER HHHHHHHHHHHHHHC	11.39	22817900
151	Ubiquitination	ALTERGKKEDYTEAE HHHHCCCCCCCCHHH	59.65	22053931
151 (in isoform 1)	Ubiquitination	-	59.65	21890473
212	Ubiquitination	SLQEIGDKNDHWFDI HHHHHCCCCCCCCCC	60.09	21906983
212 (in isoform 1)	Ubiquitination	-	60.09	21890473
212 (in isoform 2)	Ubiquitination	-	60.09	21906983
229	Phosphorylation	TEDEDLPTTFKDLLN CCCCCCCCHHHHHHH	52.76	-
242	Phosphorylation	LNNFIKTTESNIMKQ HHHHHHHHCHHHHHH	32.20	-
248	Ubiquitination	TTESNIMKQTICSYL HHCHHHHHHHHHHHH	40.26	32015554
299	Ubiquitination	WKKFKNLKYPGENDQ HHHHCCCCCCCCCCC	59.81	29967540
311	Ubiquitination	NDQSFSGKKCLKEGC CCCCCCCCCHHHCCC	38.83	29967540
315	Ubiquitination	FSGKKCLKEGCTGDM CCCCCHHHCCCCHHH	62.62	29967540
319	Phosphorylation	KCLKEGCTGDMVRML CHHHCCCCHHHHHHH	47.26	-
346	Phosphorylation	EVVRKDEYITIENLG HHHCCCCCEEEEECC	17.31	18083107
356	Phosphorylation	IENLGASYRKLISLK EEECCCCHHHHHEEE	15.95	18083107
361	Phosphorylation	ASYRKLISLKITDTD CCHHHHHEEEECCCC	33.76	24719451
363	Ubiquitination	YRKLISLKITDTDIR HHHHHEEEECCCCCC	36.45	29967540
372	Ubiquitination	TDTDIRPKISLKFNT CCCCCCCCEEEECCC	34.77	21906983
372 (in isoform 1)	Ubiquitination	-	34.77	21890473
372 (in isoform 2)	Ubiquitination	-	34.77	21906983
376	Ubiquitination	IRPKISLKFNTKDEM CCCCEEEECCCCCCC	29.76	22817900
380	Ubiquitination	ISLKFNTKDEMPIFK EEEECCCCCCCCCEE	53.44	21906983
380 (in isoform 1)	Ubiquitination	-	53.44	21890473
380 (in isoform 2)	Ubiquitination	-	53.44	21906983
392	Phosphorylation	IFKLDYNYFYHLLHI CEEECHHHHHHHHHH	10.17	-
423	Ubiquitination	MPPPLLKKELLIHKN CCCCCCCHHHHHCHH	54.27	33845483
484	Ubiquitination	LNVFPAPKKGWNMEP HCCCCCCCCCCCCCC	67.06	29967540
485	Ubiquitination	NVFPAPKKGWNMEPP CCCCCCCCCCCCCCC	69.01	29967540
497	Ubiquitination	EPPSSDISKSADILR CCCCCCCCHHHHHHH	26.08	22817900
498	Ubiquitination	PPSSDISKSADILRL CCCCCCCHHHHHHHH	50.42	29967540
528	Phosphorylation	LTESQFNSIWKKVSD CCHHHHHHHHHHHHH	30.99	22468782
532	Ubiquitination	QFNSIWKKVSDILLR HHHHHHHHHHHHHHH	31.79	22817900
542	Ubiquitination	DILLRLGMMQEDIDK HHHHHHCCCHHHHHH	2.72	22817900
580	Ubiquitination	VPEIIQRMLSCYQQG HHHHHHHHHHHHHHC	1.53	22817900
581	Ubiquitination	PEIIQRMLSCYQQGI HHHHHHHHHHHHHCC	3.31	22817900
582	Ubiquitination	EIIQRMLSCYQQGIA HHHHHHHHHHHHCCH	11.05	22817900
584	Ubiquitination	IQRMLSCYQQGIALQ HHHHHHHHHHCCHHH	10.65	22817900
612	Phosphorylation	QNEEEELSPPLMEYN HCCCCCCCCCCEECC	27.96	28348404
615	Ubiquitination	EEELSPPLMEYNINV CCCCCCCCEECCCCC	4.65	22817900
618	Ubiquitination	LSPPLMEYNINVKSH CCCCCEECCCCCCCC	13.84	22817900
635	Ubiquitination	IQFAEINKDGTSIPS EEEEEECCCCCCCCC	64.30	29967540
640	Ubiquitination	INKDGTSIPSESSTE ECCCCCCCCCCCCCC	4.34	21890473
642	Phosphorylation	KDGTSIPSESSTESL CCCCCCCCCCCCCHH	48.73	27732954
644	Phosphorylation	GTSIPSESSTESLKD CCCCCCCCCCCHHHH	47.07	27732954
645	Phosphorylation	TSIPSESSTESLKDL CCCCCCCCCCHHHHH	31.94	27732954
645	Ubiquitination	TSIPSESSTESLKDL CCCCCCCCCCHHHHH	31.94	22817900
646	Phosphorylation	SIPSESSTESLKDLQ CCCCCCCCCHHHHHH	38.58	27732954
648	Phosphorylation	PSESSTESLKDLQEV CCCCCCCHHHHHHHH	40.59	27732954
650	Ubiquitination	ESSTESLKDLQEVKS CCCCCHHHHHHHHHH	66.72	32015554
656	Ubiquitination	LKDLQEVKSKQRKKK HHHHHHHHHHHHHHH	51.70	32142685
663	Acetylation	KSKQRKKKKTKNKKN HHHHHHHHHCCCCCC	69.57	61127
664	Acetylation	SKQRKKKKTKNKKNK HHHHHHHHCCCCCCC	73.87	69811
677	Ubiquitination	NKDSKEDQVPYVVEK CCCCCCCCCCHHHHH	38.89	22053931
684	Ubiquitination	QVPYVVEKEEQLRKE CCCHHHHHHHHHHHH	55.74	29967540
690	Ubiquitination	EKEEQLRKEQANPHS HHHHHHHHHHCCHHH	63.87	29967540
703	Ubiquitination	HSVSRLIKDDASDVQ HHHHHHHHCCHHHHC	54.90	21906983
703 (in isoform 1)	Ubiquitination	-	54.90	21890473
707	Phosphorylation	RLIKDDASDVQEDSA HHHHCCHHHHCCCCH	45.36	29978859
713	Phosphorylation	ASDVQEDSAMEDKFY HHHHCCCCHHHHCCC	28.85	29978859
718	Ubiquitination	EDSAMEDKFYSLDEL CCCHHHHCCCCHHHH	32.66	29967540
730	Ubiquitination	DELHILDMIEQGSAG HHHHHHHHHHHCCCC	3.05	22817900
732	Ubiquitination	LHILDMIEQGSAGKV HHHHHHHHHCCCCCC	42.10	22817900
738	Ubiquitination	IEQGSAGKVTTDYGE HHHCCCCCCCCCCCH	35.80	21906983
738 (in isoform 1)	Ubiquitination	-	35.80	21890473
748	Ubiquitination	TDYGETEKERLARQR CCCCHHHHHHHHHHH	56.40	21906983
748 (in isoform 1)	Ubiquitination	-	56.40	21890473
759	Ubiquitination	ARQRQLYKLHYQCED HHHHHHHHHHHHHHH	37.06	29967540
768	Methylation	HYQCEDFKRQLRTVT HHHHHHHHHHHHHEE	52.11	-
768	Ubiquitination	HYQCEDFKRQLRTVT HHHHHHHHHHHHHEE	52.11	29967540
775	Phosphorylation	KRQLRTVTFRWQENQ HHHHHHEEEECHHCC	13.58	24719451
786	Ubiquitination	QENQMQIKKKDKIIA HHCCCCCCHHHHHHH	36.56	22817900
786 (in isoform 1)	Ubiquitination	-	36.56	21890473
787	Ubiquitination	ENQMQIKKKDKIIAS HCCCCCCHHHHHHHH	68.76	22817900
788	Ubiquitination	NQMQIKKKDKIIASL CCCCCCHHHHHHHHH	60.29	22817900
790	Ubiquitination	MQIKKKDKIIASLNQ CCCCHHHHHHHHHHH	44.91	22817900
794	Phosphorylation	KKDKIIASLNQQVAF HHHHHHHHHHHHHHH	19.90	27732954
816	Ubiquitination	LQRQIHAKDNEIKNL HHHHHHCCHHHHHHH	47.10	29967540
821	Ubiquitination	HAKDNEIKNLKEQLS HCCHHHHHHHHHHHH	50.47	33845483
824	Ubiquitination	DNEIKNLKEQLSMKR HHHHHHHHHHHHHHH	53.46	21906983
824 (in isoform 1)	Ubiquitination	-	53.46	21890473
830	Ubiquitination	LKEQLSMKRSQWEME HHHHHHHHHHHHHHH	45.59	29967540
832	Phosphorylation	EQLSMKRSQWEMEKH HHHHHHHHHHHHHHH	33.84	33259812
836	Ubiquitination	MKRSQWEMEKHNLES HHHHHHHHHHHCHHH	8.29	21890473
838	Ubiquitination	RSQWEMEKHNLESTM HHHHHHHHHCHHHHH	36.16	-
845	Ubiquitination	KHNLESTMKTYVSKL HHCHHHHHHHHHHHH	4.20	21890473
846	Ubiquitination	HNLESTMKTYVSKLN HCHHHHHHHHHHHHC	36.47	22817900
846 (in isoform 1)	Ubiquitination	-	36.47	21890473
851	Ubiquitination	TMKTYVSKLNAETSR HHHHHHHHHCHHHHH	35.40	21906983
851 (in isoform 1)	Ubiquitination	-	35.40	21890473
881	Ubiquitination	GLLHLEQTEKECLNQ CCCCHHHHHHHHHHH	39.38	22817900
882	Ubiquitination	LLHLEQTEKECLNQL CCCHHHHHHHHHHHH	46.69	22817900
883	Ubiquitination	LHLEQTEKECLNQLA CCHHHHHHHHHHHHH	58.05	22053931
883 (in isoform 1)	Ubiquitination	-	58.05	21890473
936	Ubiquitination	QYNEQINKVKQGFAL HHHHHHHHHHCCCCC	53.06	21906983
936 (in isoform 1)	Ubiquitination	-	53.06	21890473
938	Ubiquitination	NEQINKVKQGFALST HHHHHHHHCCCCCCC	46.44	22817900
974	Phosphorylation	GRPLVKESFFRPILT CCCCCCCHHCCCCCC	24.78	24719451
1042	Ubiquitination	ERITDRLKTAFPQQT HHHHHHHHHHCCHHH	38.41	27667366
1042 (in isoform 1)	Ubiquitination	-	38.41	21890473
1051	Ubiquitination	AFPQQTRKELTDFLR HCCHHHHHHHHHHHH	61.54	23000965
1051 (in isoform 1)	Ubiquitination	-	61.54	21890473
1054	Phosphorylation	QQTRKELTDFLRKLK HHHHHHHHHHHHHHH	26.29	24719451
1061	Ubiquitination	TDFLRKLKDAYGKSL HHHHHHHHHHHCCCH	43.26	29967540
1066	Ubiquitination	KLKDAYGKSLSELTF HHHHHHCCCHHHCCH	35.23	32015554
1081	Phosphorylation	DEIVCKISQFIDPKK HHHHHHHHHHCCCCC	12.44	-
1087	Ubiquitination	ISQFIDPKKSQSQGK HHHHCCCCCCCCCCC	62.40	22817900
1087 (in isoform 1)	Ubiquitination	-	62.40	21890473
1088	Ubiquitination	SQFIDPKKSQSQGKS HHHCCCCCCCCCCCC	60.15	22817900
1095	Phosphorylation	KSQSQGKSVSNVNCV CCCCCCCCCCCCCCC	37.29	27732954
1097	Phosphorylation	QSQGKSVSNVNCVSP CCCCCCCCCCCCCCC	42.00	29978859
1103	Phosphorylation	VSNVNCVSPSHSPSQ CCCCCCCCCCCCCCC	23.92	29978859
1105	Phosphorylation	NVNCVSPSHSPSQPD CCCCCCCCCCCCCCC	29.14	27732954
1107	Phosphorylation	NCVSPSHSPSQPDAA CCCCCCCCCCCCCCC	30.50	27732954
1109	Phosphorylation	VSPSHSPSQPDAAQP CCCCCCCCCCCCCCC	58.31	29978859
1118	Ubiquitination	PDAAQPPKPAWRPLT CCCCCCCCCCCCCCC	54.79	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DZIP3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DZIP3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DZIP3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DZIP3_HUMAN	DZIP3	physical	12538761
H2B2E_HUMAN	HIST2H2BE	physical	18206970
UB2D1_HUMAN	UBE2D1	physical	12538761
UBR3_HUMAN	UBR3	physical	22493164
RNF38_HUMAN	RNF38	physical	22493164
PCGF3_HUMAN	PCGF3	physical	22493164
RAD18_HUMAN	RAD18	physical	22493164
ATX1_HUMAN	ATXN1	physical	24326307
DZIP3_HUMAN	DZIP3	physical	18206970
UB2D2_HUMAN	UBE2D2	physical	18206970
RHG32_HUMAN	ARHGAP32	physical	25416956
HNRL1_HUMAN	HNRNPUL1	physical	25416956
ZCH10_HUMAN	ZCCHC10	physical	25416956
CEP63_HUMAN	CEP63	physical	25416956
RBM4B_HUMAN	RBM4B	physical	25416956
ZN765_HUMAN	ZNF765	physical	25416956
CARM1_HUMAN	CARM1	physical	26505218
GRIP1_HUMAN	GRIP1	physical	26505218
TIAR_HUMAN	TIAL1	physical	28514442
PKN3_HUMAN	PKN3	physical	27173435
NCK5L_HUMAN	NCKAP5L	physical	27173435
TFPT_HUMAN	TFPT	physical	27173435
YETS4_HUMAN	YEATS4	physical	27173435
GOGA5_HUMAN	GOLGA5	physical	27173435
CLOCK_HUMAN	CLOCK	physical	27173435
PSMD9_HUMAN	PSMD9	physical	27173435
GRAP1_HUMAN	GRIPAP1	physical	27173435
VPS50_HUMAN	CCDC132	physical	27173435
PF21A_HUMAN	PHF21A	physical	27173435
CAVN1_HUMAN	PTRF	physical	27173435
HAUS6_HUMAN	HAUS6	physical	27173435
RPR1A_HUMAN	RPRD1A	physical	27173435
BMAL1_HUMAN	ARNTL	physical	27173435
RABX5_HUMAN	RABGEF1	physical	27173435
NUF2_HUMAN	NUF2	physical	27173435
EIPR1_HUMAN	TSSC1	physical	27173435
RABE1_HUMAN	RABEP1	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.