GRIP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GRIP1_HUMAN
• UniProt AC: Q9Y3R0
• Protein Name: Glutamate receptor-interacting protein 1
• Gene Name: GRIP1
• Organism: Homo sapiens (Human).
• Sequence Length: 1128
• Subcellular Localization: Cytoplasmic vesicle . Endoplasmic reticulum . Cell junction, synapse, postsynaptic cell membrane. Cytoplasmic and membrane-associated with vesicles, peri-Golgi complexes and endoplasmic reticulum. Enriched in postsynaptic plasma membrane and postsyna
• Protein Description: May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons. [PubMed: 10197531 Through complex formation with NSG1, GRIA2 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity]
• Protein Sequence: MIAVSFKCRCQILRRLTKDESPYTKSASQTKPPDGALAVRRQSIPEEFKGSTVVELMKKEGTTLGLTVSGGIDKDGKPRVSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKNVGERVVLEVEYELPPVSVQGSSVIFRTVEVTLHKEGNTFGFVIRGGAHDDRNKSRPVVITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLIEYDVSVMDSVATASGPLLVEVAKTPGASLGVALTTSMCCNKQVIVIDKIKSASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEILPHHQTRLALKGPDHVKIQRSDRQLTWDSWASNHSSLHTNHHYNTYHPDHCRVPALTFPKAPPPNSPPALVSSSFSPTSMSAYSLSSLNMGTLPRSLYSTSPRGTMMRRRLKKKDFKSSLSLASSTVGLAGQVVHTETTEVVLTADPVTGFGIQLQGSVFATETLSSPPLISYIEADSPAERCGVLQIGDRVMAINGIPTEDSTFEEASQLLRDSSITSKVTLEIEFDVAESVIPSSGTFHVKLPKKHNVELGITISSPSSRKPGDPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCEDLVKLKIRKDEDNSDEQESSGAIIYTVELKRYGGPLGITISGTEEPFDPIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETVTLKIKKQTDAQSASSPKKFPISSHLSDLGDVEEDSSPAQKPGKLSDMYPSTVPSVDSAVDSWDGSAIDTSYGTQGTSFQASGYNFNTYDWRSPKQRGSLSPVTKPRSQTYPDVGLSYEDWDRSTASGFAGAADSAETEQEENFWSQALEDLETCGQSGILRELEEKADRRVSLRNMTLLATIMSGSTMSLNHEAPTPRSQLGRQASFQERSSSRPHYSQTTRSNTLPSDVGRKSVTLRKMKQEIKEIMSPTPVELHKVTLYKDSDMEDFGFSVADGLLEKGVYVKNIRPAGPGDLGGLKPYDRLLQVNHVRTRDFDCCLVVPLIAESGNKLDLVISRNPLASQKSIDQQSLPGDWSEQNSAFFQQPSHGGNLETREPTNTL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	CQILRRLTKDESPYT HHHHHHHCCCCCCCC	34.34	-
26	Phosphorylation	DESPYTKSASQTKPP CCCCCCCCCCCCCCC	25.92	25002506
28	Phosphorylation	SPYTKSASQTKPPDG CCCCCCCCCCCCCCC	45.53	25002506
30	Phosphorylation	YTKSASQTKPPDGAL CCCCCCCCCCCCCCE	42.92	25002506
43	Phosphorylation	ALAVRRQSIPEEFKG CEEEECCCCCHHHCC	38.00	23927012
44	Phosphorylation	LAVRRQSIPEEFKGS EEEECCCCCHHHCCC	3.63	32142685
49	Acetylation	QSIPEEFKGSTVVEL CCCCHHHCCCCEEEH	56.05	11922989
51	Phosphorylation	IPEEFKGSTVVELMK CCHHHCCCCEEEHHH	20.72	23927012
52	Phosphorylation	PEEFKGSTVVELMKK CHHHCCCCEEEHHHC	36.92	23927012
69	Phosphorylation	TTLGLTVSGGIDKDG CEEEEEEECCCCCCC	26.51	32142685
119	Phosphorylation	FRHDEIISLLKNVGE HCHHHHHHHHHHCCC	33.05	24719451
177	Phosphorylation	AHDDRNKSRPVVITC CCCCCCCCCCEEEEE	45.42	-
221	Phosphorylation	TTHAEAMSILKQCGQ CCHHHHHHHHHHHCC	31.64	24719451
285	O-linked_Glycosylation	IVIDKIKSASIADRC EEEECCCCCCHHHHC	30.62	30620550
285	Phosphorylation	IVIDKIKSASIADRC EEEECCCCCCHHHHC	30.62	-
287	O-linked_Glycosylation	IDKIKSASIADRCGA EECCCCCCHHHHCCC	25.96	30620550
287	Phosphorylation	IDKIKSASIADRCGA EECCCCCCHHHHCCC	25.96	-
308	Phosphorylation	ILSIDGTSMEYCTLA EEEECCCCHHHHHHH	18.36	-
352 (in isoform 3)	Phosphorylation	-	43.95	24719451
353 (in isoform 3)	Phosphorylation	-	22.29	24719451
354 (in isoform 3)	Phosphorylation	-	44.53	24719451
381	Phosphorylation	HYNTYHPDHCRVPAL CCCCCCCCCCCCCCE	39.96	24719451
383	Methylation	NTYHPDHCRVPALTF CCCCCCCCCCCCEEC	6.47	-
430	Phosphorylation	GTLPRSLYSTSPRGT CCCCHHHHCCCCCHH	15.91	29449344
431	Phosphorylation	TLPRSLYSTSPRGTM CCCHHHHCCCCCHHH	27.92	29449344
432	Phosphorylation	LPRSLYSTSPRGTMM CCHHHHCCCCCHHHH	29.24	28348404
433	Phosphorylation	PRSLYSTSPRGTMMR CHHHHCCCCCHHHHH	13.47	24719451
435	Methylation	SLYSTSPRGTMMRRR HHHCCCCCHHHHHHH	53.64	-
437	Phosphorylation	YSTSPRGTMMRRRLK HCCCCCHHHHHHHHC	14.74	-
532	Phosphorylation	MAINGIPTEDSTFEE EEECCCCCCCCCHHH	50.97	-
535	Phosphorylation	NGIPTEDSTFEEASQ CCCCCCCCCHHHHHH	28.85	24719451
587	Phosphorylation	HNVELGITISSPSSR CCEEEEEEEECCCCC	17.01	24719451
589	Phosphorylation	VELGITISSPSSRKP EEEEEEEECCCCCCC	27.78	28348404
590	Phosphorylation	ELGITISSPSSRKPG EEEEEEECCCCCCCC	25.58	28348404
592	Phosphorylation	GITISSPSSRKPGDP EEEEECCCCCCCCCC	44.73	22210691
593	Phosphorylation	ITISSPSSRKPGDPL EEEECCCCCCCCCCE	47.94	22210691
603	Phosphorylation	PGDPLVISDIKKGSV CCCCEEEEECCCCCC	26.29	22210691
609	Phosphorylation	ISDIKKGSVAHRTGT EEECCCCCCCCCCCE	25.63	24719451
614	Phosphorylation	KGSVAHRTGTLELGD CCCCCCCCCEECCCC	25.34	-
616	Phosphorylation	SVAHRTGTLELGDKL CCCCCCCEECCCCEE	19.22	-
661	Phosphorylation	IRKDEDNSDEQESSG EECCCCCCCCHHHCC	55.64	30266825
666	Phosphorylation	DNSDEQESSGAIIYT CCCCCHHHCCEEEEE	33.49	30266825
667	Phosphorylation	NSDEQESSGAIIYTV CCCCHHHCCEEEEEE	31.34	30266825
711	Phosphorylation	KGGLAERTGAIHIGD CCCHHHHCCCEEECC	23.59	-
718	Phosphorylation	TGAIHIGDRILAINS CCCEEECCEEEEECC	33.57	24719451
721	Phosphorylation	IHIGDRILAINSSSL EEECCEEEEECCCCC	4.00	-
725	Phosphorylation	DRILAINSSSLKGKP CEEEEECCCCCCCCC	18.39	-
726	Phosphorylation	RILAINSSSLKGKPL EEEEECCCCCCCCCH	34.89	-
727	Phosphorylation	ILAINSSSLKGKPLS EEEECCCCCCCCCHH	33.64	-
734	Phosphorylation	SLKGKPLSEAIHLLQ CCCCCCHHHHHHHHH	33.24	-
759	Phosphorylation	KKQTDAQSASSPKKF EECCCCCCCCCCCCC	31.66	29514088
761	Phosphorylation	QTDAQSASSPKKFPI CCCCCCCCCCCCCCC	53.04	29514088
762	Phosphorylation	TDAQSASSPKKFPIS CCCCCCCCCCCCCCC	40.22	29514088
769	Phosphorylation	SPKKFPISSHLSDLG CCCCCCCCHHCHHCC	16.37	25002506
770	Phosphorylation	PKKFPISSHLSDLGD CCCCCCCHHCHHCCC	29.21	28857561
773	Phosphorylation	FPISSHLSDLGDVEE CCCCHHCHHCCCCCC	25.93	28857561
793	Phosphorylation	QKPGKLSDMYPSTVP CCCCCHHHCCCCCCC	51.58	-
795	Phosphorylation	PGKLSDMYPSTVPSV CCCHHHCCCCCCCCC	10.06	24719451
796	Phosphorylation	GKLSDMYPSTVPSVD CCHHHCCCCCCCCCC	19.52	32142685
798	Phosphorylation	LSDMYPSTVPSVDSA HHHCCCCCCCCCCCC	31.75	-
802	Phosphorylation	YPSTVPSVDSAVDSW CCCCCCCCCCCCCCC	5.73	-
820	Phosphorylation	AIDTSYGTQGTSFQA CEECCCCCCCCCEEE	18.65	32142685
821	Phosphorylation	IDTSYGTQGTSFQAS EECCCCCCCCCEEEC	49.13	32142685
845	Phosphorylation	RSPKQRGSLSPVTKP CCCCCCCCCCCCCCC	28.06	30266825
847	Phosphorylation	PKQRGSLSPVTKPRS CCCCCCCCCCCCCCC	21.01	30266825
850	Phosphorylation	RGSLSPVTKPRSQTY CCCCCCCCCCCCCCC	38.42	23927012
854	Phosphorylation	SPVTKPRSQTYPDVG CCCCCCCCCCCCCCC	35.09	22817900
856	Phosphorylation	VTKPRSQTYPDVGLS CCCCCCCCCCCCCCC	37.96	28348404
863	Phosphorylation	TYPDVGLSYEDWDRS CCCCCCCCHHHCCCC	22.13	29978859
864	Phosphorylation	YPDVGLSYEDWDRST CCCCCCCHHHCCCCC	23.97	24719451
866	Phosphorylation	DVGLSYEDWDRSTAS CCCCCHHHCCCCCCC	44.32	24719451
867	Phosphorylation	VGLSYEDWDRSTASG CCCCHHHCCCCCCCC	7.32	24719451
869	Phosphorylation	LSYEDWDRSTASGFA CCHHHCCCCCCCCCC	31.49	27251275
873	Phosphorylation	DWDRSTASGFAGAAD HCCCCCCCCCCCCCC	34.23	32142685
886	Phosphorylation	ADSAETEQEENFWSQ CCCCHHHHHHHHHHH	71.38	24719451
901	Phosphorylation	ALEDLETCGQSGILR HHHHHHHHCCCCHHH	3.22	32645325
902	Phosphorylation	LEDLETCGQSGILRE HHHHHHHCCCCHHHH	31.91	32645325
905	Phosphorylation	LETCGQSGILRELEE HHHHCCCCHHHHHHH	18.30	24719451
911	Phosphorylation	SGILRELEEKADRRV CCHHHHHHHHHHHHH	53.34	32645325
912	Phosphorylation	GILRELEEKADRRVS CHHHHHHHHHHHHHH	67.19	32645325
913 (in isoform 2)	Phosphorylation	-	46.33	28450419
916	Phosphorylation	ELEEKADRRVSLRNM HHHHHHHHHHHHHHH	45.84	24719451
916 (in isoform 2)	Phosphorylation	-	45.84	24719451
918 (in isoform 2)	Phosphorylation	-	7.05	28450419
919 (in isoform 2)	Phosphorylation	-	21.57	28450419
920	Phosphorylation	KADRRVSLRNMTLLA HHHHHHHHHHHHHHH	4.14	-
921 (in isoform 2)	Phosphorylation	-	24.30	28450419
926	Phosphorylation	SLRNMTLLATIMSGS HHHHHHHHHHHHCCC	2.65	32645325
927	Phosphorylation	LRNMTLLATIMSGST HHHHHHHHHHHCCCC	9.74	32645325
928	Phosphorylation	RNMTLLATIMSGSTM HHHHHHHHHHCCCCC	19.72	-
928 (in isoform 2)	Phosphorylation	-	19.72	28450419
929	Phosphorylation	NMTLLATIMSGSTMS HHHHHHHHHCCCCCC	1.39	24719451
933	Phosphorylation	LATIMSGSTMSLNHE HHHHHCCCCCCCCCC	17.40	-
934	Phosphorylation	ATIMSGSTMSLNHEA HHHHCCCCCCCCCCC	17.82	-
936	Phosphorylation	IMSGSTMSLNHEAPT HHCCCCCCCCCCCCC	26.55	-
938	Phosphorylation	SGSTMSLNHEAPTPR CCCCCCCCCCCCCCH	24.52	32645325
943	Phosphorylation	SLNHEAPTPRSQLGR CCCCCCCCCHHHHHH	38.08	-
944	Phosphorylation	LNHEAPTPRSQLGRQ CCCCCCCCHHHHHHH	32.63	-
953	Phosphorylation	SQLGRQASFQERSSS HHHHHHHHHHHHHCC	21.08	20363803
970	Phosphorylation	HYSQTTRSNTLPSDV CCCCCCCCCCCCCCC	31.88	30266825
972	Phosphorylation	SQTTRSNTLPSDVGR CCCCCCCCCCCCCCC	41.09	30266825
975	Phosphorylation	TRSNTLPSDVGRKSV CCCCCCCCCCCCCHH	48.30	30266825
979	Phosphorylation	TLPSDVGRKSVTLRK CCCCCCCCCHHHHHH	28.11	32645325
981	Phosphorylation	PSDVGRKSVTLRKMK CCCCCCCHHHHHHHH	20.97	23909892
983	Phosphorylation	DVGRKSVTLRKMKQE CCCCCHHHHHHHHHH	28.12	24719451
996	Phosphorylation	QEIKEIMSPTPVELH HHHHHHHCCCCEEEE	31.14	25106551
998	Phosphorylation	IKEIMSPTPVELHKV HHHHHCCCCEEEEEE	32.43	29978859
1045	Phosphorylation	GPGDLGGLKPYDRLL CCCCCCCCCCCHHEE	4.85	-
1048	Phosphorylation	DLGGLKPYDRLLQVN CCCCCCCCHHEECCC	16.47	-
1092	Phosphorylation	NPLASQKSIDQQSLP CCCCCCCCCCCCCCC	24.62	27251275
1097	Phosphorylation	QKSIDQQSLPGDWSE CCCCCCCCCCCCHHH	30.79	27251275
1103	Phosphorylation	QSLPGDWSEQNSAFF CCCCCCHHHHHCCCC	33.76	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GRIP1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GRIP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GRIP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GRIA4_HUMAN	GRIA4	physical	11891216
GRIA3_HUMAN	GRIA3	physical	11891216
GRIA2_HUMAN	GRIA2	physical	11891216
GRAP1_HUMAN	GRIPAP1	physical	10896157
NUMBL_HUMAN	NUMBL	physical	10896157
HDAC1_HUMAN	HDAC1	physical	16649994
GRIP1_HUMAN	GRIP1	physical	16649994
EHMT2_HUMAN	EHMT2	physical	16461774
CARM1_HUMAN	CARM1	physical	11997499
CARM1_HUMAN	CARM1	physical	11983685
H31_HUMAN	HIST1H3A	physical	15471871
THA_HUMAN	THRA	physical	9849963
VDR_HUMAN	VDR	physical	14726489
CARM1_HUMAN	CARM1	physical	17882261
CBP_HUMAN	CREBBP	physical	17257825
CTNB1_HUMAN	CTNNB1	genetic	16990252
PPARG_HUMAN	PPARG	physical	17704298
FLII_HUMAN	FLII	physical	16990252
LRRF1_MOUSE	Lrrfip1	physical	16990252
GRM7_HUMAN	GRM7	physical	11891216
DZIP3_HUMAN	DZIP3	physical	26505218
AGAP2_HUMAN	AGAP2	physical	21847098
GRIA2_HUMAN	GRIA2	physical	21847098

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 219000: Fraser syndrome (FRASS)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-972, AND MASSSPECTROMETRY.
PubMed: 19690332