GRM7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GRM7_HUMAN
• UniProt AC: Q14831
• Protein Name: Metabotropic glutamate receptor 7
• Gene Name: GRM7
• Organism: Homo sapiens (Human).
• Sequence Length: 915
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity..
• Protein Sequence: MVQLRKLLRVLTLMKFPCCVLEVLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAKGPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSLTFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYASTAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAKRADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRRNVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAHALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRNVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTNTSNPGYRLIGQWTDELQLNIEDMQWGKGVREIPASVCTLPCKPGQRKKTQKGTPCCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAVIPVFLAMLGIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIWFGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGVPENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGMLYMPKVYIIIFHPELNVQKRKRSFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPNSPAAKKKYVSYNNLVI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	RKLLRVLTLMKFPCC HHHHHHHHHCCCCHH	23.19	-
98	N-linked_Glycosylation	SDPNLLPNVTLGARI CCCCCCCCCCCCHHH	39.10	UniProtKB CARBOHYD
223	Phosphorylation	LGWNYVSTLASEGSY HCCCHHHHCCCCCCC	19.12	23911959
226	Phosphorylation	NYVSTLASEGSYGEK CHHHHCCCCCCCCHH	45.67	23911959
229	Phosphorylation	STLASEGSYGEKGVE HHCCCCCCCCHHHHH	26.39	23911959
264	Phosphorylation	PQERKDRTIDFDRII CHHHCCCCCCHHHHH	34.72	19664994
280	Phosphorylation	QLLDTPNSRAVVIFA HHHCCCCCCEEEEEC	23.87	25106551
458	N-linked_Glycosylation	YIRNVNFNGSAGTPV HHHCCCCCCCCCCCE	38.00	UniProtKB CARBOHYD
486	N-linked_Glycosylation	IFQYQTTNTSNPGYR EEEEEECCCCCCCEE	44.92	UniProtKB CARBOHYD
572	N-linked_Glycosylation	YDQRPNENRTGCQDI CCCCCCCCCCCCCCC	54.15	UniProtKB CARBOHYD
675	Phosphorylation	ISYAALLTKTNRIYR HHHHHHHHHCHHHHH	36.35	18491316
677	Phosphorylation	YAALLTKTNRIYRIF HHHHHHHCHHHHHHH	25.21	18491316
681	Phosphorylation	LTKTNRIYRIFEQGK HHHCHHHHHHHHCCC	8.40	-
819	Phosphorylation	AQSAEKLYIQTTTLT CCCCCEEEEEEEEEE	11.31	24043423
822	Phosphorylation	AEKLYIQTTTLTISM CCEEEEEEEEEEEEE	16.52	24043423
823	Phosphorylation	EKLYIQTTTLTISMN CEEEEEEEEEEEEEE	11.93	24043423
824	Phosphorylation	KLYIQTTTLTISMNL EEEEEEEEEEEEEEC	25.87	24043423
826	Phosphorylation	YIQTTTLTISMNLSA EEEEEEEEEEEECCH	14.65	24043423
828	Phosphorylation	QTTTLTISMNLSASV EEEEEEEEEECCHHH	9.07	24043423
832	Phosphorylation	LTISMNLSASVALGM EEEEEECCHHHHHHH	17.31	24043423
834	Phosphorylation	ISMNLSASVALGMLY EEEECCHHHHHHHHH	12.44	24043423
841	Phosphorylation	SVALGMLYMPKVYII HHHHHHHHCCCEEEE	11.50	24043423
862	Phosphorylation	NVQKRKRSFKAVVTA CHHHCHHHHHHHHHH	33.85	-
874	Phosphorylation	VTAATMSSRLSHKPS HHHHHHHHHHCCCCC	26.81	24670416
889	Sumoylation	DRPNGEAKTELCENV CCCCCHHCHHHHHCC	37.92	-
889	Sumoylation	DRPNGEAKTELCENV CCCCCHHCHHHHHCC	37.92	-
890	Phosphorylation	RPNGEAKTELCENVD CCCCHHCHHHHHCCC	41.04	23286773
900	Phosphorylation	CENVDPNSPAAKKKY HHCCCCCCHHHHHCE	22.70	27732954

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GRM7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GRM7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GRM7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PICK1_HUMAN	PICK1	physical	11007882
GNAQ_HUMAN	GNAQ	physical	10550060
PICK1_HUMAN	PICK1	physical	11891216
GRIP1_HUMAN	GRIP1	physical	11891216
SDCB1_HUMAN	SDCBP	physical	11891216

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.