dbPTM

FLII_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	FLII_HUMAN
UniProt AC	Q13045
Protein Name	Protein flightless-1 homolog
Gene Name	FLII
Organism	Homo sapiens (Human).
Sequence Length	1269
Subcellular Localization	Nucleus. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell junction, focal adhesion. Colocalizes to actin-rich structures in blastocysts and, together with HRAS, RHOA and CDC42, in migrating fibroblasts
Protein Description	May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling. Involved in early embryonic development (By similarity). May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation..
Protein Sequence	MEATGVLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLVMPPKPADRAAEWYNIDFSLQNQLRLAGASPATVAAAAAAGSGPKDPMARKMRLRRRKDSAQDDQAKQVLKGMSDVAQEKNKKQEESADARAPSGKVRRWDQGLEKPRLDYSEFFTEDVGQLPGLTIWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGSLNWEIYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTVREEMGDESEEFLQVFDNDISYIEGGTASGFYTVEDTHYVTRMYRVYGKKNIKLEPVPLKGTSLDPRFVFLLDRGLDIYVWRGAQATLSSTTKARLFAEKINKNERKGKAEITLLVQGQELPEFWEALGGEPSEIKKHVPEDFWPPQPKLYKVGLGLGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILDCWSDVFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHATVSRSLEGTEAQVFKAKFKNWDDVLTVDYTRNAEAVLQSPGLSGKVKRDAEKKDQMKADLTALFLPRQPPMSLAEAEQLMEEWNEDLDGMEGFVLEGKKFARLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKKEDKEEKAEGKEGEEATAEAEEKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVVRMTQQQENPKFLSHFKRKFIIHRGKRKAVQGAQQPSLYQIRTNGSALCTRCIQINTDSSLLNSEFCFILKVPFESEDNQGIVYAWVGRASDPDEAKLAEDILNTMFDTSYSKQVINEGEEPENFFWVGIGAQKPYDDDAEYMKHTRLFRCSNEKGYFAVTEKCSDFCQDDLADDDIMLLDNGQEVYMWVGTQTSQVEIKLSLKACQVYIQHMRSKEHERPRRLRLVRKGNEQHAFTRCFHAWSAFCKALA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEATGVLP -------CCCCCCCC	36.30	22223895
1	Sulfoxidation	-------MEATGVLP -------CCCCCCCC	36.30	28183972
4	Phosphorylation	----MEATGVLPFVR ----CCCCCCCCEEE	30.99	21406692
16	Phosphorylation	FVRGVDLSGNDFKGG EEECEECCCCCCCCC	30.96	28857561
19	Ubiquitination	GVDLSGNDFKGGYFP CEECCCCCCCCCCCC	50.59	22817900
21	Acetylation	DLSGNDFKGGYFPEN ECCCCCCCCCCCCHH	55.05	19608861
21	Ubiquitination	DLSGNDFKGGYFPEN ECCCCCCCCCCCCHH	55.05	27667366
28	Ubiquitination	KGGYFPENVKAMTSL CCCCCCHHHHHHHHH	40.61	27667366
30	Ubiquitination	GYFPENVKAMTSLRW CCCCHHHHHHHHHCE	43.98	21963094
39	Ubiquitination	MTSLRWLKLNRTGLC HHHHCEEECCCCCCC	36.43	27667366
62	Phosphorylation	LQKLEHLSVSHNNLT HHHHHHHCCCCCCCC	24.39	28857561
64	Phosphorylation	KLEHLSVSHNNLTTL HHHHHCCCCCCCCCH	19.68	28857561
76	Phosphorylation	TTLHGELSSLPSLRA CCHHHHHHCCHHHHH	26.06	24732914
77	Phosphorylation	TLHGELSSLPSLRAI CHHHHHHCCHHHHHH	57.85	24732914
80	Phosphorylation	GELSSLPSLRAIVAR HHHHCCHHHHHHHHH	35.46	24719451
81	Ubiquitination	ELSSLPSLRAIVARA HHHCCHHHHHHHHHH	3.96	27667366
90	Phosphorylation	AIVARANSLKNSGVP HHHHHHHHHHHCCCC	39.47	29514088
91	Ubiquitination	IVARANSLKNSGVPD HHHHHHHHHHCCCCC	6.46	29967540
92	Ubiquitination	VARANSLKNSGVPDD HHHHHHHHHCCCCCC	49.22	21906983
102	Ubiquitination	GVPDDIFKLDDLSVL CCCCCCCCCCCCCEE	51.87	29967540
242	Ubiquitination	LTRVPECLYTLPSLR CCCCCHHHHCCHHHH	3.31	29967540
243	Phosphorylation	TRVPECLYTLPSLRR CCCCHHHHCCHHHHH	20.21	27642862
247	Phosphorylation	ECLYTLPSLRRLNLS HHHHCCHHHHHCCCC	37.31	24719451
249	Ubiquitination	LYTLPSLRRLNLSSN HHCCHHHHHCCCCCC	45.43	21963094
261	Ubiquitination	SSNQITELSLCIDQW CCCCCCHHHHHHHHE	3.38	29967540
285	Ubiquitination	RNQLTSLPSAICKLS HHHHCCHHHHHHHHH	22.83	29967540
290	Acetylation	SLPSAICKLSKLKKL CHHHHHHHHHHCHHH	50.08	25953088
290	Ubiquitination	SLPSAICKLSKLKKL CHHHHHHHHHHCHHH	50.08	29967540
292	Ubiquitination	PSAICKLSKLKKLYL HHHHHHHHHCHHHHH	22.80	21963094
293	Ubiquitination	SAICKLSKLKKLYLN HHHHHHHHCHHHHHC	74.82	-
296	Ubiquitination	CKLSKLKKLYLNSNK HHHHHCHHHHHCCCC	53.45	29967540
298	Phosphorylation	LSKLKKLYLNSNKLD HHHCHHHHHCCCCCC	16.83	29083192
301	Phosphorylation	LKKLYLNSNKLDFDG CHHHHHCCCCCCCCC	32.52	29083192
303	Ubiquitination	KLYLNSNKLDFDGLP HHHHCCCCCCCCCCC	49.61	21906983
304	Ubiquitination	LYLNSNKLDFDGLPS HHHCCCCCCCCCCCC	10.44	29967540
315	Ubiquitination	GLPSGIGKLTNLEEF CCCCCCCHHCCHHHH	50.66	29967540
323	Sulfoxidation	LTNLEEFMAANNNLE HCCHHHHHHHCCCCC	3.78	30846556
327	Ubiquitination	EEFMAANNNLELVPE HHHHHHCCCCCCCCH	50.14	29967540
333	Ubiquitination	NNNLELVPESLCRCP CCCCCCCCHHHCCCH	37.78	29967540
344	Ubiquitination	CRCPKLRKLVLNKNH CCCHHHHHHHCCCCC	54.08	29967540
352 (in isoform 2)	Phosphorylation	-	4.38	27050516
355 (in isoform 2)	Phosphorylation	-	2.55	26270265
363 (in isoform 2)	Phosphorylation	-	33.69	25159151
370	Ubiquitination	TEIEVLDVRENPNLV HEEEEEECCCCCCCC	7.86	29967540
381	Phosphorylation	PNLVMPPKPADRAAE CCCCCCCCCCCCCCH	47.14	33259812
381	Ubiquitination	PNLVMPPKPADRAAE CCCCCCCCCCCCCCH	47.14	29967540
388	Ubiquitination	KPADRAAEWYNIDFS CCCCCCCHHCCCCCH	49.89	33845483
390	Phosphorylation	ADRAAEWYNIDFSLQ CCCCCHHCCCCCHHH	8.18	27642862
392	Ubiquitination	RAAEWYNIDFSLQNQ CCCHHCCCCCHHHHH	3.12	27667366
395	Phosphorylation	EWYNIDFSLQNQLRL HHCCCCCHHHHHHHH	25.87	22210691
401	Ubiquitination	FSLQNQLRLAGASPA CHHHHHHHHCCCCHH	16.84	24816145
406	Phosphorylation	QLRLAGASPATVAAA HHHHCCCCHHHHHHH	17.72	25159151
409	Phosphorylation	LAGASPATVAAAAAA HCCCCHHHHHHHHHC	17.67	25159151
410	Ubiquitination	AGASPATVAAAAAAG CCCCHHHHHHHHHCC	3.56	24816145
417	Ubiquitination	VAAAAAAGSGPKDPM HHHHHHCCCCCCCHH	28.54	29967540
418	Phosphorylation	AAAAAAGSGPKDPMA HHHHHCCCCCCCHHH	47.39	25159151
421	Ubiquitination	AAAGSGPKDPMARKM HHCCCCCCCHHHHHH	77.36	24816145
425	Phosphorylation	SGPKDPMARKMRLRR CCCCCHHHHHHHHHH	17.21	33259812
427	Ubiquitination	PKDPMARKMRLRRRK CCCHHHHHHHHHHHH	20.87	22817900
432	Ubiquitination	ARKMRLRRRKDSAQD HHHHHHHHHHCCCCH	55.37	33845483
436	Phosphorylation	RLRRRKDSAQDDQAK HHHHHHCCCCHHHHH	30.75	27273156
436	Ubiquitination	RLRRRKDSAQDDQAK HHHHHHCCCCHHHHH	30.75	27667366
442	Ubiquitination	DSAQDDQAKQVLKGM CCCCHHHHHHHHHHH	15.96	22817900
443	Ubiquitination	SAQDDQAKQVLKGMS CCCHHHHHHHHHHHH	34.99	33845483
445	Ubiquitination	QDDQAKQVLKGMSDV CHHHHHHHHHHHHHH	6.17	24816145
446	Ubiquitination	DDQAKQVLKGMSDVA HHHHHHHHHHHHHHH	3.53	22817900
447	Ubiquitination	DQAKQVLKGMSDVAQ HHHHHHHHHHHHHHH	54.43	21906983
449	Sulfoxidation	AKQVLKGMSDVAQEK HHHHHHHHHHHHHHH	2.71	30846556
450	Phosphorylation	KQVLKGMSDVAQEKN HHHHHHHHHHHHHHH	37.29	28857561
455	Ubiquitination	GMSDVAQEKNKKQEE HHHHHHHHHHHHHHH	49.19	24816145
456	Ubiquitination	MSDVAQEKNKKQEES HHHHHHHHHHHHHHH	63.08	24816145
459	Ubiquitination	VAQEKNKKQEESADA HHHHHHHHHHHHHHH	72.79	-
461	Ubiquitination	QEKNKKQEESADARA HHHHHHHHHHHHHCC	63.90	29967540
463	Phosphorylation	KNKKQEESADARAPS HHHHHHHHHHHCCCC	30.60	-
471	Ubiquitination	ADARAPSGKVRRWDQ HHHCCCCCCCCCHHC	31.27	22817900
472	Ubiquitination	DARAPSGKVRRWDQG HHCCCCCCCCCHHCC	36.58	29967540
481	Ubiquitination	RRWDQGLEKPRLDYS CCHHCCCCCCCCCHH	68.77	22817900
482	Ubiquitination	RWDQGLEKPRLDYSE CHHCCCCCCCCCHHH	40.24	22817900
487	Phosphorylation	LEKPRLDYSEFFTED CCCCCCCHHHHHCCC	18.07	26074081
488	Phosphorylation	EKPRLDYSEFFTEDV CCCCCCHHHHHCCCC	27.82	26074081
492	Phosphorylation	LDYSEFFTEDVGQLP CCHHHHHCCCCCCCC	36.27	26074081
523	Phosphorylation	EAFHGKFYEADCYIV HHHCCCEEECCEEEE	17.44	-
528	Phosphorylation	KFYEADCYIVLKTFL CEEECCEEEEEEEEE	8.46	-
561	Phosphorylation	TLDKKACSAIHAVNL CCCHHHHHHHHHHHH	34.81	28857561
573	Ubiquitination	VNLRNYLGAECRTVR HHHHHHCCCCHHHHH	14.68	24816145
576	Ubiquitination	RNYLGAECRTVREEM HHHCCCCHHHHHHHH	4.36	29967540
616	Ubiquitination	FYTVEDTHYVTRMYR EEEEECHHHEEEEEE	27.64	27667366
617	Ubiquitination	YTVEDTHYVTRMYRV EEEECHHHEEEEEEE	12.95	24816145
620	Ubiquitination	EDTHYVTRMYRVYGK ECHHHEEEEEEEECC	15.30	29967540
623	Ubiquitination	HYVTRMYRVYGKKNI HHEEEEEEEECCCCC	13.07	29967540
626	Ubiquitination	TRMYRVYGKKNIKLE EEEEEEECCCCCEEE	31.44	24816145
627	Ubiquitination	RMYRVYGKKNIKLEP EEEEEECCCCCEEEE	25.59	24816145
628	Ubiquitination	MYRVYGKKNIKLEPV EEEEECCCCCEEEEE	60.59	24816145
631	Acetylation	VYGKKNIKLEPVPLK EECCCCCEEEEECCC	57.08	23236377
631	Ubiquitination	VYGKKNIKLEPVPLK EECCCCCEEEEECCC	57.08	29967540
638	Acetylation	KLEPVPLKGTSLDPR EEEEECCCCCCCCHH	54.81	25953088
638	Ubiquitination	KLEPVPLKGTSLDPR EEEEECCCCCCCCHH	54.81	-
657	Phosphorylation	LDRGLDIYVWRGAQA EECCCEEEEECCCCC	8.14	-
660	Ubiquitination	GLDIYVWRGAQATLS CCEEEEECCCCCCCC	22.11	27667366
665	Phosphorylation	VWRGAQATLSSTTKA EECCCCCCCCHHHHH	18.32	21406692
667	Phosphorylation	RGAQATLSSTTKARL CCCCCCCCHHHHHHH	22.68	21406692
667	Ubiquitination	RGAQATLSSTTKARL CCCCCCCCHHHHHHH	22.68	29967540
668	Phosphorylation	GAQATLSSTTKARLF CCCCCCCHHHHHHHH	43.11	21406692
669	Phosphorylation	AQATLSSTTKARLFA CCCCCCHHHHHHHHH	29.01	21406692
670	Phosphorylation	QATLSSTTKARLFAE CCCCCHHHHHHHHHH	25.34	21406692
670	Ubiquitination	QATLSSTTKARLFAE CCCCCHHHHHHHHHH	25.34	27667366
671	Ubiquitination	ATLSSTTKARLFAEK CCCCHHHHHHHHHHH	31.43	21906983
675	Ubiquitination	STTKARLFAEKINKN HHHHHHHHHHHCCCC	7.41	33845483
678	Ubiquitination	KARLFAEKINKNERK HHHHHHHHCCCCCCC	48.42	29967540
680	Ubiquitination	RLFAEKINKNERKGK HHHHHHCCCCCCCCC	52.77	24816145
681	Ubiquitination	LFAEKINKNERKGKA HHHHHCCCCCCCCCE	64.75	24816145
691	Ubiquitination	RKGKAEITLLVQGQE CCCCEEEEEEECCEE	12.92	21963094
697	Ubiquitination	ITLLVQGQELPEFWE EEEEECCEECHHHHH	31.78	21963094
701	Ubiquitination	VQGQELPEFWEALGG ECCEECHHHHHHHCC	75.83	22817900
704	Ubiquitination	QELPEFWEALGGEPS EECHHHHHHHCCCHH	39.06	29967540
715	Ubiquitination	GEPSEIKKHVPEDFW CCHHHHHHHCCCCCC	56.34	29967540
719	Ubiquitination	EIKKHVPEDFWPPQP HHHHHCCCCCCCCCC	65.83	33845483
730	Ubiquitination	PPQPKLYKVGLGLGY CCCCCEEEECCCCCE	40.02	33845483
735	Ubiquitination	LYKVGLGLGYLELPQ EEEECCCCCEEECCC	4.98	21963094
737	Phosphorylation	KVGLGLGYLELPQIN EECCCCCEEECCCCC	11.31	20090780
741	Ubiquitination	GLGYLELPQINYKLS CCCEEECCCCCEEEC	24.51	21963094
745	Ubiquitination	LELPQINYKLSVEHK EECCCCCEEECCCCC	18.22	21963094
746	Ubiquitination	ELPQINYKLSVEHKQ ECCCCCEEECCCCCC	29.78	21890473
746	Ubiquitination	ELPQINYKLSVEHKQ ECCCCCEEECCCCCC	29.78	21906983
747	Ubiquitination	LPQINYKLSVEHKQR CCCCCEEECCCCCCC	4.97	21963094
750	Ubiquitination	INYKLSVEHKQRPKV CCEEECCCCCCCCCC	41.83	21890473
751	Ubiquitination	NYKLSVEHKQRPKVE CEEECCCCCCCCCCC	29.41	21963094
752	Ubiquitination	YKLSVEHKQRPKVEL EEECCCCCCCCCCCC	34.20	21963094
755	Ubiquitination	SVEHKQRPKVELMPR CCCCCCCCCCCCHHH	42.42	22817900
756	Ubiquitination	VEHKQRPKVELMPRM CCCCCCCCCCCHHHH	51.00	22817900
760	Sulfoxidation	QRPKVELMPRMRLLQ CCCCCCCHHHHHHHH	0.94	21406390
768	Phosphorylation	PRMRLLQSLLDTRCV HHHHHHHHHHHCCCE	30.76	20068231
772	Phosphorylation	LLQSLLDTRCVYILD HHHHHHHCCCEEEEE	26.41	20068231
777	Ubiquitination	LDTRCVYILDCWSDV HHCCCEEEEECCCCC	0.99	27667366
779	Ubiquitination	TRCVYILDCWSDVFI CCCEEEEECCCCCHH	23.45	22817900
781	Ubiquitination	CVYILDCWSDVFIWL CEEEEECCCCCHHHC	9.38	21963094
791	Ubiquitination	VFIWLGRKSPRLVRA CHHHCCCCCHHHHHH	64.11	21963094
792	Phosphorylation	FIWLGRKSPRLVRAA HHHCCCCCHHHHHHH	17.56	-
801	Phosphorylation	RLVRAAALKLGQELC HHHHHHHHHHHHHHH	3.95	32645325
801	Ubiquitination	RLVRAAALKLGQELC HHHHHHHHHHHHHHH	3.95	21963094
802	Ubiquitination	LVRAAALKLGQELCG HHHHHHHHHHHHHHH	45.93	21963094
807	Ubiquitination	ALKLGQELCGMLHRP HHHHHHHHHHHHCCC	2.05	21963094
809	Ubiquitination	KLGQELCGMLHRPRH HHHHHHHHHHCCCCC	34.02	22817900
814	Ubiquitination	LCGMLHRPRHATVSR HHHHHCCCCCCCCCC	22.97	22817900
815	Ubiquitination	CGMLHRPRHATVSRS HHHHCCCCCCCCCCC	31.84	22817900
818	Phosphorylation	LHRPRHATVSRSLEG HCCCCCCCCCCCCCC	16.94	19293151
819	Ubiquitination	HRPRHATVSRSLEGT CCCCCCCCCCCCCCC	4.67	21963094
821	Ubiquitination	PRHATVSRSLEGTEA CCCCCCCCCCCCCCH	40.71	27667366
822	Phosphorylation	RHATVSRSLEGTEAQ CCCCCCCCCCCCCHH	24.22	28857561
823	Ubiquitination	HATVSRSLEGTEAQV CCCCCCCCCCCCHHH	7.37	22817900
825	Ubiquitination	TVSRSLEGTEAQVFK CCCCCCCCCCHHHHH	33.86	21963094
826	Phosphorylation	VSRSLEGTEAQVFKA CCCCCCCCCHHHHHH	20.83	20860994
831	Ubiquitination	EGTEAQVFKAKFKNW CCCCHHHHHHHCCCC	4.18	27667366
832	Methylation	GTEAQVFKAKFKNWD CCCHHHHHHHCCCCC	52.38	-
832	Ubiquitination	GTEAQVFKAKFKNWD CCCHHHHHHHCCCCC	52.38	27667366
833	Ubiquitination	TEAQVFKAKFKNWDD CCHHHHHHHCCCCCC	15.85	22817900
834	Ubiquitination	EAQVFKAKFKNWDDV CHHHHHHHCCCCCCE	58.42	22817900
835	Ubiquitination	AQVFKAKFKNWDDVL HHHHHHHCCCCCCEE	9.88	21890473
836	Ubiquitination	QVFKAKFKNWDDVLT HHHHHHCCCCCCEEE	57.32	21963094
845	Phosphorylation	WDDVLTVDYTRNAEA CCCEEEEECCCCHHH	33.57	32645325
846	Phosphorylation	DDVLTVDYTRNAEAV CCEEEEECCCCHHHH	11.85	26074081
847	Phosphorylation	DVLTVDYTRNAEAVL CEEEEECCCCHHHHH	17.00	26074081
851	Ubiquitination	VDYTRNAEAVLQSPG EECCCCHHHHHCCCC	42.74	21963094
853	Ubiquitination	YTRNAEAVLQSPGLS CCCCHHHHHCCCCCC	3.63	22817900
856	Phosphorylation	NAEAVLQSPGLSGKV CHHHHHCCCCCCCCC	19.44	19664994
858	Ubiquitination	EAVLQSPGLSGKVKR HHHHCCCCCCCCCCC	37.41	22817900
859	Ubiquitination	AVLQSPGLSGKVKRD HHHCCCCCCCCCCCC	7.48	22817900
860	Phosphorylation	VLQSPGLSGKVKRDA HHCCCCCCCCCCCCH	42.35	23401153
861	Ubiquitination	LQSPGLSGKVKRDAE HCCCCCCCCCCCCHH	43.76	21963094
862	Ubiquitination	QSPGLSGKVKRDAEK CCCCCCCCCCCCHHH	41.00	21906983
863	Ubiquitination	SPGLSGKVKRDAEKK CCCCCCCCCCCHHHH	7.58	21963094
864	Ubiquitination	PGLSGKVKRDAEKKD CCCCCCCCCCHHHHH	48.31	22817900
868	Ubiquitination	GKVKRDAEKKDQMKA CCCCCCHHHHHHHHH	66.00	22817900
869	Ubiquitination	KVKRDAEKKDQMKAD CCCCCHHHHHHHHHH	64.47	22817900
870	Ubiquitination	VKRDAEKKDQMKADL CCCCHHHHHHHHHHH	44.70	22817900
873	Ubiquitination	DAEKKDQMKADLTAL CHHHHHHHHHHHHHH	5.76	21963094
874	Ubiquitination	AEKKDQMKADLTALF HHHHHHHHHHHHHHH	32.87	21906983
878	Phosphorylation	DQMKADLTALFLPRQ HHHHHHHHHHHCCCC	23.12	28857561
896	Ubiquitination	SLAEAEQLMEEWNED CHHHHHHHHHHHHHC	3.34	33845483
903	Ubiquitination	LMEEWNEDLDGMEGF HHHHHHHCCCCCCCE	47.01	22817900
907	Ubiquitination	WNEDLDGMEGFVLEG HHHCCCCCCCEEECC	4.55	21963094
919	Ubiquitination	LEGKKFARLPEEEFG ECCCEECCCCHHHHC	54.64	21963094
940	Ubiquitination	CYVFLCRYWVPVEYE EEEEEEECEEECCCC	15.12	33845483
943	Ubiquitination	FLCRYWVPVEYEEEE EEEECEEECCCCHHH	10.08	21890473
946	Phosphorylation	RYWVPVEYEEEEKKE ECEEECCCCHHHHHH	28.95	28796482
947	Ubiquitination	YWVPVEYEEEEKKED CEEECCCCHHHHHHH	45.48	22817900
949	Ubiquitination	VPVEYEEEEKKEDKE EECCCCHHHHHHHHH	64.28	21890473
951	Ubiquitination	VEYEEEEKKEDKEEK CCCCHHHHHHHHHHH	65.82	21963094
952	Ubiquitination	EYEEEEKKEDKEEKA CCCHHHHHHHHHHHH	74.54	29967540
957	Ubiquitination	EKKEDKEEKAEGKEG HHHHHHHHHHCCCCH	64.41	22817900
958	Ubiquitination	KKEDKEEKAEGKEGE HHHHHHHHHCCCCHH	53.48	22817900
960	Ubiquitination	EDKEEKAEGKEGEEA HHHHHHHCCCCHHHH	80.16	29967540
961	Ubiquitination	DKEEKAEGKEGEEAT HHHHHHCCCCHHHHH	37.87	21963094
962	Ubiquitination	KEEKAEGKEGEEATA HHHHHCCCCHHHHHH	54.79	21906983
963	Ubiquitination	EEKAEGKEGEEATAE HHHHCCCCHHHHHHH	80.73	21963094
968	Phosphorylation	GKEGEEATAEAEEKQ CCCHHHHHHHHHHHC	28.45	28674419
973	Ubiquitination	EATAEAEEKQPEEDF HHHHHHHHHCCHHHH	65.13	21963094
974	Ubiquitination	ATAEAEEKQPEEDFQ HHHHHHHHCCHHHHE	63.76	23000965
980	Ubiquitination	EKQPEEDFQCIVYFW HHCCHHHHEEEEEEE	7.84	23000965
982	Ubiquitination	QPEEDFQCIVYFWQG CCHHHHEEEEEEEEC	1.99	23000965
991	Ubiquitination	VYFWQGREASNMGWL EEEEECCCCCCCCEE	64.37	24816145
996	Ubiquitination	GREASNMGWLTFTFS CCCCCCCCEEEEEEE	22.08	29967540
1004	Ubiquitination	WLTFTFSLQKKFESL EEEEEEEHHHHHHHH	8.27	29967540
1007	Acetylation	FTFSLQKKFESLFPG EEEEHHHHHHHHCCC	41.21	25953088
1007	Malonylation	FTFSLQKKFESLFPG EEEEHHHHHHHHCCC	41.21	26320211
1007	Ubiquitination	FTFSLQKKFESLFPG EEEEHHHHHHHHCCC	41.21	29967540
1010	Phosphorylation	SLQKKFESLFPGKLE EHHHHHHHHCCCCEE	38.14	27762562
1015	Ubiquitination	FESLFPGKLEVVRMT HHHHCCCCEEEEEEC	41.53	29967540
1018	Ubiquitination	LFPGKLEVVRMTQQQ HCCCCEEEEEECCCC	4.85	23000965
1024	Ubiquitination	EVVRMTQQQENPKFL EEEEECCCCCCCHHH	43.31	23000965
1026	Ubiquitination	VRMTQQQENPKFLSH EEECCCCCCCHHHHH	71.77	23000965
1028	Ubiquitination	MTQQQENPKFLSHFK ECCCCCCCHHHHHHH	28.20	21890473
1029	Ubiquitination	TQQQENPKFLSHFKR CCCCCCCHHHHHHHH	71.20	23000965
1032	Phosphorylation	QENPKFLSHFKRKFI CCCCHHHHHHHHHEE	29.97	24961811
1034	Ubiquitination	NPKFLSHFKRKFIIH CCHHHHHHHHHEEEE	8.01	21890473
1035	Ubiquitination	PKFLSHFKRKFIIHR CHHHHHHHHHEEEEC	49.61	23000965
1036	Ubiquitination	KFLSHFKRKFIIHRG HHHHHHHHHEEEECC	37.87	23000965
1037	Ubiquitination	FLSHFKRKFIIHRGK HHHHHHHHEEEECCH	41.32	23000965
1045	Ubiquitination	FIIHRGKRKAVQGAQ EEEECCHHHHCCCCC	34.68	24816145
1046	Ubiquitination	IIHRGKRKAVQGAQQ EEECCHHHHCCCCCC	57.29	24816145
1055	Phosphorylation	VQGAQQPSLYQIRTN CCCCCCCCCEEEECC	35.06	28857561
1060	Ubiquitination	QPSLYQIRTNGSALC CCCCEEEECCCCEEE	13.45	23503661
1102	Phosphorylation	EDNQGIVYAWVGRAS CCCCCEEEEEEECCC	7.88	-
1104	Ubiquitination	NQGIVYAWVGRASDP CCCEEEEEEECCCCH	3.87	23503661
1107	Ubiquitination	IVYAWVGRASDPDEA EEEEEEECCCCHHHH	22.69	21963094
1114	Ubiquitination	RASDPDEAKLAEDIL CCCCHHHHHHHHHHH	21.39	23503661
1115	Ubiquitination	ASDPDEAKLAEDILN CCCHHHHHHHHHHHH	46.30	23503661
1118	Ubiquitination	PDEAKLAEDILNTMF HHHHHHHHHHHHHHH	56.89	21963094
1151	Ubiquitination	FWVGIGAQKPYDDDA EEEEECCCCCCCCCH	41.88	21963094
1161	Ubiquitination	YDDDAEYMKHTRLFR CCCCHHHHHHCEEEE	1.61	21963094
1162	Ubiquitination	DDDAEYMKHTRLFRC CCCHHHHHHCEEEEE	40.71	21963094
1163	Ubiquitination	DDAEYMKHTRLFRCS CCHHHHHHCEEEEEC	10.33	22817900
1167	Ubiquitination	YMKHTRLFRCSNEKG HHHHCEEEEECCCCC	7.16	21963094
1172	Ubiquitination	RLFRCSNEKGYFAVT EEEEECCCCCEEEEE	31.40	21963094
1173	Acetylation	LFRCSNEKGYFAVTE EEEECCCCCEEEEEE	64.26	26051181
1173	Ubiquitination	LFRCSNEKGYFAVTE EEEECCCCCEEEEEE	64.26	21963094
1175	Phosphorylation	RCSNEKGYFAVTEKC EECCCCCEEEEEECH	10.22	25159151
1179	Phosphorylation	EKGYFAVTEKCSDFC CCCEEEEEECHHHHC	26.71	28102081
1192	Ubiquitination	FCQDDLADDDIMLLD HCCCCCCCCCEEEEE	62.50	24816145
1207	Ubiquitination	NGQEVYMWVGTQTSQ CCEEEEEEEECCCCE	2.80	22817900
1211	Ubiquitination	VYMWVGTQTSQVEIK EEEEEECCCCEEEEE	32.97	21963094
1217	Ubiquitination	TQTSQVEIKLSLKAC CCCCEEEEEHHHHHH	5.97	22817900
1218	Ubiquitination	QTSQVEIKLSLKACQ CCCEEEEEHHHHHHH	20.65	22817900
1221	Ubiquitination	QVEIKLSLKACQVYI EEEEEHHHHHHHHHH	6.21	21963094
1222	Ubiquitination	VEIKLSLKACQVYIQ EEEEHHHHHHHHHHH	43.68	21963094
1227	Phosphorylation	SLKACQVYIQHMRSK HHHHHHHHHHHHCCC	2.96	-
1236	Ubiquitination	QHMRSKEHERPRRLR HHHCCCCCCCCCCEE	39.85	24816145
1246	Ubiquitination	PRRLRLVRKGNEQHA CCCEEEEECCCHHHH	45.84	24816145
1247	Ubiquitination	RRLRLVRKGNEQHAF CCEEEEECCCHHHHH	59.62	24816145
1273	Ubiquitination	KALA----------- HHHC-----------		24816145
1274	Ubiquitination	ALA------------ HHC------------		24816145

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
64	S	Phosphorylation	Kinase	ULK1	O75385	PSP
436	S	Phosphorylation	Kinase	AKT1	P31749	PSP
436	S	Phosphorylation	Kinase	SGK3	Q96BR1	Uniprot
818	T	Phosphorylation	Kinase	SGK3	Q96BR1	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of FLII_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of FLII_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LRRF1_HUMAN	LRRFIP1	physical	9525888
ODO2_HUMAN	DLST	physical	16169070
LRRF2_HUMAN	LRRFIP2	physical	10366446
LRRF1_HUMAN	LRRFIP1	physical	10366446
IF1AX_HUMAN	EIF1AX	physical	22939629
CN166_HUMAN	C14orf166	physical	22863883
RTCB_HUMAN	RTCB	physical	22863883
DDX1_HUMAN	DDX1	physical	22863883
DHX9_HUMAN	DHX9	physical	22863883
EI2BG_HUMAN	EIF2B3	physical	22863883
HNRPM_HUMAN	HNRNPM	physical	22863883
IF2B3_HUMAN	IGF2BP3	physical	22863883
K1C18_HUMAN	KRT18	physical	22863883
MRE11_HUMAN	MRE11A	physical	22863883
NMT1_HUMAN	NMT1	physical	22863883
PDCD6_HUMAN	PDCD6	physical	22863883
PRKDC_HUMAN	PRKDC	physical	22863883
RFC2_HUMAN	RFC2	physical	22863883
RFC4_HUMAN	RFC4	physical	22863883
RL27_HUMAN	RPL27	physical	22863883
SRSF5_HUMAN	SRSF5	physical	26496610
TBG1_HUMAN	TUBG1	physical	26496610
LRRF1_HUMAN	LRRFIP1	physical	26496610

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of FLII_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Exploring proteomes and analyzing protein processing by massspectrometric identification of sorted N-terminal peptides."; Gevaert K., Goethals M., Martens L., Van Damme J., Staes A.,Thomas G.R., Vandekerckhove J.; Nat. Biotechnol. 21:566-569(2003). Cited for: PROTEIN SEQUENCE OF 1-11, AND ACETYLATION AT MET-1.	12665801 [Abstract]
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-21, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-856, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Identification of Flightless-I as a substrate of the cytokine-independent survival kinase CISK."; Xu J., Liao L., Qin J., Xu J., Liu D., Songyang Z.; J. Biol. Chem. 284:14377-14385(2009). Cited for: PHOSPHORYLATION AT SER-436 AND THR-818, AND INTERACTION WITH SGK3.	19293151 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-856, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-856, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-856, AND MASSSPECTROMETRY.	18691976 [Abstract]
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column."; Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.; Anal. Sci. 24:161-166(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-856, AND MASSSPECTROMETRY.	18187866 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-406 AND SER-856, ANDMASS SPECTROMETRY.	16964243 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-436 AND SER-856, ANDMASS SPECTROMETRY.	17081983 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-856, AND MASSSPECTROMETRY.	15302935 [Abstract]