dbPTM

ODO2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ODO2_HUMAN
UniProt AC	P36957
Protein Name	Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
Gene Name	DLST
Organism	Homo sapiens (Human).
Sequence Length	453
Subcellular Localization	Mitochondrion matrix . Nucleus . Mainly localizes in the mitochondrion. A small fraction localizes to the nucleus, where the 2-oxoglutarate dehydrogenase complex is required for histone succinylation.
Protein Description	Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex (By similarity). The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) (By similarity). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. [PubMed: 29211711 A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A]
Protein Sequence	MLSRSRCVSRAFSRSLSAFQKGNCPLGRRSLPGVSLCQGPGYPNSRKVVINNSVFSVRFFRTTAVCKDDLVTVKTPAFAESVTEGDVRWEKAVGDTVAEDEVVCEIETDKTSVQVPSPANGVIEALLVPDGGKVEGGTPLFTLRKTGAAPAKAKPAEAPAAAAPKAEPTAAAVPPPAAPIPTQMPPVPSPSQPPSGKPVSAVKPTVAPPLAEPGAGKGLRSEHREKMNRMRQRIAQRLKEAQNTCAMLTTFNEIDMSNIQEMRARHKEAFLKKHNLKLGFMSAFVKASAFALQEQPVVNAVIDDTTKEVVYRDYIDISVAVATPRGLVVPVIRNVEAMNFADIERTITELGEKARKNELAIEDMDGGTFTISNGGVFGSLFGTPIINPPQSAILGMHGIFDRPVAIGGKVEVRPMMYVALTYDHRLIDGREAVTFLRKIKAAVEDPRVLLLDL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	O-linked_Glycosylation	-----MLSRSRCVSR -----CCCHHHHHHH	27.23	30379171
5	O-linked_Glycosylation	---MLSRSRCVSRAF ---CCCHHHHHHHHH	27.01	30379171
53	Phosphorylation	RKVVINNSVFSVRFF CEEEEECCEEEEEEE	21.76	29083192
56	Phosphorylation	VINNSVFSVRFFRTT EEECCEEEEEEEEEE	15.38	29083192
74	Succinylation	KDDLVTVKTPAFAES CCCEEEECCHHHHCC	39.15	23954790
74	Ubiquitination	KDDLVTVKTPAFAES CCCEEEECCHHHHCC	39.15	-
75	Phosphorylation	DDLVTVKTPAFAESV CCEEEECCHHHHCCC	18.60	27251275
81	Phosphorylation	KTPAFAESVTEGDVR CCHHHHCCCCCCCCC	30.80	25693802
83	Phosphorylation	PAFAESVTEGDVRWE HHHHCCCCCCCCCHH	43.46	30108239
108	Phosphorylation	EVVCEIETDKTSVQV EEEEEEECCCCEEEC	48.75	28060719
110	Lipoylation	VCEIETDKTSVQVPS EEEEECCCCEEECCC	50.55	-
110	N6-lipoyllysine	VCEIETDKTSVQVPS EEEEECCCCEEECCC	50.55	-
111	Phosphorylation	CEIETDKTSVQVPSP EEEECCCCEEECCCC	36.62	28060719
112	Phosphorylation	EIETDKTSVQVPSPA EEECCCCEEECCCCC	19.12	28060719
117	Phosphorylation	KTSVQVPSPANGVIE CCEEECCCCCCCEEE	37.48	28060719
138	Phosphorylation	GGKVEGGTPLFTLRK CCEECCCCCCEEEEE	27.89	21406692
142	Phosphorylation	EGGTPLFTLRKTGAA CCCCCCEEEEECCCC	33.08	24719451
154	Malonylation	GAAPAKAKPAEAPAA CCCCCCCCCCCCCCC	44.01	26320211
154	Acetylation	GAAPAKAKPAEAPAA CCCCCCCCCCCCCCC	44.01	-
203	Malonylation	GKPVSAVKPTVAPPL CCCCCCCCCCCCCCC	34.39	26320211
203	Ubiquitination	GKPVSAVKPTVAPPL CCCCCCCCCCCCCCC	34.39	-
205	Phosphorylation	PVSAVKPTVAPPLAE CCCCCCCCCCCCCCC	24.47	20068231
217	Ubiquitination	LAEPGAGKGLRSEHR CCCCCCCCCCCHHHH	54.99	21890473
221	Acetylation	GAGKGLRSEHREKMN CCCCCCCHHHHHHHH	42.68	-
221	Ubiquitination	GAGKGLRSEHREKMN CCCCCCCHHHHHHHH	42.68	-
221	Phosphorylation	GAGKGLRSEHREKMN CCCCCCCHHHHHHHH	42.68	20068231
267	Succinylation	QEMRARHKEAFLKKH HHHHHHHHHHHHHHH	45.22	27452117
267	Ubiquitination	QEMRARHKEAFLKKH HHHHHHHHHHHHHHH	45.22	-
267	2-Hydroxyisobutyrylation	QEMRARHKEAFLKKH HHHHHHHHHHHHHHH	45.22	-
267	Malonylation	QEMRARHKEAFLKKH HHHHHHHHHHHHHHH	45.22	26320211
267	Ubiquitination	QEMRARHKEAFLKKH HHHHHHHHHHHHHHH	45.22	19608861
267	Acetylation	QEMRARHKEAFLKKH HHHHHHHHHHHHHHH	45.22	19608861
272	Acetylation	RHKEAFLKKHNLKLG HHHHHHHHHHCCCHH	45.60	19608861
273	Acetylation	HKEAFLKKHNLKLGF HHHHHHHHHCCCHHH	39.61	2402213
277	Ubiquitination	FLKKHNLKLGFMSAF HHHHHCCCHHHHHHH	52.46	-
277	Acetylation	FLKKHNLKLGFMSAF HHHHHCCCHHHHHHH	52.46	23954790
277	Malonylation	FLKKHNLKLGFMSAF HHHHHCCCHHHHHHH	52.46	26320211
282	Phosphorylation	NLKLGFMSAFVKASA CCCHHHHHHHHHHHH	19.12	-
307	Ubiquitination	AVIDDTTKEVVYRDY EEECCCCCEEEEECC	51.08	21906983
307	Acetylation	AVIDDTTKEVVYRDY EEECCCCCEEEEECC	51.08	23236377
323	Phosphorylation	DISVAVATPRGLVVP CEEEEEECCCCEEEE	13.61	-
338	Sulfoxidation	VIRNVEAMNFADIER EECCHHHCCHHHHHH	2.41	21406390
353	Ubiquitination	TITELGEKARKNELA HHHHHHHHHHHCCCE	52.25	21906983
437	Methylation	REAVTFLRKIKAAVE HHHHHHHHHHHHHHC	34.17	-
440	2-Hydroxyisobutyrylation	VTFLRKIKAAVEDPR HHHHHHHHHHHCCCC	33.07	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ODO2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ODO2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ODO2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DLG5_HUMAN	DLG5	physical	16169070
PROF2_HUMAN	PFN2	physical	16169070
ZHX1_HUMAN	ZHX1	physical	16169070
ZBT16_HUMAN	ZBTB16	physical	16169070
SIAH2_HUMAN	SIAH2	physical	15466852
RM39_HUMAN	MRPL39	physical	22939629
RM40_HUMAN	MRPL40	physical	22939629
RM15_HUMAN	MRPL15	physical	22939629
RM49_HUMAN	MRPL49	physical	22939629
ODB2_HUMAN	DBT	physical	26344197
STML2_HUMAN	STOML2	physical	26344197
FLOT1_HUMAN	FLOT1	physical	29128334
SQSTM_HUMAN	SQSTM1	physical	29128334
CHTOP_HUMAN	CHTOP	physical	29128334
NOP10_HUMAN	NOP10	physical	29128334
P53_HUMAN	TP53	physical	29128334
PPIA_HUMAN	PPIA	physical	29128334
FLOT2_HUMAN	FLOT2	physical	29128334
PROF1_HUMAN	PFN1	physical	29128334
KCRB_HUMAN	CKB	physical	29128334
CKAP4_HUMAN	CKAP4	physical	29128334
TOP1_HUMAN	TOP1	physical	29128334
NHP2_HUMAN	NHP2	physical	29128334
H2AV_HUMAN	H2AFV	physical	29128334
DHB4_HUMAN	HSD17B4	physical	29128334
PDIA3_HUMAN	PDIA3	physical	29128334
DDX23_HUMAN	DDX23	physical	29128334
RBM8A_HUMAN	RBM8A	physical	29128334
SAP18_HUMAN	SAP18	physical	29128334
NOP58_HUMAN	NOP58	physical	29128334
H1X_HUMAN	H1FX	physical	29128334
FBRL_HUMAN	FBL	physical	29128334
NOP56_HUMAN	NOP56	physical	29128334
ATPG_HUMAN	ATP5C1	physical	29128334
CHM4B_HUMAN	CHMP4B	physical	29128334
SFXN1_HUMAN	SFXN1	physical	29128334
ENPL_HUMAN	HSP90B1	physical	29128334
1433E_HUMAN	YWHAE	physical	29128334
DKC1_HUMAN	DKC1	physical	29128334
SERPH_HUMAN	SERPINH1	physical	29128334
H10_HUMAN	H1F0	physical	29128334
MIC19_HUMAN	CHCHD3	physical	29128334
TAGL2_HUMAN	TAGLN2	physical	29128334
RAB1B_HUMAN	RAB1B	physical	29128334
MDHM_HUMAN	MDH2	physical	29128334
LMNA_HUMAN	LMNA	physical	29128334
RAB5C_HUMAN	RAB5C	physical	29128334
TCPB_HUMAN	CCT2	physical	29128334
LMNB1_HUMAN	LMNB1	physical	29128334
MIC60_HUMAN	IMMT	physical	29128334
CAAP1_HUMAN	CAAP1	physical	29128334
NH2L1_HUMAN	NHP2L1	physical	29128334
DESM_HUMAN	DES	physical	29128334
H2A1D_HUMAN	HIST1H2AD	physical	29128334
HCD2_HUMAN	HSD17B10	physical	29128334
PDIA6_HUMAN	PDIA6	physical	29128334
ATD3A_HUMAN	ATAD3A	physical	29128334
RA1L2_HUMAN	HNRNPA1L2	physical	29128334
RAP1A_HUMAN	RAP1A	physical	29128334
ANXA2_HUMAN	ANXA2	physical	29128334
RMXL2_HUMAN	RBMXL2	physical	29128334
CDK1_HUMAN	CDK1	physical	29128334
RM12_HUMAN	MRPL12	physical	29128334
PGAM1_HUMAN	PGAM1	physical	29128334
EMD_HUMAN	EMD	physical	29128334
STML2_HUMAN	STOML2	physical	29128334
PININ_HUMAN	PNN	physical	29128334
RAB1A_HUMAN	RAB1A	physical	29128334
IF5A1_HUMAN	EIF5A	physical	29128334
RAB7A_HUMAN	RAB7A	physical	29128334
BAG2_HUMAN	BAG2	physical	29128334
UBA1_HUMAN	UBA1	physical	29128334
H2AY_HUMAN	H2AFY	physical	29128334
EF2_HUMAN	EEF2	physical	29128334
HMGA2_HUMAN	HMGA2	physical	29128334
ACOT9_HUMAN	ACOT9	physical	29128334
CHM2A_HUMAN	CHMP2A	physical	29128334
UCHL1_HUMAN	UCHL1	physical	29128334
RL30_HUMAN	RPL30	physical	29128334
TOP2A_HUMAN	TOP2A	physical	29128334
ODPB_HUMAN	PDHB	physical	29128334
MYH14_HUMAN	MYH14	physical	29128334
PR38A_HUMAN	PRPF38A	physical	29128334
SF3B6_HUMAN	SF3B6	physical	29128334
NTPCR_HUMAN	NTPCR	physical	29128334
ETFB_HUMAN	ETFB	physical	29128334
RHOA_HUMAN	RHOA	physical	29128334
RT11_HUMAN	MRPS11	physical	29128334
MYL1_HUMAN	MYL1	physical	29128334
RT17_HUMAN	MRPS17	physical	29128334
RANG_HUMAN	RANBP1	physical	29128334
PERI_HUMAN	PRPH	physical	29128334
HSPB1_HUMAN	HSPB1	physical	29128334
GSTP1_HUMAN	GSTP1	physical	29128334
EF1D_HUMAN	EEF1D	physical	29128334
TPIS_HUMAN	TPI1	physical	29128334
1A02_HUMAN	HLA-A	physical	29128334
1A03_HUMAN	HLA-A	physical	29128334
1A01_HUMAN	HLA-A	physical	29128334
1A26_HUMAN	HLA-A	physical	29128334
IMDH2_HUMAN	IMPDH2	physical	29128334
VDAC2_HUMAN	VDAC2	physical	29128334
ADT2_HUMAN	SLC25A5	physical	29128334
QCR2_HUMAN	UQCRC2	physical	29128334
PIMT_HUMAN	PCMT1	physical	29128334
TAXB1_HUMAN	TAX1BP1	physical	29128334
HP1B3_HUMAN	HP1BP3	physical	29128334
MYO6_HUMAN	MYO6	physical	29128334
1433T_HUMAN	YWHAQ	physical	29128334
1433Z_HUMAN	YWHAZ	physical	29128334
PAL4A_HUMAN	PPIAL4B	physical	29128334
FSCN1_HUMAN	FSCN1	physical	29128334
TIF1B_HUMAN	TRIM28	physical	29128334
LDHB_HUMAN	LDHB	physical	29128334
PRP19_HUMAN	PRPF19	physical	29128334
PRDX3_HUMAN	PRDX3	physical	29128334
HNRH3_HUMAN	HNRNPH3	physical	29128334
DREB_HUMAN	DBN1	physical	29128334
DESP_HUMAN	DSP	physical	29128334
ADT3_HUMAN	SLC25A6	physical	29128334
SND1_HUMAN	SND1	physical	29128334
RPN1_HUMAN	RPN1	physical	29128334
RNPS1_HUMAN	RNPS1	physical	29128334
PRS6B_HUMAN	PSMC4	physical	29128334
ATPO_HUMAN	ATP5O	physical	29128334
P5CR2_HUMAN	PYCR2	physical	29128334
RAB5A_HUMAN	RAB5A	physical	29128334
TCPH_HUMAN	CCT7	physical	29128334
EF1G_HUMAN	EEF1G	physical	29128334
MYO1D_HUMAN	MYO1D	physical	29128334
PLEC_HUMAN	PLEC	physical	29128334
AP3D1_HUMAN	AP3D1	physical	29128334
TRAP1_HUMAN	TRAP1	physical	29128334
CALX_HUMAN	CANX	physical	29128334
RABL6_HUMAN	RABL6	physical	29128334
XRCC6_HUMAN	XRCC6	physical	29128334
1433G_HUMAN	YWHAG	physical	29128334
AINX_HUMAN	INA	physical	29128334
IMB1_HUMAN	KPNB1	physical	29128334
MYO1B_HUMAN	MYO1B	physical	29128334
RT14_HUMAN	MRPS14	physical	29128334
NP1L1_HUMAN	NAP1L1	physical	29128334
MYH11_HUMAN	MYH11	physical	29128334
AK17A_HUMAN	AKAP17A	physical	29128334
TOM22_HUMAN	TOMM22	physical	29128334
THIL_HUMAN	ACAT1	physical	29128334
CAZA2_HUMAN	CAPZA2	physical	29128334
PDC6I_HUMAN	PDCD6IP	physical	29128334
MLEC_HUMAN	MLEC	physical	29128334
OAT_HUMAN	OAT	physical	29128334
RM02_HUMAN	MRPL2	physical	29128334
TECR_HUMAN	TECR	physical	29128334
GELS_HUMAN	GSN	physical	29128334
COR1C_HUMAN	CORO1C	physical	29128334
SFSWA_HUMAN	SFSWAP	physical	29128334
TR150_HUMAN	THRAP3	physical	29128334
SFXN3_HUMAN	SFXN3	physical	29128334
RM49_HUMAN	MRPL49	physical	29128334
CHRD1_HUMAN	CHORDC1	physical	29128334
FAS_HUMAN	FASN	physical	29128334
LAP2A_HUMAN	TMPO	physical	29128334
LAP2B_HUMAN	TMPO	physical	29128334
COPZ1_HUMAN	COPZ1	physical	29128334
RBM4_HUMAN	RBM4	physical	29128334
SAFB1_HUMAN	SAFB	physical	29128334
LUC7L_HUMAN	LUC7L	physical	29128334
KINH_HUMAN	KIF5B	physical	29128334
2AAA_HUMAN	PPP2R1A	physical	29128334
TAP1_HUMAN	TAP1	physical	29128334
DHX8_HUMAN	DHX8	physical	29128334
RPN2_HUMAN	RPN2	physical	29128334
PUR6_HUMAN	PAICS	physical	29128334
ODP2_HUMAN	DLAT	physical	29128334
GAR1_HUMAN	GAR1	physical	29128334
ENOB_HUMAN	ENO3	physical	29128334
THOC1_HUMAN	THOC1	physical	29128334
CWC15_HUMAN	CWC15	physical	29128334
KNOP1_HUMAN	KNOP1	physical	29128334
RRBP1_HUMAN	RRBP1	physical	29128334
PRP6_HUMAN	PRPF6	physical	29128334
TPM4_HUMAN	TPM4	physical	29128334
SYEP_HUMAN	EPRS	physical	29128334
PLRG1_HUMAN	PLRG1	physical	29128334
RAD50_HUMAN	RAD50	physical	29128334
SMCA5_HUMAN	SMARCA5	physical	29128334
ACINU_HUMAN	ACIN1	physical	29128334
GNL3_HUMAN	GNL3	physical	29128334
PHRF1_HUMAN	PHRF1	physical	29128334
ZN512_HUMAN	ZNF512	physical	29128334
TPM1_HUMAN	TPM1	physical	29128334
RALYL_HUMAN	RALYL	physical	29128334
MAGD2_HUMAN	MAGED2	physical	29128334
LBR_HUMAN	LBR	physical	29128334
SRP68_HUMAN	SRP68	physical	29128334
FMR1_HUMAN	FMR1	physical	29128334
EFTS_HUMAN	TSFM	physical	29128334
BRD7_HUMAN	BRD7	physical	29128334
SYAM_HUMAN	AARS2	physical	29128334
MY18A_HUMAN	MYO18A	physical	29128334
NEUL_HUMAN	NLN	physical	29128334
H2AW_HUMAN	H2AFY2	physical	29128334
SNF5_HUMAN	SMARCB1	physical	29128334
ILF2_HUMAN	ILF2	physical	29128334
DDX21_HUMAN	DDX21	physical	29128334
CING_HUMAN	CGN	physical	29128334
IF4G1_HUMAN	EIF4G1	physical	29128334
IF4A3_HUMAN	EIF4A3	physical	29128334
ATD3C_HUMAN	ATAD3C	physical	29128334
HSDL2_HUMAN	HSDL2	physical	29128334
ACL6A_HUMAN	ACTL6A	physical	29128334
PRS4_HUMAN	PSMC1	physical	29128334
HYOU1_HUMAN	HYOU1	physical	29128334
AT2A1_HUMAN	ATP2A1	physical	29128334
SYDC_HUMAN	DARS	physical	29128334
PUR2_HUMAN	GART	physical	29128334
E2AK2_HUMAN	EIF2AK2	physical	29128334
DSG2_HUMAN	DSG2	physical	29128334
NCOA5_HUMAN	NCOA5	physical	29128334
RAGP1_HUMAN	RANGAP1	physical	29128334
LMNB2_HUMAN	LMNB2	physical	29128334
PABP1_HUMAN	PABPC1	physical	29128334
PICAL_HUMAN	PICALM	physical	29128334
TTBK1_HUMAN	TTBK1	physical	29128334
DYHC1_HUMAN	DYNC1H1	physical	29128334
MTA2_HUMAN	MTA2	physical	29128334
CMC2_HUMAN	SLC25A13	physical	29128334
MTA1_HUMAN	MTA1	physical	29128334
YTDC1_HUMAN	YTHDC1	physical	29128334
TAF5_HUMAN	TAF5	physical	29128334
NOC3L_HUMAN	NOC3L	physical	29128334
MCM3_HUMAN	MCM3	physical	29128334
TOP2B_HUMAN	TOP2B	physical	29128334
NUP93_HUMAN	NUP93	physical	29128334
CRNL1_HUMAN	CRNKL1	physical	29128334
ZO1_HUMAN	TJP1	physical	29128334
SYMC_HUMAN	MARS	physical	29128334
CCD80_HUMAN	CCDC80	physical	29128334
BPTF_HUMAN	BPTF	physical	29128334
MDC1_HUMAN	MDC1	physical	29128334
MYO1C_HUMAN	MYO1C	physical	29128334
HPS5_HUMAN	HPS5	physical	29128334
TNR6C_HUMAN	TNRC6C	physical	29128334
H2A1B_HUMAN	HIST1H2AE	physical	29128334
HBA_HUMAN	HBA1	physical	29128334
BOLA2_HUMAN	BOLA2	physical	29128334

Drug and Disease Associations

Kegg Disease
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ODO2_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-267, AND MASS SPECTROMETRY.	19608861 [Abstract]