TTBK1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TTBK1_HUMAN
• UniProt AC: Q5TCY1
• Protein Name: Tau-tubulin kinase 1
• Gene Name: TTBK1
• Organism: Homo sapiens (Human).
• Sequence Length: 1321
• Subcellular Localization: Cytoplasm .
• Protein Description: Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU..
• Protein Sequence: MQCLAAALKDETNMSGGGEQADILPANYVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEKYEHRMLLKHMPSEFHLFLDHIASLDYFTKPDYQLIMSVFENSMKERGIAENEAFDWEKAGTDALLSTSTSTPPQQNTRQTAAMFGVVNVTPVPGDLLRENTEDVLQGEHLSDQENAPPILPGRPSEGLGPSPHLVPHPGGPEAEVWEETDVNRNKLRINIGKSPCVEEEQSRGMGVPSSPVRAPPDSPTTPVRSLRYRRVNSPESERLSTADGRVELPERRSRMDLPGSPSRQACSSQPAQMLSVDTGHADRQASGRMDVSASVEQEALSNAFRSVPLAEEEDFDSKEWVIIDKETELKDFPPGAEPSTSGTTDEEPEELRPLPEEGEERRRLGAEPTVRPRGRSMQALAEEDLQHLPPQPLPPQLSQGDGRSETSQPPTPGSPSHSPLHSGPRPRRRESDPTGPQRQVFSVAPPFEVNGLPRAVPLSLPYQDFKRDLSDYRERARLLNRVRRVGFSHMLLTTPQVPLAPVQPQANGKEEEEEEEEDEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEAAAAVALGEVLGPRSGSSSEGSERSTDRSQEGAPSTLLADDQKESRGRASMADGDLEPEEGSKTLVLVSPGDMKKSPVTAELAPDPDLGTLAALTPQHERPQPTGSQLDVSEPGTLSSVLKSEPKPPGPGAGLGAGTVTTGVGGVAVTSSPFTKVERTFVHIAEKTHLNVMSSGGQALRSEEFSAGGELGLELASDGGAVEEGARAPLENGLALSGLNGAEIEGSALSGAPRETPSEMATNSLPNGPALADGPAPVSPLEPSPEKVATISPRRHAMPGSRPRSRIPVLLSEEDTGSEPSGSLSAKERWSKRARPQQDLARLVMEKRQGRLLLRLASGASSSSSEEQRRASETLSGTGSEEDTPASEPAAALPRKSGRAAATRSRIPRPIGLRMPMPVAAQQPASRSHGAAPALDTAITSRLQLQTPPGSATAADLRPKQPPGRGLGPGRAQAGARPPAPRSPRLPASTSAARNASASPRSQSLSRRESPSPSHQARPGVPPPRGVPPARAQPDGTPSPGGSKKGPRGKLQAQRATTKGRAGGAEGRAGAR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	AAALKDETNMSGGGE HHHHHCCCCCCCCCC	46.48	-
75	Acetylation	QQPKQVLKMEVAVLK CCHHHHHHHHHHHHH	33.87	7678573
83	Sumoylation	MEVAVLKKLQGKDHV HHHHHHHHHCCCCCE	41.71	-
83	Sumoylation	MEVAVLKKLQGKDHV HHHHHHHHHCCCCCE	41.71	-
169	Phosphorylation	MGRLPSTYRKCYMLD CCCCCCHHHHHHHHH	16.65	-
224	Phosphorylation	GRHDDLWSLFYMLVE CCCHHHHHHHHHHHH	18.85	-
227	Phosphorylation	DDLWSLFYMLVEFAV HHHHHHHHHHHHHHH	8.54	22210691
296	Phosphorylation	IMSVFENSMKERGIA HHHHHHHHHHHCCCC	24.84	27050516
320	Phosphorylation	AGTDALLSTSTSTPP HCCCEEECCCCCCCC	22.59	27732954
321	Phosphorylation	GTDALLSTSTSTPPQ CCCEEECCCCCCCCC	35.67	27732954
322	Phosphorylation	TDALLSTSTSTPPQQ CCEEECCCCCCCCCC	19.58	27732954
323	Phosphorylation	DALLSTSTSTPPQQN CEEECCCCCCCCCCC	36.39	27732954
324	Phosphorylation	ALLSTSTSTPPQQNT EEECCCCCCCCCCCH	38.39	27732954
325	Phosphorylation	LLSTSTSTPPQQNTR EECCCCCCCCCCCHH	38.79	27732954
331	Phosphorylation	STPPQQNTRQTAAMF CCCCCCCHHHHHHEE	21.59	27732954
344	Phosphorylation	MFGVVNVTPVPGDLL EECEEEECCCCCHHH	17.23	27732954
355	Phosphorylation	GDLLRENTEDVLQGE CHHHHCCHHHHHCCC	28.89	27732954
365	Phosphorylation	VLQGEHLSDQENAPP HHCCCCCCCCCCCCC	38.87	27732954
432	Phosphorylation	SRGMGVPSSPVRAPP HCCCCCCCCCCCCCC	44.88	27732954
433	Phosphorylation	RGMGVPSSPVRAPPD CCCCCCCCCCCCCCC	22.73	27732954
441	Phosphorylation	PVRAPPDSPTTPVRS CCCCCCCCCCCCCCC	29.89	25307156
443	Phosphorylation	RAPPDSPTTPVRSLR CCCCCCCCCCCCCCC	47.92	27732954
444	Phosphorylation	APPDSPTTPVRSLRY CCCCCCCCCCCCCCE	24.14	27732954
448	Phosphorylation	SPTTPVRSLRYRRVN CCCCCCCCCCEEECC	19.89	25921289
456	Phosphorylation	LRYRRVNSPESERLS CCEEECCCCHHHCCC	27.47	25884760
459	Phosphorylation	RRVNSPESERLSTAD EECCCCHHHCCCCCC	31.25	26657352
463	Phosphorylation	SPESERLSTADGRVE CCHHHCCCCCCCCCC	27.98	25884760
464	Phosphorylation	PESERLSTADGRVEL CHHHCCCCCCCCCCC	33.10	25884760
476	Phosphorylation	VELPERRSRMDLPGS CCCCHHHCCCCCCCC	37.87	27732954
483	Phosphorylation	SRMDLPGSPSRQACS CCCCCCCCCCHHHHH	20.12	27732954
485	Phosphorylation	MDLPGSPSRQACSSQ CCCCCCCCHHHHHCC	38.43	27732954
490	Phosphorylation	SPSRQACSSQPAQML CCCHHHHHCCCCEEE	34.72	27732954
491	Phosphorylation	PSRQACSSQPAQMLS CCHHHHHCCCCEEEE	39.81	27732954
498	Phosphorylation	SQPAQMLSVDTGHAD CCCCEEEECCCCCCC	16.77	22210691
501	Phosphorylation	AQMLSVDTGHADRQA CEEEECCCCCCCHHC	28.81	27732954
515	Phosphorylation	ASGRMDVSASVEQEA CCCCCCCCHHHHHHH	15.57	27732954
517	Phosphorylation	GRMDVSASVEQEALS CCCCCCHHHHHHHHH	20.76	27732954
524	Phosphorylation	SVEQEALSNAFRSVP HHHHHHHHHHHHCCC	32.91	27732954
529	Phosphorylation	ALSNAFRSVPLAEEE HHHHHHHCCCCCCCC	22.95	27732954
540	Phosphorylation	AEEEDFDSKEWVIID CCCCCCCCCCEEEEE	32.25	27732954
627	Phosphorylation	LSQGDGRSETSQPPT CCCCCCCCCCCCCCC	51.24	27732954
629	Phosphorylation	QGDGRSETSQPPTPG CCCCCCCCCCCCCCC	33.63	27732954
630	Phosphorylation	GDGRSETSQPPTPGS CCCCCCCCCCCCCCC	36.32	27732954
634	Phosphorylation	SETSQPPTPGSPSHS CCCCCCCCCCCCCCC	47.14	27732954
637	Phosphorylation	SQPPTPGSPSHSPLH CCCCCCCCCCCCCCC	25.16	27732954
639	Phosphorylation	PPTPGSPSHSPLHSG CCCCCCCCCCCCCCC	37.99	27732954
641	Phosphorylation	TPGSPSHSPLHSGPR CCCCCCCCCCCCCCC	33.23	27732954
645	Phosphorylation	PSHSPLHSGPRPRRR CCCCCCCCCCCCCCC	59.17	27732954
693	Phosphorylation	QDFKRDLSDYRERAR HHHCCCCHHHHHHHH	36.56	-
695	Phosphorylation	FKRDLSDYRERARLL HCCCCHHHHHHHHHH	15.82	-
711	Phosphorylation	RVRRVGFSHMLLTTP HHHHHCCCEEEECCC	11.32	27174698
716	Phosphorylation	GFSHMLLTTPQVPLA CCCEEEECCCCCCCC	32.25	27174698
717	Phosphorylation	FSHMLLTTPQVPLAP CCEEEECCCCCCCCC	16.22	27174698
786	Phosphorylation	GEVLGPRSGSSSEGS HHHHCCCCCCCCCCC	46.27	26074081
788	Phosphorylation	VLGPRSGSSSEGSER HHCCCCCCCCCCCCC	31.75	26074081
789	Phosphorylation	LGPRSGSSSEGSERS HCCCCCCCCCCCCCC	35.61	26074081
790	Phosphorylation	GPRSGSSSEGSERST CCCCCCCCCCCCCCC	47.91	23403867
793	Phosphorylation	SGSSSEGSERSTDRS CCCCCCCCCCCCCCC	26.28	26074081
797	Phosphorylation	SEGSERSTDRSQEGA CCCCCCCCCCCCCCC	41.47	25307156
821	Phosphorylation	KESRGRASMADGDLE HHHCCCCCCCCCCCC	17.09	27732954
835	Phosphorylation	EPEEGSKTLVLVSPG CCCCCCEEEEEECCC	24.64	25332170
840	Phosphorylation	SKTLVLVSPGDMKKS CEEEEEECCCCCCCC	21.00	27732954
847	Phosphorylation	SPGDMKKSPVTAELA CCCCCCCCCCCCCCC	21.05	27732954
850	Phosphorylation	DMKKSPVTAELAPDP CCCCCCCCCCCCCCC	20.14	27732954
943	Phosphorylation	KTHLNVMSSGGQALR HCCEEEECCCCCCCC	22.88	-
944	Phosphorylation	THLNVMSSGGQALRS CCEEEECCCCCCCCC	28.93	-
999	Phosphorylation	EIEGSALSGAPRETP EEECCHHCCCCCCCH	32.40	24719451
1041	Phosphorylation	PEKVATISPRRHAMP HHHCEEECCCCCCCC	14.17	29396449
1121	Phosphorylation	SEEQRRASETLSGTG HHHHHHHHHHHCCCC	29.33	27732954
1123	Phosphorylation	EQRRASETLSGTGSE HHHHHHHHHCCCCCC	24.59	27732954
1125	Phosphorylation	RRASETLSGTGSEED HHHHHHHCCCCCCCC	41.55	27732954
1127	Phosphorylation	ASETLSGTGSEEDTP HHHHHCCCCCCCCCC	33.87	27732954
1129	Phosphorylation	ETLSGTGSEEDTPAS HHHCCCCCCCCCCCC	37.34	27732954
1133	Phosphorylation	GTGSEEDTPASEPAA CCCCCCCCCCCCCCC	24.84	27732954
1136	Phosphorylation	SEEDTPASEPAAALP CCCCCCCCCCCCCCC	45.37	27732954
1152	Phosphorylation	KSGRAAATRSRIPRP CCCCCHHHHCCCCCC	25.17	-
1200	Phosphorylation	QLQTPPGSATAADLR ECCCCCCCCCHHHCC	28.37	-
1202	Phosphorylation	QTPPGSATAADLRPK CCCCCCCCHHHCCCC	24.87	-
1232	Phosphorylation	ARPPAPRSPRLPAST CCCCCCCCCCCCCCH	17.20	24117733
1238	Phosphorylation	RSPRLPASTSAARNA CCCCCCCCHHHHHHC	22.43	27732954
1239	Phosphorylation	SPRLPASTSAARNAS CCCCCCCHHHHHHCC	25.21	27732954
1240	Phosphorylation	PRLPASTSAARNASA CCCCCCHHHHHHCCC	19.89	27732954
1246	Phosphorylation	TSAARNASASPRSQS HHHHHHCCCCCCHHC	32.59	22817900
1248	Phosphorylation	AARNASASPRSQSLS HHHHCCCCCCHHCCC	20.53	22817900
1253	Phosphorylation	SASPRSQSLSRRESP CCCCCHHCCCCCCCC	29.56	22817900
1259	Phosphorylation	QSLSRRESPSPSHQA HCCCCCCCCCCCCCC	28.94	27732954
1261	Phosphorylation	LSRRESPSPSHQARP CCCCCCCCCCCCCCC	48.60	27732954
1263	Phosphorylation	RRESPSPSHQARPGV CCCCCCCCCCCCCCC	32.35	27732954

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TTBK1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TTBK1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TTBK1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TTBK2_HUMAN	TTBK2	physical	17353931
NU205_HUMAN	NUP205	physical	17353931
GBRL2_HUMAN	GABARAPL2	physical	17353931
HEAT1_HUMAN	HEATR1	physical	17353931

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.