dbPTM

TTBK2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TTBK2_HUMAN
UniProt AC	Q6IQ55
Protein Name	Tau-tubulin kinase 2
Gene Name	TTBK2
Organism	Homo sapiens (Human).
Sequence Length	1244
Subcellular Localization	Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytosol. Nucleus. Localizes to the transition zone in primary cilia in response to cell cyc
Protein Description	Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro..
Protein Sequence	MSGGGEQLDILSVGILVKERWKVLRKIGGGGFGEIYDALDMLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHVCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTTLRLGRQILESIESIHSVGFLHRDIKPSNFAMGRFPSTCRKCYMLDFGLARQFTNSCGDVRPPRAVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVVGQLPWRKIKDKEQVGSIKERYDHRLMLKHLPPEFSIFLDHISSLDYFTKPDYQLLTSVFDNSIKTFGVIESDPFDWEKTGNDGSLTTTTTSTTPQLHTRLTPAAIGIANATPIPGDLLRENTDEVFPDEQLSDGENGIPVGVSPDKLPGSLGHPRPQEKDVWEEMDANKNKIKLGICKAATEEENSHGQANGLLNAPSLGSPIRVRSEITQPDRDIPLVRKLRSIHSFELEKRLTLEPKPDTDKFLETCLEKMQKDTSAGKESILPALLHKPCVPAVSRTDHIWHYDEEYLPDASKPASANTPEQADGGGSNGFIAVNLSSCKQEIDSKEWVIVDKEQDLQDFRTNEAVGHKTTGSPSDEEPEVLQVLEASPQDEKLQLGPWAENDHLKKETSGVVLALSAEGPPTAASEQYTDRLELQPGAASQFIAATPTSLMEAQAEGPLTAITIPRPSVASTQSTSGSFHCGQQPEKKDLQPMEPTVELYSPRENFSGLVVTEGEPPSGGSRTDLGLQIDHIGHDMLPNIRESNKSQDLGPKELPDHNRLVVREFENLPGETEEKSILLESDNEDEKLSRGQHCIEISSLPGDLVIVEKDHSATTEPLDVTKTQTFSVVPNQDKNNEIMKLLTVGTSEISSRDIDPHVEGQIGQVAEMQKNKISKDDDIMSEDLPGHQGDLSTFLHQEGKREKITPRNGELFHCVSENEHGAPTRKDMVRSSFVTRHSRIPVLAQEIDSTLESSSPVSAKEKLLQKKAYQPDLVKLLVEKRQFKSFLGDLSSASDKLLEEKLATVPAPFCEEEVLTPFSRLTVDSHLSRSAEDSFLSPIISQSRKSKIPRPVSWVNTDQVNSSTSSQFFPRPPPGKPPTRPGVEARLRRYKVLGSSNSDSDLFSRLAQILQNGSQKPRSTTQCKSPGSPHNPKTPPKSPVVPRRSPSASPRSSSLPRTSSSSPSRAGRPHHDQRSSSPHLGRSKSPPSHSGSSSSRRSCQQEHCKPSKNGLKGSGSLHHHSASTKTPQGKSKPASKLSR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSGGGEQLD ------CCCCCCCCE	58.40	24043423
12	Phosphorylation	GEQLDILSVGILVKE CCCCEEEEEEHHHHH	20.73	24043423
70	Sumoylation	MEVAVLKKLQGKDHV HHHHHHHHHCCCCCE	41.71	-
70	Sumoylation	MEVAVLKKLQGKDHV HHHHHHHHHCCCCCE	41.71	-
109	Phosphorylation	ADLRRSQSRGTFTIS HHHHHHHCCCCEEEH	33.64	24043423
112	Phosphorylation	RRSQSRGTFTISTTL HHHHCCCCEEEHHHH	19.25	24043423
114	Phosphorylation	SQSRGTFTISTTLRL HHCCCCEEEHHHHHH	17.54	24043423
116	Phosphorylation	SRGTFTISTTLRLGR CCCCEEEHHHHHHHH	16.57	24043423
117	Phosphorylation	RGTFTISTTLRLGRQ CCCEEEHHHHHHHHH	26.46	24043423
118	Phosphorylation	GTFTISTTLRLGRQI CCEEEHHHHHHHHHH	11.77	24043423
211	Phosphorylation	GRHDDLWSLFYMLVE CCCHHHHHHHHHHHH	18.85	-
242	Phosphorylation	VGSIKERYDHRLMLK HCCHHHHHCHHHHHH	19.72	-
305	Phosphorylation	EKTGNDGSLTTTTTS HHCCCCCCCEEEECC	25.96	27732954
307	Phosphorylation	TGNDGSLTTTTTSTT CCCCCCCEEEECCCC	24.64	27732954
308	Phosphorylation	GNDGSLTTTTTSTTP CCCCCCEEEECCCCC	27.69	27732954
309	Phosphorylation	NDGSLTTTTTSTTPQ CCCCCEEEECCCCCC	23.88	27732954
310	Phosphorylation	DGSLTTTTTSTTPQL CCCCEEEECCCCCCC	19.36	27732954
311	Phosphorylation	GSLTTTTTSTTPQLH CCCEEEECCCCCCCC	23.22	27732954
312	Phosphorylation	SLTTTTTSTTPQLHT CCEEEECCCCCCCCC	28.35	27732954
313	Phosphorylation	LTTTTTSTTPQLHTR CEEEECCCCCCCCCC	40.16	27732954
314	Phosphorylation	TTTTTSTTPQLHTRL EEEECCCCCCCCCCC	14.59	28985074
319	Phosphorylation	STTPQLHTRLTPAAI CCCCCCCCCCCHHHH	35.65	27732954
322	Phosphorylation	PQLHTRLTPAAIGIA CCCCCCCCHHHHCCC	13.95	27050516
332	Phosphorylation	AIGIANATPIPGDLL HHCCCCCCCCCCCHH	22.89	27080861
371	Phosphorylation	SPDKLPGSLGHPRPQ CCCCCCCCCCCCCCC	29.28	25159151
402	Phosphorylation	LGICKAATEEENSHG EEEEHHHCCCCCCCC	49.11	25850435
407	Phosphorylation	AATEEENSHGQANGL HHCCCCCCCCCCCCC	32.07	25850435
419	Phosphorylation	NGLLNAPSLGSPIRV CCCCCCCCCCCCEEE	42.84	25921289
422	Phosphorylation	LNAPSLGSPIRVRSE CCCCCCCCCEEEECC	23.58	25921289
428	Phosphorylation	GSPIRVRSEITQPDR CCCEEEECCCCCCCC	30.41	25850435
431	Phosphorylation	IRVRSEITQPDRDIP EEEECCCCCCCCCCH	29.96	25850435
445	Phosphorylation	PLVRKLRSIHSFELE HHHHHHHCCCCEEEE	34.78	23401153
448	Phosphorylation	RKLRSIHSFELEKRL HHHHCCCCEEEECCE	20.81	25159151
463	Phosphorylation	TLEPKPDTDKFLETC ECCCCCCHHHHHHHH	50.01	-
476	Ubiquitination	TCLEKMQKDTSAGKE HHHHHHHHCCCCCHH	60.52	-
478	Phosphorylation	LEKMQKDTSAGKESI HHHHHHCCCCCHHCH	27.75	28450419
479	Phosphorylation	EKMQKDTSAGKESIL HHHHHCCCCCHHCHH	45.20	28450419
484	Phosphorylation	DTSAGKESILPALLH CCCCCHHCHHHHHHC	32.67	28450419
499	Phosphorylation	KPCVPAVSRTDHIWH CCCCCCCCCCCCEEE	31.41	20068231
574	Phosphorylation	NEAVGHKTTGSPSDE CCCCCCCCCCCCCCC	30.62	27732954
575	Phosphorylation	EAVGHKTTGSPSDEE CCCCCCCCCCCCCCC	40.23	27732954
577	Phosphorylation	VGHKTTGSPSDEEPE CCCCCCCCCCCCCCH	21.09	27732954
579	Phosphorylation	HKTTGSPSDEEPEVL CCCCCCCCCCCCHHH	60.39	27732954
592	Phosphorylation	VLQVLEASPQDEKLQ HHHHHHCCCCCCCCC	17.45	27732954
613	Phosphorylation	NDHLKKETSGVVLAL CHHCCCCCCCEEEEE	39.39	22468782
614	Phosphorylation	DHLKKETSGVVLALS HHCCCCCCCEEEEEE	30.59	-
621	Phosphorylation	SGVVLALSAEGPPTA CCEEEEEECCCCCCC	20.76	-
633	Phosphorylation	PTAASEQYTDRLELQ CCCCCHHHCCCEECC	13.42	22468782
668	Phosphorylation	EGPLTAITIPRPSVA CCCEEEEEECCCCCC	23.59	24719451
701	Phosphorylation	DLQPMEPTVELYSPR CCCCCCCEEEEECCC	17.20	22468782
706	Phosphorylation	EPTVELYSPRENFSG CCEEEEECCCCCCCC	30.06	28122231
751	Phosphorylation	NIRESNKSQDLGPKE CHHHCCCCCCCCCCC	32.93	-
777	Phosphorylation	FENLPGETEEKSILL ECCCCCCCCCEEEEE	56.19	27732954
781	Phosphorylation	PGETEEKSILLESDN CCCCCCEEEEEECCC	23.03	30576142
786	Phosphorylation	EKSILLESDNEDEKL CEEEEEECCCCCCCC	45.78	30266825
794	Phosphorylation	DNEDEKLSRGQHCIE CCCCCCCCCCCCEEE	45.49	25159151
817	Phosphorylation	VIVEKDHSATTEPLD EEEECCCCCCCCCCC	37.13	29255136
819	Phosphorylation	VEKDHSATTEPLDVT EECCCCCCCCCCCCC	34.41	29255136
820	O-linked_Glycosylation	EKDHSATTEPLDVTK ECCCCCCCCCCCCCC	35.01	OGP
820	Phosphorylation	EKDHSATTEPLDVTK ECCCCCCCCCCCCCC	35.01	28450419
828	Phosphorylation	EPLDVTKTQTFSVVP CCCCCCCCEEEEECC	24.39	-
830	Phosphorylation	LDVTKTQTFSVVPNQ CCCCCCEEEEECCCC	24.10	-
845	Acetylation	DKNNEIMKLLTVGTS CCCCCEEEHEEECCC	46.11	19828417
851	Phosphorylation	MKLLTVGTSEISSRD EEHEEECCCCCCCCC	20.89	27732954
852	Phosphorylation	KLLTVGTSEISSRDI EHEEECCCCCCCCCC	27.31	27732954
855	Phosphorylation	TVGTSEISSRDIDPH EECCCCCCCCCCCCC	18.44	27732954
856	Phosphorylation	VGTSEISSRDIDPHV ECCCCCCCCCCCCCC	39.37	27732954
877	Acetylation	VAEMQKNKISKDDDI HHHHHHCCCCCCCCH	56.23	19828425
879	Phosphorylation	EMQKNKISKDDDIMS HHHHCCCCCCCCHHC	31.48	-
936	Phosphorylation	TRKDMVRSSFVTRHS CHHHHHHHHHHCCCC	19.40	23322592
937	Phosphorylation	RKDMVRSSFVTRHSR HHHHHHHHHHCCCCC	17.11	23322592
940	Phosphorylation	MVRSSFVTRHSRIPV HHHHHHHCCCCCCCH	22.21	24719451
943	Phosphorylation	SSFVTRHSRIPVLAQ HHHHCCCCCCCHHHH	28.72	23322592
958	Phosphorylation	EIDSTLESSSPVSAK HHHHHCCCCCCCCHH	38.95	27732954
959	Phosphorylation	IDSTLESSSPVSAKE HHHHCCCCCCCCHHH	29.32	27732954
960	Phosphorylation	DSTLESSSPVSAKEK HHHCCCCCCCCHHHH	38.30	27732954
963	Phosphorylation	LESSSPVSAKEKLLQ CCCCCCCCHHHHHHH	36.69	27732954
985	Ubiquitination	LVKLLVEKRQFKSFL HHHHHHHHHHHHHHH	43.98	-
1035	Phosphorylation	VDSHLSRSAEDSFLS CCCHHHCCCCCCCHH	32.41	29083192
1039	Phosphorylation	LSRSAEDSFLSPIIS HHCCCCCCCHHHHHC	21.42	21712546
1042	Phosphorylation	SAEDSFLSPIISQSR CCCCCCHHHHHCCCC	16.43	21712546
1046	Phosphorylation	SFLSPIISQSRKSKI CCHHHHHCCCCCCCC	23.87	23403867
1048	Phosphorylation	LSPIISQSRKSKIPR HHHHHCCCCCCCCCC	34.58	23403867
1101	Phosphorylation	RYKVLGSSNSDSDLF HEEECCCCCCCHHHH	38.26	28857561
1103	Phosphorylation	KVLGSSNSDSDLFSR EECCCCCCCHHHHHH	40.20	21548880
1105	Phosphorylation	LGSSNSDSDLFSRLA CCCCCCCHHHHHHHH	35.71	27732954
1130	Phosphorylation	RSTTQCKSPGSPHNP CCCCCCCCCCCCCCC	41.96	27732954
1133	Phosphorylation	TQCKSPGSPHNPKTP CCCCCCCCCCCCCCC	26.77	27732954
1139	Phosphorylation	GSPHNPKTPPKSPVV CCCCCCCCCCCCCCC	46.19	20363803
1143	Phosphorylation	NPKTPPKSPVVPRRS CCCCCCCCCCCCCCC	28.80	20363803
1150	Phosphorylation	SPVVPRRSPSASPRS CCCCCCCCCCCCCCC	25.20	30266825
1152	Phosphorylation	VVPRRSPSASPRSSS CCCCCCCCCCCCCCC	42.50	30266825
1154	Phosphorylation	PRRSPSASPRSSSLP CCCCCCCCCCCCCCC	25.78	30266825
1157	Phosphorylation	SPSASPRSSSLPRTS CCCCCCCCCCCCCCC	27.88	26699800
1158	Phosphorylation	PSASPRSSSLPRTSS CCCCCCCCCCCCCCC	36.85	26699800
1159	Phosphorylation	SASPRSSSLPRTSSS CCCCCCCCCCCCCCC	43.57	24719451
1180	Phosphorylation	RPHHDQRSSSPHLGR CCCCCCCCCCCCCCC	29.54	28348404
1181	Phosphorylation	PHHDQRSSSPHLGRS CCCCCCCCCCCCCCC	50.51	28348404
1182	Phosphorylation	HHDQRSSSPHLGRSK CCCCCCCCCCCCCCC	20.00	28348404
1240	Phosphorylation	QGKSKPASKLSR--- CCCCCCCHHHCC---	42.53	-
1243	Phosphorylation	SKPASKLSR------ CCCCHHHCC------	39.41	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TTBK2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TTBK2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TTBK2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
CE164_HUMAN	CEP164	physical	22863007

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
604432	Spinocerebellar ataxia 11 (SCA11)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TTBK2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-786, AND MASSSPECTROMETRY.	19413330 [Abstract]