SFXN1_HUMAN - dbPTM
SFXN1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SFXN1_HUMAN
UniProt AC Q9H9B4
Protein Name Sideroflexin-1
Gene Name SFXN1
Organism Homo sapiens (Human).
Sequence Length 322
Subcellular Localization Mitochondrion membrane
Multi-pass membrane protein.
Protein Description Might be involved in the transport of a component required for iron utilization into or out of the mitochondria..
Protein Sequence MSGELPPNINIKEPRWDQSTFIGRANHFFTVTDPRNILLTNEQLESARKIVHDYRQGIVPPGLTENELWRAKYIYDSAFHPDTGEKMILIGRMSAQVPMNMTITGCMMTFYRTTPAVLFWQWINQSFNAVVNYTNRSGDAPLTVNELGTAYVSATTGAVATALGLNALTKHVSPLIGRFVPFAAVAAANCINIPLMRQRELKVGIPVTDENGNRLGESANAAKQAITQVVVSRILMAAPGMAIPPFIMNTLEKKAFLKRFPWMSAPIQVGLVGFCLVFATPLCCALFPQKSSMSVTSLEAELQAKIQESHPELRRVYFNKGL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MSGELPPNI
------CCCCCCCCC		40.7622814378
2Phosphorylation------MSGELPPNI
------CCCCCCCCC		40.7627486199
11UbiquitinationELPPNINIKEPRWDQ
CCCCCCCCCCCCCCC		4.7827667366
12UbiquitinationLPPNINIKEPRWDQS
CCCCCCCCCCCCCCC		58.1224816145
19PhosphorylationKEPRWDQSTFIGRAN
CCCCCCCCCEEEEEC		23.8624719451
20PhosphorylationEPRWDQSTFIGRANH
CCCCCCCCEEEEECE		17.4024719451
25UbiquitinationQSTFIGRANHFFTVT
CCCEEEEECEEEEEC		14.5021963094
46PhosphorylationLTNEQLESARKIVHD
CCHHHHHHHHHHHHH		41.8020068231
49UbiquitinationEQLESARKIVHDYRQ
HHHHHHHHHHHHHHC		49.1233845483
72AcetylationENELWRAKYIYDSAF
HHHHHHHEEEEECCC		24.4925825284
72UbiquitinationENELWRAKYIYDSAF
HHHHHHHEEEEECCC		24.4927667366
722-HydroxyisobutyrylationENELWRAKYIYDSAF
HHHHHHHEEEEECCC		24.49-
73PhosphorylationNELWRAKYIYDSAFH
HHHHHHEEEEECCCC		12.0628152594
75PhosphorylationLWRAKYIYDSAFHPD
HHHHEEEEECCCCCC		10.7628152594
77PhosphorylationRAKYIYDSAFHPDTG
HHEEEEECCCCCCCC		18.8328152594
862-HydroxyisobutyrylationFHPDTGEKMILIGRM
CCCCCCCEEEEEEEC		32.36-
86UbiquitinationFHPDTGEKMILIGRM
CCCCCCCEEEEEEEC		32.3621906983
141UbiquitinationTNRSGDAPLTVNELG
CCCCCCCCEEHHHCC		33.0527667366
162UbiquitinationTTGAVATALGLNALT
CHHHHHHHHHHHHHH		7.0133845483
173PhosphorylationNALTKHVSPLIGRFV
HHHHHCHHHHHHCHH		17.4421406692
202UbiquitinationLMRQRELKVGIPVTD
HCCCCCCCCCCEEEC		33.3921906983
218PhosphorylationNGNRLGESANAAKQA
CCCCCHHHHHHHHHH		25.6528102081
223UbiquitinationGESANAAKQAITQVV
HHHHHHHHHHHHHHH		37.5421906983
227PhosphorylationNAAKQAITQVVVSRI
HHHHHHHHHHHHHHH		20.5124719451
232PhosphorylationAITQVVVSRILMAAP
HHHHHHHHHHHHHCC		11.2921712546
244UbiquitinationAAPGMAIPPFIMNTL
HCCCCCCCHHHHHHH		14.2832015554
2532-HydroxyisobutyrylationFIMNTLEKKAFLKRF
HHHHHHHHHHHHHHC		53.14-
291PhosphorylationCALFPQKSSMSVTSL
HHHCCCCCCCCCHHH		26.4828857561
292PhosphorylationALFPQKSSMSVTSLE
HHCCCCCCCCCHHHH		23.3228857561
293SulfoxidationLFPQKSSMSVTSLEA
HCCCCCCCCCHHHHH		4.8828183972
294PhosphorylationFPQKSSMSVTSLEAE
CCCCCCCCCHHHHHH		24.9628857561
296PhosphorylationQKSSMSVTSLEAELQ
CCCCCCCHHHHHHHH		21.9328348404
297PhosphorylationKSSMSVTSLEAELQA
CCCCCCHHHHHHHHH		23.2728348404
305UbiquitinationLEAELQAKIQESHPE
HHHHHHHHHHHHCHH		31.7722817900
314MethylationQESHPELRRVYFNKG
HHHCHHHHHHHHCCC		25.10115916821
320UbiquitinationLRRVYFNKGL-----
HHHHHHCCCC-----		52.25-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SFXN1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SFXN1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SFXN1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TM14B_HUMANTMEM14Bphysical
22939629
SFXN3_HUMANSFXN3physical
22939629
TOM70_HUMANTOMM70Aphysical
22939629
SSRA_HUMANSSR1physical
22939629
TAP1_HUMANTAP1physical
22939629
T126A_HUMANTMEM126Aphysical
22939629
TOM20_HUMANTOMM20physical
22939629
VATE1_HUMANATP6V1E1physical
22939629
TIM50_HUMANTIMM50physical
22939629
TOM7_HUMANTOMM7physical
22939629
THIO_HUMANTXNphysical
22939629
UCRI_HUMANUQCRFS1physical
22939629
TM14C_HUMANTMEM14Cphysical
22939629
UBQL1_HUMANUBQLN1physical
22939629
DDI1_HUMANDDI1physical
26186194
DDI1_HUMANDDI1physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SFXN1_HUMAN

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Related Literatures of Post-Translational Modification

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